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Application of mannose-modified fullerene immunomodulator selectively polarizes tumor-associated macrophages potentiating antitumor immunity

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Nano Research 2023年第11期16卷 12855-12863页

作者： Haoyu Wang Lei Li Xinran Cao Mingming Zhen Chunru Wang chunli bai Beijing National Laboratory for Molecular Sciences Key Laboratory of Molecular Nanostructure and NanotechnologyCAS Research/Education Center for Excellence in Molecular SciencesInstitution Institute of ChemistryChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

Polarization of tumor associated macrophages(TAMs)has been a promising therapeutic paradigm for ***,how to achieve precise regulation of TAMs and high efficiency of tumor immunotherapy is still a huge ***,we report dicarboxy fullerene modified with mannose(DCFM)as an immunomodulator to selectively polarize TAMs and prominently boost anti-tumor *** dicarboxy fullerene molecule was synthesized through the Prato reaction and further covalently bonded with mannose,obtaining the DCFM with well-defined *** to the exist of mannose in DCFM,it could accurately recognize mannose receptor in *** cellular experiment results showed that mannose modification could notably promote the uptake of DCFM by the immunosuppressive M2-type macrophages that effectively reprogrammed M2-type macrophages into anti-tumor M1-type macrophages,leading to enhance the phagocytosis of tumor cells by macrophages and inhibiting tumor cells ***,we observed that DCFM could significantly distribute into tumor tissues by in vivo fluorescence ***,DCFM exhibited a superior anti-tumor efficiency in the subcutaneous colorectal tumor *** addition,it showed that DCFM precisely polarized TAMs into M1-type macrophages and actively increased the infiltration of cytotoxic T lymphocytes(CTLs),inducing profound tumor growth inhibition.

关键词： fullerene mannose macrophage targeting tumor-associated macrophage polarization cancer immunotherapy

Progress on molecular self-assembly of alkanethiols

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Chinese Science Bulletin 1998年第9期43卷 705-710页

作者： Wenli Deng Linjing Yang Chen Wang chunli bai Chinese Acad Sci Inst Chem STM Lab Beijing 100080 Peoples R China

Molecular self-assembly became an interesting research project which was paid much attention by many scientists. This article briefly tells readers the suggestion, principle and the newest progresses on self-assembly.... 详细信息

关键词： progress self-assembly alkanethiols.

Structure of self-assembled monolayer of NPAN on Au(111) electrode

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Chinese Science Bulletin 2003年第18期48卷 1952-1955页

作者： YANG Guangzheng ZENG Qingdao WAN Lijun bai chunli Institute of Chemistry Chinese Academy of Sciences(CAS)Beijing 100080China Graduate School of CAS Beijing 100080China

Adsorption of 4-(4-nitrophenylazo)-1-naphthol (NPAN), an azobenzene derivative, on Au(111) has been in-vestigated in aqueous HClO4 solution by using the cyclic voltammetry and scanning tunneling microscopy (STM). The molecule is found to form a stable monolayer on the elec-trode with a (6×4) structure relative to the underlying Au(111) lattice. Cyclic voltammograms show that the redox reactions occurring on the electrode are retarded by the formation of the monolayer. A structural model is proposed for the two-dimensional adlayer.

关键词： Au(111) azobenzene self-assembled monolayer STM.

Circular dichroism spectroscopic studies on structures formed by telomeric DNA sequences in vitro

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Chinese Science Bulletin 2000年第21期45卷 1959-1963页

作者： ZHANG Xiaoyan CAO Enhua SUN Xueguang bai chunli Institute of Biophysics Chinese Academy of SciencesBeijing 100101China Institute of Chemistry Chinese Academy of SciencesBeijing 100101China

Telomere plays an important role in cellular processes, such as cell aging, death and carcinogenisis. Having special sequences, it can form quadrupiex structure in vitro. Circular dichroism (CD) spectroscopic studies show that TTAGGG, (TTAGGG)2 and (TTAGGG)4 can all form quadrupiex in vitro and exist mainly as parallel quadrupiex without metal ions. Both K+ and Na+ can stabilize the tetrameric structure and facilitate the forming of anti-parallel conformation. Furthermore, the conformations of quadrupiex can also be affected by sequence length, the nature and concentration of metal ions.

关键词： human telomere quadruplex conformation CD spectrum K+ Na+ cation concentration.

Ordered arrays of semi-crown ligands on an Au(111) electrode surface: in situ STM study

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Science China Chemistry 2004年第4期47卷 320-325页

作者： PAN Gebo LI Huijing YUAN Qunhui CHEN Yongjun WAN Lijun bai chunli Institute of Chemistry Chinese Academy of Sciences Beijing 100080 China Institute of Chemistry Chinese Academy of Sciences Beijing 100080 China Institute of Chemistry Chinese Academy of Sciences Beijing 100080 China Institute of Chemistry Chinese Academy of Sciences Beijing 100080 China Institute of Chemistry Chinese Academy of Sciences Beijing 100080 China (Institute of Chemistry Chinese Academy of Sciences Beijing 100080 China)

In situ scanning tunneling microscopy (STM) and cyclic voltammetry were employed to investigate the adsorption structures of three semi-crown ligands on an Au(111) surface under the potential control. It is found that all the molecules formed ordered arrays in 0.1 mol/L HClO4 solution, although their geometric structures are complex and asymmetric. The driving force was supposed to come from the balance between intermolecular and molecule-substrate interactions. High resolution STM images revealed internal molecular structures, orientations and packing arrangements in the ordered adlayers. The results are useful for preparing ordered arrays of transition metal-mediated nanostructures.

关键词： Au(111) cyclic voltammetry ordered array in situ STM

Assemble four-arm DNA junctions into nanoweb

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Chinese Science Bulletin 2001年第19期46卷 1618-1621页

作者： ZHOU Chunqing TAN Zukun WANG Chen bai chunli CAO Enhua STM Lab Institute of ChemistryChinese Academy of SciencesBeijing 100080China Institute of Biophysics Chinese Academy of SciencesBeijing 100101China

DNA is of structural polymorphism, which is useful in nanoarchitecture; especially, four-arm DNA junctions can be used to assemble nanowebs. The static four-arm DNA junctions were designed and synthesized. One-arm DNA and two-arm DNA came out simultaneously with the four-arm DNA junction’s formation. A new method, termed the two-step method, was proposed and the productivity of four-arm DNA junctions was increased. A nanoweb was assembled successfully, but it showed irregularity itself. It was not the same as we expected. We consider that it is a result from the flexibility of four-arm DNA junction.

关键词： nucleic acid self-assembly nanotechnology atomic force microscopy.

Circular dichroism spectra of different structures formed by the oligonucleotides

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Chinese Science Bulletin 1998年第17期43卷 1456-1460页

作者： Xueguang Sun Enhua Cao chunli bai Yujian He Jingfen Qin Chinese Acad Sci Inst Biophys Beijing 100101 Peoples R China Chinese Acad Sci Inst Chem Beijing 100080 Peoples R China

Under different conditions, oligonucleotides can form several different DNA structures such as duplex, triplex and quadruplex. All these structures exhibit an obvious difference in their CD spectra. The common characteristic is that they show a negative band at 240 nm, while in the range of 260-300 nm, the spectra are different from each other. Many factors such as chain direction, sugar puckering mode, orientation of the glycosyl bond, base stacking and sequence can affect their conformation and then show diversity and complexity in their spectra. By studying and comparing these spectra, more information about their conformations can be obtained to help predict some new structures. Furthermore, the spectra can also provide a base to study their potential biological functions.

关键词： duplex triplex quadruplex CD spectrum.

Mechanism for the Nanometer Scale Modification on HOPG Surface by Scanning Tunneling Microscope

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Chinese Physics Letters 1993年第9期10卷 535-538页

作者： WANG Zhonghuai DAI Changchun ZHANG Pingchen HUANG Guizhen LI Renli GUO Yi bai chunli Institute of Chemistry Acadenua.Sinica.Beijing 100080

A technique applying voltage across the tunnel junction for wnting permanent features on graphite with lines about 10nm wiidth using our home-built scanning tunneling microscope has been ***-tip effects while modifying the surface are often *** phenomciifi are explained in terms of the strong electric field existing at the junction between the tip an<7 the *** addition,the shape of the structure indented by the tip is in agreement with that of the tip.

关键词： surface. Tunnel tunneling

Controlled assembly of copper phthalocyanine with 1-iodooctadecane

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Chinese Science Bulletin 2003年第15期48卷 1519-1524页

作者： LEI Shengbin, WANG Chen, WAN Lijun & bai chunli Center of Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080, China Correspondence should be addressed to bai chunli (e-mail: clbai@ ***) Center of Molecular Sciences Institute of Chemistry Chinese Academy of Sciences Beijing 100080 China

The binary assembly behavior of 1-iodoocta- decane with substituted phthalocyanine (Pc) is studied using the scanning tunneling microscopy (STM). By altering the substituted alkyl groups attached to the phthalocyanine ring, either uniform assembly or phase separation behavior can be observed. It is suggested that the strength of intermolecular interaction between phthalocyanine molecules is the determining factor for the assembly structure.

关键词：铜酞菁碘代十八烷扫描隧道电子显微镜化学结构