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Design of artificial biomimetic channels with Na^(+)permeation rate and selectivity potentially outperforming the natural sodium channel

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Nano Research 2024年第9期17卷 8638-8646页

作者： Zhi Zhu Yan Zhao Chao Chang Shaojian Yan Tingyu Sun Shiyu Gu Yangmei Li Dengsong Zhang chunlei wang Xiao Cheng Zeng School of Optical-Electrical and Computer Engineering University of Shanghai for Science and TechnologyShanghai 200093China Innovation Laboratory of Terahertz Biophysics National Innovation Institute of Defense TechnologyBeijing 100071China School of Physics Peking UniversityBeijing 100871China International Joint Laboratory of Catalytic Chemistry College of SciencesShanghai UniversityShanghai 200444China Department of Materials Science and Engineering City University of Hong KongHong Kong 999077China

Artificial ion channels that enable high-efficiency ion transport have important implications in nanofluidics and biomedical applications such as drug ***,we show a simulation-based chemical design of a biomimetic sodium channel that possesses permeation rate and selectivity potentially higher than those of the state-of-the-art natural vertebrate voltage-gated sodium ***,our theoretical findings have undergone empirical testing,aligning well with the Arrhenius law as derived from a diverse range of experimental *** high-efficiency ion transport is achieved by anchoring the carboxylate functional groups within the channel filter.A key chemical guiding principle underlying the ion channel design is that the free-energy barrier for the Na^(+)passage across the channel should be comparable to typical thermal energy at room *** the implementation of the chemical design,we found that the relatively low free-energy barrier can be attributed to the compensation effect of the carboxylate groups to the partially lost oxygen shell of the ion within the ion channel,as well as to the consonant vibration of the ions inside and outside the *** mechanistic understanding brings new insight,at the molecular level,into the high-efficiency ion transport across the designed membrane *** proof of principle achieved from the simulations will stimulate future experimental confirmation and potential applications of the high-performance artificial channels in nanofluidics and in bioinspired iontronics.

关键词： sodium channels anchoring carboxylate functional groups molecular dynamics simulations low free-energy barrier for ion passage thermal kinetic energy

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Microstructure and thermoelectric properties of nanoparticled copper selenide alloys synthesized using a microwave-assisted hydrothermal method

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ChemPhysMater 2023年第3期2卷 207-216页

作者： Mahwish Khan Jinze Zhai Wenbin Su Fahad Mehmood Tingting Chen Juanjuan Feng Hongchao wang chunlei wang School of Physics State Key Laboratory of Crystal MaterialsShandong UniversityJinan 250100China

With the fabrication of high-performance thermoelectric(TE)materials,developments are being made in enhanc-ing the figure of merit,zT,of TE ***-like binary copper selenide(Cu_(2) Se)chalcogenides recently gained significant recognition because of their anomalous but fascinating electrical and thermal transport *** this study,a facile synthesis technique was adopted in fabricating Cu_(2) Se nanoparticles using a rapid microwave-assisted hydrothermal route at different reaction *** results were compared with those of the Cu_(2) Se solid-state(SS)sample synthesized using the traditional melting and annealing technique.X-ray diffrac-tion patterns revealed successful synthesis of nanoparticles and a phase transition from orthorhombic𝛼-phase and cubic𝛽-phase to a single orthorhombic structure after *** electron microscopic images revealed that although the grain sizes of the nanoparticle(NP)bulk samples increased with the reaction time of the microwave hydrothermal process,the grain sizes were significantly smaller than that of the SS ***,NP bulk samples exhibited plenty of nano-grains and pores that are absent in the SS *** size and distribution of the grains and pores were measured to study their effects on the transport of carriers and *** NP30 sample exhibited the highest power factor of 983.3μW K−2 m at 673 K among the NP samples,exhibiting intermediate values of resistivity and Seebeck coefficient that are close to those of the SS ***,the NP samples exhibited appreciably lower thermal conductivity than the SS sample that is attributed to strengthened phonon *** minimum thermal conductivity of the NP05 sample,0.78 WK−1 m−1 at 348 K,is 1.7 times lower than that of the SS ***,a maximum zT of 0.56 at 673 K,being approximately 1.3 times higher than that of the SS sample owing to the optimized thermal conductivity,was achieved for the NP30 *** value

关键词： Cu_(2)Se alloys Microwave hydrothermal synthesis Nanoparticles Multiscale microstructure Thermoelectric performance

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The TET3 inflammasome senses unique long HSV-1 proteins for virus particle budding from the nucleus

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Cellular & Molecular Immunology 2024年第11期21卷 1322-1334页

作者： Qiannv Liu Weitao Li Yan Qian chunlei wang Chun Kong Mengqian Li Liangliang Sun Lang Sun Yanli Pang Changtao Jiang Shuo wang Pengyan Xia Department of Immunology School of Basic Medical SciencesPeking UniversityBejing 100191China NHC Key Laboratory of Medical Immunology Peking UniversityBejing 100191China Key Laboratory of Molecular Immunology Chinese Academy of Medical SciencesBeijing 100191China State Key Laboratory of Female Fertility Preservation Center for Reproductive MedicineDepartment of Obstetrics and GynecologyPeking University Third HospitalBeijing 100191China National Clinical Research Center for Obstetrics and Gynecology Peking University Third HospitalBeijing 100191China Department of Physiology and Pathophysiology School of Basic Medical SciencesState Key Laboratory of Vascular Homeostasis and RemodelingPeking UniversityBeijing 100191China Center for Obesity and Metabolic Disease Research School of Basic Medical SciencesPeking UniversityBeijing 100191China CAS Key Laboratory of Pathogen Microbiology and Immunology Institute of MicrobiologyChinese Academy of Sciences100101 BejingChina

Inflammasomes play important roles in resisting infections caused by various ***-1 is a highly contagious virus among *** process by which HSV-1 particles bud from the nucleus is unique to herpes viruses,but the specific mechanism is still ***,we screened genes involved in HSV-1 *** found that TET3 plays an essential role in HSV-1 ***3 recognizes the UL proteins of HSV-1 and,upon activation,can directly bind to caspase-1 to activate an ASC-independent inflammasome in the *** subsequent cleavage of GSDMD in the nucleus is crucial for the budding of HSV-1 particles from the *** the perforation ability of GSDMD on the nuclear membrane can significantly reduce the maturation and spread of *** results may provide a new approach for the treatment of HSV-1 in the future.

关键词： HSV-1 unique long proteins TET3 ASC-independent inflammasome

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Quaternary chalcogenides: Promising thermoelectric material and recent progress

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Science China Materials 2020年第1期63卷 8-15页

作者： Teng wang Taichang Huo Hongchao wang chunlei wang School of Physics State Key Laboratory of Crystal MaterialsShandong UniversityJinan 250100China State Key Laboratory of Metastable Materials Science and Technology Yanshan UniversityQinhuangdao 066000China

Depletion of natural resources(oil,gas and coal)and increasing global warming urge the researchers to develop new methods for energy *** world’s demand of alternative clean energy is becoming more and more *** conversion of waste heat into useful electrical energy is an eco-friendly and straight forward approach to solve the worldwide power problems.

关键词： Peltier效应硫属化合物热电材料协同调控热电性能非化学计量晶格结构晶格热导率

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Stable water droplets on composite structures formed by embedded water into fully hydroxylated β-cristobalite silica

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Chinese Physics B 2021年第1期30卷 191-196页

作者： Hanqi Gong Chonghai Qi Junwei Yang Jige Chen Xiaoling Lei Liang Zhao chunlei wang Division of Interfacial Water and Key Laboratory of Interfacial Physics and Technology Shanghai Institute of Applied PhysicsChinese Academy of SciencesShanghai 201800China University of Chinese Academy of Sciences Beijing 100049China School of Physics Shandong UniversityJinan 250100China School of Arts and Sciences Shanghai Dianji UniversityShanghai 201306China Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai 201210China Department of Physics East China University of Science and TechnologyShanghai 200237China College of Physical Science and Technology Yangzhou UniversityJiangsu 225009China

Using molecular dynamics simulations, we have revealed a novel wetting phenomenon with a droplet on composite structures formed by embedded water into(111) surface of β-cristobalite hydroxylated silica. This can be attributed to the formation of a composite structure composed of embedded water molecules and the surface hydroxyl(–OH) groups,which reduces the number of hydrogen bonds between the composite structure and the water droplet above the composite structure. Interestingly, a small uniform strain(±3%) applied to the crystal lattice of the hydroxylated silica surface can result in a notable change of the contact angles(> 40°) on the surface. The finding provides new insights into the correlation between the molecular-scale interfacial water structures and the macroscopic wettability of the hydroxylated silica surface.

关键词： lattice strain surface wettability embedded water hydrogen bonds

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The neuropeptide CGRP enters the macrophage cytosol to suppress the NLRP3 inflammasome during pulmonary infection

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Cellular & Molecular Immunology 2023年第3期20卷 264-276页

作者： Fangrui Zhu Dou Yu Xiwen Qin Yan Qian Juan Ma Weitao Li Qiannv Liu chunlei wang Yan Zhang Yi Li Dong Jiang Shuo wang Pengyan Xia Department of Immunology School of Basic Medical SciencesPeking University100191 BeijingChina NHC Key Laboratory of Medical Immunology Peking University100191 BejingChina Key Laboratory of Molecular Immunology Chinese Academy of Medical Sciences100191 BejingChina CAS Key Laboratory of Pathogen Microbiology and Immunology Institute of MicrobiologyChinese Academy of Sciences100101 BejingChina Center for Biosafety Mega-Science Chinese Academy of SciencesWuhanHubei 430071China Department of Anesthesiology Peking University Third Hospital100191 BeijingChina Department of Sports Medicine Peking University Third Hospital100191 BejingChina Beijing Key Laboratory of Sports Injuries Institute of Sports Medicine of Peking University100191 BejingChina

The NLRP3 inflammasome plays an essential role in resistance to bacterial infection. The nervous system secretes multiple neuropeptides affecting the nervous system as well as immune cells. The precise impact of the neuropeptide CGRP on NLRP3 inflammasome activation is still unclear. Here, we show that CGRP negatively regulates the antibacterial process of host cells. CGRP prevents NLRP3 inflammasome activation and reduces mature IL-1β secretion. Following NLRP3 inflammasome stimulation that triggers endosome leakage, CGRP internalized to endosomal compartments is released into the cell cytosol. Cytosolic CGRP binds directly to NLRP3 and dismantles the NLRP3-NEK7 complex, which is crucial for NLRP3 inflammasome activation. CGRP administration exacerbates bacterial infection, while the treatment with a CGRP antagonist has the opposite effect. Our study uncovers a unique role of CGRP in inhibiting inflammasome activation during infections, which might shed new light on antibacterial therapies in the future.

关键词： Neuropeptide CGRP NLRP3 Inflammasome Suppressor

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Understanding the role of miRNAs in the pathogenesis of brain arteriovenous malformations

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BIOCELL 2022年第1期46卷 27-35页

作者： ILGIZ GAREEV OZAL BEYLERLI chunlei wang ANDREI SOKHATSKII YANCHAO LIANG HUAN XIANG CHUNYANG LIU XUN XU YANG GUANG Bashkir State Medical University UfaRepublic of BashkortostanRussia Department of Neurosurgery the First Affiliated Hospital of Harbin Medical UniversityHarbinChina Institute of Brain Science Harbin Medical UniversityHarbinChina

Brain arteriovenous malformations(AVMs)are abnormal vessels that are prone to rupture,ausing life threatening intracerebral hemorrhage(ICH).Understanding the moleaular basis of pathogenesis,timely diagnosis,and treatment of brain AVMs are some of the urgent problems in neur osur ***(miRNAs)are small endogenous RNAs that regulate gene-epression *** are involved in almost all biological procsss,induding cell proliferation,apoptosis,and cell *** studies have shown that miRNAs an be involved in brain AVMs formation and *** are also extracellular forms of *** miRNAs have been detected in the blood circulation and other body *** to their stability and resistance to endogenous RNase activity,circulating miRNAs have been proposed as diagnostic and prognostic biomarkers for various diseases,such as tumors,cardiovascular and autoimmune *** this review,we summarized the role of some miRNAs in brain AVMs pathogenesis and discussed their potential cdinical appliation as non-invasive biomarkers.

关键词： Brain arteriovenous malformations MiRNA Pathogenesis Biomarker

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热电材料、器件设计和应用新进展

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科学通报 2021年第16期66卷 2024-2032页

作者：王春雷山东大学物理学院济南250100

热电效应是能够把热能和电能相互转换的一种耦合效应.利用这一物理效应可以实现固体制冷和发电.目前,具有优良热电效应的材料通常是半导体合金材料,在制冷方面的应用技术成熟,但在发电方面的实际应用仍局限于太空能源.近几年出现了锰酸... 详细信息

热电效应是能够把热能和电能相互转换的一种耦合效应.利用这一物理效应可以实现固体制冷和发电.目前,具有优良热电效应的材料通常是半导体合金材料,在制冷方面的应用技术成熟,但在发电方面的实际应用仍局限于太空能源.近几年出现了锰酸钙和铜铁矿结构等氧化物新型热电材料.人们利用不同的制备工艺,调控材料的微结构,改善氧化物材料的热电性能.为了满足不同的应用需求,提高电功率输出,人们对传统热电模块的几何形状进行了优化,设计了新型热电器件,对其性能进行了模拟和实证.除直接利用热电效应进行发电,近几年也开展了与其他发电模式联合发电的研究工作.

关键词：热电效应锰酸钙铜铁矿模块应用

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Geometric and Electronic Structure of Squaric Acid from DFT Calculation

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Journal of Materials Science & Technology 2004年第2期20卷 206-208页

作者： Xuyan XUE, chunlei wang and Weilie ZHONGSchool of Physics and Microelectronics, State Key Laboratory of Crystal Materials, Shandong University, Jinan 250100, China Shandong Univ Sch Phys & Microelect State Key Lab Crystal Mat Jinan 250100 Peoples R China

The crystal and electronic structure of antiferroelectric squaric acid is studied using density functional theory method, and the exchange correlation effects are treated by the generalized approximation. In order to understand the ferroelectricity of H2SQ in the molecular plane and the antiferroelectricity in whole crystal, the density of states, charge density distribution and band structure are calculated. The result showed that O2p and C2p play important roles in the interactions between layers. The hybridizations of 02s-Hls and 02p-Hls are responsible for the tendency to ferroelectricity within each layer.

关键词： Antiferroelectricity Electronic structure Squaric acid

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Photocatalytic hydrogen evolution activity over MoS_2/ZnIn_2S_4 microspheres

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Chinese Journal of Catalysis 2017年第12期38卷 2067-2075页

作者： Bo Chai Chun Liu chunlei wang Juntao Yan Zhandong Ren School of Chemical and Environmental Engineering Wuhan Polytechnic University Wuhan 430023 Hubei China

MoS2/ZnIn2S4composites with MoS2anchored on the surface of ZnIn2S4microspheres were synthesized by a two‐step hydrothermal *** obtained samples were characterized by X‐ray diffraction,field emission scanning electron microscopy,energy dispersive X‐ray spectroscopy,high‐resolution transmission electron microscopy,X‐ray photoelectron spectroscopy,Raman spectroscopy,ultraviolet–visible diffuse reflectance absorption spectroscopy,nitrogen adsorption–desorption measurements,photoluminescence spectroscopy,and photoelectrochemical *** influence of the loading of MoS2on the photocatalytic H2evolution activity was investigated using lactic acid as a sacrificial reagent.A H2evolution rate of343μmol/h was achieved under visible light irradiation over the1wt%MoS2/ZnIn2S4composite,corresponding to an apparent quantum efficiency of about3.85%at420nm monochromatic *** marked improvement of the photocatalytic H2evolution activity compared with ZnIn2S4can be ascribed to efficient transfer and separation of photogenerated charge carriers and facilitation of the photocatalytic H2evolution reaction at the MoS2active sites.

关键词： Composite Cocatalyst Photocatalytic hydrogen evolution Charge carrier Separation

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