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The role of axon guidance molecules in the pathogenesis of epilepsy

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Neural Regeneration Research 2025年第5期20卷 1244-1257页

作者： Zheng Liu chunhua Pan Hao Huang Department of Neurology Affiliated Hospital of Zunyi Medical UniversityZunyiGuizhou ProvinceChina

Current treatments for epilepsy can only manage the symptoms of the condition but cannot alter the initial onset or halt the progression of the disease. Consequently, it is crucial to identify drugs that can target novel cellular and molecular mechanisms and mechanisms of action. Increasing evidence suggests that axon guidance molecules play a role in the structural and functional modifications of neural networks and that the dysregulation of these molecules is associated with epilepsy susceptibility. In this review, we discuss the essential role of axon guidance molecules in neuronal activity in patients with epilepsy as well as the impact of these molecules on synaptic plasticity and brain tissue remodeling. Furthermore, we examine the relationship between axon guidance molecules and neuroinflammation, as well as the structural changes in specific brain regions that contribute to the development of epilepsy. Ample evidence indicates that axon guidance molecules, including semaphorins and ephrins, play a fundamental role in guiding axon growth and the establishment of synaptic connections. Deviations in their expression or function can disrupt neuronal connections, ultimately leading to epileptic seizures. The remodeling of neural networks is a significant characteristic of epilepsy, with axon guidance molecules playing a role in the dynamic reorganization of neural circuits. This, in turn, affects synapse formation and elimination. Dysregulation of these molecules can upset the delicate balance between excitation and inhibition within a neural network, thereby increasing the risk of overexcitation and the development of epilepsy. Inflammatory signals can regulate the expression and function of axon guidance molecules, thus influencing axonal growth, axon orientation, and synaptic plasticity. The dysregulation of neuroinflammation can intensify neuronal dysfunction and contribute to the occurrence of epilepsy. This review delves into the mechanisms associated with

关键词： axon guidance drug-resistant epilepsy epilepsy nerve regeneration nervous system diseases neural pathways neuroinflammatory diseases neuronal plasticity neurons synaptic remodeling

Unmasking Social Robots’Camouflage:A GNN-Random Forest Framework for Enhanced Detection

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Computers, Materials & Continua 2025年第1期82卷 467-483页

作者： Weijian Fan chunhua Wang Xiao Han Chichen Lin School of Data Science and Intelligent Media Communication University of ChinaBeijing100024China School of Computer and Cyber Sciences Communication University of ChinaBeijing100024China Institute of Communication Studies Communication University of ChinaBeijing100024China State Key Laboratory of Media Convergence and Communication Communication University of ChinaBeijing100024China

The proliferation of robot accounts on social media platforms has posed a significant negative impact,necessitating robust measures to counter network anomalies and safeguard content *** robot detection has emerged as a pivotal yet intricate task,aimed at mitigating the dissemination of misleading *** graphbased approaches have attained remarkable performance in this realm,they grapple with a fundamental limitation:the homogeneity assumption in graph convolution allows social robots to stealthily evade detection by mingling with genuine human *** unravel this challenge and thwart the camouflage tactics,this work proposed an innovative social robot detection framework based on enhanced HOmogeneity and Random Forest(HORFBot).At the core of HORFBot lies a homogeneous graph enhancement strategy,intricately woven with edge-removal techniques,tometiculously dissect the graph intomultiple revealing ***,leveraging the power of contrastive learning,the proposed methodology meticulously trains multiple graph convolutional networks,each honed to discern nuances within these tailored *** culminating stage involves the fusion of these feature-rich base classifiers,harmoniously aggregating their insights to produce a comprehensive detection *** experiments on three social robot detection datasets have shown that this method effectively improves the accuracy of social robot detection and outperforms comparative methods.

关键词： Social robot detection graph neural networks random forest homophily heterophily

生长周期对有机金属化学气相沉积法制备SiO_2-InP光子晶体的影响

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光学学报 2007年第3期27卷 482-486页

作者：谭春华黄旭光范广涵华南师范大学信息光电子科技学院光子信息技术广东省高校重点实验室广州510631 华南师范大学信息光电子科技学院光电子材料与技术研究所广州510631

有机金属化学气相沉积(MOCVD)方法在人工蛋白石空隙中填充了磷化铟(InP)晶体以改变这类材料的光学行为,在选择了InP的生长条件的基础上进行了周期生长试验。利用扫描电子显微镜(SEM)和紫外可见光谱(UV-Vis)对人工蛋白石晶体及其填充InP... 详细信息

有机金属化学气相沉积(MOCVD)方法在人工蛋白石空隙中填充了磷化铟(InP)晶体以改变这类材料的光学行为,在选择了InP的生长条件的基础上进行了周期生长试验。利用扫描电子显微镜(SEM)和紫外可见光谱(UV-Vis)对人工蛋白石晶体及其填充InP后的形貌和反射谱特性进行了分析。结果发现,采用周期生长方式有利于InP在模板空隙中的填充,且在反应时间相同的条件下,反应周期数越多,InP在空隙中的填充率越高,填充率增加反过来增大了二氧化硅球和空隙之间的折射率差,从而可控地对所制备光子晶体光子带隙进行调制。实验表明InP具有较好的生长质量,此项研究为制备三维InP光子晶体打下了基础。

关键词：光学材料光子晶体人工蛋白石有机金属化学气相沉积光子带隙

Lipid droplets in the nervous system:involvement in cell metabolic homeostasis

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Neural Regeneration Research 2025年第3期20卷 740-750页

作者： Yuchen Zhang Yiqing Chen Cheng Zhuang Jingxuan Qi Robert chunhua Zhao Jiao Wang School of Life Sciences Shanghai UniversityShanghaiChina School of Medicine Shanghai UniversityShanghaiChina Institute of Basic Medical Sciences Chinese Academy of Medical Sciences School of Basic MedicinePeking Union Medical CollegeBeijingChina Center of Excellence in Tissue Engineering Chinese Academy of Medical SciencesBeijingChina Beijing Key Laboratory of New Drug Development and Clinical Trial of Stem Cell Therapy BeijingChina

Lipid droplets serve as primary storage organelles for neutral lipids in neurons,glial cells,and other cells in the nervous *** droplet formation begins with the synthesis of neutral lipids in the endoplasmic ***,lipid droplets were recognized for their role in maintaining lipid metabolism and energy homeostasis;however,recent research has shown that lipid droplets are highly adaptive organelles with diverse functions in the nervous *** addition to their role in regulating cell metabolism,lipid droplets play a protective role in various cellular stress ***,lipid droplets exhibit specific functions in neurons and glial *** of lipid droplet formation leads to cellular dysfunction,metabolic abnormalities,and nervous system *** review aims to provide an overview of the role of lipid droplets in the nervous system,covering topics such as biogenesis,cellular specificity,and ***,it will explore the association between lipid droplets and neurodegenerative *** the involvement of lipid droplets in cell metabolic homeostasis related to the nervous system is crucial to determine the underlying causes and in exploring potential therapeutic approaches for these diseases.

关键词： Alzheimer's disease lipid droplet biogenesis lipid droplets lipid metabolism nervous system neurodegenerative disorders oxidative stress Parkinson's disease

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中外优秀男子400m栏选手栏间技术的比较

体育科研 2016年第3期37卷 100-103页

作者：谈春华上海市第二体育运动学校上海201199

通过大量的资料和文献查阅,概述了男子400 m栏栏间跑技术的分类及技术要点。以国内外部分优秀男子400 m栏运动员为例,从栏间跑技术节奏、栏间跑速度及栏间变化跑等3个方面对国内外优秀选手栏间跑技术做了系统的比较分析,了解国内选手在... 详细信息

通过大量的资料和文献查阅,概述了男子400 m栏栏间跑技术的分类及技术要点。以国内外部分优秀男子400 m栏运动员为例,从栏间跑技术节奏、栏间跑速度及栏间变化跑等3个方面对国内外优秀选手栏间跑技术做了系统的比较分析,了解国内选手在栏间跑技术方面与国外选手的差距,提出了改善国内选手栏间跑技术的建议,为今后栏间技术训练制定更科学、合理的计划提出参考,以帮助国内选手优化栏间跑技术。

关键词：男子 400m栏栏间技术比较

基于区域科技创新联盟的创新资源耦合模式研究

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科技管理研究 2013年第13期33卷 16-19,28页

作者：陈雄辉谭春华华南师范大学教育信息技术学院广东广州510631 华南师范大学信息光电子科技学院广东广州510631

科技创新联盟是区域创新系统的一种新形式,联盟内的各类创新资源相互作用实质是一种耦合过程,该耦合创新系统由创新主体、创新客体、耦合驱动力构成。从创新主体不同需求出发,讨论了四种不同的耦合模式:需求型、成本型、利润型、复杂型。

关键词：联盟科技创新耦合模式

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我国高职教育质量评价的变迁、困境与出路

职教论坛 2020年第1期36卷 145-149页

作者：谭春华王庭之江苏医药职业学院

《国家职业教育改革实施方案》对职业教育办学质量的督导评价提出了明确要求,逐步建立高职质量评价体系已是大势所趋,而我国高职教育质量评价经历了以满足办学条件为主、重视人才培养为主、建立示范引领为主和以质量发展为主的变迁,评... 详细信息

《国家职业教育改革实施方案》对职业教育办学质量的督导评价提出了明确要求,逐步建立高职质量评价体系已是大势所趋,而我国高职教育质量评价经历了以满足办学条件为主、重视人才培养为主、建立示范引领为主和以质量发展为主的变迁,评价科学化和规范化有了进一步的发展,但也存在评价主体的单一化、评价目标的偏颇性、评价方法的定势化、评价过程的模糊化的困境,在新时代要全力推动高职教育质量评价的发展,理应从基于学情认知的质量评价精准化、基于院校自主的质量评价综合化、基于多方参与的质量评价多元化和基于学科介入的质量评价科学化等方面入手,通过高质量评价来推动建立中国特色高职教育发展体系。

关键词：高职教育质量评价变迁困境出路