检索结果-南通市图书馆

Genome-wide identification,molecular evolution,and functional characterization of fructokinase gene family in apple reveal its role in improving salinity tolerance

在线全文

学校读者我要写书评

暂无评论

Journal of Integrative Agriculture 2024年第11期23卷 3723-3736页

作者： Jing Su Lingcheng Zhu Pingxing Ao Jianhui Shao chunhua ma College of Landscape and Horticulture Yunnan Agricultural UniversityKunming650201YunnanChina State Key Laboratory of Crop Stress Biology for Arid Areas College of HorticultureShaanxi Key Laboratory of AppleNorthwest A&F UniversityYangling712100ShaanxiChina College of Plant protection Yunnan Agricultural UniversityKunming650201YunnanChina

Fructokinase(FRK)is a regulator of fructose signaling in plants and gateway proteins that catalyze the initial step in fructose metabolism through *** previous study demonstrated that MdFRK2 protein exhibit not only high affinity for fructose,but also high enzymatic activity due to ***,genome-wide identification of the MdFRK gene family and their evolutionary dynamics in apple are yet to be reported.A systematic genome-wide analysis in this study identified a total of nine MdFRK gene members,which could phylogenetically be clustered into seven *** location and synteny analysis of MdFRKs revealed that their expansion in the apple genome is primarily driven by tandem and segmental duplication *** expression patterns of MdFRKs were observed in four source-sink tissues and at five different apple fruit developmental stages,which suggested their potential crucial roles in the apple fruit development and sugar *** transcription-quantitative PCR(RT-qPCR)identified candidate NaCl or drought stress responsive MdFRKs,and transgenic apple plants overexpressing MdFRK2 exhibited considerably enhanced salinity *** results will be useful for understanding the functions of MdFRKs in the regulation of apple fruit development and salt stress response.

关键词： apple fructokinase evolutionary patterns MdFRK2 salinity tolerance

Fiscal Pressure,Land Finance and Ratchet Effects of House Prices

在线全文

学校读者我要写书评

暂无评论

China Finance and Economic Review 2018年第1期7卷 73-94页

作者： Yunfeng Tang chunhua ma School of Public Administration Zhejiang University of Finance&Economics Zhejiang University of Finance&Economics China

In this paper,we focus on the issues of local governments’fiscal pressure,land finance and house prices,and systematically analyze how local governments’fiscal pressure and land finance lead to China’s ratcheting up of house *** results show that to release the fiscal pressure,local governments tend to increase land revenue and obtain high real estate related revenue by raising house *** this sense,the increase of the land transfer price will result in the increase of the cost of real estates,and eventually leading to the increase of house *** is to say,local governments’fiscal pressure will not only result in the increase of house prices directly but also consolidate the ratchet effects of house prices.

关键词： land finance fiscal pressure ratchet effects of house prices

Photocatalytic Transition-Metal-Free Direct 3-Acetalation of Quinoxaline-2(1H)-ones

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Chemistry 2022年第22期40卷 2655-2662页

作者： chunhua ma Hui Meng Jing Li Xianguang Yang Yuqin Jiang Bing Yu Collaborative Innovation Centre of Henan Provincefor Green manufacturing of Fine Chemicals Key Laboratory of Green Chemical Media and ReactionsMinistry of EducationHenan Engineering Research Centre of Chiral Hydroxyl PharmaceuticalHenan Engineering Laboratoryof Chemical Pharmaceutical and Biomedical MaterialsSchool of Chemistry and Chemical EngineeringHenanNormal UniversityXinxiangHenan453007China Green Catalysis Centre College of ChemistryZhengzhou UniversityZhengzhouHenan 45001China

A general transition-metal-free visible-light-promoted 3-acetalation reaction of quinoxaline-2(1H)-ones was developed under mild *** employing 1,2,3,5-tetrakis(carbazol-9-yl)-4,6-dicyanobenzene(4CzIPN)as an inexpensive photocatalyst,and glyoxylic acid acetal as a radical source,various acetalated quinoxaline-2(1H)-ones were constructed in moderate to good ***,the versatility of this protocol is highlighted by the successful application in the late-stage modification of drug molecules and the various functionality *** excellent antitumor activity of the acetalated product demonstrated that this streamlined and sustainable approach could have emerged as a powerful strategy for structural modification in medicinal chemistry.

关键词： Photocatalysis Transition-metal-free Synthetic methods Radical reactions Antitumor activity

Development of peptidomimetic hydroxamates as PfA-M1 and PfA-M17 dual inhibitors: Biological evaluation and structural characterization by cocrystallization

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2022年第5期33卷 2550-2554页

作者： Anil Kumar marapaka Priyanka Sankoju Guozhen Zhang Yongzheng Ding chunhua ma Vijaykumar Pillalamarri Renu Sudhakar Bharati Reddi Puran Singh Sijwali Yingjie Zhang Anthony Addlagatta Department of Medicinal Chemistry Key Laboratory of Chemical Biology(Ministry of Education)School of Pharmaceutical SciencesCheeloo College of MedicineShandong UniversityJi’nan 250012China Department Applied Biology CSIR-Indian Institute of Chemical TechnologyTarnakaHyderabadTelangana-500007India Academy of Scientific and Innovative Research(AcSIR) Ghaziabad-201002India CSIR-Centre for Cellular and Molecular Biology TarnakaHyderabadTelangana-500007India

Plasmodium parasites causing malaria have developed resistance to most of the antimalarials in use,in-cluding the artemisinin-based combinations,which are the last line of defense against *** ne-cessitates the discovery of new targets and the development of novel *** falciparum alanyl aminopeptidase(PfA-M1)and leucyl aminopeptidase(PfA-M17)belong to the M1 and M17 family of metalloproteases respectively and play critical roles in the asexual erythrocytic stage of *** enzymes have been suggested as potential antimalarial drug *** we describe the devel-opment of peptidomimetic hydroxamates as PfA-M1 and PfA-M17 dual *** of the compounds described in this study display inhibition at sub-micromolar range against the recombinant PfA-M1 and *** importantly,compound 26 not only exhibits potent malarial aminopeptidases inhibitory activities(PfA-M1 K i=0.11±0.0002μmol/L,PfA-M17 K_(i)=0.05±0.005μmol/L),but also possesses remarkable selectivity over the mammalian counterpart(pAPN K_(i)=17.24±0.08μmol/L),which endows 26 with strong inhibition of the malarial parasite growth and negligible cytotoxicity on human cell *** structures of PfA-M1 at atomic resolution in complex with four different compounds including compound 26 establish the structural basis for their inhibitory ***,the terminal ureidoben-zyl group of 26 explores the S2' region where differences between the malarial and mammalian enzymes are apparent,which rationalizes the selectivity of ***,our data provide important insights for the rational and structure-based design of selective and dual inhibitors of malarial aminopeptidases that will likely lead to novel chemotherapeutics for the treatment of malaria.

关键词： Aminopeptidase Dual inhibitor Antimalaria Peptidomimetic Plasmodium falciparum

Comparative genomics reveals the diversification of triterpenoid biosynthesis and origin of ocotilloltype triterpenes in Panax

在线全文

学校读者我要写书评

暂无评论

Plant Communications 2023年第4期4卷 271-285页

作者： Zijiang Yang Xiaobo Li Ling Yang Sufang Peng Wanling Song Yuan Lin Guisheng Xiang Ying Li Shuang Ye chunhua ma Jianhua Miao Guanghui Zhang Wei Chen Shengchao Yang Yang Dong National&Local Joint Engineering Research Center on Germplasm Innovation&Utilization of Chinese Medicinal materials in Southwest China Yunnan Agricultural UniversityKunmingChina The Key Laboratory of Medicinal Plant Biology of Yunnan Province Yunnan Agricultural UniversityKunmingChina College of Food Science and Technology Yunnan Agricultural UniversityKunmingChina Guangxi Key Laboratory of Medicinal Resources Protection and Genetic Improvement Guangxi Botanical Garden of Medicinal PlantsNanningChina Yunnan Plateau Characteristic Agriculture Industry Research Institute KunmingChina

Gene duplication is assumed to be the major force driving the evolution of metabolite biosynthesis in *** from functional burdens,duplicated genes can mutate toward novelties until fixed due to selective ***,the extent to which this mechanism has driven the diversification of metabolite biosynthesis remains to be *** we performed comparative genomics analysis and functional characterization to evaluate the impact of gene duplication on the evolution of triterpenoid biosynthesis using Panax species as *** that whole-genome duplications(WGDs)occurred independently in Araliaceae and Apiaceae *** genomics revealed the evolutionary trajectories of triterpenoid biosynthesis in plants,which was mainly promoted by WGDs and tandem *** synthase(LAS)was likely derived from a tandemduplicate of cycloartenol synthase that predated the emergence of *** episodic diversifying selection,the LAS gene duplicates produced by g whole-genome triplication have given rise to triterpene biosynthesis in core eudicots through ***,functional characterization revealed that oxidosqualene cyclases(OSCs)responsible for synthesizing dammarane-type triterpenes in Panax species were also capable of producing ocotilloltype *** and biochemical evidence suggested that Panax genes encoding the above OSCs originated from the specialization of one OSC gene duplicate produced from a recent WGD shared by Araliaceae(Pg-b).Our results reveal the crucial role of gene duplication in diversification of triterpenoid biosynthesis in plants and provide insight into the origin of ocotillol-type triterpenes in Panax species.

关键词： gene duplication Panax genomes whole-genome duplications triterpenoid biosynthesis ocotilloltype triterpenes specialization

去家庭化和儿童非正规照顾:欧洲跨国比较研究

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

社会学研究 2022年第4期37卷 69-92,227,228页

作者：马春华中国社会科学社会学研究所

本文以父母劳动力“去商品化”程度、儿童照顾“去家庭化”程度构建分析框架,使用EU-SILC数据分析欧洲31国儿童照顾现状。本文发现,北欧各国去家庭化程度最高,非正规照顾处于边缘;东欧各国去家庭化程度最低,以非正规照顾为主。父母劳动... 详细信息

本文以父母劳动力“去商品化”程度、儿童照顾“去家庭化”程度构建分析框架,使用EU-SILC数据分析欧洲31国儿童照顾现状。本文发现,北欧各国去家庭化程度最高,非正规照顾处于边缘;东欧各国去家庭化程度最低,以非正规照顾为主。父母劳动力性质、各国福利体制、性别平等指数等对非正规照顾程度存在一定影响。在国家和市场尚不能提供充足正规照顾资源的中国,儿童非正规照顾应受到重视和支持,使其与儿童正规照顾、父母照顾相互支撑,共同成为支持生育的重要工具。

关键词：儿童非正规照顾去家庭化欧洲跨国比较研究

现代、民族与性别--试论中国现代主义文论的三维结构

在线全文

学校读者我要写书评

暂无评论

南开学报（哲学社会科学版） 2021年第2期 149-158页

作者：马春花中国海洋大学文学与新闻传播学院山东青岛266100

作为20世纪中国最为重要的文艺思潮之一,现代主义及其理论批判构成20世纪80年代文论的重要内容。总体上看,现代主义在中国的接受过程伴随着双重焦虑:被延迟的现代化焦虑与民族文化主体性焦虑。由此造成的现代主义与民族主义、第一世界... 详细信息

作为20世纪中国最为重要的文艺思潮之一,现代主义及其理论批判构成20世纪80年代文论的重要内容。总体上看,现代主义在中国的接受过程伴随着双重焦虑:被延迟的现代化焦虑与民族文化主体性焦虑。由此造成的现代主义与民族主义、第一世界与第三世界间的内在张力结构,成为中外学者探讨中国现代主义的基本二元论框架。这些二元论架构带来了启示与盲点,将性别维度植入中国现代主义文论,在全球本土化视野中洞察现代主义的权力关系及其性别修辞,即可在揭示现代主义文艺隐含父权无意识的同时,尝试建立现代、民族与性别互动对话的三维理论结构。

关键词：现代主义民族寓言性别

在线全文

学校读者我要写书评

暂无评论

延安文艺“仙姑”改造叙事研究

南开学报（哲学社会科学版） 2018年第2期 111-120页

作者：马春花中国海洋大学文学与新闻传播学院

"仙姑"改造叙事是延安文艺中的重要内容,并直接关联于延安时代的社会改造运动。以《小二黑结婚》《太阳照在桑干河上》《白毛女》等经典文本为中心,来分析其中的仙姑形象及其改造叙事,即可重估性别建构、民间信仰与革命政治之间的复杂关... 详细信息

"仙姑"改造叙事是延安文艺中的重要内容,并直接关联于延安时代的社会改造运动。以《小二黑结婚》《太阳照在桑干河上》《白毛女》等经典文本为中心,来分析其中的仙姑形象及其改造叙事,即可重估性别建构、民间信仰与革命政治之间的复杂关系,进而从延安道路的经典叙事中,发现一个女性主体的别样革命/性景观:首先,延安文艺中的仙姑形象既意味着女性身份的污/巫名化,又显示出女性自我赋权的无限可能;其次,社会改造运动的理性规训一方面令仙姑祛魅,另一方面又让这个被压抑的她者得以显影;最后,女性极其复杂多样的权力实践,依然是现代乡土政治结构中的重要组成部分。延安文艺中的仙姑叙事歧义层叠,既是中国女性被现代革命改造的故事,也是中国女性对话革命并改造现代的故事。

关键词： “仙姑”叙事乡土中国延安政治女性主义

在线全文

学校读者我要写书评

暂无评论

务农情境下的工作—家庭冲突研究

中国农业大学学报（社会科学版） 2024年第3期41卷 181-202页

作者：马春华中国社会科学院社会学研究所

本文基于CSS2021年的数据讨论了务农情境下的工作—家庭冲突。研究发现,双向工作—家庭冲突,即“工作对家庭干扰”(WIF)和“家庭对工作干扰”(FIW)不仅存在于非农群体中,也存在于务农群体中。务农群体FIW水平甚至超过了非农群体。在不... 详细信息

本文基于CSS2021年的数据讨论了务农情境下的工作—家庭冲突。研究发现,双向工作—家庭冲突,即“工作对家庭干扰”(WIF)和“家庭对工作干扰”(FIW)不仅存在于非农群体中,也存在于务农群体中。务农群体FIW水平甚至超过了非农群体。在不同的情境中,工作—家庭冲突水平不同,影响因素也不同。因此,在工作—家庭冲突研究、工作—家庭平衡研究和工作—家庭增益研究中,无论是质性研究还是量化研究,都应该将务农群体纳入研究视野;在政策制定层面,国家应关注务农群体在工作—家庭平衡上的需求,他们不仅面临着工作—家庭冲突的困扰,也相对更为脆弱,更需要政策支持。

关键词：工作—家庭冲突务农群体非农群体 WIF FIW

维普期刊数据库博看期刊