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基于Budyko理论的长江典型流域径流演变与归因分析

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水土保持研究 2025年第1期32卷 172-180页

作者：宋阁庆马晓燕王茂林袁春慧杨陈王飞邓悦甘肃省水文站兰州理工大学能源与动力工程学院扶风县水利工作站

[目的]探究变化环境下的长江典型流域径流演变和驱动因素，量化气候变化及下垫面变化对流域径流变化的贡献率，以期为白水江流域水资源优化配置和流域治理提供科学依据。[方法]采用Mann-Kendall趋势检验、交叉小波分析和Budyko理论等研... 详细信息

[目的]探究变化环境下的长江典型流域径流演变和驱动因素，量化气候变化及下垫面变化对流域径流变化的贡献率，以期为白水江流域水资源优化配置和流域治理提供科学依据。[方法]采用Mann-Kendall趋势检验、交叉小波分析和Budyko理论等研究方法，分析了白水江流域1970—2016年的年径流量演变规律及其影响因素。[结果](1)白水江流域年径流量呈显著(p<0.05)下降趋势，径流和降水突变年份均在1994年。(2)白水江流域年径流量与年降水量呈正相关性关系，径流深在影响期(1995—2016年)相比基准期(1970—1994年)对年降水量最敏感，其次为潜在蒸散发量和下垫面参数。(3)量化解析了下垫面、年降水量和潜在蒸散发量对白水江流域径流的贡献率，其中，下垫面贡献率为46.14%,降水量贡献率为41.02%,潜在蒸散发量贡献率为12.84%。[结论]1970—2016年白水江流域年径流量和年降水量均呈下降趋势，白水江流域径流的驱动因素是由于气候和人类活动的综合影响。降水是导致白水江流域径流减少的主要气候因素，下垫面变化是白水江流域径流减少的一个关键因素。

关键词： Budyko理论径流归因分析白水江流域

A web-based platform for rice microarray annotation and data analysis

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Science China(Life Sciences) 2010年第12期53卷 1467-1473页

作者： CHEN DiJun ZHANG Fan yuan chunhui LU Jing LI Xia CHEN Ming College of Bioinformatics Science and Technology Harbin Medical UniversityHarbin 150086China College of Life Science Zhejiang UniversityHangzhou 310058China Zhejiang California International Nanosystems Institute Zhejiang UniversityHangzhou 310058China

Rice(Oryza sativa) feeds over half of the global population.A web-based integrated platform for rice microarray annotation and data analysis in various biological contexts is presented,which provides a convenient query for comprehensive annotation compared with similar *** with existing rice microarray data,it provides online analysis methods from the perspective of *** comprehensive bioinformatics analysis platform is composed of five modules,including data retrieval,microarray annotation,sequence analysis,results visualization and data *** BioChip module facilitates the retrieval of microarray data information via identifiers of "Probe Set ID","Locus ID" and "Analysis Name".The BioAnno module is used to annotate the gene or probe set based on the gene function,the domain information,the KEGG biochemical and regulatory pathways and the potential microRNA which regulates the *** BioSeq module lists all of the related sequence information by a microarray probe *** BioView module provides various visual results for the microarray *** BioAnaly module is used to analyze the rice microarray's data set.

关键词： rice microarray annotation data analysis

A General Method to Study the Sound Radiation of a Finite Cylindrical Shell Based on Elastic Theory

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Journal of Marine Science and Application 2012年第2期11卷 258-264页

作者： Junjie Zhang chunhui yuan Xianming Zhu Tianyun Li Huazhong University of Science and Technology Wuhan 430074 China National Key Laboratory on Ship I Tbration and Noise China Ship Development and Design Center Wuhan 430064 China

A general method was proposed to study the sound and vibration of a finite cylindrical shell with elastic theory. This method was developed through comprehensive analysis of the uncoupled Helmholtz equation obtained by the decomposition of elastic equations and the structure of the solution of a finite cylindrical shell analyzed by thin shell theory. The proposed method is theoretically suitable for arbitrary thickness of the shell and any frequency. Also, the results obtained through the method can be used to determine the range of application of the thin shell theory. Furthermore, the proposed method can deal with the problems limited by the thin shell theory. Additionally, the method can be suitable for several types of complex cylindrical shell such as the ring-stiffened cylindrical shell, damped cylindrical shell, and double cylindrical shell.

关键词： finite cylindrical shell elastic theory sound radiation thin shell theory

Classification of four distinct osteoarthritis subtypes with a knee joint tissue transcriptome atlas

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Bone Research 2020年第4期8卷 406-415页

作者： chunhui yuan Zongyou Pan Kun Zhao Jun Li Zixuan Sheng Xudong Yao Hua Liu Xiaolei Zhang Yang Yang Dongsheng Yu Yu Zhang Yuzi Xu Zhi-Yong Zhang Tianlong Huang Wanlu Liu Hongwei Ouyang Dr.Li Dak Sum&Yip Yio Chin Center for Stem Cells and Regenerative Medicine and Department of Orthopedic Surgery of the Second Affiliated HospitalZhejiang University School of MedicineHangzhouChina Zhejiang University-University of Edinburgh Institute Zhejiang University School of Medicineand Key Laboratory of Tissue Engineering and Regenerative Medicine of Zhejiang ProvinceZhejiang University School of MedicineHangzhouChina Department of Sports Medicine Zhejiang University School of MedicineHangzhouChina Department of Orthopedics The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityWenzhouChina China Orthopedic Regenerative Medicine Group(CORMed) HangzhouChina Department of Orthopedics Zhejiang Provincial People’s HospitalHangzhou Medical CollegeHangzhouChina Translational Research Centre of Regenerative Medicine and 3D Printing Technologies of Guangzhou Medical University State Key Laboratory of Respiratory DiseaseThe Third Affiliated Hospital of Guangzhou Medical UniversityGuangzhouChina The Second Xiangya Hospital of Central South University ChangshaChina

The limited molecular classifications and disease signatures of osteoarthritis(OA)impede the development of prediagnosis and targeted therapeutics for OA *** classify and understand the subtypes of OA,we collected three types of tissue including cartilage,subchondral bone,and synovium from multiple clinical centers and constructed an extensive transcriptome atlas of OA *** applying unsupervised clustering analysis to the cartilage transcriptome,OA patients were classified into four subtypes with distinct molecular signatures:a glycosaminoglycan metabolic disorder subtype(C1),a collagen metabolic disorder subtype(C2),an activated sensory neuron subtype(C3),and an inflammation subtype(C4).Through ligand-receptor crosstalk analysis of the three knee tissue types,we linked molecular functions with the clinical symptoms of different OA *** example,the Gene Ontology functional term of vasculature development was enriched in the subchondral bone-cartilage crosstalk of C2 and the cartilage-subchondral bone crosstalk of C4,which might lead to severe osteophytes in C2 patients and apparent joint space narrowing in C4 *** on the marker genes of the four OA subtypes identified in this study,we modeled OA subtypes with two independent published RNA-seq datasets through random forest *** findings of this work contradicted traditional OA diagnosis by medical imaging and revealed distinct molecular subtypes in knee OA patients,which may allow for precise diagnosis and treatment of OA.

关键词： diagnosis subtypes knee

胰腺神经内分泌肿瘤肝转移的外科治疗争议与展望

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中华外科杂志 2023年第10期61卷 839-844页

作者：李炳琦原春辉北京大学第三医院普通外科北京100191

在过去的20年间, 胰腺神经内分泌肿瘤(pNEN)的发病率不断升高。肝脏是其最常见的转移部位, 肝转移是pNEN患者重要的预后因素。虽然对于pNEN肝转移有包括生物治疗、化疗、靶向治疗、肽受体放射性核素治疗、局部治疗在内的多种治疗方式, ... 详细信息

在过去的20年间, 胰腺神经内分泌肿瘤(pNEN)的发病率不断升高。肝脏是其最常见的转移部位, 肝转移是pNEN患者重要的预后因素。虽然对于pNEN肝转移有包括生物治疗、化疗、靶向治疗、肽受体放射性核素治疗、局部治疗在内的多种治疗方式, 但手术仍是唯一可能达到治愈目的的治疗方式。目前对于pNEN肝转移的外科治疗仍存在较多争议, 如胰腺神经内分泌瘤(pNET)G3合并肝转移患者能否接受手术治疗;术前如何更加全面且准确地对pNET肝转移患者进行分级诊疗、Ⅱ型pNET肝转移患者如何选择最佳的外科治疗策略、如何确定减瘤手术的最佳获益人群、如何进一步优化pNET肝移植的米兰标准等。本文对目前pNEN治疗的主要争议展开讨论, 并为后续的临床研究提出展望。

关键词：胰腺肿瘤肿瘤转移神经内分泌肿瘤肝转移外科治疗

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加载对设备基座导纳测量的影响研究

振动与冲击 2005年第4期24卷 129-131页

作者：原春晖邵汉林汪浩华中科技大学武汉430074 中国船舶工业噪声检测中心武汉430064

裸基座导纳是隔振设计的重要参数,但工程中常需要在设备安装状态下测量基座的导纳,这会给基座导纳测量带来误差。从理论上证明,这种误差在某些条件下可以忽略。即设备刚性安装时机脚导纳应远大于基座导纳;弹性安装时隔振器与设备机脚导... 详细信息

裸基座导纳是隔振设计的重要参数,但工程中常需要在设备安装状态下测量基座的导纳,这会给基座导纳测量带来误差。从理论上证明,这种误差在某些条件下可以忽略。即设备刚性安装时机脚导纳应远大于基座导纳;弹性安装时隔振器与设备机脚导纳之差应远大于基座导纳;设备弹性安装时对基座导纳测量的影响总可以忽略不计。文中假设条件较符合工程实际,结论对工程中导纳的测量有实际指导意义。

关键词：导纳测量加载基座

Pregnancy and the disease recurrence of patients previously treated for differentiated thyroid cancer:A systematic review and meta analysis

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Chinese Medical Journal 2024年第5期137卷 547-555页

作者： Rui Shan Xin Li Ming Tao Wucai Xiao Jing Chen Fang Mei Shibing Song Bangkai Sun chunhui yuan Zheng Liu Department of Maternal and Child Health School of Public HealthPeking UniversityBeijing 100191China Department of General Surgery Peking University Third HospitalBeijing 100191China Department of Pathology Peking University Third HospitalSchool of Basic Medical SciencesPeking University Health Science CenterBeijing 100191China Information Management and Big Data Center Peking University Third HospitalBeijing 100191China

Background:Differentiated thyroid cancer(DTC)is commonly diagnosed in women of child-bearing age,but whether pregnancy influences the prognosis of DTC remains *** study aimed to summarize existing evidence regarding the association of pregnancy with recurrence risk in patients previously treated for ***:We searched PubMed,Embase,Web of Science,Cochrane,and Scopus based on the prespecified protocol registered at PROSPERO(CRD42022367896).After study selection,two researchers independently extracted data from the included *** quantitative data synthesis,we used random-effects meta-analysis models to pool the proportion of recurrence(for pregnant women only)and odds ratio(OR;comparing the risk of recurrence between the pregnancy group and the nonpregnancy group),*** we conducted subgroup analyses to explore whether risk of recurrence differed by response to therapy status or duration of follow-up *** also assessed quality of the included ***:A total of ten studies were *** sample size ranged from 8 to 235,with participants’age at pregnancy or delivery ranging from 28 to 35 *** follow-up time varied from 0.1 to 36.0 *** pooled proportion of recurrence in all pregnant patients was 0.13(95%confidence intervals[CI]:0.06-0.25;I^(2):0.58).Among six included studies reporting response to therapy status before pregnancy,we observed a trend for increasingly higher risk of recurrence from excellent,indeterminate,and biochemically incomplete to structurally incomplete response to therapy(P trend0.05)or the OR of recurrence in studies with a comparison group(P>0.05).Two included studies t

关键词： Thyroid cancer Pregnancy Recurrence Women Systematic review Meta-analysis

我国分配制度的历史演进及其对社会和谐的影响

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生产力研究 2009年第2期 82-85,133页

作者：袁春晖盐城工学院江苏盐城224051

建国以来,我国的收入分配制度经历了"平均分配-单一的按劳分配-按劳分配为主体,多种分配方式并存"三个阶段。文章通过分析分配制度的变化对社会和谐的影响,指出加强政府调节在构建社会主义和谐社会中的意义。

关键词：分配制度和谐社会政府调节

Using a Nomogram to Preoperatively Predict Distant Metastasis of Pancreatic Neuroendocrine Tumor in Elderly Patients

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Chinese Medical Sciences Journal 2021年第3期36卷 218-224页

作者： Gang Li Yuntao Bing Maolin Tian chunhui yuan Dianrong Xiu Department of General Surgery Peking University Third HospitalBeijing 100191China

Objective To establish a nomogram for predicting the distant metastasis risk of pancreatic neuroendocrine tumors(pNETs)in elderly *** We extracted data of patients with diagnosis of pNETs at age≥65 years old between 1973 and 2015 from the Surveillance,Epidemiology,and End Results(SEER)*** eligible patients were divided randomly into a training cohort and validation ***-and multivariate logistic regression analyses were performed on the training cohort to identify independent factors for distant metastasis.A nomogram was developed based on the independent risk factors using rms packages of R software,and was validated internally by the training cohort and externally by the validation cohort using C-index and calibration *** A total of 411 elderly patients were identified,of which 260 were assigned to training cohort and 151 to validation *** and multivariate logistic regression analyses indicated the tumor site(body/tail of pancreas:odds ratio[OR]=2.282;95%confidence interval[CI]:1.174–4.436,P<0.05),histological grade(poorly differentiated/undifferentiated:OR=2.600,95%CI:1.266–5.339,P<0.05),T stage(T2:OR=8.913,95%CI:1.985–40.010,P<0.05;T3:OR=11.830,95%CI:2.530–55.350,P<0.05;T4:OR=68.650,95%CI:8.020–587.600,P<0.05),and N stage(N1:OR=3.480,95%CI:1.807–6.703,P<0.05)were identified as independent risk factors for distant metastasis of pNETs in *** nomogram exhibited good predicting accuracy,with a C-index of 0.809(95%CI:0.757–0.861)in internal validation and 0.795(95%CI:0.723–0.867)in external validation,*** predicted distant metastasis rates were in satisfactory agreement with the observed values by the calibration *** The nomogram we established showed high discriminative ability and accuracy in evaluation of distant metastasis risk in elderly pNETs patients,and could provide a reference for individualized tumor evaluation and treatment decision in elderly pNETs patients.

关键词： nomogram pancreatic neuroendocrine tumor distant metastasis elderly patients