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Nano Research 2022年第5期15卷 4544-4551页

作者： Liying Wang chunlei dai Yifen Fang Xinru You Jun Wu School of Biomedical Engineering Sun Yat-sen UniversityShenzhen 518057China Department of Cardiology the Affiliated TCM Hospital of Guangzhou Medical UniversityGuangzhou 510180China Department of Pediatrics the Seventh Affiliated Hospital of Sun Yat-sen UniversityShenzhen 518107China

Many anticancer drugs have limited clinical applications owing to their unsatisfactory therapeutic efficacy or side *** situation can be improved by drug delivery systems or drug modification ***,to improve the therapeutic efficacy and safety of the traditional anticancer drug 6-mercaptopurine(6-MP),we dimerized 6-MP to form a disulfide bond-containing drug dimer and prepared a cysteine-based poly(disulfide amide)with redox-responsive capability as a drug ***,dimeric 6-MP(DMP)was synthesized via the oxidization of iodine and self-assembled with the poly(disulfide amide)to form dual redox-responsive DMP-loaded NPs(DMP-NPs).The 6-MP itself could hardly be loaded into nanoparticles(NPs)owing to its hydrophobicity,while the DMP-NPs showed a higher drug loading capacity over 6-MP,small particle size,and favorable *** abundant disulfide bonds in polymer backbones and drug payloads,DMP-NPs could rapidly respond to high levels of glutathione(GSH)and release drugs in a controllable *** importantly,both cellular and animal experiments demonstrated the enhanced anticancer efficacy of DMP-NPs against lymphoma and their high ***,this drug dimer-loaded dual redox-responsive drug delivery system provides new options for improving the applications of traditional drugs and developing drug delivery systems with enhanced drug effects and high safety.

关键词： 6-mercaptopurine(6-MP) dimer redox-responsive nanoparticle(NPs) cancer therapy

TWO-GRID ALGORITHM OF H^(1)-GALERKIN MIXED FINITE ELEMENT METHODS FOR SEMILINEAR PARABOLIC INTEGRO-DIFFERENTIAL EQUATIONS

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Journal of Computational Mathematics 2022年第5期40卷 667-685页

作者： Tianliang Hou Chunmei Liu chunlei dai Luoping Chen Yin Yang School of Mathematics and Statistics Beihua UniversityJilin 132013China College of Science Hunan University of Science and EngineeringYongzhou 425199China School of Mathematics Southwest Jiaotong UniversityChengdu 611756China Hunan Key Laboratory for Computation and Simulation in Science and Engineering Key Laboratory of Intelligent Computing&Information Processing of Ministry of EducationSchool of Mathematics and Computational ScienceXiangtan UniversityXiangtan 411105China

In this paper,we present a two-grid discretization scheme for semilinear parabolic integro-differential equations by H1-Galerkin mixed finite element *** use the lowest order Raviart-Thomas mixed finite elements and continuous linear finite element for spatial discretization,and backward Euler scheme for temporal ***,a priori error estimates and some superclose properties are ***,a two-grid scheme is presented and its convergence is *** the proposed two-grid scheme,the solution of the nonlinear system on a fine grid is reduced to the solution of the nonlinear system on a much coarser grid and the solution of two symmetric and positive definite linear algebraic equations on the fine grid and the resulting solution still maintains optimal ***,a numerical experiment is implemented to verify theoretical results of the proposed *** theoretical and numerical results show that the two-grid method achieves the same convergence property as the one-grid method with the choice h=H^(2).

关键词： Semilinear parabolic integro-differential equations H^(1)-Galerkin mixed finite element method A priori error estimates Two-grid Superclose.

Redox responsive polymeric nanoparticles enhance the efficacy of cyclin dependent kinase 7 inhibitor for enhanced treatment of prostate cancer

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Chinese Chemical Letters 2024年第8期35卷 443-448页

作者： Yiran Tao chunlei dai Zhaoxiang Xie Xinru You Kaiwen Li Jun Wu Hai Huang Department of Urology Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China Department of Urology The Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhou 510120China Biomedical Innovation Center The Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhou 510120China School of Biomedical Engineering Sun Yat-sen UniversityShenzhen 518107China Center for Nanomedicine and Department of Anesthesiology Brigham and Women’s HospitalHarvard Medical SchoolBostonMA 02115United States Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Sun Yat-sen Memorial HospitalSun Yat-Sen UniversityGuangzhou 510120China Department of Urology The Sixth Affiliated Hospital of Guangzhou Medical UniversityQingyuan People’s HospitalQingyuan 511518China Bioscience and Biomedical Engineering Thrust The Hong Kong University of Science and Technology(Guangzhou)Guangzhou 511400China Division of Life Science The Hong Kong University of Science and TechnologyHong KongChina Guangdong Provincial Clinical Research Center for Urological Diseases Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China

Traditional therapies such as surgery and endocrine therapy no longer meet the clinical needs in prostate cancer treatment,and more effective treatments are urgently *** studies have reported that targeted inhibition of the transcription factor cyclin dependent kinase 7(CDK7)could effectively suppress prostate cancer ***,the toxicity of CDK7 inhibitors such as THZ1 is the main limitation of the clinical *** this work,we synthesized Cys8E(C8E)nanoparticles(NPs)loaded with THZ1(C8E@THZ1),a novel GSH-targeting and stimuli-responsive nano-delivery platform,and investigated its anti-tumor potential and biosafety *** vitro,C8E@THZ1 potently inhibited the proliferation and promoted the apoptosis of prostate cancer *** tumor-bearing mice,C8E@THZ1 inhibited tumors by up to 85%,while the damage of THZ1 to liver function was effectively *** results confirmed that inhibition of CDK7 can effectively block the progression of prostate cancer,and that Cys8E NPs is a highly prospective delivery platform to promote the clinical application of CDK7 inhibitors.

关键词： Prostate cancer Nanoparticles CDK7 THZ1 THZ1@Cys8E NPs

Effects of polymer molecular weight on in vitro and in vivo performance of nanoparticle drug carriers for lymphoma therapy

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Chinese Chemical Letters 2023年第4期34卷 133-140页

作者： Xinru You Liying Wang Junfu Zhang Tong Tong chunlei dai Chun Chen Jun Wu Department of Pediatrics The Seventh Affiliated Hospital of Sun Yat-sen UniversityShenzhen 518107China School of Biomedical Engineering Sun Yat-sen UniversityShenzhen 518057China Department of Urology The Seventh Affiliated Hospital of Sun Yat-sen UniversityShenzhen 518107China

The clinical efficacy of chemotherapeutic drugs is hindered by their poor aqueous solubility, low bioavailability and severe side effects. In recent years, polymeric nanocarriers have been used for drug delivery to improve the efficacy of many chemotherapeutics. In this study, a series of biodegradable phenylalaninebased poly(ester amide)(Phe-PEA) with tunable molecular weights(MWs) were synthesized to systematically investigate the relationship between the polymer MW and the efficacy of the corresponding polymeric nanoparticles(NPs). The results indicated that a range of polymers with different MWs can be obtained by varying the monomer ratio or reaction time. Doxorubicin(DOX), a classic clinical lymphoma treatment strategy, was selected as a model drug. The loading capacity and stability of the higher MW polymeric NPs were superior to those of the lower MW ones. Moreover, in vitro and in vivo data revealed that high MW polymeric NPs had better anticancer efficacy against lymphoma and higher biosafety than low MW polymeric nanoparticles and DOX. Therefore, this study suggests the importance of polymer MW for drug delivery systems and provides valuable guidance for the design of enhanced polymeric drug carriers for lymphoma treatment.

关键词： Nanoparticles Drug delivery Lymphoma therapy Polymer molecular weight Poly(ester amide)

Highly efficient and non-doped red conjugated polymer dot for photostable cell imaging

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Chinese Chemical Letters 2023年第6期34卷 387-390页

作者： Mengqi Wu Qidong Wei Caihong Xian chunlei dai Xuehan He Changfeng Wu Guoming Sun Lei Chen School of Biomedical Engineering Sun Yat-sen UniversityShenzhen 518107China Teaching and Experiment Centre Sun Yat-sen UniversityShenzhen 518107China Department of Biomedical Engineering Southern University of Science and TechnologyShenzhen 518055China College of Chemistry and Environmental Science Hebei UniversityAffiliated Hospital of Hebei UniversityBaoding 071002China

By introducing a naphthothiadiazole(NT)unit as the main building block,a non-doped and red emissive conjugated polymer poly(9,9-dihexylfluorene-alt-naphthothiadiazole)(PFNT)is readily obtained through a two-step *** the NT unit has a large twist angle with its neighboring segment,the aggregation-induced quenching(AIQ)effect of PFNT can be effectively suppressed in the condensed *** a result,the corresponding PFNT polymer dot(Pdot)exhibits a high fluorescence quantum yield of53.2%with peak emission at 616 nm,which is one of the most efficient red Pdots *** Pdot shows good biocompatibility and can be employed for living cell fluorescent imaging with high *** also can be used for specific subcellular organelle imaging through immunofluorescence ***,the PFNT Pdot demonstrates much better photostability for long-time cell fluorescence imaging than commercial red *** high performances of PFNT Pdot make it a promising fluorescent probe for practical bioapplications.

关键词： Conjugated polymer dot Cell imaging Naphthothiadiazole Photostability Non-doped

Prediction of Driver Gene Matching in Lung Cancer NOG/PDX Models Based on Artificial Intelligence

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Engineering 2022年第8期8卷 102-114页

作者： Yayi He Haoyue Guo Li Diao Yu Chen Junjie Zhu Hiran C.Fernando Diego Gonzalez Rivas Hui Qi chunlei dai Xuzhen Tang Jun Zhu Jiawei dai Kan He Dan Chan Yang Yang School of Medicin5 Tongji UniversityShanghai 200092China Department of Medical Oncology Shanghai Pulmonary HospitalSchool of Medicin5Tongji UniversityShanghai 200433China Department of Automation School of Electronic Information and Electrical Engineerin7Shanghai Jiao Tong UniversityShanghai 200240China Spine Center Orthopedic DepartmentShanghai Changzheng HospitalShanghai 200003China Department of Thoracic Surgery Shanghai Pulmonary HospitalSchool of Medicin5Tongji UniversityShanghai 200433China School of Materials Science and Engineerin7 Tongji UniversityShanghai 201804China Department of Thoracic Surgery Allegheny General HospitalPittsburg8PA 15212USA Department of Thoracic Surgery and Minimally Invasive Thoracic Surgery Unit(UCTMI) Coruna University HospitalCoruna 15006Spain Oncology and Immunology BU Research Service DivisionWuXi Appte3Shanghai 200131China SJTU–Yale Joint Center for Biostatistics and Data Scienc5 Department of Bioinformatics and BiostatisticsSchool of Life Sciences and BiotechnologyShanghai Jiao Tong UniversityShanghai 200240China Division of Medical Oncology Department of Medicin5University of Colorado Anschutz Medical CampusAuror1CO 80045USA

Patient-derived tumor xenografts(PDXs)are a powerful tool for drug discovery and screening in ***,current studies have led to little understanding of genotype mismatches in PDXs,leading to massive economic ***,we established PDX models from 53 lung cancer patients with a genotype matching rate of 79.2%(42/53).Furthermore,17 clinicopathological features were examined and input in stepwise logistic regression(LR)models based on the lowest Akaike information criterion(AIC),least absolute shrinkage and selection operator(LASSO)-LR,support vector machine(SVM)recursive feature elimination(SVM-RFE),extreme gradient boosting(XGBoost),gradient boosting and categorical features(Cat Boost),and the synthetic minority oversampling technique(SMOTE).Finally,the performance of all models was evaluated by the accuracy,area under the receiver operating characteristic curve(AUC),and F1 score in 100 testing *** multivariable LR models revealed that age,number of driver gene mutations,epidermal growth factor receptor(EGFR)gene mutations,type of prior chemotherapy,prior tyrosine kinase inhibitor(TKI)therapy,and the source of the sample were powerful ***,Cat Boost(mean accuracy=0.960;mean AUC=0.939;mean F1 score=0.908)and the eight-feature SVM-RFE(mean accuracy=0.950;mean AUC=0.934;mean F1 score=0.903)showed the best performance among the ***,application of the SMOTE improved the predictive capability of most models,except Cat *** on the SMOTE,the ensemble classifier of single models achieved the highest accuracy(mean=0.975),AUC(mean=0.949),and F1 score(mean=0.938).In conclusion,we established an optimal predictive model to screen lung cancer patients for non-obese diabetic(NOD)/Shi-scid,interleukin-2 receptor(IL-2R)γ^(null)(NOG)/PDX models and offer a general approach for building predictive models.

关键词： Machine learning Patient-derived tumor xenografts NOG mice

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我院临床药师在内分泌科的工作与体会

中国药房 2007年第5期18卷 399-400页

作者：戴春雷江苏南通市第一人民医院药剂科南通市226001

目的探讨临床药师在内分泌科的作用。方法介绍我院临床药师开展药学服务的经验与体会。结果与结论我院临床药师采用跟随医师查房、解决有关问题、编写药历、宣传药品不良反应等方式,可体现自身价值,但仍需不断提高自身业务水平。

关键词：内分泌科临床药师药学服务

Advances on bioremediation of oil-contaminated soil in cold region

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Chinese Journal Of Geochemistry 2006年第B8期25卷 96-97页

作者： Xiaoyan LIU Jingxin SUN Guocheng MAO chunlei dai Chun LI Qianya ZHU Yingli LI Geoscience College Daqing Petroleum Institute Daqing 163318 China Security and Environment Protection Department Daqing Petroleum Administrative Bureau Daqing 163453 China

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风力发电机组传动系统扭振特性分析

太阳能学报 2019年第5期40卷 1448-1455页

作者：张建华高源戴春蕾于东霞扬州大学水利与能源动力工程学院

根据风力发电机组三质量传动系统动力学模型,建立传动系统状态空间模型,运用现代控制理论方法对传动系统在外界扰动下的扭振特性进行详细分析,并揭示自由振荡频率与传动系统参数的内在关系。在此基础上运用Matlab/Simulink下对传动系统... 详细信息

根据风力发电机组三质量传动系统动力学模型,建立传动系统状态空间模型,运用现代控制理论方法对传动系统在外界扰动下的扭振特性进行详细分析,并揭示自由振荡频率与传动系统参数的内在关系。在此基础上运用Matlab/Simulink下对传动系统建模,并在时域下与控制理论的分析结论进行仿真对比,验证理论分析的正确性。通过对自由振荡频率的对比分析,论证采用风力发电机组传动系统三质量模型的必要性,并为风电机组传动系统的抗共振设计提供科学依据。

关键词：风力发电机组传动系统暂态特性扭振自由振荡频率

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叠层片式陶瓷电感器寄生电容的提取

电子元件与材料 2011年第1期30卷 41-45页

作者：刘宁戴春雷深圳顺络电子股份有限公司开发部广东深圳518110

寄生电容是叠层片式电感器的重要参数,对电感器的Q值和谐振频率影响很大。如何准确估计寄生电容的大小成为电感器设计的一个难题。采用AnsoftQ3D软件建立了叠层片式陶瓷电感器的3D静电场有限元模型,计算了各电极间的杂散电容,然后建立... 详细信息

寄生电容是叠层片式电感器的重要参数,对电感器的Q值和谐振频率影响很大。如何准确估计寄生电容的大小成为电感器设计的一个难题。采用AnsoftQ3D软件建立了叠层片式陶瓷电感器的3D静电场有限元模型,计算了各电极间的杂散电容,然后建立电感器的等效电容网络,列出节点电压方程并求解得到寄生电容。计算结果和测量结果基本一致。瓷体介电常数、内部电极线宽、膜厚、端头宽度和立式电极结构等,是影响叠层片式陶瓷电感器寄生电容的因素。

关键词：叠层片式陶瓷电感器寄生电容杂散电容有限元法