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Journal of Pharmaceutical Analysis 2016年第4期6卷 249-255页

作者： Shuangqin Wang Jingjing Zhang Juan Liu Guangsheng Qian chunmei fu West China School of Pharmacy Sichuan University

For quality control purpose,an approach of combining chromatographic fingerprint of Huaijiao pill（HP）and simultaneous determination of its major bioactive components was developed using high performance liquid chromatography coupled with diode array detector（HPLC-DAD）.For fingerprint analysis,16 peaks were selected as the characteristic peaks to evaluate the similarities of different samples collected from different batches of three manufacturers.The similarities of 17 Huaijiao pill samples were beyond 0.966,indicating that samples from different batches and manufacturers were,to some extent,consistent.Additionally,simultaneous quantification of seven bioactive markers,namely sophoricoside,baicalin,naringin,genistein,rutin,quercetin and 5-O-methylvisammioside,in HP was performed to interpret the quality consistency.The validation of the proposed approach was acceptable,with the accuracy of 90.2%-106.9%in recovery test.The intra-day and inter-day precisions of the method were evaluated and the RSD values were less than 2.81%.The results from the quantitative data showed that the contents of six marker compounds（except for 5-O-methylvisammioside） were quite consistent between batches produced by one manufacturer and significantly distinctive among different manufacturers.The proposed approach was expected to be developed as a powerful tool for the quality control of HP.

关键词： Chromatographic fingerprint HPLC-DAD Huaijiao pill

Core-shell lipid-polymer nanoparticles as a promising ocular drug delivery system to treat glaucoma

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Chinese Chemical Letters 2020年第2期31卷 494-500页

作者： Yang Zhou Aiping Fang Fazhan Wang Huili Li Quansheng Jin Lingjing Huang chunmei fu Jun Zeng Zhaohui Jin Xiangrong Song State Key Laboratory of Biotherapy and Cancer Center/Department of Pharmacy West China Hospitaland Collaborative Innovation Center for BiotherapySichuan UniversityChengdu 610041China West China School of Pharmacy Sichuan UniversityChengdu 610041China

Nowadays,tremendous researches have been focused on the core-shell lipid-polymer nanoparticles(LPNs) due to the advantages of both liposomes and polymer nanoparticles.In this work,LPNs were applied to encapsulate brinzolamide(Brz-LPNs) for achieving sustained drug release,improving drug corneal permeation and enhancing drug topical therapeutic effect.The structure of Brz-LPNs was composed of poly(lactic-co-glycolic) acid(PLGA) nanocore which encapsulated Brz(Brz-NPs) and lipid shell around the core.Brz-LPNs were prepared by a modified thin-film dispersion method.With the parameters optimization of Brz-LPNs,optimal Brz-LPNs showed an average particle size of151.23±1.64 nm with a high encapsulation efficiency(EE) of 86.7%±2.28%.The core-shell structure of Brz-LPNs were confirmed by transmission electronic microscopy(TEM).Fourier transformed infrared spectra(FTIR) analysis proved that Brz was successfully entrapped into Brz-LPNs.Brz-LPNs exhibited obvious sustained release of Brz,compared with AZOPT^■ and Brz-LPs.furthermore,the corneal accumulative permeability of Brz-LPNs significantly increased compared to the commercial available formulation(AZOPT^■) in vitro.Moreover,Brz-LPNs(1 mg/mL Brz) showed a more sustained and effective intraocular pressure(IOP) reduction than Brz-LPs(1 mg/mL) and AZOPT^■(10 mg/mL Brz) in vivo.In conclusion,Brz-LPNs,as promising ocular drug delivery systems,are well worth developing in the future for glaucoma treatment.

关键词： Core-shell lipid-polymer nanoparticles Ocular drug delivery system Sustained release Corneal permeation Intraocular pressure

降糖舒胶囊结合西格列汀对老年T2DM患者糖脂代谢及胰岛功能的影响

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糖尿病新世界 2024年第8期27卷 90-93页

作者：谢靖林燕傅春梅龙岩人民医院药剂科福建龙岩364000

目的探究老年2型糖尿病(Type 2 Diabetes Mellitus,T2DM)患者采用降糖舒胶囊结合西格列汀的临床疗效。方法选取2022年1月-2023年12月龙岩人民医院收治的80例T2DM患者为研究对象,依据随机数表法分为两组,各40例。对照组采用磷酸西格列汀... 详细信息

目的探究老年2型糖尿病(Type 2 Diabetes Mellitus,T2DM)患者采用降糖舒胶囊结合西格列汀的临床疗效。方法选取2022年1月-2023年12月龙岩人民医院收治的80例T2DM患者为研究对象,依据随机数表法分为两组,各40例。对照组采用磷酸西格列汀治疗,观察组采用磷酸西格列汀+降糖舒胶囊治疗。对比两组糖脂代谢水平、胰岛功能、炎性因子水平。结果观察组各项糖脂代谢水平低于对照组,差异有统计学意义(P均<0.05)。观察组各项胰岛功能均优于对照组,差异有统计学意义(P均<0.05)。观察组各项炎性因子水平低于对照组,差异有统计学意义(P均<0.05)。结论在对老年T2DM治疗时,磷酸西格列汀联合降糖舒胶囊可改善糖脂代谢水平,提高胰岛素功能。

关键词：老年 2型糖尿病降糖舒胶囊西格列汀胰岛素功能

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结肠冗长症研究进展

中国中医药现代远程教育 2024年第7期22卷 161-163页

作者：傅春梅许增华余杨红江西中医药大学临床医学院江西南昌330006 江西省儿童医院消化内科江西南昌330006 江西省儿童医院放射科江西南昌330006

结肠冗长症是一种先天性结肠畸形疾病,是顽固性便秘的重要原因,也是儿童便秘的常见病因。目前该病发展主要集中在诊断技术更新和手术治疗两方面,相关的治疗性研究较少,缺乏行之有效的非手术治疗方法。此文从病理机制、诊断和治疗方面整... 详细信息

结肠冗长症是一种先天性结肠畸形疾病,是顽固性便秘的重要原因,也是儿童便秘的常见病因。目前该病发展主要集中在诊断技术更新和手术治疗两方面,相关的治疗性研究较少,缺乏行之有效的非手术治疗方法。此文从病理机制、诊断和治疗方面整理该疾病的现有发展状况,以期为该病非手术治疗研究提供新的思路和方向。

关键词：结肠冗长症病理机制诊断治疗综述

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再生铝棒生产项目产污环节研究

中国铸造装备与技术 2024年第1期59卷 22-26页

作者：付春梅勾东东韩小问李青河北欣众环保科技有限公司河北沧州061000

为摸清再生铝棒生产项目污染物排放情况,系统梳理再生铝棒生产项目典型生产工艺,逐一分析各生产环节的污染物产生情况,其中重点关注的污染物是废气和固体废物。全面排查再生铝棒生产项目各环节的污染物产生,有助于再生铝棒行业绿色可持... 详细信息

为摸清再生铝棒生产项目污染物排放情况,系统梳理再生铝棒生产项目典型生产工艺,逐一分析各生产环节的污染物产生情况,其中重点关注的污染物是废气和固体废物。全面排查再生铝棒生产项目各环节的污染物产生,有助于再生铝棒行业绿色可持续发展。

关键词：再生铝产污环节废气固体废物

Machine learning-assisted efficient design of Cu-based shape memory alloy with specific phase transition temperature

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International Journal of Minerals,Metallurgy and Materials 2024年第4期31卷 773-785页

作者： Mengwei Wu Wei Yong Cunqin fu chunmei Ma Ruiping Liu Department of Materials Science and Engineering China University of Mining&Technology(Beijing)Beijing 100083China Institute for Advanced Materials and Technology University of Science and Technology BeijingBeijing 100083China

The martensitic transformation temperature is the basis for the application of shape memory alloys(SMAs),and the ability to quickly and accurately predict the transformation temperature of SMAs has very important practical significance.In this work,machine learning(ML)methods were utilized to accelerate the search for shape memory alloys with targeted properties(phase transition temperature).A group of component data was selected to design shape memory alloys using reverse design method from numerous unexplored data.Component modeling and feature modeling were used to predict the phase transition temperature of the shape memory alloys.The experimental results of the shape memory alloys were obtained to verify the effectiveness of the support vector regression(SVR)model.The results show that the machine learning model can obtain target materials more efficiently and pertinently,and realize the accurate and rapid design of shape memory alloys with specific target phase transition temperature.On this basis,the relationship between phase transition temperature and material descriptors is analyzed,and it is proved that the key factors affecting the phase transition temperature of shape memory alloys are based on the strength of the bond energy between atoms.This work provides new ideas for the controllable design and performance optimization of Cu-based shape memory alloys.

关键词： machine learning support vector regression shape memory alloys martensitic transformation temperature

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再生铜熔炼工艺“三废”治理研究

中国铸造装备与技术 2024年第2期59卷 55-57页

作者：付春梅勾东东韩小问李春雨河北欣众环保科技有限公司河北沧州061000 沧州安能环保工程有限公司河北沧州061000

再生铜生产项目污染物防控的最重要环节就是熔炼工序,熔炼全过程中以废气污染物对环境影响最为显著。通过对再生铜企业污染状况调查,重点分析再生铜生产原辅材料、反射炉机构及其熔炼机理、生产过程、污染物种类和治理措施可行性等方面... 详细信息

再生铜生产项目污染物防控的最重要环节就是熔炼工序,熔炼全过程中以废气污染物对环境影响最为显著。通过对再生铜企业污染状况调查,重点分析再生铜生产原辅材料、反射炉机构及其熔炼机理、生产过程、污染物种类和治理措施可行性等方面,确定熔炼污染物是否能够稳定达标排放。

关键词：再生铜熔炼污染物

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临床药学专业药物分析实验教学探索

药学教育 2024年第1期40卷 72-75页

作者：刘秀秀付春梅熊茉君尹红梅四川大学华西药学院成都610041

为提高临床药学专业药物分析实验课教学质量,该文结合临床药学专业的特点,从教学模式、教学策略和评价体系等方面对临床药学专业药物分析实验教学进行反思和探索,以期提高实验教学效果。

关键词：药物分析实验教学临床药学教学改革

Transient induction of actin cytoskeletal remodeling associated with dedifferentiation,proliferation,and redifferentiation stimulates cardiac regeneration

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Acta Pharmaceutica Sinica B 2024年第6期14卷 2537-2553页

作者： Wenbin fu Qiao Liao Yu Shi Wujian Liu Hongmei Ren chunmei Xu Chunyu Zeng Department of Cardiology Daping Hospitalthe Third Military Medical University(Army Medical University)Chongqing 400042China Key Laboratory of Geriatric Cardiovascular and Cerebrovascular Disease Research Ministry of Education of ChinaChongqing 400042China Chongqing Key Laboratory for Hypertension Research Chongqing Cardiovascular Clinical Research CenterChongqing Institute of CardiologyChongqing 400042China State Key Laboratory of Trauma Burns and Combined InjuryDaping Hospitalthe Third Military Medical UniversityChongqing 400042China Cardiovascular Research Center Chongqing CollegeUniversity of Chinese Academy of SciencesChongqing 400042China State Key Laboratory of Trauma and Chemical Poisoning Chongqing 400042China

The formation of new and functional cardiomyocytes requires a 3-step process:dedifferentiation,proliferation,and redifferentiation,but the critical genes required for efficient dedifferentiation,proliferation,and redifferentiation remain unknown.In our study,a circular trajectory using single-nucleus RNA sequencing of the pericentriolar material 1 positive(PCM1^(+))cardiomyocyte nuclei from hearts 1 and 3 days after surgery-induced myocardial infarction(MI)on postnatal Day 1 was reconstructed and demonstrated that actin remodeling contributed to the dedifferentiation,proliferation,and redifferentiation of cardiomyocytes after injury.We identified four top actin-remodeling regulators,namely Tmsb4x,Tmsb10,Dmd,and Ctnna3,which we collectively referred to as 2D2P.Transiently expressed changes of 2D2P,using a polycistronic non-integrating lentivirus driven by Tnnt2(cardiac-specific troponin T)promoters(Tnnt2-2D2P-NIL),efficiently induced transiently proliferative activation and actin remodeling in postnatal Day 7 cardiomyocytes and adult hearts.furthermore,the intramyocardial delivery of Tnnt2-2D2P-NIL resulted in a sustained improvement in cardiac function without ventricular dilatation,thickened septum,or fatal arrhythmia for at least 4 months.In conclusion,this study highlights the importance of actin remodeling in cardiac regeneration and provides a foundation for new gene-cocktail-therapy approaches to improve cardiac repair and treat heart failure using a novel transient and cardiomyocyte-specific viral construct.

关键词： Single cell analysis Actin remodeling Tmsb4x Tmsb10 Dmd Ctnna3 Myocardial infarction Cardiomyocytes proliferation Cardiac regeneration Genetic therapy

Transcriptome and morphological analyses of double flower formation in Dianthus chinensis

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Horticultural Plant Journal 2024年第1期10卷 181-193页

作者： Xiaoni Zhang Shengnan Lin Quanshu Wu Qijian Wang chunmei Shi Manzhu Bao Mohammed Bendahmane Xiaopeng fu Zhiqiang Wu Guangdong Laboratory for Lingnan Modern Agriculture Genome Analysis Laboratory of the Ministry of AgricultureAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhenGuangdong 518120China Key Laboratory of Horticultural Plant Biology College of Horticulture and Forestry SciencesHuazhong Agricultural UniversityWuhanHubei 430070China Laboratoire Reproduction et Development des Plantes INRA-CNRS-Lyon1-ENSEcole Normale Superieure de LyonLyon 520074France

The double flower developmental process is regulated via a complex transcriptional regulatory network.To understand this highly dynamic and complex developmental process of Dianthus spp.,we performed a comparative analysis of floral morphology and transcriptome dynamics in simple flowers and double flowers.We found that the primordium of double flowers of‘X’was larger in size compared to that of simple flowers of‘L’in Dianthus chinensis.RNA-seq and Weighted Gene Co-expression Network Analysis(WGCNA)during flower development,identified stage-specific gene network modules.Expression analysis by RNA-seq indicated that a group of genes related to floral meristem identity,primordia position and polarity were highly expressed in double flowers genotypes compared to simple flowers genotypes,suggesting their roles in double-petal formation.A total of 21 DEGs related to petal number were identified between simple and double flowers.The experiments of in situ hybridization revealed that DcaAP2L,DcaLFY and DcaUFO genes were expressed in the intra-sepal boundary and petal boundary.We proposed a potential transcriptional regulatory network for simple and double flower development.This study provides novel insights into the molecular mechanism underlying double flower formation in Dianthus spp.

关键词： Dianthus spp. Petal boundary Floral morphology Double flower Co-expression network