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舍曲林对强迫症患者临床症状、执行功能和职业功能的远期效果

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中华行为医学与脑科学杂志 2014年第6期23卷 507-510页

作者：丘春柳汕头大学医学院第一附属医院精神心理科汕头515041

目的探讨舍曲林对强迫症临床症状、执行功能和职业功能的远期效果.方法对强迫症患者按随机分组原则,研究组48例以舍曲林治疗,对照组44例以氯米帕明治疗,好转后以相对稳定剂量维持,均辅以心理治疗和康复活动.于治疗前、治疗2周末、4周... 详细信息

目的探讨舍曲林对强迫症临床症状、执行功能和职业功能的远期效果.方法对强迫症患者按随机分组原则,研究组48例以舍曲林治疗,对照组44例以氯米帕明治疗,好转后以相对稳定剂量维持,均辅以心理治疗和康复活动.于治疗前、治疗2周末、4周末、6周末、8周末各时点分别调查和比较两组患者的强迫症状检出率;随访2年,以耶鲁布朗强迫症量表（Y-BOCS）总分减分率评估8周末和2年的临床疗效,完成连线测验A和B（TMT-A和TMT-B）、Stroop测验、社会功能缺陷筛选量表（SDSS）以评估执行功能和社会职业功能,并进行组间比较.结果研究组治疗4周末的强迫观念（62.5％）和6周末的强迫行为检出率（18.8％）均显著低于对照组（分别为81.8％和38.6％,P＜0.05）,但8周末（8.3％～22.9％）和2年的强迫症状检出率（6.3％～12.5％）与对照组（分别为20.5％～40.9％和15.9％～22.7％）之间差异无统计学意义（P＞0.05）.8周末和2年的临床疗效两组之间差异也无统计学意义（P＞0.05）.治疗2年后研究组的连线测验B时间[（46.4±6.4）s]和彩色文字的颜色阅读时间[Stroop-CW（132.2±14.9）s]均显著短于对照组[分别为（49.3±6.5）s和（138.8±15.7）s,P＜0.05].治疗第2年随访显示SDSS总分及职业功能因子分研究组均显著低于对照组（P＜0.01）,而就业率研究组（72.9％）显著高于对照组（47.7％,P＜0.05）.研究组不良反应总发生率（12.5％）显著低于对照组（43.2％,P＜0.05）.结论舍曲林对强迫症临床症状的效果与氯米帕明相当,但远期对改善执行功能和职业功能显著更优.

关键词：强迫症舍曲林执行功能社会功能

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体制机制创新:“双高计划”背景下高职院校改革的生长点

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职教论坛 2021年第12期37卷 143-148页

作者：王春柳浙江工贸职业技术学院

“双高计划”学校作为引领职业教育改革发展的领头雁和排头兵,必须是创新型学校,要以体制机制创新为突破口,促进系统性变革和整体性创新。文章探讨了“双高计划”背景下高职院校体制机制创新的重要性,通过对高职院校现有体制机制创新的... 详细信息

“双高计划”学校作为引领职业教育改革发展的领头雁和排头兵,必须是创新型学校,要以体制机制创新为突破口,促进系统性变革和整体性创新。文章探讨了“双高计划”背景下高职院校体制机制创新的重要性,通过对高职院校现有体制机制创新的现状分析,指出办学体制机制不完善、治理体制机制不健全、质量保障机制不匹配、激励评价机制不科学等困境,并结合浙江工贸职业技术学院的建设实践,提出了“双高计划”背景下高职院校体制机制创新变革的对策与路径。

关键词：体制机制创新双高计划高职院校生长点

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Imperatorin suppresses proliferation and angiogenesis of human colon cancer cell by targeting HIF-1α via the m TOR/p70S6K/4EBP1 and MAPK pathways

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Imperatorin suppresses proliferation and angiogenesis of hum...

中国化学会第十一届全国天然有机化学学术会议

作者： chunliu Mi Juan Ma Ke Si Wang Xuejun Jin Key laboratory of Natural Resources of Changbai Mountain ＆ Functional Molecules Ministry of education Molecular Medicine Research Center College of Pharmacy Yanbian University

Imperatorin is an active natural furocoumarin component originating from the traditional Chinese medicine Angelica dahurica and has been shown to exhibit multiple bioeffector functions, including anti-cancer activity. However, the mechanism by which imperatorin inhibits tumor growth is not fully understood. We here demonstrated the effect of imperatorin on HIF-1 activation. Imperatorin showed a potent inhibitory activity against HIF-1 activation induced by hypoxia in various human cancer cell lines. This compound markedly decreased the hypoxia-induced accumulation of HIF-1α protein dose-dependently, whereas it did not affect the expressions of HIF-1β and topoisomerase-I（Topo-I）. Further analysis revealed that imperatorin inhibited HIF-1α protein synthesis, without affecting the expression level of HIF-1α m RNA or degradation of HIF-1α protein. Moreover, the phosphorylation levels of mammalian target of rapamycin（m TOR）, ribosomal protein S6 kinase（p70S6K）, e IF4 E binding protein-1（4E-BP1）, eukaryotic initiation factor 4E（e IF4E）, extracellular signalregulated kinase-1/2（ERK1/2）, SAPK/JNK and p38 were significantly suppressed by imperatorin. Furthermore, imperatorin prevented hypoxia-induced expression of HIF-1 target genes and flow cytometric analysis indicated that imperatorin induced G1 phase arrest in human colon cancer cell（HCT116）. We found that imperatorin administration inhibits tumor growth and blocks tumor angiogenesis in a xenograft tumor model. Taken together, our results suggested that imperatorin is an effective inhibitor of HIF-1, thereby, providing new perspectives into the mechanism of its anticancer activity.

关键词： imperatorin HIF-1α translation antitumor

Advances in reactive co-precipitation technology for preparing high-performance cathodes

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Green Carbon 2023年第2期1卷 193-209页

作者： Zhenzhen Wang li Yang chunliu Xu Jingcai Cheng Junmei Zhao Qingshan Huang Chao Yang Key laboratory of Biofuels Qingdao Institute of Bioenergy and Bioprocess Technology(QIBEBT)Chinese Academy of Sciences(CAS)QingdaoShandong 266101China CAS Key laboratory of Green Process and Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China Shandong Energy Institute Qingdao 266101ShandongChina Qingdao New Energy Shandong laboratory Qingdao 266101ShandongChina

Reactive crystallization plays an essential role in the synthesis of high-quality precursors with a narrow particle size distribution,dense packing,and high *** features are beneficial in the fabrication of high-specific-capacity and long-cycle-life cathodes for lithium-ion and sodium-ion ***,in industrial production,designing and scaling-up crystallizers involves the use of semi-empirical approaches,making it challenging to satisfactorily meet techno-economic ***,there is still a lack of in-depth knowledge on the theoretical models and technical calculations of the current co-precipitation *** review elaborates on critical advances in the theoretical guidelines and process regulation strategies using a reactive crystallizer for the preparation of precursors by *** research progress on the kinetic models of co-precipitation reactive crystallization is *** addition,the regulation strategies for the reactive crystallization process of lithium-ion ternary cathodes are described in *** include the influence of different reactive crystallizer structures on the precursor's morphology and performance,the intelligent online measurement of efficient reactive crystallizers to ensure favorable conditions of co-precipitation,and preparing the precursor with a high tap density by increasing its solid holdup.A controllable reactive crystallization process is described in terms of the structural design with concentration gradient materials and bulk gradient doping of advantageous elements(such as magnesium ion)in lithium-ion cathodes and the fabrication of sodium-ion cathodes with three typical materials-Prussian blue analogues,transition metal oxides,and polyanionic phosphate compounds being involved.

关键词： Reactive crystallization Kinetic models Crystallizer Regulation strategy Cathode materials

Artemisinin inhibits inflammatory response via regulating NF-κB and MAPK signaling pathways

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Artemisinin inhibits inflammatory response via regulating NF...

中国化学会第十一届全国天然有机化学学术会议

作者： Ke Si Wang chunliu Mi Juan Ma Xuejun Jin Key laboratory of Natural Resources of Changbai Mountain ＆ Functional Molecules Ministry of education Molecular Medicine Research Center College of Pharmacy Yanbian University

Artemisinin, isolated from the Chinese plant Artemisia annua, has been used for many years to treat different forms of malarial parasites. In this study, we explored the antiinflammatory activity of artemisinin and the underlying mechanism of this action. We demonstrated that the anti-inflammatory effects of artemisinin in TPA-induced skin inflammation in mice. Then the artemisinin significantly inhibited the expression of NF-κB reporter gene induced by TNF-α in a dose-dependent manner. Artemisinin also inhibited TNF-α induced phosphorylation and degradation of IκBα, p65 nuclear translocation. Furthermore, pretreatment of cells with artemisinin prevented the TNF-α-induced expression of NF-κB target genes, such as anti-apoptosis（c-IAP1, Bcl-2, and FlIP）, proliferation（COX-2, cyclin D1）, invasion（MMP-9）, angiogenesis（VEGF）, and major inflammatory cytokines（TNF-α, i NOS, and MCP1）. We also proved that artemisinin potentiated TNF-α-induced apoptosis. Moreover, artemisinin significantly impaired the ROS production and phosphorylation of p38 and ERK, but did not affect the phosphorylation of JNK. Taken together, artemisinin may be a potentially useful therapeutic agent for inflammatory-related diseases.

关键词： Artemisinin Inflammation Nuclear factor-κB(NF-κB) IκBα MAPK

FcRn receptor specific nanoparticles conjugated with functional peptide for oral delivry

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FcRn receptor specific nanoparticles conjugated with functio...

2015年中国药学大会暨第十五届中国药师周

作者： Miaorong Yu Dengning Xia chunliu Zhu Shiyan Guo Yong Gan Shanghai Institute of Materia Medica Chinese Academy of Sciences

＜正＞INTRODUCTION The intestinal epithelial barrier（IEB） is a physical and physiological barrier that regulates the passage of substances from the intestinal lumen to systemic *** to the presence of IEB,the bioavai...

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Perillyl alcohol efficiently scavenges activity of cellular ROS and inhibits the translational expression of hypoxia-inducible factor-1α via m TOR/4E-BP1 signaling pathways

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Perillyl alcohol efficiently scavenges activity of cellular ...

中国化学会第十一届全国天然有机化学学术会议

作者： Juan Ma Jing li Ke Si Wang chunliu Mi Xuejun Jin Key laboratory of Natural Resources of Changbai Mountain ＆ Functional Molecules Ministry of education Molecular Medicine Research Center College of Pharmacy Yanbian University

＜正＞Perillyl alcohol（POH）is a dietary monoterpene present in a variety of plants with a pure or mixed form,and it is one of the very few natural substances with anticancer ***,the mechanism by which POH unleashes its anticancer activity in tumor cells remains *** here demonstrated the effect of POH on hypoxia-inducible factor-1α（HIF-1α）*** showed the potent inhibitory activity against HIF-1 activation

关键词： perillyl alcohol(POH) HIF-1 m TOR cell cycle anticancer

Carotid atherosclerotic tissue characterization by intravascular optical coherence tomography:An ex vivo validation study

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Carotid atherosclerotic tissue characterization by intravasc...

第十二届全国生物力学学术会议暨第十四届全国生物流变学学术会议

作者： chunliu He Yuxiang Huang Yifan Yin Manyi Xie Zhonglin li Zhiyong li State Key laboratory of Bioelectronics Southeast University School of Biological Science and Medical Engineering Southeast University School of Chemistry Physics and Mechanical EngineeringQueensland University of Technology

Objective Cerebrovascular events, otherwise referred to as stroke, are causes of mortality and morbidity inthe world that occur when atherosclerotic plaques in the arteries suddenly rupture, leading to the obstruction of the blood flow to the brain. It is now well established that the tissue components plays an important role for the stability or vulnerability of atherosclerotic plaques. Intravascular optical coherence tomography (IVOCT) has been reported to have the potential in the identification and quantization of plaque components The aim of this

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基于ASPEN软件的戊烷发泡剂生产实践及增产措施

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石油炼制与化工 2024年第3期55卷 61-66页

作者：穆海涛刘春柳中国石化青岛炼油化工有限责任公司山东青岛266071

炼化企业中,戊烷发泡剂可以利用预加氢装置拔出的轻石脑油组分进行生产,而国家标准GB T 22053—2020对发泡剂质量要求更加严格。通过构建预加氢装置汽提塔、分馏塔及脱戊烷塔的ASPEN PlUS模型,对戊烷发泡剂生产流程的控制参数进行分析测... 详细信息

炼化企业中,戊烷发泡剂可以利用预加氢装置拔出的轻石脑油组分进行生产,而国家标准GB T 22053—2020对发泡剂质量要求更加严格。通过构建预加氢装置汽提塔、分馏塔及脱戊烷塔的ASPEN PlUS模型,对戊烷发泡剂生产流程的控制参数进行分析测算,制定了生产调整方案。工业试验结果表明:戊烷发泡剂组成与脱戊烷塔塔顶灵敏板温度密切相关,保证塔顶发泡剂组分质量分数差值范围为±2%,其塔顶温度变化需控制±0.3℃。同时,从汽提塔操作、产品牌号、加工原油种类等方面入手,对戊烷发泡剂增产效果进行分析,提高企业的经济效益。

关键词：预加氢装置汽提塔戊烷发泡剂灵敏板温度

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