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Light-up lipid droplets for the visualization of lipophagy and atherosclerosis by coumarin-derived bioprobe

Chinese Chemical Letters 2021年第8期32卷 2385-2389页

作者： Jinrong Zheng Shuheng qin Lijuan Gui Hua Li Lixue Fan Yifei Yang Haiyan chen Hui Xu Zhenwei Yuan department of Biomedical engineering School of EngineeringChina Pharmaceutical UniversityNanjing 210009China School of pharmacy Key Laboratory of Molecular Pharmacology and Drug Evaluation(Yantai University)Ministry of EducationCollaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of ShandongYantai UniversityYantai 264005China department of Food Quality and Safety College of Food Science and Engineering/Collaborative Innovation Center for Modern Grain Circulation and Safety/Key Laboratory of Grains and Oils Quality Control and ProcessingNanjing University of Finance and EconomicsNanjing 210023China

Lipid droplets(LDs) are intracellular lipid-metabolism organelles that involved in many physiological processes,metabolic disorders as well as diseases such as ***,the specific probes that can visually locate abnormal LDs-rich tissues and track LDs-associated behavior to the naked eye with adequate biosafety still are ***,we develop a new design strategy of LDs-targeted probe based on the solvatochromism of coumarin *** results revealed that the emission wavelength of coumarin fluorophores gradually red shift in different solvents with increasing polarity,while absorption wavelength almost *** a result,the enlarged stokes shift of coumarin was emerged from oil to ***,properly reducing water solubility and adding electronic donor at the structure of coumarins can enlarge this type of *** discovery was utilized to develop suitable probe for the image of LDs and LDs-rich tissues with high resolution and ***,LDs-associated behavior was visible to the naked eye during the process of lipophagy and *** deem that the developed probe here offers a new possibility to accurately diagnosis and analyse LDs-related diseases in clinic and preclinical study.

关键词： Lipid droplets probe Lipophagy Atherosclerosis

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加密传输在工控系统安全中的可行性研究

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自动化学报 2018年第3期44卷 434-442页

作者：梁耀冯冬芹徐珊珊陈思媛高梦州浙江大学工业控制技术国家重点实验室多伦多大学计算机与电子工程学院

针对需要对现场数据加密的工业控制系统(Industrial control system,ICS),基于稳定性判据设计一种加密传输机制的可行性评估模型,结合超越方程D-subdivision求解法,提出一种数据加密长度可行域求解算法.改进IAE(Integral absolute error... 详细信息

针对需要对现场数据加密的工业控制系统(Industrial control system,ICS),基于稳定性判据设计一种加密传输机制的可行性评估模型,结合超越方程D-subdivision求解法,提出一种数据加密长度可行域求解算法.改进IAE(Integral absolute error)并提出Truncated IAE(TIAE)-based指标,用于评估可行域内不同数据长度对系统实时性能的影响.利用嵌入式平台测定的加密算法执行时间与数据长度的关系,评估了两种对称加密算法应用在他励直流电机控制系统中的可行性,验证了可行域求解算法的准确性,并获得了实时性能随数据长度的变化规律.

关键词：工业控制系统加密传输稳定性数据加密长度可行域实时性能 TIAE—based指标

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Study on semi-active control of mega-sub controlled structure by Mr damper subject to random wind loads

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Earthquake engineering and engineering Vibration 2008年第3期7卷 285-294页

作者： qin Xiangjun Zhang Xun＇an Sheldon Cherry department of Mechanics and Civil engineering Northwestern Polytechnical University Xi ＇an 710072 China department of Civil engineering University of British Columbia Vancouver Canada

The recently proposed mega-sub controlled structure （MSCS）, a new type of structure associated with the design and construction of super-tall buildings, has attracted the attention of designers for use in enhancing the control effectiveness in mega-frame buildings. In this paper, a dynamic equation and method to assemble parameter matrixes for a mega-sub controlled structure under random wind loads is presented. Semi-active control using magnetorheological dampers for the MSCS under random wind loads is investigated, and is compared with a corresponding system without dampers. A parametric study of the relative stiffness ratio and relative mass ratio between the mega-frame and the substructures, as well as the additional column stiffness ratio that influences the response control effectiveness of the MSCS, is discussed. The studies reveal, for the first time, that different control mechanisms exist. The results indicate that the proposed structure employing semi-active control can offer an effective control mechanism. Guidelines for selecting parameters are provided based on the analytical study.

关键词： mega-sub controlled structure (MSCS) semi-active control magnetorheological damper relative stiffness ratio relative mass ratio additional column stiffness ratio wind load

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Motion planning Based Coordinated control for Hydraulic Excavators

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Chinese Journal of Mechanical engineering 2009年第1期22卷 97-101页

作者： GAO Yingjie JIN Yanchao ZHANG qin Hebei province Key Laboratory of Fluid power Transmission and control Yanshan University Qinhuangdao 066004 China Eaton Hydraulics systems （Jining） Co. Ltd Jining 272023 China department of Agricultural and Biological engineering University of Illinois at Urbana-Champaign Urbana-Champaign IL 61801 USA

Hydraulic excavator is one type of the most widely applied construction equipment for various applications mainly because of its versatility and mobility. Among the tasks performed by a hydraulic excavator, repeatable level digging or flat surface finishing may take a large percentage. Using automated functions to perform such repeatable and tedious jobs will not only greatly increase the overall productivity but more importantly also improve the operation safety. For the purpose of investigating the technology without loss of generality, this research is conducted to create a coordinate control method for the boom, arm and bucket cylinders on a hydraulic excavator to perform accurate and effective works. On the basis of the kinematic analysis of the excavator linkage system, the tip trajectory of the end-effector can be determined in terms of three hydraulic cylinders coordinated motion with a visualized method. The coordination of those hydraulic cylinders is realized by controlling three electro-hydraulic proportional valves coordinately. Therefore, the complex control algorithm of a hydraulic excavator can be simplified into coordinated motion control of three individual systems. This coordinate control algorithm was validated on a wheeled hydraulic excavator, and the validation results indicated that this developed control method could satisfactorily accomplish the auto-digging function for level digging or flat surface finishing.

关键词： hydraulic excavator motion planning coordinated control

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ZnO压敏电阻微观结构参数与宏观电气性能的关联机制

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电工技术学报 2024年第5期39卷 1454-1463页

作者：孟鹏飞郭敬科张恒志秦锋谢施君雷潇吴红梅胡军四川大学电气工程学院成都610065 国网西藏电科院拉萨850000 西北核技术研究所西安710024 国网四川省电科院成都610041 西藏农牧学院林芝860000 清华大学电机系北京100084

ZnO压敏电阻是金属氧化物避雷器的核心部件,在抑制电力系统过电压方面发挥了重要的作用。随着特高压输电技术的发展,对ZnO压敏电阻的残压、通流容量等电气特性提出了更高的要求。该文从材料计算的角度出发,以基于Voronoi模型的ZnO压敏... 详细信息

ZnO压敏电阻是金属氧化物避雷器的核心部件,在抑制电力系统过电压方面发挥了重要的作用。随着特高压输电技术的发展,对ZnO压敏电阻的残压、通流容量等电气特性提出了更高的要求。该文从材料计算的角度出发,以基于Voronoi模型的ZnO压敏电阻优化计算模型为基础,计算研究了晶粒尺寸、尺寸不均匀度、晶粒电阻率等微观结构参数与多种宏观电气性能之间的关联机制,将多变量、多目标的最优化问题,极大地简化为仅包含三类优化变量、两类优化目标的最优化问题,并制定出具有针对性的优化策略和步骤,为ZnO压敏电阻性能的改进提供了重要理论依据,对高性能避雷器的设计制造具有重要意义。

关键词： ZnO压敏电阻材料计算微观结构电气性能关联机制

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毛木耳蛛网病致病菌生物学特性及杀菌剂敏感性分析

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菌物学报 2024年第8期43卷 13-22页

作者：谢江涛覃再丽刘雪刘江田风华贵州大学农学院植物保护植物病理教研室贵州贵阳550025 贵州大学食用菌研究院贵州贵阳550025 吉林农业大学食药用菌教育部工程研究中心吉林长春130118 贵阳市蔬菜技术推广站贵州贵阳550081 贵州省食用菌产业技术体系贵州贵阳550025

2022年6月贵州省贵阳市毛木耳Auricularia cornea栽培基地有蛛网病发生,发病率可达30%,经鉴定该病原菌为真菌菌寄生Hypomyces mycophilus。为深入了解和防控该病害,本研究对病原菌的生物学特性进行了探究,并利用菌丝生长抑制法测定了病... 详细信息

2022年6月贵州省贵阳市毛木耳Auricularia cornea栽培基地有蛛网病发生,发病率可达30%,经鉴定该病原菌为真菌菌寄生Hypomyces mycophilus。为深入了解和防控该病害,本研究对病原菌的生物学特性进行了探究,并利用菌丝生长抑制法测定了病原菌对4种生物源农药和3种化学农药的敏感性。研究发现,该病原菌的最适温度为25℃,最适pH值为6,可溶性淀粉、酵母浸粉和孟加拉红琼脂培养基对菌丝生长有利,光照条件无显著性影响。杀菌剂敏感性分析表明,枯草芽孢杆菌可湿性粉剂和丙环唑乳油对病原菌都有较强的抑制作用,EC_(50)分别为0.018 mg/L和0.022 mg/L,且0.100 mg/L的枯草芽孢杆菌对毛木耳菌丝生长的抑制率为12.63%,表明枯草芽孢杆菌在真菌菌寄生和毛木耳中具有较好的选择毒性。该研究结果将为毛木耳蛛网病的防控提供一定的理论依据。

关键词：毛木耳蛛网病真菌寄生菌杀菌剂筛选选择毒性

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State and Mode Feedback control for Discrete-time Markovian Jump Linear systems With controllable MTpM

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IEEE/CAA Journal of Automatica Sinica 2019年第3期6卷 830-837页

作者： Jin Zhu qin Ding Maksym Spiryagin Wanqing Xie IEEE the department of Automation University of Science and Technology of China the Centre for railway engineering Central Queensland University the School of Information Science and Technology University of Science and Technology of China

In this note, the state and mode feedback control problems for a class of discrete-time Markovian jump linear systems(MJLSs) with controllable mode transition probability matrix(MTpM) are investigated. In most achievements, controller design of MJLSs pays more attention to state/output feedback control for stability, while the system cost in practice is out of consideration. In this paper, we propose a control mechanism consisting of two parts: finite-path-dependent state feedback controller design with which uniform stability of MJLSs can be ensured, and mode feedback control which aims to decrease system cost. Differing from the traditional state/output feedback controller design, the main novelty is that the proposed control mechanism not only guarantees system stability, but also decreases system cost effectively by adjusting the occurrence probability of system modes. The effectiveness of the proposed mechanism is illustrated via numerical examples.

关键词： controllable mode transition probability matrix(MTpM) Markovian jump linear systems(MJLSs) stabilization system cost

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On decoupled or coupled control of bank-to-turn missiles

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Science china(Information Sciences) 2015年第5期58卷 195-207页

作者： DUAN ZhiSheng HUANG Lin YANG JianYing qin GuoZheng State Key Lab for Turbulence and Complex systems and department of Mechanics and engineering Science College of Engineering Peking University

In this paper, the differences between decoupled and coupled control of bank-to-turn(BTT) missiles have been studied in detail from three aspects: stabilizability, linear quadratic regulator(LQr) control and tracking control. It is found that for some parameters the BTT missile can be controlled by a decoupled way,especially for stabilizability and LQr control. However, for some others, the BTT missile cannot be decoupled and a coupled control method is needed. Therefore, for a practical flight control system, the decouplability should be studied before giving a decoupled control method. In addition, in order to avoid the disadvantages of LQr control method, an improved H∞controller design method is given. Combined with tracking control problem, a new H∞control method is established for trajectory tracking.

关键词： BTT missile decoupled control coupled control tracking control

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Bifurcation suppression of nonlinear systems via dynamic output feedback and its applications to rotating stall control

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控制理论与应用（英文版） 2005年第4期3卷 334-340页

作者： pengnian chen Huashu qin Shengwei MEI department of Mathematics China Institute of Metrology Hangzhou Zhejiang 310034 China Institute of systems Science The Chinese Academy of Sciences Beijing 100080 China department of Electrical engineering Tsinghua University Beijing 100084 China

This paper deals with the problems of bifurcation suppression and bifurcation suppression with stability of nonlinear systems. Necessary conditions and sufficient conditions for bifurcation suppression via dynamic output feedback are presented; Sufficient conditions for bifurcation suppression with stability via dynamic output feedback are obtained. As an application, a dynamic compensator,which guarantees that the bifurcation point of rotating stall in axial flow compressors is stably suppressed, is constructed.

关键词： Nonlinear system Bifurcation control Stability Dynamic output feedback

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Optogenetics:a novel optical manipulation tool for medical investigation

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International Journal of Ophthalmology(English edition) 2012年第4期5卷 517-522页

作者： Jun-ping Yao, Zheng-qin Yin College of Biology engineering Chongqing University Chongqing 400044 China department of Ophthalmology the Third Military Medical University Chongqing 400038 China Chongqing Key Lab of Visual Damage and regeneration and restoration Chongqing 400038 China

Optogenetics is a new and rapidly evolving gene and neuroengineering technology that allows optical control of specific populations of neurons without affecting other neurons in the brain at high temporal and spatial resolution. By heterologous expression of the light-sensitive membrane proteins, cell type-specific depolarization or hyperpolarization can be optically induced on a millisecond time scale. Optogenetics has the higher selectivity and specificity compared to traditional electrophysiological techniques and pharmaceutical methods. It has been a novel promising tool for medical research. Because of easy handling, high temporal and spatial precision, optogenetics has been applied to many aspects of nervous system research, such as tactual neural circuit, visual neural circuit, auditory neural circuit and olfactory neural circuit, as well as research of some neurological diseases. The review highlights the recent advances of optogenetics in medical study.

关键词： light-sensitive proteins optogenetics optical manipulation medical

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