检索结果-南通市图书馆

Association of Renin Binding Protein(RnBP) Gene Polymorphisms with Essential Hypertension in the Hani Minority of Southwestern China

在线全文

学校读者我要写书评

暂无评论

Journal of Genetics and Genomics 2013年第8期40卷 433-436页

作者： Yilong Dong Yun Ding Yina Cun chunjie xiao Laboratory for Conservation and Utilization of Bio-resources and Human Genetics Center School of MedicineYunnan University

Essential hypertension is one of the most common multi- factorial diseases, affecting 20%--30% of the human popula- tion （Ibrahim and Damasceno, 2012）. Based on the results of twin studies, adoption studies and statistical analyses of blood pressure （BP） across various pedigrees, it has been estimated that 30%--50% of the variability in blood pressure among the general population is genetically determined （Garcia et al., 2003）. Although the genetic mechanisms of essential hyper- tension have not been studied well, investigations for the genes that constitute the renin-angiotensin system （RAS） appear to be particularly promising, since this system plays a central role in the regulation of blood pressure （Ferrario, 2010）.

关键词： Association of Renin Binding Protein RnBP Gene Polymorphisms with Essential Hypertension in the Hani Minority of Southwestern China gene SNPs

Evolutionary characteristics of exons expressed at different abundance levels in mammals

在线全文

学校读者我要写书评

暂无评论

Chinese Science Bulletin 2009年第19期54卷 3546-3554页

作者： YU HaiJing FANG Lin LI Xin ZHANG xiaoYan YE Jia LI Jie HU WeiHong ZHENG BingRong xiao chunjie Key Laboratory of Bioresources Conservation and Utilization & Human Genetics Center of Yunnan University Kunming 650091 China Beijing Genomics Institute at Shenzhen Shenzhen 518083 China CAS-Max Planck Junior Research Group and State Key Laboratory of Genetic Resources and Evolution Kunming Institute of Zoology Chinese Academy of Sciences Kunming 650223 China

With comparative genomics approaches, we evaluated the evolutionary characteristics of conservation of exons which are expressed abundantly, moderately or lowly in mammals. Using non-coding regions and pseudogenes as controls, sequence identity, phastCons and Ka/Ks analyses were carried out and our results showed that as the exons of high abundance are highly conserved, the minor and low exons also showed conservative characteristics in evolution. Our findings suggested that the exons with less abundance which constitute a large proportion of distinct species in transcriptome of organisms are under functional constraint and might play certain roles in enriching biological complexity in the evolution of organisms.

关键词：哺乳动物进化特征 Ka/Ks

Delay-dependent exponential stability analysis for stochastic systems with mixed delays

在线全文

学校读者我要写书评

暂无评论

Delay-dependent exponential stability analysis for stochasti...

Association of WNK1 exon 1 polymorphisms with essential hypertension in Hani and Yi minorities of China

第三十九届中国控制会议

作者： xiao chunjie Hou Ting College of Mathematics and Systems Science Shandong University of Science and Technology School of Mathematics and Statistics Shandong Normal University

In this paper, mean-square exponential stability for stochastic systems with mixed delays is investigated. By constructing an appropriate Lyapunov-Krasovskii functional（LKF）, a delay-dependent stability（DDS） condition is given in terms of linear matrix inequalities（LMIs）. In particular, the obtained criterion shows that stability of stochastic time-delay systems（STDSs） is independent of the size of the diffusion delays. Finally, a numerical example is presented to verify the feasibility of the main results.

关键词： Delays Exponential stability Stochastic systems

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Journal of Genetics and Genomics 2011年第4期38卷 165-171页

作者： Yina Cun Jin Li Wenru Tang xiaozhi Sheng Haijing Yu Bingrong Zheng chunjie xiao Laboratory for Conservation and Utilization of Bio-resources and Human Genetics Center of Yunnan UniversityKunming 650091China

The association of polymorphisms in exon 1 of the WNK1 gene with essential hypertension in the minority groups of Hani and Yi of China was investigated in the case-control *** sequence of 1257 bp containing the WNK1 gene exon 1 was determined in 1307 individuals（649 essential hypertension subjects and 658 controls）to identify SNPs in Hani and Yi minority *** of eleven previously known SNPs （rs3168640,rs11885,rs11554421 and rs34880640）were *** SNP analysis indicated that SNPs rs11885 and rs11554421 were significantly associated with hypertension in both Hani and Yi populations,and rs34880640 was significantly associated with hypertension in Hani but not in Yi population,adjusted for *** analysis indicated that the haplotype H1 significantly decreased the risk of hypertension in both *** results suggested that WNK1 polymorphisms were involved in the predisposition of essential hypertension in Hani and Yi populations and its effects showed a clear population *** finding supported the importance of population specificity in determining the genetic factors associated with diseases and thus disease treatment.

关键词： WNK1 SNPs Haplotype Essential hypertension Hani population Yi population

Gene admixture in ethnic populations in upper part of Silk Road revealed by mtDNA polymorphism

在线全文

学校读者我要写书评

暂无评论

Science China(Life Sciences) 2008年第5期51卷 435-444页

作者： YANG LiuQi, TAN SiJie, YU HaiJing, ZHENG BingRong, QIAO EnFa, DONG YongLi, ZAN RuiGuang & xiao chunjie Key Laboratory of Bioresources Conservation and Utilization & Human Genetics Center, Yunnan University, Kunming 650091, China Key Laboratory of Bioresources Conservation Utilization & Human Genetics Center Yunnan University Kunming 650091 China

To evaluate the gene admixture on the current genetic landscape in Gansu Corridor (GC) in China, the upper part of the ancient Silk Road which connects the Eastern and Central Asia, we examined mitochondrial DNA (mtDNA) polymorphisms of five ethnic populations in this study. Using PCR-RFLP and sequencing, we analyzed mtDNA haplotypes in 242 unrelated samples in three ethnic populations from the GC region and two ethnic populations from the adjacent Xinjiang Uygur Autonomous Region of China. We analyzed the data in comparison with the previously reported data from Eastern, Central and Western Asia and Europe. We found that both European-specific haplogroups and Eastern Asian-specific haplogroups exist in the Gansu Corridor populations, while a modest matrilineal gene flow from Europeans to this region was revealed. The Gansu Corridor populations are genetically located between Eastern Asians and Central Asians, both of who contributed significantly to the maternal lineages of the GC populations. This study made the landscape of the gene flow and admixture along the Silk Road from Europe, through Central Asia, to the upper part of the Silk Road more complete.

关键词： polymorphism mtDNA gene admixture Gansu Corridor

Polymorphisms in PPARD,PPARG and APM1 associated with four types of Traditional Chinese Medicine constitutions

在线全文

学校读者我要写书评

暂无评论

Journal of Genetics and Genomics 2010年第6期37卷 371-379页

作者： Yanrui Wu Yina Cun Jing Dong Jingru Shao Shengjun Luo Shengjie Nie Haijing Yu Bingrong Zheng Qi Wang chunjie xiao Human Genetics Center of Yunnan University Kunming 650091 China The General Hospital of the Air Force Beijing 100036 China Center for Studies in Constitution Research of Traditional Chinese Medicine Beijing University of Chinese Medicine Beijing 100029 China

Based on the theory of constitution of Traditional Chinese Medicine （TCM）, the human population is divided into nine constitutions including one balanced constitution （Normality） and eight unbalanced constitutions （Yang-deficiency, Yin-deficiency, Phlegm-wetness, Qi-deficiency, Wetness-heat, Blood stasis, Depressed constitution, and Inherited special constitution）. Different constitutions have specific metabolic features and different susceptibility to certain diseases. However, whether a genetic basis accounts for such constitution classification is yet to be determined. Here we performed a genetic study to assess the association between genetic variations of metabolic genes including PPARD, PPARG and APM1 and the constitutions. A total of 233 individuals of the Han population in China were classified into four groups, Normality, Yang-deficiency, Yin-deficiency and Phlegm-wetness with whom 23 single nucleotide polymorphisms （SNPs） in the three genes were genotyped using polymerase chain reaction-restriction fragment length polymorphism （PCR-RFLP） method. Biased distribution of PPARD rs2267669 and rs2076167, APM1 rs7627128 and rs1063539 in Yang-deficiency, PPARG Prol2Ala in Yin-deficiency and PPARD rs2076167, APMI rs266729 and rs7627128 in Phlegm-wetness were observed. The frequencies of Haplotypel3 （Hapl3） of PPARG in Yin-deficiency, Hap25 of APM1 in Yang-deficiency and Hap2 of PPARD and Hapl4 of PPARG in Phlegm-wetness, were significantly different from those in Normality, suggesting those might be group-associated haplotypes. These results suggested that single SNP and haplotypes ofPPARD, PPARG and APM1 may underlie the genetic basis of the constitutions classified in TCM.

关键词： Traditional Chinese Medicine constitution classification PPARD PPARG APM1 SNP

基诺族、布朗族和拉祜族的4种红细胞血型分布

在线全文

学校读者我要写书评

暂无评论

人类学学报 2000年第3期19卷 238-243页

作者：肖蘅郝露萍张明秋肖春杰云南大学生命科学与化学学院生物系昆明650091 中国科学院遗传研究所北京100101 云南省计划生育科学技术研究所昆明650021

调查了云南基诺族、布朗族和拉祜族各 1 0 0人的 ABO、Rh、MN和 P血型系统。结果表明 ,ABO血型系统中 p基因频率拉祜族最高 ( 0 .2 4 2 0 ) ,基诺族最低 ( 0 .0 779) ,布朗族居中( 0 .2 1 44 )。 r基因频率是基诺族最高 ( 0 .6971 ) ,... 详细信息

调查了云南基诺族、布朗族和拉祜族各 1 0 0人的 ABO、Rh、MN和 P血型系统。结果表明 ,ABO血型系统中 p基因频率拉祜族最高 ( 0 .2 4 2 0 ) ,基诺族最低 ( 0 .0 779) ,布朗族居中( 0 .2 1 44 )。 r基因频率是基诺族最高 ( 0 .6971 ) ,拉祜族最低 ( 0 .52 88) ,布朗族居中 ( 0 .5964)。Rh血型系统中 ,基诺族和拉祜族都是以 CCDee和 Cc DE-为常见类型 ,而且都是 CCDee最高 ,Cc DE-次之。拉祜族和基诺族的 CDe频率分别为 0 .7433和 0 .6950 ;c DE频率分别为 0 .1 871和0 .2 51 7;基因频率 d为零。MN血型系统中 ,这 3个民族都是基因频率 m>n。P血型系统中 ,本次调查的 3个民族的 p1基因频率在全国已调查过的汉族和少数民族中均是最高值 (拉祜族0 .50 99,布朗族 0 .4690 ,基诺族 0 .4359)

关键词：红细胞血型基因频率人类群体遗传学少数民族

CMA1基因标签单核苷酸多态与云南彝族原发性高血压的关联研究

在线全文

学校读者我要写书评

暂无评论

中华医学遗传学杂志 2014年第4期31卷 449-454页

作者：吴艳瑞李茜杨科肖春杰昆明医科大学细胞生物学与医学遗传学系 650500 云南大学人类遗传学研究中心

目的探讨糜蛋白酶（ehymase，CMA1）基因标签单核苷酸多态（tag single nucleotide polymorphism，tag SNPs）与云南彝族原发性高血压的关系。方法采用聚合酶链反应一限制性片段长度多态性方法，对303例高血压患者和312名对照个体进行4... 详细信息

目的探讨糜蛋白酶（ehymase，CMA1）基因标签单核苷酸多态（tag single nucleotide polymorphism，tag SNPs）与云南彝族原发性高血压的关系。方法采用聚合酶链反应一限制性片段长度多态性方法，对303例高血压患者和312名对照个体进行4个tagSNPs（rs1956921、rs1800876、rs5244和rs1885108）位点的多态性检测。结果（1）CMA1基因4个tag SNPs位点等位基因和基因型在高血压组和对照组间的频率分布差异无统计学意义（P〉0．05）。（2）高血压组男性rs1956921C等位基因的频率显著高于对照组男性（P=0．009）。（3）由rs1956921和rs5244构建的单倍型C-T在高血压组男性中的频率显著高于对照组男性（P=0．009）。结论云南彝族人群中，rs1956921C等位基因以及由rs1956921和rs5244两个位点构建的单倍型C-T可能是男性原发性高血压发生的危险因子。

关键词： CMA1基因遗传多态性原发性高血压彝族

MEX3A在非小细胞肺癌中的表达与功能研究

在线全文

学校读者我要写书评

暂无评论

中国肿瘤临床 2020年第15期47卷 763-768页

作者：朱贝郭小朋董天祺肖春杰黄石市中医医院(市传染病医院)湖北中医药大学黄石临床学院医学检验科黄石市435000 云南大学医学院

目的:探究MEX3A基因在非小细胞肺癌(non-small cell lung cancer,NSCLC)中的表达水平及沉默MEX3A基因后对NSCLC增殖、侵袭、迁移和凋亡及周期的影响.方法:通过mRNA转录组分析及癌症基因图谱(The Cancer Genome Atlas,TCGA)数据库信息分... 详细信息

目的:探究MEX3A基因在非小细胞肺癌(non-small cell lung cancer,NSCLC)中的表达水平及沉默MEX3A基因后对NSCLC增殖、侵袭、迁移和凋亡及周期的影响.方法:通过mRNA转录组分析及癌症基因图谱(The Cancer Genome Atlas,TCGA)数据库信息分析,筛选出在NSCLC中显著高表达的MEX3A基因.通过qRT-PCR检测MEX3A在4种常见NSCLC细胞系中的mRNA表达水平,发现MEX3A在A549和NCI-H292中显著高表达.利用RNA干扰技术(RNA interference,RNAi)沉默A549和NCI-H292中MEX3A的表达,CCK8及Transwell试验检测沉默MEX3A表达后对NSCLC增殖、侵袭及迁移的影响,流式细胞术分析沉默MEX3A表达后对A549和NCI-H292细胞周期及凋亡的影响.结果:MEX3A在A549和NCI-H292中高表达.沉默MEX3A后NSCLC增殖、侵袭及迁移被显著抑制,细胞周期阻滞于G2/M期,促进细胞凋亡.结论:MEX3A作为NSCLC的促癌基因,参与了NSCLC的生长及增殖过程.

关键词： MEX3A 非小细胞肺癌基因沉默促癌基因