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In situ injectable hydrogel encapsulating Mn/NO-based immune nano-activator for prevention of postoperative tumor recurrence

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Asian Journal of Pharmaceutical Sciences 2024年第2期19卷 102-119页

作者： Shengnan Huang Chenyang Zhou Chengzhi Song Xiali Zhu Mingsan Miao chunming li Shaofeng Duan Yurong Hu Academy of Chinese Medical Sciences Henan University of Chinese MedicineZhengzhou 450046China School of Pharmaceutical Sciences Henan Key Laboratory of Targeting Therapy and Diagnosis for Critical DiseasesZhengzhou UniversityZhengzhou 450001China Center for Quantitative Biology Peking UniversityBeijing 100871China School of Pharmaceutical Sciences Henan University of Chinese MedicineZhengzhou 450046China Department of Pharmacy Chongqing University Cancer HospitalChongqing 400030China School of Pharmaceutical Sciences Henan UniversityZhengzhou 450046China

Postoperative tumor recurrence remains a predominant cause of treatment failure. In this study, we developed an in situ injectable hydrogel, termed MPB-NO@DOX + ATRA gel, which was locally formed within the tumor resection cavity. The MPB-NO@DOX + ATRA gel was fabricated by mixing a thrombin solution, a fibrinogen solution containing all-trans retinoic acid (ATRA), and a Mn/NO-based immune nano-activator termed MPB-NO@DOX. ATRA promoted the differentiation of cancer stem cells, inhibited cancer cell migration, and affected the polarization of tumor-associated macrophages. The outer MnO2 shell disintegrated due to its reaction with glutathione and hydrogen peroxide in the cytoplasm to release Mn2+ and produce O2, resulting in the release of doxorubicin (DOX). The released DOX entered the nucleus and destroyed DNA, and the fragmented DNA cooperated with Mn2+ to activate the cGAS-STING pathway and stimulate an anti-tumor immune response. In addition, when MPB-NO@DOX was exposed to 808 nm laser irradiation, the Fe-NO bond was broken to release NO, which downregulated the expression of PD-L1 on the surface of tumor cells and reversed the immunosuppressive tumor microenvironment. In conclusion, the MPB-NO@DOX + ATRA gel exhibited excellent anti-tumor efficacy. The results of this study demonstrated the great potential of in situ injectable hydrogels in preventing postoperative tumor recurrence.

关键词： Post-sur gical tumor recurrence In situl hydrogel Immunotherapy Tumor micr oenvir onment Manganese(Ⅱ) Nitic oxide

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In situ injectable hydrogel encapsulating Mn/NO-based immune nano-activator for prevention of postoperative tumor recurrence

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Asian Journal of Pharmaceutical Sciences 2024年第02期 104-121页

作者： Shengnan Huang Chenyang Zhou Chengzhi Song Xiali Zhu Mingsan Miao chunming li Shaofeng Duan Yurong Hu Academy of Chinese Medical Sciences Henan University of Chinese Medicine School of Pharmaceutical Sciences Henan Key Laboratory of Targeting Therapy and Diagnosis for Critical Diseases Zhengzhou University Center for Quantitative Biology Peking University School of Pharmaceutical Sciences Henan University of Chinese Medicine Department of Pharmacy Chongqing University Cancer Hospital School of Pharmaceutical Sciences Henan University

Postoperative tumor recurrence remains a predominant cause of treatment failure. In this study, we developed an in situ injectable hydrogel, termed MPB-NO@DOX + ATRA gel,which was locally formed within the tumor resection cavity. The MPB-NO@DOX + ATRA gel was fabricated by mixing a thrombin solution, a fibrinogen solution containing all-trans retinoic acid（ATRA）, and a Mn/NO-based immune nano-activator termed MPB-NO@*** promoted the differentiation of cancer stem cells, inhibited cancer cell migration,and affected the polarization of tumor-associated macrophages. The outer MnO2shell disintegrated due to its reaction with glutathione and hydrogen peroxide in the cytoplasm to release Mn2+and produce O2, resulting in the release of doxorubicin（DOX）. The released DOX entered the nucleus and destroyed DNA, and the fragmented DNA cooperated with Mn2+to activate the cGAS-STING pathway and stimulate an anti-tumor immune *** addition, when MPB-NO@DOX was exposed to 808 nm laser irradiation, the Fe-NO bond was broken to release NO, which downregulated the expression of PD-L1 on the surface of tumor cells and reversed the immunosuppressive tumor *** conclusion, the MPB-NO@DOX + ATRA gel exhibited excellent anti-tumor efficacy. The results of this study demonstrated the great potential of in situ injectable hydrogels in preventing postoperative tumor recurrence.

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基于无线通信技术的电力运行自动化控制系统设计

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通信电源技术 2024年第14期41卷 52-54页

作者：李春明国网黑龙江省电力有限公司明水县供电分公司黑龙江绥化151700

文章提出一种基于无线通信技术的电力运行自动化控制系统设计方案,旨在提高电网的智能化水平并确保电力供应的安全稳定。系统设计包括数据采集模块、无线通信模块、中央控制模块及执行模块,并通过仿真实验验证其可行性和有效性。实验结... 详细信息

文章提出一种基于无线通信技术的电力运行自动化控制系统设计方案,旨在提高电网的智能化水平并确保电力供应的安全稳定。系统设计包括数据采集模块、无线通信模块、中央控制模块及执行模块,并通过仿真实验验证其可行性和有效性。实验结果表明,该系统在数据采集精度、无线通信性能以及故障响应速度方面均表现出色,为智能电网的发展提供了可靠的技术支持。

关键词：无线通信技术电力自动化智能电网

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Two-Order Approximate and Large Stepsize Numerical Direction Based on the Quadratic Hypothesis and Fitting Method

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IEEE/CAA Journal of Automatica Sinica 2020年第3期7卷 901-909页

作者： Xiaoli Yin chunming li Yuan Zhang School of Mechanical and Electrical Engineering China University of Petroleum(East China)Qingdao 266580 Shengli College in China University of Petroleum(East China) Dongying 257061China School of Pipeline and Civil Engineering China University of Petroleum(East China)Qingdao 266580

Many effective optimization algorithms require partial derivatives of objective functions, while some optimization problems' objective functions have no derivatives. According to former research studies, some search directions are obtained using the quadratic hypothesis of objective functions. Based on derivatives, quadratic function assumptions, and directional derivatives, the computational formulas of numerical first-order partial derivatives, second-order partial derivatives, and numerical second-order mixed partial derivatives were constructed. Based on the coordinate transformation relation, a set of orthogonal vectors in the fixed coordinate system was established according to the optimization direction. A numerical algorithm was proposed, taking the second order approximation direction as an example. A large stepsize numerical algorithm based on coordinate transformation was proposed. Several algorithms were validated by an unconstrained optimization of the two-dimensional Rosenbrock objective function. The numerical second order approximation direction with the numerical mixed partial derivatives showed good results. Its calculated amount is 0.2843% of that of without second-order mixed partial derivative. In the process of rotating the local coordinate system 360°, because the objective function is more complex than the quadratic function, if the numerical direction derivative is used instead of the analytic partial derivative, the optimization direction varies with a range of 103.05°. Because theoretical error is in the numerical negative gradient direction, the calculation with the coordinate transformation is 94.71% less than the calculation without coordinate transformation. If there is no theoretical error in the numerical negative gradient direction or in the large-stepsize numerical optimization algorithm based on the coordinate transformation, the sawtooth phenomenon occurs. When each numerical mixed partial derivative takes more than one point, th

关键词： Directional derivative numerical differential optimization method quadratic function hypothesis

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基于彩虹模型的慢性呼吸系统疾病整合型药学服务模式构建与政策建议

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医药导报 2024年第7期43卷 1165-1170页

作者：钟丹李春明杨雪何霜霜李冬幸海燕陆军特色医学中心(大坪医院)药剂科重庆400042 重庆市卫生健康委员会基层卫生处重庆401147

目的构建慢性呼吸系统疾病整合型药学服务模式,并提出政策建议。方法综合运用实地走访、半结构化访谈、问卷调查等方法对重庆市医共体用药衔接改革成效及药学服务情况展开调研;利用彩虹模型从宏观、中观、微观、支持要素4个层面对存在... 详细信息

目的构建慢性呼吸系统疾病整合型药学服务模式,并提出政策建议。方法综合运用实地走访、半结构化访谈、问卷调查等方法对重庆市医共体用药衔接改革成效及药学服务情况展开调研;利用彩虹模型从宏观、中观、微观、支持要素4个层面对存在的难点进行剖析,并据此构建整合型药学服务模型。结果医共体内仍存在“三医”联动需进一步加强、配套政策不够完善、信息化支撑作用不明显、用药清单不够科学、专科协作不足、药学服务标准化有待提升等问题;建议宏观层面加强“三医”联动、提高基层医疗服务能力、完善人力资源统筹机制;中观层面继续深化医共体内药学服务改革、横向增加专科协作;微观层面建立医共体药事委员会、制定分级诊疗药学技术规范、创新“人才+技术”培养模式;支持要素层面强化区域内信息化支撑、完善激励及考核机制。结论该文创新性地构建了慢性呼吸系统疾病整合型药学服务模式,可为慢病的分级诊疗规范化建设提供参考。

关键词：整合型药学服务慢性呼吸系统疾病分级诊疗彩虹模型政策建议

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基于改进灰狼优化的桥梁检测爬壁机器人全覆盖路径规划

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计算机应用 2024年第3期44卷 966-971页

作者：黄海新于广威程寿山李春明河北工业大学土木与交通学院天津300401 交通运输部公路科学研究所北京100080 天津市交通运输基础设施养护集团有限公司天津300401

基于爬壁机器人对混凝土桥梁健康进行自动巡检是推动桥梁管养智能化的有效途径,而合理的路径规划对机器人全面获取检测数据尤为重要。针对爬壁机器人电源重量限制与巡检时能源补充困难这一工程实际问题,充分考虑主梁、高墩等桥梁构件巡... 详细信息

基于爬壁机器人对混凝土桥梁健康进行自动巡检是推动桥梁管养智能化的有效途径,而合理的路径规划对机器人全面获取检测数据尤为重要。针对爬壁机器人电源重量限制与巡检时能源补充困难这一工程实际问题,充分考虑主梁、高墩等桥梁构件巡检场景,将能量消耗指标作为性能评价优化目标函数并建立相应约束条件,进而提出全覆盖路径规划评价模型。针对传统灰狼优化(GWO)算法易陷入局部最优的不足,提出一种改进的灰狼优化(IGWO)算法。IGWO算法通过K-means聚类改善了灰狼初始种群在搜索空间难以保持相对均匀分布的特性;以非线性收敛因子提高算法局部开发能力和全局搜索性能;结合粒子群算法个体优越性的思想对位置更新公式进行改进,提升算法的模型求解能力。仿真对比实验结果表明,IGWO算法相较于GWO、差分进化(DE)与遗传算法(GA)等全局优化算法,稳定性更好,能耗降低了10.2%~16.7%,迭代次数与求解时间分别减少了19.3%~36.9%和12.8%~32.3%,路径重复率降低了0.23~1.91个百分点,同时路径长度缩短1.6%~11.0%。

关键词：灰狼优化桥梁检测爬壁机器人全覆盖路径规划能耗模型

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Pre-research on Enhanced Heat Transfer Method for Special Vehicles at High Altitude Based on Machine Learning

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Chinese Journal of Mechanical Engineering 2023年第2期36卷 314-326页

作者： chunming li Xiaoxia Sun Hongyang Gao Yu Zhang China North Vehicle Research Institute Beijing 100072China Mechanical Engineering Department Zhejiang University City CollegeHangzhou 310015China

The performance of an integrated thermal management system signi?cantly in?uences the stability of special-purpose vehicles;thus,enhancing the heat transfer of the radiator is of great signi?*** research methods for radiators include?uid mechanics numerical simulations and experimental measurements,both of which are time-consuming and *** the surrogate model to the analysis of the?ow and heat transfer in louvered?ns can effectively reduce the computational cost and obtain more data.A simpli?ed louvered-?n heat transfer unit was established,and computational?uid dynamics(CFD)simulations were conducted to obtain the?ow and heat transfer characteristics of the geometric structure.A three-factor and six-level orthogonal design was established with three structural parameters:angleθ,length a,and pitch L_p of the louvered?*** results of the orthogonal design were subjected to a range analysis,and the effects of the three parametersθ,a,and L_p on the j,f,and JF factors were ***,a proxy model of the heat transfer performance for louvered?ns was established based onthe arti?cial neural network algorithm,and the model was trained with the data obtained by the orthogonal ***,the?n structure with the largest JF factor was *** with the original model,the optimizedmodel improved the heat transfer factor j by 2.87%,decreased the friction factor f by 30.4%,and increased the comprehensive factor JF by 15.7%.

关键词： Louvered fins Numerical simulation Machine learning Comprehensive performance

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浅析地铁综合检测车二系弹簧加装内圈高圆弹簧方案

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哈尔滨铁道科技 2024年第1期 29-31页

作者：王嘉彬李春明哈尔滨哈铁装备制造有限公司黑龙江哈尔滨150080

成都地铁3号线G0306综合检测车升级后,车辆运行时一系减震器与车体底面发生摩擦现象,影响减振器正常使用及车辆运行安全。针对该现象对G0306综合检测车进行整改,整改技术方案为在原有二系弹簧组基础上加装内圈高圆弹簧,加大车架下平面... 详细信息

成都地铁3号线G0306综合检测车升级后,车辆运行时一系减震器与车体底面发生摩擦现象,影响减振器正常使用及车辆运行安全。针对该现象对G0306综合检测车进行整改,整改技术方案为在原有二系弹簧组基础上加装内圈高圆弹簧,加大车架下平面与转向架上平面间距,保证车辆运行时,一系减震器正常工作不与车体下平面发生摩擦。加装内圈弹簧后将车辆调平,在试车线进行动态测试,结果满足设计要求。

关键词：地铁综合检测车二系弹簧内圈弹簧计算验证

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Nutrient status and pollution levels in five areas around a manganese mine in southern China

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Frontiers of Environmental Science & Engineering 2020年第6期14卷 97-107页

作者： Kehui liu Xiaolu liang chunming li Fangming Yu Yi li Key Laboratory of Ecology of Rare and Endangered Species and Environmental Protection(Ministry of Education) Guangxi Normal UniversityGuilin 541004China College of life Science Guangxi Normal UniversityGuilin 541004China College of Environment and Resource Guangxi Normal UniversityGuilin 541004China

Nutrient status and pollution levels are the main factors affecting soil *** nutrient status and pollution levels in five areas,an unexplored mine area(UA),an explored mine area(EA),a tailings area(TA),a reclamation area(RA)and an agricultural area(AA),around the Pingle manganese mine in Guangxi,China,were assessed in this *** results showed that the average total phosphorus in these five areas ranged from 1.05 to 1.57 mg/kg,corresponding to grades of extremely high and *** average total nitrogen values were 0.19,0.69,0.93,1.24 and 1.67 mg/kg in EA,TA,RA,UA and AA,corresponding to grades of very low,low,medium-low,medium-high and medium-high,*** average organic matter values were 12.78,8.92,22.77,21.29 and 29.11 mg/kg in EA,TA,RA,UA and AA,which corresponded to grades of medium-low,low,medium-high,medium-high and medium-high,*** these results indicated that the total phosphorus was sufficient in these areas,while the total nitrogen and organic matter were insufficient in EA,TA and *** available concentrations of Mn and Zn corresponded to the intermediate grade,while the values for Cu corresponded to the very low grade;these might be another factor restricting ecological *** and ecological risk assessments based on the single contamination index,Nemerow multi-factor index and potential ecological risk index showed that the five tested areas around the Mn mine were considered heavily polluted and presented high ecological *** and Cd were the dominant pollutants.

关键词： Ecological reclamation Ecological risk assessment Heavy metal Mn mine Soil nutrients

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印度智库金奈中国研究中心(C3S)的建设及影响力分析

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科技智囊 2024年第7期 55-61页

作者：张金杰李春明中国国家图书馆北京100081

[研究目的]印度金奈中国研究中心(C3S)作为世界知名智库,其在智库建设方面的独特范式和显著成果具有一定研究价值。深入剖析该中心的影响力机制,为我国智库建设提供有益借鉴。[研究方法]深入探究其发展进程,从人才管理与培育、高质量学... 详细信息

[研究目的]印度金奈中国研究中心(C3S)作为世界知名智库,其在智库建设方面的独特范式和显著成果具有一定研究价值。深入剖析该中心的影响力机制,为我国智库建设提供有益借鉴。[研究方法]深入探究其发展进程,从人才管理与培育、高质量学术研究、智库产品多元传播这三个关键维度,揭示了该智库增强影响力的核心策略。[研究结论]研究显示,金奈中国研究中心的建设与发展成果,对我国创建世界顶级专项智库和特色智库具有重要启示,有助于我国在强化智库传播力和影响力方面积极创新,在提高智库质量与成果转化率方面精准施策,推动我国智库事业繁荣,为国家治理和社会进步提供更有力的智慧支持。

关键词：金奈中国研究中心(C3S) 印度智库 C3S青年头脑(YMC3S) 成果转化机制多元传播策略

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