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Evaluate the characteristics and clinical significance of “toxic twin-leaf” sign in spinal epidural metastases before percutaneous vertebroplasty

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Journal of Interventional Medicine 2020年第2期3卷 83-88页

作者： Xiqi Sun Qinghua Tian chungen wu Yongde Cheng Department of Diagnostic and Interventional Radiology Shanghai Sixth People’s Hospital East Affiliated to Shanghai University of Medicine&Health SciencesShanghai201316China

Objective: Our study aimed to analyze morphological features of spinal epidural metastases using magnetic resonance imaging(MRI) and investigate the formation mechanism and clinical significance of the "toxic twinleaf" sign in spinal epidural *** and methods: We retrospectively studied 108 patients with spinal epidural metastases who underwent MRI. Patients were divided into "toxic twin-leaf" sign group(group A) and irregular group(group B). Chi-square test was used to analyze data on sex, vertebra location, presence of fracture in the corresponding vertebral body,involvement of the corresponding pedicle, and the primary tumor. Further, group data were analyzed using the rank sum test;p 0.05). Intergroup differences in the rate of spinal stenosis on axial and sagittal images were ***: MRI axial sequences clearly revealed the morphology of spinal epidural metastases. Detection of the"toxic twin-leaf" sign in spinal epidural metastases was of great clinical significance. Furthermore, determining the degree of spinal stenosis in the axial sequence provided a more accurate evaluation of patients’ condition compared to the sagittal sequence.

关键词： "Toxic twin-leaf"sign Magnetic resonance imaging Spinal metastasis

Comparison of the postoperative pain change and spinal stenosis rate between percutaneous vertebroplasty combined with radiofrequency ablation and with ^(125)I particle implantation in the treatment of metastatic spinal cord compression:A retrospective st

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Journal of Interventional Medicine 2021年第4期4卷 197-202页

作者： Yu He Shilong Han chungen wu Fei Ge Jianbo Wang Department of Interventional Radiology Shanghai Sixth People's Hospital Affiliated to Shanghai Jiaotong UniversityShanghaiChina Department of Intervention and Vascular Surgery Shanghai Tenth People's Hospital Affiliated to Shanghai Tongji University School of MedicineShanghaiChina Medical Department Shanghai Sixth People's Hospital Affiliated to Shanghai Jiaotong UniversityShanghaiChina

Background context:Metastatic spinal cord compression(MSCC)seriously affects the survival ***:The therapeutic effects of two treatment strategies for MSCC:percutaneous vertebroplasty(PVP)combined with radiofrequency ablation(RFA)and PVP combined with^(125)I particle implantation,were *** design:Retrospective *** sample:40 patients with MSCC were divided into two groups:19 cases in the RFA group and 21 cases in the^(125)I ***:All patients were accessed to determine the differences in pain,which was evaluated using the visual analog scale(VAS)at 1 week,1 month,and 3 months after the operation,and spinal stenosis rates(SSRs),which were measured at 1 and 3 months after the operation,between the two ***:The VAS scores and SSRs at baseline were comparable between the RFA group and the^(125)I group(7.19±2.07 vs 7.42±1.95,37.7%±11.2%vs 41.1%±11.4%).The VAS scores and SSRs at 1 month and 3 months after the operation were significantly reduced in both groups,compared with those at *** VAS scores and SSRs in the^(125)I group were lower than those in the RFA group at 3 months after the operation(1.09±0.97 vs 1.75±1.06 p=0.048 and 12.3%±6.4%vs 18.1%±10.1%p=0.034),while the VAS scores at1 week after the operation in the RFA group were lower than those in the^(125)I group(4.39±1.34 vs 5.05±1.82 p=0.049).Conclusion:PVP combined with RFA has a slight advantage in relieving pain in the short term,while PVP combined with^(125)I particle implantation may have a better effect in the relieving pain and decreasing the SSRs at 3 months after the operation.

关键词： Metastatic spinal cord compression Pain management Vertebroplasty Radiofrequency ablation ^(125)I particle

Percutaneous osteoplasty for extraspinal metastases

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Journal of Interventional Medicine 2018年第3期1卷 137-142页

作者： Qinghua Tian Yongde Cheng chungen wu Department of Radiology the Affiliated Sixth People's Hospital Shanghai Jiaotong University

As an extension of percutaneous vertebroplasty(PVP), percutaneous osteoplasty(POP) refers broadly to percutaneous bone cement injected into various parts of the body and narrowly to cement injected into extraspinal bone lesions. POP mainly includes such surgeries as percutaneous sacroplasty, percutaneous acetabuloplasty, percutaneous femoral osteoplasty, and percutaneous iliac osteoplasty(Figure 1). Currently, POP is a positive and an effective treatment for extraspinal bone lesions in that it can rapidly relieve pain, effectively prevent pathological fractures, and partially inactivate tumors, with few complications. The aim of this review is to detail the POP techniques and report their safety and efficacy in the treatment of extraspinal metastases.

关键词： percutaneous osteoplasty percutaneous vertebroplasty extraspinal metastases

Silk fibroins modify the atmospheric low temperature plasma-treated poly (3-hydroxybutyrate-co-3-hydroxyhexanoate) film for the application of cardiovascular tissue engineering

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Journal of Biomedical Science and Engineering 2010年第12期3卷 1146-1155页

作者： Huaxiao Yang Min Sun Ping Zhou Luanfeng Pan chungen wu 不详

Tissue engineered scaffold is one of the hopeful therapies for the patients with organ or tissue damages. The key element for a tissue engineered scaffold material is high biocompatibility. Herein the poly (3-hydroxybutyrate-co-3-hydroxyhexanoate) (PHBHHx) film was irradiated by the low temperature atmospheric plasma and then coated by the silk fibroins (SF). After plasma treatment, the surface of PHBHHx film became rougher and more hydrophilic than that of original film. The experiment of PHBHHx flushed by phosphate buffer solution (PBS) proves that the coated SF shows stronger immobilization on the plasma-treated film than that on the untreated film. The cell viability assay demonstrates that SF-coated PHBHHx films treated by the plasma significantly supports the proliferation and growth of the human smooth muscle cells (HSMCs). Furthermore, the scanning electron microscopy and hemotoylin and eosin (HE) staining show that HSMCs formed a cell sub-monolayer and secreted a large amount of extracellular matrix (ECM) on the films after one week's culture. The silk fibroins modify the plasma-treated PHBHHx film, providing a material potentially applicable in the cardiovascular tissue engi-neering.

关键词： Biocompatible Cardiovascular Tissue Engineering Low Temperature Plasma Poly (3-Hydroxybutyrate-Co-3-Hydroxyhexanoate) (PHBHHx) Silk Fibroin

基于Nrf2/SIRT3/SOD2途径探讨正清风痛宁抗骨质疏松的作用机制

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中国骨质疏松杂志 2021年第10期27卷 1443-1447,1544页

作者：吴春根陈平吴雯昱谭利琴南昌大学第四附属医院疼痛科江西南昌330003 北京中医药大学北京100029

目的观察正清风痛宁对骨质疏松大鼠的改善作用,并基于Nrf2/SIRT3/SOD2途径探讨其内在的作用机制。方法80只SD大鼠随机分为正常对照组(n=20),骨质疏松组(n=20),正清风痛宁组(n=20),对照药白藜芦醇组(n=20)。除正常对照组外,其余大鼠灌胃... 详细信息

目的观察正清风痛宁对骨质疏松大鼠的改善作用,并基于Nrf2/SIRT3/SOD2途径探讨其内在的作用机制。方法80只SD大鼠随机分为正常对照组(n=20),骨质疏松组(n=20),正清风痛宁组(n=20),对照药白藜芦醇组(n=20)。除正常对照组外,其余大鼠灌胃醋酸泼尼松[5 mg/(kg·d)]4周诱导骨质疏松症,正清风痛宁组给予正清风痛宁[20 mg/(kg·d)],对照药组给予白藜芦醇[5 mg/(kg·d)],正常对照组及骨质疏松组给予等量0.5%CMC-Na溶液,连续8周。检测各组大鼠血清降钙素(CT)、碱性磷酸酶(ALP)、超氧化物歧化酶2(SOD2)、丙二醇(MDA),血清骨钙素(BGP)、Ⅰ型胶原羧基末端交联肽(β-CTX)水平;骨密度及股骨近端孔隙。HE染色观察股骨病理改变;测定骨组织中Nrf2、SIRT3蛋白的表达情况。结果骨质疏松组大鼠血清CT、ALP、BGP水平及SOD2活性明显降低,β-CTX水平及MDA水平明显升高,骨密度明显降低,股骨近端孔隙率明显升高,HE染色显示骨小梁稀疏、变细、断裂、结构紊乱,骨组织中Nrf2、SIRT3蛋白表达明显降低。与骨质疏松组比较,正清风痛宁组大鼠血清ALP、CT、BGP水平及SOD2活性明显升高,β-CTX及MDA水平明显降低,骨密度明显升高,股骨近端孔隙率明显降低,骨组织结构有明显改善,骨小梁排列整齐且明显增粗,骨组织中Nrf2、SIRT3蛋白表达明显升高。结论正清风痛宁能显著改善醋酸泼尼松诱导的大鼠骨质疏松,其机制可能与Nrf2/SIRT3/SOD2通路作用有关。

关键词：正清风痛宁骨质疏松 Nrf2 SIRT3 SOD2

CT引导下经皮椎体成形术治疗胸椎转移性肿瘤

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中国脊柱脊髓杂志 2009年第5期19卷 341-344页

作者：徐建广吴春根上海交通大学附属第六人民医院骨科上海市200233 上海交通大学附属第六人民医院放射科上海市200233

目的:探讨CT引导下经皮椎体成形术治疗胸椎转移性肿瘤的安全性及疗效。方法:2004年4月～2006年2月共治疗胸椎转移性肿瘤患者18例,共30个椎体,患者均有顽固性胸背痛,术前VAS评分平均8.6分,伴脊髓压迫者6例,术前Frankel分级C级2例,D级4例... 详细信息

目的:探讨CT引导下经皮椎体成形术治疗胸椎转移性肿瘤的安全性及疗效。方法:2004年4月～2006年2月共治疗胸椎转移性肿瘤患者18例,共30个椎体,患者均有顽固性胸背痛,术前VAS评分平均8.6分,伴脊髓压迫者6例,术前Frankel分级C级2例,D级4例,均应用CT引导下经皮椎体成形术行病变椎体内骨水泥注射治疗。随访观察并发症发生情况及治疗效果。结果:30个椎体在CT引导下均一次穿刺成功,单侧注射骨水泥12例,平均注入量2.75ml;双侧注射6例,平均注入量4.7ml,无骨水泥渗漏及神经损害加重情况发生。15例局麻药效消失后疼痛明显缓解,2例72h后疼痛缓解,1例无效。随访6～24个月,平均11.4个月。术后1周时VAS评分平均2.62分,末次随访时VAS评分平均2.94分,与术前比较均有显著改善(P<0.01)。末次随访时6例脊髓压迫者神经功能2例C级恢复至D级,其余均恢复至E级。2例原发灶为肝癌及1例肺癌患者死亡,其余患者手术椎体未发生新的病理性骨折及脊髓压迫加重。结论:CT引导下经皮椎体成形术具有良好的止痛及预防病理性骨折作用,是治疗胸椎转移性肿瘤安全、有效的方法。

关键词：胸椎转移性肿瘤 CT 经皮椎体成形术

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介入治疗在少见症状性良性骨病变中的应用

介入放射学杂志 2019年第6期28卷 551-555页

作者：宋红梅吴春根田庆华易飞上海健康医学院附属第六人民医院东院放射介入科

目的探讨经皮骨水泥成形术(POP)治疗少见症状性良性骨病变的临床疗效。方法收集2006年6月至2018年5月共17例行POP治疗的良性骨病变患者的临床资料,所有患者均术中或术前取病理,病理结果示:椎体嗜酸性肉芽肿4例(共6个椎体),脊索细胞瘤3例... 详细信息

目的探讨经皮骨水泥成形术(POP)治疗少见症状性良性骨病变的临床疗效。方法收集2006年6月至2018年5月共17例行POP治疗的良性骨病变患者的临床资料,所有患者均术中或术前取病理,病理结果示:椎体嗜酸性肉芽肿4例(共6个椎体),脊索细胞瘤3例,S1椎体及髂骨骨样骨瘤3例,骨纤维结构不良1例,跟骨血管瘤1例,距骨骨囊肿1例,动脉瘤样骨囊肿2例,髋臼腱鞘囊肿1例,髂骨棕色瘤1例,术后随访时间至少3个月,根据Mac Nab标准评定患者手术疗效。结果所有患者均顺利完成手术,1例髋臼骨样骨瘤患者周围软组织内少许骨水泥外渗,1例椎体嗜酸性肉芽肿患者邻近椎间盘内少许骨水泥渗漏,1例嗜酸性肉芽肿患者4个月后邻近椎体病变,再次手术治疗,所有患者临床症状均有一定程度改善,生活质量提高。结论POP治疗少见症状性良性骨病变临床效果良好、创伤小、并发症少,长期随访效果明确。

关键词：骨水泥成形术射频良性骨病变

“钢筋混凝土术”治疗股骨上段骨转移瘤围手术期中预见性护理的应用

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介入放射学杂志 2021年第8期30卷 828-831页

作者：邵海燕牟凌吴春根上海交通大学附属第六人民医院诊断和介入放射科 200233

目的探讨预见性护理措施在降低"钢筋混凝土术"治疗股骨上段骨转移瘤围手术期并发症中的作用。方法选取2013年6月至2020年3月于我院介入科行"钢筋混凝土手术"治疗的30例股骨上段骨转移瘤患者,随机等分为两组,对照组采用常规护理,观察组... 详细信息

目的探讨预见性护理措施在降低"钢筋混凝土术"治疗股骨上段骨转移瘤围手术期并发症中的作用。方法选取2013年6月至2020年3月于我院介入科行"钢筋混凝土手术"治疗的30例股骨上段骨转移瘤患者,随机等分为两组,对照组采用常规护理,观察组在常规护理的基础上予以预见性护理措施,比较两组并发症的发生率的差异。结果 30例股骨上段骨转移瘤患者在护理干预下均积极配合完成"钢筋混凝土术"治疗,两组患者的临床基线资料差异无统计学意义(P>0.05),观察组并发症发生率明显低于对照组,分别为6.7%和46.7%(P<0.05),差异有统计学意义。结论预见性护理可以有效降低"钢筋混凝土术"治疗股骨上段骨转移瘤围手术期并发症的发生率。

关键词：钢筋混凝土术预见性护理并发症股骨转移瘤

隐神经射频与关节腔注射曲安奈德治疗膝骨性关节炎的效果比较

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实用医学杂志 2023年第13期39卷 1652-1656页

作者：陈平谭利琴吴春根南昌大学第四附属医院疼痛科南昌330002

目的比较隐神经射频与关节腔注射曲安奈德治疗膝骨性关节炎的临床效果。方法选择从2021年6月到2022年6月收治符合研究标准的膝骨性关节炎患者60例,并随机分为对照组和研究组,每组各30例患者。研究组运用超声引导下隐神经脉冲射频治疗,... 详细信息

目的比较隐神经射频与关节腔注射曲安奈德治疗膝骨性关节炎的临床效果。方法选择从2021年6月到2022年6月收治符合研究标准的膝骨性关节炎患者60例,并随机分为对照组和研究组,每组各30例患者。研究组运用超声引导下隐神经脉冲射频治疗,对照组运用关节腔内注射曲安奈德治疗。比较两组患者在治疗前,治疗后1周、1个月及6个月的视觉疼痛模拟评分(VAS)和WOMAC评分,并观察是否有并发症的发生。结果研究发现两组都无并发症发生。两组治疗后1周、1个月的VAS评分差异有统计学意义(P<0.05),研究组在治疗后1、6个月后的VAS评分要低于对照组。两组疗后1周、1个月及6个月的WOMAC评分差异有统计学意义(P<0.05),对照组在治疗后1个月及6个月的WOMAC评分高于研究组(P<0.05)。结论超声引导下隐神经脉冲射频可有效减轻骨性关节炎疼痛,其临床疗效优于关节腔内注射激素治疗。

关键词：超声引导隐神经脉冲射频膝骨性关节炎