检索结果-南通市图书馆

Acta Pharmaceutica Sinica B 2019年第1期9卷 107-117页

作者： chunliu Zhu Shuang Gong Jinsong Ding Miaorong Yu Ejaj Ahmad Yi Feng Yong Gan Engineering Research Center of Modern Preparation Technology of Traditional Chinese Medicine Shanghai University of Traditional Chinese Medicine Shanghai Institute of Materia Medica Chinese Academy of Science Xiangya School of Pharmaceutical Science Central South University

Increasing the degree of supersaturation of drugs and maintaining their proper stability are very important in improving the oral bioavailability of poorly soluble drugs by a supersaturated drug delivery system(SDDS). In this study, we reported a complex system of Soluplus–Copovidone(Soluplus–PVPVA)loaded with the model drug silybin(SlB) that could not only maintain the stability of a supersaturated solution but also effectively promote oral absorption. The antiprecipitation effect of the polymers on SlB was observed using the solvent-shift method. In addition, the effects of the polymers on absorption were detected by cellular uptake and transport experiments. The mechanisms by which the Soluplus–PVPVA complex promotes oral absorption were explored by dynamic light scattering, transmission electron microscopy, fluorescence spectra and isothermal titration calorimetry analyses. Furthermore, a pharmacokinetic study in rats was used to demonstrate the advantages of the Soluplus–PVPVA complex. The results showed that Soluplus and PVPVA spontaneously formed complexes in aqueous solution via the adsorption of PVPVA on the hydrophilichydrophobic interface of the Soluplus micelle, and the Soluplus–PVPVA complex significantly increased the absorption of SlB. In conclusion, the Soluplus–PVPVA complex is a potential SDDS for improving the bioavailability of hydrophobic drugs.

关键词： Silybin Soluplus PVPVA Complex Supersaturated drug delivery system Oral bioavailability

UMBREllA: user demand privacy preserving framework based on association rules and differential privacy in social networks

在线全文

学校读者我要写书评

暂无评论

Science China(Information Sciences) 2019年第3期62卷 205-207页

作者： chunliu YAN Ziyi NI Bin CAO Rongxing lU Shaohua WU Qinyu ZHANG Harbin Institute of Technology (Shenzhen) Faculty of Computer Science University of New Brunswick

Dear editor,The past several years have witnessed that people deeply rely on online services, such as shopping,transportation, and medical services. At the same time, privacy leakage has been a hot topic in social net... 详细信息

关键词： user demand privacy preserving framework based on association rules and differential privacy in social networks Figure

Existence and Stability of Standing Waves with Prescribed l²-Norm for a Class of Schrödinger-Bopp-Podolsky System

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Journal of Applied Mathematics and Physics 2022年第7期10卷 2245-2267页

作者： chunliu liu School of Mathematical Sciences Tiangong University Tianjin China

In this paper, we look for solutions to the following Schrödinger-Bopp-Podolsky system with prescribed l2-norm constraint , where q ≠ 0, a, ρ> 0 are constants. At first, by the classical minimizing argument, we obtain a ground state solution to the above problem for sufficiently small ρwhen . Secondly, in the case p = 6, we show the nonexistence of positive solutions by using a liouville-type result. Finally, we argue by contradiction to investigate the orbital stability of standing waves for .

关键词： Schrödinger-Bopp-Podolsky System Standing Waves Normalized Solution Orbital Stability

A Fresnel Reflection-Based Optical Fiber Sensor System for Remote Refractive Index Measurement Using an OTDR

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Photonic Sensors 2014年第1期4卷 48-52页

作者： Jianying Yuan chunliu Zhao Manping Ye Juan Kang Zaixuan Zhang Shangzhong Jin Institute of Optoelectronic Technology China Jiliang UniversityHangzhou310018China

In this paper, we propose a Fresnel reflection-based optical fiber sensor system for remote refractive index measurement using the optical time domain reflectometry technique as an interrogation method. The surrounding refractive index from a long distance away can be measured easily by using this sensor system, which operates based on testing the Fresnel reflection intensity from the fiber-sample interface. This system is a simple configuration, which is easy to handle. Experimental results showed that the range of this measurement could reach about 100.8km, and the refractive index sensitivities were from 38.71 dB/RIU to 304.89 dB/RIU in the refractive index （RI） range from 1.3486 to 1.4525.

关键词： Fresnel reflection optical fiber sensor remote measurement OTDR

Automatic Calcified Plaques Detection in the OCT Pullbacks Using Convolutional Neural Networks

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

医用生物力学 2019年第A1期34卷 109-110页

作者： chunliu He Yifan Yin Jiaqiu Wang Biao Xu Zhiyong li The School of Biological Science and Medical Engineering Southeast UniversityNanjing210096China The Schoolof Chemistry Physics and Mechanical EngineeringQueensland University of TechnologyBrisbaneQLD4000Australia Department of Cardiology Affiliated Drum Tower HospitalSchool of MedicineNanjing UniversityNanjing21000China

Background Coronary artery calcification is a well-known marker of atherosclerotic plaque ***-resolution intravascular optical coherence tomography(OCT)imaging has shown the potential to characterize the details of coronary calcification in *** routine clinical practice,it is a time-consuming and laborious task for clinicians to review the over 250 images in a single ***,the imbalance label distribution within the entire pullbacks is another problem,which could lead to the failure of the classifier *** the success of deep learning methods with other imaging modalities,a thorough understanding of calcified plaque detection using Convolutional Neural Networks(CNNs)within pullbacks for future clinical decision was *** All 33 IVOCT clinical pullbacks of 33 patients were taken from Affiliated Drum Tower Hospital,Nanjing University between December 2017 and December *** ground-truth annotation,three trained experts determined the type of plaque that was present in a *** experts assigned the labels'no calcified plaque','calcified plaque'for each OCT *** experts were provided the all images for *** final label was determined based on consensus between the experts,different opinions on the plaque type were resolved by asking the experts for a repetition of their *** the implement of algorithm,all OCT images was resized to a resolution of 300×300,which matched the range used with standard architectures in the natural image *** the study,we randomly selected 26 pullbacks for training,the remaining data were ***,imbalance label distribution within entire pullbacks was great challenge for various CNNs *** order to resolve the problem,we designed the following ***,we fine-tuned twenty different CNNs architecture,including customize CNN architectures and pretrained CNN *** the nature of OCT images,customize CNN architectures were des

关键词： Calcified plaque intravascular optical coherence tomography deep learning imbalance label distribution convolutional neural networks

Zeolite Thin Film-Coated Fiber Sensors Based on Fabry-Perot Interferometer for Detection of Chemical Vapors

在线全文

学校读者我要写书评

暂无评论

Photonic Sensors 2015年第2期5卷 137-141页

作者： Xiangping NING chunliu ZHAO Feifei SHI Juan KANG Institute of Optoelectronic Technology China Jiliang University Hangzhou 310018 China

A novel zeolite-coated fiber sensors for detection of volatile organic compounds （VOCs） based on the Fabry-Perot interferometer was proposed and demonstrated. The sensor comprised a polycrystalline silicalite thin film grown up on the cleaved end face of a standard single-mode fiber. The inline Fabry-Perot cavity was composed by the end face of the single-mode fiber and the thin film. The sensor device operated by measuring the interference signal, which was a function of the amount of chemical vapor adsorption in its crystalline micro porous structure. Experimental results showed that the proposed VOC sensor worked well and the sensitivities were 2.78×10^-3dB/ppm when the concentration ranged from 350ppm to 2100ppm and 1.23×10^-3 dB/ppm when the concentration ranged from 2100ppm to 5250 ppm.

关键词： Zeolite film volatile organic compound (VOC) sensor Fabry-Perot interferometer

Numerical Investigation Into a Surface Plasmon Resonance Sensor Based on Optical Fiber Microring

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Photonic Sensors 2017年第2期7卷 105-112页

作者： chunliu ZHAO Yanru WANG Dongning WANG Zhewen DING Institute of Optoelectronic Technology China Jiliang University Hangzhou 310018 China

A reflective surface plasmon resonance （SPR） sensor based on optical fiber microring is proposed. In such a sensor, plasmons on the outer surface of the metallized channels containing analyte can be excited by a fundamental mode of a thin-core fiber （TCF）. The refractive index （RI） sensing can be achieved as the surface plasmons are sensitive to changes in the refrective index of the analyte. Numerical simulation results show that the resonance spectrum shifts toward the shorter wavelength gradually when the analyte refractive index increases from 1.0 to 1.33, whereas it shifts toward the longer wavelength gradually when the analyte refractive index increases from 1.33 to 1.43, and there is a turning point at the refractive index value of 1.33. The highest sensitivity achieved is up to 2.30×10^3nm/RIU near the refractive index value of 1.0. Such a compact sensor has potential for gaseous substance monitoring.

关键词： Fiber optics surface plasmons sensors microstructure

Worm-like micelles facilitate the intestinal mucus diffusion and drug accumulation for enhancing colorectal cancer therapy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Chemical letters 2024年第6期35卷 427-432页

作者： Yihan Zhou Duo Gao Yaying Wang li liang Qingyu Zhang Wenwen Han Jie Wang chunliu Zhu Xinxin Zhang Yong Gan State Key laboratory of Drug Research and Center of Pharmaceutics Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China School of Chinese Materia Medica Nanjing University of Chinese MedicineNanjing 210023China University of Chinese Academy of Sciences Beijing 100049China NMPA Key laboratory for Quality Research and Evaluation of Pharmaceutical Excipients National Institutes for Food and Drug ControlBeijing 100050China School of Pharmacy Shanghai University of Traditional Chinese MedicineShanghai 201203China

local delivery of nanoparticles holds promise for colorectal cancer(CRC)***,the presence of the mucus layer on the epithelium poses a significant challenge to drug delivery,thereby adversely affecting treatment *** is crucial to develop efficient drug delivery carriers that can effectively overcome mucus barriers to treat colorectal ***,we utilized poly(1,4-butadiene)-b-poly(ethylene oxide)polymers to prepare four distinct geometries of polymeric micelles,namely linear micelles(lMs),worm-like micelles(WlMs),large spherical micelles(lSMs),and small spherical micelles(SSMs)to investigate the influence of shape effects on overcoming colonic mucosal *** found that the carriers exhibited diverse shapes while maintaining comparable physicochemical *** these,WlMs had an aspect ratio similar to segmented filamentous bacteria,which exhibited superior mucus penetration ability,leading to prolonged drug release kinetics and faster entry into epithelial cells compared to ***,rectally administrated 10-hydroxycamptothecin-loaded WlMs traversed the colorectal mucus in orthotopic CRC nude mice model,penetrated and accumulated within tumor tissue,and effectively aggregated within cancer cells,thereby inducing significantly robust antitumor outcomes in *** findings underscore the significance of shape design in overcoming colonic mucosal absorption barriers,offering a novel approach for the development of drug delivery carriers tailored for effective tumor therapy.

关键词： Worm-like micelles Mucus penetration Shape dependent Transmucosal delivery Colorectal cancer

Effect of Particle Size on Silicon Nitride Ceramic Slurry by Stereolithography

在线全文

学校读者我要写书评

暂无评论

Journal of Wuhan University of Technology(Materials Science) 2023年第3期38卷 514-519页

作者：汪春柳 ZHANG Jinyong 雷丽文 School of Materials Science and Engineering Wuhan University of TechnologyWuhan 430070China State Key laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan 430070China

The effects of particle size,gradation and solid loading of silicon nitride (Si_(3)N_(4)) on the rheological behavior and curing properties of ceramic slurry are studied by stereolithography (SlA).The results show that the particle size of Si_(3)N_(4) powder has a signif icant influence on the rheological properties and stability of the *** m_(D50=1.3μm):m_(D50=2.3μm)=3:7,the slurry viscosity is low and the sedimentation is *** most important thing is that with the increase of the solid loading of the slurry,the viscosity of the slurry increases,the stability becomes higher,and the curing thickness *** curing thickness of Si_(3)N_(4) ceramic slurry with solid loading of 50 vol% can reach nearly 50μ*** above results finally show that the process optimizes the formulation of the slurry in rheological and curing properties.

关键词： silicon nitride stereolithography dispersion stability