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Chinese Physics B 2018年第5期27卷 504-512页

作者： chunjie zheng Tianqing Jia Hua Zhao Yingjie Xia Shian Zhang Zhenrong Sun State Key Laboratory of Precision Spectroscopy College of Physics and Materials East China Normal University Shanghai 200062 China

This paper reports the plasmonic lasing of a split ring filled with gain material in water. The lasing mode（1500 nm）is far from the pump mode（980 nm）, which can depress the detection noise from the pump light. The laser intensities of the two modes simultaneously increase by more than 10^3 in amplitude, which can intensify the absorption efficiency of the pumping light and enhance the plasmonic lasing. The plasmonic lasing is a sensitive sensor. When a single protein nanoparticle（n = 1.5, r = 1.25 nm） is trapped in the gap of the split ring, the lasing spectrum moves by 0.031 nm, which is much larger than the detection limit of 10^-5 nm. Moreover, the lasing intensity is also very sensitive to the trapped nanoparticle. It reduces to less than 1/600 when a protein nanoparticle（n = 1.5, r = 1.25 nm） is trapped in the gap.

关键词： label-free detection split-ring resonators plasmonic lasing single molecules and single nanoparticles

The equivalent potential of water molecules for electronic structure of lysine

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Science China(Physics,Mechanics & Astronomy) 2007年第1期50卷 15-30页

作者： LI chunjie zheng HaoPing WANG XueMei Pohl Institute of Solid State Physics Tongji UniversityShanghai 200092China

In order to get more reliable electronic structures of proteins in aqueous solution, it is necessary to construct a potential of water molecules for protein’s electronic structure calculation. The lysine is a hydrophilic amino acid. It is positively charged (Lys+) in neutral water solution. The first-principles, all-electron, ab initio calcula-tions, based on the density functional theory, have been performed to construct such an equivalent potential of water molecules for lysine (Lys+). The process consists of three parts. First, the electronic structure of the cluster containing Lys+ and water molecules is calculated. By adjusting the positions of water molecules, the geometric structure of the cluster having minimum total energy is determined. Then, based on the structure, the electronic structure of Lys+ with the potential of water molecules is calculated using the self-consistent cluster-embedding (SCCE) method. Finally, the electronic structure of Lys+ with the potential of dipoles is calculated. The dipoles are adjusted so that the electronic structure of Lys+ with the potential of dipoles is close to that of water molecules. Thus the equivalent potential of water molecules for the electronic structure of lysine is obtained. The major effect of water molecules on lysine’s electronic structure is raising the occupied eigenvalues about 0.5032 eV, and broadening energy gap 89%. The effect of water molecules on the electronic structure of lysine can be simulated by dipoles potential.

关键词： lysine electronic structure water molecule free cluster calculation self-consistent cluster-embedding calculation

Studies of surface processes of electrocatalytic reduction of CO_(2) on Pt(210), Pt(310) and Pt(510)

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Science China Chemistry 2007年第5期50卷 593-598页

作者： FAN chunjie FAN YouJun ZHEN ChunHua zheng QingWei SUN ShiGang State Key Laboratory of Physical Chemistry of Solid Surfaces Department of ChemistryCollege of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China

Surface processes of CO_(2)reduction on Pt(210),Pt(310),and Pt(510)electrodes were studied by cyclic *** surface structures of these platinum single crystal electrodes were obtained by various treatment *** experimental results illustrated that the electrocatalytic activity of Pt single crystal electrodes towards CO_(2)reduction is decreased in an order of Pt(210)>Pt(310)>Pt(510),i.e.,with the decrease of(110)step density on well-defined *** the surfaces were reconstructed due to oxygen adsorption,the catalytic activity of all the three electrodes has been enhanced to a cer-tain *** the activity order remains unchanged,the electrocatalytic activity has been en-hanced more significantly as the density of(110)step sites is more intensive on the Pt single crystal *** has revealed that the more open the surface structure is,the more active the Pt single crystal electrode will be,and the easier for the electrode to be transformed into a surface structure that exhib-its higher activity under external ***,the relatively ordered surfaces of Pt single crystal electrode are comparatively stable under the same external *** present study has gained knowledge on the interaction between CO_(2)and Pt single crystal electrode surfaces at a micro-scopic level,and thrown new insight into understanding the surface processes of electrocatalytic re-duction of CO_(2).

关键词： Pt single crystal electrode stepped surface CO_(2)electro-catalyticreduction surface processes

络合剂高效液相色谱法测定施尔康片中铜、铁、锌、镁的含量

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沈阳药科大学学报 1997年第3期14卷 179-181,195页

作者：赵春杰田立军张仲元佟志清曹炳星沈阳药科大学药学系

络合剂高效液相色谱法测定施尔康片中铜、铁、锌、镁的含量赵春杰田立军张仲元佟志清曹炳星首次报告了高效液相色谱法同时测定高效施尔康中微量元素铜、铁、锌和镁的含量．研究了四苯基卟啉和金属离子的络合反应条件和络合物的稳定性，... 详细信息

络合剂高效液相色谱法测定施尔康片中铜、铁、锌、镁的含量赵春杰田立军张仲元佟志清曹炳星首次报告了高效液相色谱法同时测定高效施尔康中微量元素铜、铁、锌和镁的含量．研究了四苯基卟啉和金属离子的络合反应条件和络合物的稳定性，考察了这些络合物的吸收光谱和测定的...

关键词：小青龙胶囊盐酸麻黄碱酸性染料比色法

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农业废弃物的好氧堆肥研究进展

科技创新导报 2021年第33期18卷 42-46,50页

作者：杨晓茵朱慧萍罗俊涛陈诺郑纯杰秦建桥刘沙沙肇庆学院环境与化学工程学院广东肇庆526061

好氧堆肥工艺具有低能耗、可节约大量时间、产品有机肥质量高等特点,将农业废弃物变“废”为宝,达到“资源化”“无害化”的目的,符合我国固体废物污染环境防治的基本原则。本文介绍了好氧堆肥技术的原理和过程,对好氧堆肥工艺及其影响... 详细信息

好氧堆肥工艺具有低能耗、可节约大量时间、产品有机肥质量高等特点,将农业废弃物变“废”为宝,达到“资源化”“无害化”的目的,符合我国固体废物污染环境防治的基本原则。本文介绍了好氧堆肥技术的原理和过程,对好氧堆肥工艺及其影响因素的研究现状进行了分析与总结,并对好氧堆肥工艺的优缺点进行对比,以期为好氧堆肥技术的应用和推广提供参考依据。

关键词：农业废弃好氧堆肥影响因素好氧堆肥工艺

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微生物菌剂在堆肥中的应用研究进展

山东化工 2022年第12期51卷 100-102页

作者：陈诺郑纯杰杨晓茵朱慧萍罗俊涛秦建桥刘沙沙肇庆学院环境与化学工程学院广东肇庆526061

堆肥化是处理固体废弃物的有效技术,在堆肥过程中接种微生物菌剂可以加快有机物的分解,缩短堆肥时间,促进堆肥材料的腐熟,提高堆肥产品的质量。本文总结了微生物菌剂对堆肥理化指标(温度、pH值、含水率、有机质的含量、有害气体和C/N比... 详细信息

堆肥化是处理固体废弃物的有效技术,在堆肥过程中接种微生物菌剂可以加快有机物的分解,缩短堆肥时间,促进堆肥材料的腐熟,提高堆肥产品的质量。本文总结了微生物菌剂对堆肥理化指标(温度、pH值、含水率、有机质的含量、有害气体和C/N比)的影响,分析了微生物菌剂提高堆肥效率和品质的原因,并总结不同微生物菌剂(真菌、放线菌、细菌和霉菌等菌种)在堆肥中的作用和功能。

关键词：微生物菌剂堆肥细菌群落

An Update on the Clinical Pipelines of New Antibacterial Drugs Developed in China

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Engineering 2024年第7期38卷 52-68页

作者： Xinyi Yang Congran Li Xiukun Wang Zhonghui zheng Peiyi Sun chunjie Xu Luni Chen Jiandong Jiang Staffan Normark Birgitta Henriques-Normark Xuefu You Beijing Key Laboratory of Antimicrobial Agents/Laboratory of Pharmacology Institute of Medicinal BiotechnologyChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050China Division for Medicinal Microorganism-Related Strains CAMS Collection Center of Pathogenic MicroorganismsChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050China State Key Laboratory of Bioactive Substances and Functions of Natural Medicines Institute of Medicinal BiotechnologyChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050China Shandong Xinhua Pharmaceutical Co. Ltd.Zibo 255005China Department of Microbiology Tumor and Cell BiologyKarolinska InstitutetStockholm SE-17177Sweden State Key Laboratory of Bioactive Substances and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050China Institute of Medicinal Biotechnology Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050China Clinical Microbiology Karolinska University HospitalBioclinicumStockholm SE-17176Sweden

Antibacterial resistance is a global health threat that requires further concrete action on the part of all *** this context,one of the biggest concerns is whether enough new antibacterial drugs are being discovered and *** several high-quality reviews on clinical antibacterial drug pipelines from a global perspective were published recently,none provides comprehensive information on original antibacterial drugs at clinical stages in *** this review,we summarize the latest progress of novel antibacterial drugs approved for marketing and under clinical evaluation in China since *** was obtained by consulting official websites,searching commercial databases,retrieving literature,asking personnel from institutions or companies,and other means,and a considerable part of the data covered here has not been included in other *** of June 30,2023,a total of 20 antibacterial projects from 17 Chinese pharmaceutical companies or developers were identified and *** them,two new antibacterial drugs that belong to traditional antibiotic classes were approved by the National Medical Products Administration(NMPA)in China in 2019 and 2021,respectively,and 18 antibacterial agents are in clinical development,with one under regulatory evaluation,five in phase-3,six in phase-2,and six in *** of the clinical candidates are new analogs or monocomponents of traditional antibacterial pharmacophore types,including two dual-acting hybrid antibiotics and a recombinant antibacterial ***,despite there being 17 antibacterial clinical candidates,our analysis indicates that there are still relatively few clinically differentiated antibacterial agents in stages of clinical development in ***,Chinese pharmaceutical companies and institutions will develop more innovative and clinically differentiated candidates with good market potential in the future research and development(R&D)of original antibacterial drugs.

关键词： Antimicrobial resistance New antibiotics Clinical pipelines WHO priority pathogens National Mega-Project for Innovative Drugs

Evolutionary characteristics of exons expressed at different abundance levels in mammals

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Chinese Science Bulletin 2009年第19期54卷 3546-3554页

作者： YU HaiJing FANG Lin LI Xin ZHANG XiaoYan YE Jia LI Jie HU WeiHong zheng BingRong XIAO chunjie Key Laboratory of Bioresources Conservation and Utilization & Human Genetics Center of Yunnan University Kunming 650091 China Beijing Genomics Institute at Shenzhen Shenzhen 518083 China CAS-Max Planck Junior Research Group and State Key Laboratory of Genetic Resources and Evolution Kunming Institute of Zoology Chinese Academy of Sciences Kunming 650223 China

With comparative genomics approaches, we evaluated the evolutionary characteristics of conservation of exons which are expressed abundantly, moderately or lowly in mammals. Using non-coding regions and pseudogenes as controls, sequence identity, phastCons and Ka/Ks analyses were carried out and our results showed that as the exons of high abundance are highly conserved, the minor and low exons also showed conservative characteristics in evolution. Our findings suggested that the exons with less abundance which constitute a large proportion of distinct species in transcriptome of organisms are under functional constraint and might play certain roles in enriching biological complexity in the evolution of organisms.

关键词：哺乳动物进化特征 Ka/Ks

Self-fueling ferroptosis-inducing microreactors based on p H-responsive Lipiodol Pickering emulsions enable transarterial ferro-embolization therapy

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National Science Review 2024年第1期11卷 74-85页

作者： chunjie Wang Lei Zhang Zhijuan Yang Dongxu Zhao zheng Deng Jialu Xu Yumin Wu Yu Hao Ziliang Dong Liangzhu Feng Zhuang Liu Institute of Functional Nano & Soft Materials (FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices Soochow University Center of Interventional Radiology & Vascular Surgery Department of Radiology Zhongda Hospital Medical School Southeast University Department of Interventional Radiology The First Afflliated Hospital of Soochow University

Lipiodol chemotherapeutic emulsions remain one of the main choices for the treatment of unresectable hepatocellular carcinoma（HCC） via transarterial chemoembolization（TACE）. However, the limited stability of Lipiodol chemotherapeutic emulsions would lead to rapid drug diffusion, which would reduce the therapeutic benefit and cause systemic toxicity of administrated chemotherapeutics. Therefore, the development of enhanced Lipiodol-based formulations is of great significance to enable effective and safe TACE treatment. Herein, a stable water-in-oil Lipiodol Pickering emulsion（LPE） stabilized by pH-dissociable calcium carbonate nanoparticles and hemin is prepared and utilized for efficient encapsulation of lipoxygenase（LOX）. The obtained LOX-loaded CaCO3&hemin-stabilized LPE（LHCa-LPE） showing greatly improved emulsion stability could work as a pH-responsive and self-fueling microreactor to convert polyunsaturated fatty acids（PUFAs）, a main component of Lipiodol, to cytotoxic lipid radicals through the cascading catalytic reaction driven by LOX and hemin, thus inducing ferroptosis of cancer cells. As a result, such LHCa-LPE upon transcatheter embolization can effectively suppress the progression of orthotopic N1S1 HCC in rats. This study highlights a concise strategy to prepare pH-responsive and stable LPE-based self-fueling microreactors, which could serve as bifunctional embolic and ferroptosis-inducing agents to enable proof-of-concept transarterial ferro-embolization therapy of HCC.

关键词： CaCO3 nanoparticles Pickering emulsion ferroptosis lipid peroxidation transarterial ferro-embolization

Development of a biosensor assessing SARS-CoV-2 main protease proteolytic activity in living cells for antiviral drugs screening

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Virologica Sinica 2022年第3期37卷 459-461页

作者： Yuan Zhang chunjie Li Xianliang Ke Dan Luo Yan Liu Quanjiao Chen Hanzhong Wang Xiaohui Song Zhenhua zheng Key Laboratory of Special Pathogens and Biosafety Center for Emerging Infectious DiseasesWuhan Institute of VirologyChinese Academy of SciencesWuhan430071China Department of Gastroenterology Wuhan Children's HospitalTongji Medical CollegeHuazhong University of Science&TechnologyWuhan430015China Department of Obstetrics Wuhan Children's HospitalWuhan Maternal and Child Healthcare HospitalTongji Medical CollegeHuazhong University of Science&TechnologyWuhan430015China University of the Chinese Academy of Sciences Beijing100049China

Dear Editor,The Coronavirus disease 2019(COVID-19)pandemic is caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).The genome of this virus encodes two overlapping polyproteins,pp1a and pp1ab(Wu et al.,2020;Zhou et al.,2020).The functional polypeptides are released from those two polyproteins by extensive proteolytic events.

关键词： protease drugs