检索结果-南通市图书馆

基于数据挖掘探讨益气养阴类中成药治疗糖尿病用药规律

在线全文

学校读者我要写书评

暂无评论

新中医 2024年第20期56卷 8-14页

作者：孙文杰赵能江李博张智海代春美杨叔禹厦门大学附属第一医院中医工作室福建厦门361003 锦州医科大学药学院辽宁锦州121001 厦门大学医学院中西医结合中心福建厦门361003

目的:采用数据挖掘方法探讨益气养阴类中成药治疗糖尿病用药规律。方法:筛选2020年版《国家医保目录》、2020年版《中华人民共和国药典》、2018年版《国家基本药物目录》以及相关糖尿病防治指南中治疗糖尿病的益气养阴类中成药,利用古... 详细信息

目的:采用数据挖掘方法探讨益气养阴类中成药治疗糖尿病用药规律。方法:筛选2020年版《国家医保目录》、2020年版《中华人民共和国药典》、2018年版《国家基本药物目录》以及相关糖尿病防治指南中治疗糖尿病的益气养阴类中成药,利用古今医案云平台对中成药的使用频次、性味归经、关联规则、聚类和复杂网络进行分析。结果:共纳入38个益气养阴类中成药,涉及92味中药。治疗糖尿病的高频药物有黄芪、地黄、五味子、天花粉等,性味以甘、(微)寒为主,主入肺、肾经。益气养阴类中成药治疗糖尿病的常用药物组合有地黄-麦冬、麦冬-五味子、葛根-黄芪等;聚类分析得到枸杞子-五倍子-人参-知母-丹参-天花粉-黄芪-地黄-葛根-五味子-麦冬、牡丹皮-女贞子-山药-山茱萸-茯苓-泽泻、玉竹-牛膝-石膏-玄参-党参、黄连-苍术-黄精-荔枝核、水蛭-太子参、甘草-红参等6首新处方;复杂网络分析得到黄芪-地黄-五味子核心中药组合。结论:益气养阴类中成药治疗糖尿病的核心药物为黄芪、地黄、五味子,其用药以益气养阴药为主,常兼清热、活血以治疗糖尿病肾病及糖尿病视网膜病变等多种并发症,临床常选择消渴方、津立达、渴络欣等中成药对症治疗。

关键词：糖尿病益气养阴中成药古今医案云平台用药规律

Macrophage-derived exosomal miR-342-3p promotes the progression of renal cell carcinoma through the NEDD4L/CEP55 axis

在线全文

学校读者我要写书评

暂无评论

Oncology Research 2021年第5期29卷 331-349页

作者： JIAFU FENG BEI XU chunmei dai YAODONG WANG GANG XIE WENYU YANG BIN ZHANG XIAOHAN LI JUN WANG NHC Key Laboratory of Nuclear Technology Medical Transformation(Mianyang Central Hospital) Mianyang621000China Departments of Clinical Laboratory Mianyang Central HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaMianyang621000China Medical Technology Institute Chengdu University of Traditional Chinese MedicineChengdu611137China Departments of Urology Surgery Mianyang Central HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaMianyang621000China Departments of Pathology Mianyang Central HospitalSchool ofMedicineUniversity of Electronic Science and Technology of ChinaMianyang621000China Department of Medical Laboratory Affiliated Hospital of Southwest Medical UniversityLuzhou646000China

Due to its difﬁculty in early diagnosis and lack of sensitivity to chemotherapy and radiotherapy,renal cell carcinoma(RCC)remains to be a frequent cause of cancer-related ***,we probed into new targets for its early diagnosis and treatment for ***(miRNA)data of M2-EVs and RCC were searched on the Gene Expression Omnibus database,followed by the prediction of the potential downstream *** of target genes was measured via RT-qPCR and Western blot,respectively.M2 macrophage was obtained viaﬂow cytometry with M2-EVs *** binding ability of miR-342-3p to NEDD4L and to CEP55 ubiquitination was studied with their roles in the physical abilities of RCC cells *** tumor-bearing mouse models and lung metastasis models were prepared to observe in vivo role of target genes.M2-EVs induced RCC growth and ***-342-3p showed high expression in both M2-EVs and RCC cells.M2-EVs carrying miR-342-3p promoted RCC cell abilities to proliferate,invade and *** RCC cells,M2-EV-derived miR-342-3p could speciﬁcally bind to NEDD4L and consequently elevate CEP55 protein expression via suppressing NEDD4L,thereby exerting tumor-promoting ***55 could be degraded by ubiquitination under the function of NEDD4L,and miR-342-3p delivered by M2-EVs facilitated the RCC occurrence and development by activating the PI3K/AKT/mTOR signaling *** conclusion,M2-EVs promote RCC growth and metastasis by delivering miR-342-3p to suppress NEDD4L and subsequently inhibit CEP55 ubiquitination and degradation via activation of the PI3K/AKT/mTOR signaling pathway,strongly driving the proliferative,migratory and invasive of RCC cells.

关键词： Renal cell carcinoma M2 macrophage miR-342-3p NEDD4L CEP55 PI3K/AKT/mTOR signaling pathway

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

药学与临床药学专业的教育现状与生态学分析

中国医学教育技术 2024年第2期38卷 150-154页

作者：孙玉琦代春美董秋菊郭斌刘俊鹏蔡东锦州医科大学药学院辽宁锦州121001

中国药学高等教育经历百年沧桑,逐渐形成门类齐全、专业丰富的教育体系。药学和临床药学是分别以提供“药学产品”和“药学服务”为主的两个极其重要的本科专业。文章对2023年教育部直属和省属公办高校的药学专业、临床药学专业培养目... 详细信息

中国药学高等教育经历百年沧桑,逐渐形成门类齐全、专业丰富的教育体系。药学和临床药学是分别以提供“药学产品”和“药学服务”为主的两个极其重要的本科专业。文章对2023年教育部直属和省属公办高校的药学专业、临床药学专业培养目标、院校地域分布、重点院校和院校类别情况进行统计;从教育生态学的视角对从事药学、临床药学专业教育的行政管理人员、教师、学生等生态主体要素,管理制度、课程体系等生态客体要素,内部环境和外部环境等生态环境要素进行分析,为协调药学、临床药学各生态学要素之间的关系,推动药学教育发展提出建议。

关键词：药学专业临床药学专业教育现状教育生态学

Metal–ligand interfaces for well-defined gold nanoclusters

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 2024年第3期67卷 806-823页

作者： Dan Yang Yating Wu Zhaotong Yuan chunmei Zhou Yihu dai Xiaoyue Wan Yan Zhu Yanhui Yang Institute of Advanced Synthesis School of Chemistry and Molecular EngineeringNanjing Tech UniversityNanjing 211816China School of Chemistry and Chemical Engineering Nanjing UniversityNanjing 210093China College of Material and Chemical Engineering Minjiang UniversityFuzhou 350108China

Ligand engineering for well-defined gold nanoclusters(Au NCs) is getting more extensive attention. Organizing the Au-ligand interfaces on gold NCs can achieve the structural and functional control. This review focuses on the Au-ligand interfaces including gold-phosphorus(Au-P), gold-sulfur(Au-S), gold-selenium(Au-Se), gold-carbon(Au-C), and gold-nitrogen(Au-N), derived from the bonding between Au atoms and the different ligands(e.g., organic phosphine, thiolate, selenolate, alkynyl,n-heterocyclic carbene and nitrogenous ligands). The formation mechanism of Au-ligand interfaces is well discussed. In addition, the effects of Au-ligand interfaces on the stability, optical property, and catalysis are also presented. We hope the advances in this research area can boost the development of Au NC sciences.

关键词： Au nanoclusters well-defined structures metal–ligand interfaces formation mechanism structure–property correlation

基于网络药理学和动物试验研究守正代茶饮增强免疫功能的潜在作用机制

在线全文

学校读者我要写书评

暂无评论

成都中医药大学学报 2024年第4期47卷 14-23页

作者：李朝晖李金融任颖苏全贵苏忆明许舒瑜代春美杨叔禹安溪县中医院福建泉州362000 南普陀中医院福建厦门361000 锦州医科大学辽宁锦州121000 厦门大学附属第一医院福建厦门361000

目的:采用网络药理学和体内试验研究守正代茶饮对正常小鼠免疫增强的潜在作用机制。方法:通过TCMSP、Swiss Target Prediction数据库获取守正代茶饮的活性成分及对应靶标;GeneCards数据库得到免疫相关靶点并与药物靶点取交集;通过STRING... 详细信息

目的:采用网络药理学和体内试验研究守正代茶饮对正常小鼠免疫增强的潜在作用机制。方法:通过TCMSP、Swiss Target Prediction数据库获取守正代茶饮的活性成分及对应靶标;GeneCards数据库得到免疫相关靶点并与药物靶点取交集;通过STRING和DAVID数据库,对交集靶点进行PPI网络分析和GO、KEGG富集分析,于Cytoscape 3.9.1构建“守正代茶饮-潜在活性化合物-靶点”和“成分-靶点-通路”网络,AutoDock Tools进行分子对接验证。小鼠碳廓清试验、迟发型变态反应试验、血清溶血素试验及Western Blot对部分靶点进行验证。结果:守正代茶饮的活性成分108种,增强免疫力交集靶点114个,核心成分为槲皮素、β-谷甾醇、山柰酚、豆甾醇、木犀草素等;关键靶点为PTGS2、HSP90AB1、PRKACA、RELA、Akt1等;主要参与药物的应答、基因表达的正调节、凋亡过程的负调控、TNF、PI3K-Akt、IL-17等生物过程和信号通路;关键靶点和核心成分亲和力较强。动物试验结果显示,与空白组比较,守正代茶饮低、中、高剂量组增强小鼠迟发型变态反应水平;中、高剂量组改善巨噬细胞吞噬活性;中、高剂量组p-PI3K、p-Akt、p-P65蛋白表达均上调(P<0.01)。结论:守正代茶饮具有增强免疫力的功能,可能通过PI3K-Akt/NF-κB信号通路促进免疫活性物质的释放,发挥免疫调节作用。

关键词：守正代茶饮增强免疫力网络药理学分子对接 PI3K-Akt/NF-κB通路

Alloy as advanced catalysts for electrocatalysis:From materials design to applications

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2024年第6期35卷 104-122页

作者： Pingfan Zhang Shihuan Hong Ning Song Zhonghui Han Fei Ge Gang dai Hongjun Dong chunmei Li Advanced Chemical Engineering Laboratory of Green Materials and Energy of Jiangsu Province Institute of Green Chemistry and Chemical TechnologySchool of Chemistry and Chemical EngineeringJiangsu UniversityZhenjiang 212013China Daqo Group Co.Ltd. Zhenjiang 212221China Key Laboratory of Groundwater Resources and Environment Ministry of EducationJilin Provincial Key Laboratory of Water Resource and EnvironmentCollege of New Energy and EnvironmentJilin UniversityChangchun 130021China

With the deep integration of electrochemical research with energy,environment,catalysis,and other fields,more and more new electrochemical catalytic reactions have entered our research *** catalysts have recently emerged as a new type of nanomaterial due to the rapid development of kinetic controlled synthesis *** materials offer several advantages over monometallic catalysts,including larger element combinations,complex geometries,bifunctional sites,and reduced use of precious *** paper provides a review of alloy electrocatalysts that are designed and prepared specifically for electrocatalytic *** use of alloy materials in electrocatalyst design is also discussed,highlighting their widespread application in this ***,various synthesis methods and synthesis mechanisms are systematically *** that,by correlating the properties of materials with the structure,relevant strategies toward advanced alloy electrocatalysts including composition regulation,size,morphology,surface engineering,defect engineering,interface engineering and strain engineering are *** addition,the important electrocatalytic applications and mechanisms of alloy electrocatalysts are described and ***,the current challenges and prospects regarding the development of alloy nanomaterials are *** review serves as a springboard from a fundamental understanding of alloy structural dynamics to design and various applications of electrocatalysts,particularly in energy and environmental sustainability.

关键词： Alloy Nanomaterial Electrocatalyst Materials design Electrocatalysis

An intelligent prediction model of epidemic characters based on multi-feature

在线全文

学校读者我要写书评

暂无评论

CAAI Transactions on Intelligence Technology 2024年第3期9卷 595-607页

作者： Xiaoying Wang chunmei Li Yilei Wang Lin Yin Qilin Zhou Rui Zheng Qingwu Wu Yuqi Zhou Min dai Information Center Third Affiliated Hospital of Sun Yat‐sen UniversityGuangzhouChina School of Computer Science Qufu Normal UniversityRizhaoChina Department of Allergy Third Affiliated Hospital of Sun Yat‐sen UniversityGuangzhou China 4Department of Otorhinolaryngology‐Head and Neck Surgery Third Affiliated Hospital of Sun Yat‐sen UniversityGuangzhouChina Department of Pulmonary and Critical Care Medicine Third Affiliated Hospital of Sun Yat‐sen UniversityGuangzhouChina Department of Traditional Chinese Medicine Third Affiliated Hospital of Sun Yat‐sen UniversityGuangzhouChina

The epidemic characters of Omicron(***-scale transmission)are significantly different from the initial variants of *** data generated by large-scale transmission is important to predict the trend of epidemic ***,the re-sults of current prediction models are inaccurate since they are not closely combined with the actual situation of Omicron *** consequence,these inaccurate results have negative impacts on the process of the manufacturing and the service industry,for example,the production of masks and the recovery of the tourism *** authors have studied the epidemic characters in two ways,that is,investigation and ***,a large amount of data is collected by utilising the Baidu index and conduct questionnaire survey concerning epidemic ***,theβ-SEIDR model is established,where the population is classified as Susceptible,Exposed,Infected,Dead andβ-Recovered persons,to intelligently predict the epidemic characters of *** thatβ-Recovered persons denote that the Recovered persons may become Sus-ceptible persons with probabilityβ.The simulation results show that the model can accurately predict the epidemic characters.

关键词： artificial intelligence big data data analysis evaluation feature extraction intelligent information processing medical applications

无碱玻璃配合料熔化过程中的物化反应和能量消耗——叶腊石与高岭土和石英砂组合之间的比较

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

硅酸盐学报 2011年第4期39卷 652-656页

作者：代春梅李金平淄博中材庞贝捷金晶玻纤有限公司山东淄博255086 大连理工大学工程力学系辽宁大连116024

采用X射线衍射法研究了两种分别以叶腊石为主要原料但不含石英砂和以高岭土与石英砂为主要原料的无碱玻璃配合料从室温到1200℃的物化反应。采用差热-热重同步分析仪研究了这两种配合料从室温到1400℃的能量消耗以及吸放热反应。结果表... 详细信息

采用X射线衍射法研究了两种分别以叶腊石为主要原料但不含石英砂和以高岭土与石英砂为主要原料的无碱玻璃配合料从室温到1200℃的物化反应。采用差热-热重同步分析仪研究了这两种配合料从室温到1400℃的能量消耗以及吸放热反应。结果表明:以叶腊石为主要原料的无碱玻璃配合料比以高岭土为主要原料的配合料在熔化过程中少消耗的能量为50J/g;将配合料由固态转变成玻璃态,以及保持这种随机的不规则玻璃态所需的能量很高,约占总能耗的55%～56%。

关键词：玻璃纤维无碱玻璃物化反应能量消耗

Heme oxygenase-1 ameliorates oxidative stress-induced endothelial senescence via regulating endothelial nitric oxide synthase activation and coupling

在线全文

学校读者我要写书评

暂无评论

Heme oxygenase-1 ameliorates oxidative stress-induced endoth...