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Fulminant myocarditis induced by SARS-CoV-2 infection without severe lung involvement:insights into COvID-19 pathogenesis

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Journal of Genetics and Genomics 2024年第6期51卷 608-616页

作者： Han Du Zhongtao Du Liang Wang Hong Wang Mingjun Jia chunge zhang Yun Liu Cheng zhang Ya zhang Ruifeng zhang Shuang zhang Ning zhang Zhenghai Ma Chen Chen Wenjun Liu Hui Zeng George F.Gao Xiaotong Hou Yuhai Bi College of Life Science and Technology Xinjiang UniversityUrumchiXinjiang 830046China CAS Key Laboratory of Pathogen Microbiology and Immunology Institute of MicrobiologyCenter for Influenza Research and Early-warning(CASCIRE)CAS-TWAS Center of Excellence for Emerging Infectious Diseases(CEEID)Chinese Academy of SciencesBeijing 100101China Beijing Anzhen Hospital Capital Medical UniversityBeijing 100029China College of Veterinary Medicine Shanxi Agricultural UniversityTaiyuanShanxi 030031China University of Chinese Academy of Sciences Beijing 100049China Beijing Shijitan Hospital Capital Medical UniversityBeijing 100038China

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection often leads to pulmonary *** sequelae,including myocarditis and heart failure,have also been ***,the study presents two fulminant myocarditis cases infected by SARS-CoV-2 exhibiting remarkable elevation of cardiac biomarkers without significant pulmonary injury,as determined by imaging *** staining reveals the viral antigen within cardiomyocytes,indicating that SARSCoV-2 could directly infect the *** full viral genomes from respiratory,anal,and myocardial specimens are obtained via next-generation *** analyses of the whole genome and spike gene indicate that viruses in the myocardium/pericardial effusion and anal swabs are closely related and cluster together yet diverge from those in the respiratory *** addition,unique mutations are found in the anal/myocardial strains compared to the respiratory strains,suggesting tissue-specific virus mutation and *** findings indicate genetically distinct SARS-CoV-2 variants have infiltrated and disseminated within myocardial tissues,independent of pulmonary injury,and point to different infection routes between the myocardium and respiratory tract,with myocardial infections potentially arising from intestinal *** findings highlight the potential for systemic SARS-CoV-2 infection and the importance of a thorough multi-organ assessment in patients for a comprehensive understanding of thepathogenesisof COVID-19.

关键词： COVID-19 SARS-CoV-2 Fulminant myocarditis Myocardium Infection

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H10N3禽流感病毒安徽分离株遗传多样性研究

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病毒学报 2024年第5期40卷 1022-1032页

作者：李珊董卉姚雪张春鸽邢薇佳李娟史卫峰山东第一医科大学(山东省医学科学院)山东省高等学校新发传染病重点实验室济南250117 山东第一医科大学(山东省医学科学院)临床与基础医学院(基础医学研究所)病原生物学系济南250117 山东第一医科大学(山东省医学科学院)公共卫生与健康管理学院济南250117 中国科学院流感研究与预警中心中国科学院微生物研究所病原微生物与免疫学重点实验室北京100101

2021年4月我国江苏确诊全球第一例人感染H10N3禽流感病例,研究我国活禽市场H10N3亚型禽流感病毒(Avian influenza virus,AIV)的遗传多样性和分子特征,将为理解人感染H10N3病毒的进化来源、评估其溢出风险提供理论依据。为此,2021年6-12... 详细信息

2021年4月我国江苏确诊全球第一例人感染H10N3禽流感病例,研究我国活禽市场H10N3亚型禽流感病毒(Avian influenza virus,AIV)的遗传多样性和分子特征,将为理解人感染H10N3病毒的进化来源、评估其溢出风险提供理论依据。为此,2021年6-12月我们对安徽地区活禽市场销售家禽及环境中H10N3 AIV进行实时荧光定量RT-PCR检测,共分离鉴定到6株H10N3病毒(AH01-AH06),其中1株为11月份环境样本分离株,其余5株为6月、11月和12月鸡咽拭子分离株。高通量测序和生物信息学分析表明,同一活禽市场分离到的毒株表现出一定的遗传多样性和重配模式差异:4株H10N3分离株(AH01-AH04)间核苷酸同源性均高于99.00%,而A/chicken/Anhui/11-30-YHZGS024-O/2021(AH05)株的MP基因片段和A/chicken/Anhui/06-26-YHZGS006-O/2021(AH06)株的PA、MP基因片段与其他分离株的核苷酸同源性较低,均低于97.04%。系统发育分析显示,本研究6株H10N3分离株与人源H10N3病毒的HA和NA基因均位于欧亚进化分支,它们的内部基因都来自H9N2亚型AIV。特别是分离株AH06与人感染H10N3病毒八个基因均位于同一进化分支,而分离株AH01-AH05的PA基因与人感染H3N8和H9N2毒株、MP基因与人感染H9N2毒株的亲缘关系较近。分子遗传特征分析显示,6株H10N3 AIV的血凝素蛋白均携带G228S等哺乳动物适应性突变,提高了对人源受体的结合能力。综上,本研究证实了禽源H10N3病毒在安徽省活禽市场的持续流行,揭示了禽源H10N3病毒的遗传多样性以及新型感染人的H10N3在我国家禽中传播,强调其携带多个哺乳动物适应性突变,为评估H10N3 AIV潜在公共卫生风险提供了理论依据。

关键词：禽流感病毒活禽市场 H10N3 遗传多样性

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Resource Intensity Aware Job Scheduling in A Distributed Cloud

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China Communications 2014年第A2期11卷 175-184页

作者： HUANG Daochao ZHU chunge zhang Hong LIU Xinran National Computer Network Emergency Response Technical Team Coordination Center of China (CNCERT or CNCERT/CC) No.A3 Yumin Road Chaoyang District Beijing China 100029

A Dominant Resource Fairness （DRF） based scheme for job scheduling in distributed cloud computing systems which was modeled as multi-job scheduling and multi-resource allocation coupling problem is proposed, where the resource pool is constructed from a large number of distributed heterogeneous servers, representing different points in the configuration space of resources such as processing, memory, storage and bandwidth. By introducing dominant resource share of jobs and virtual machines, the multi-job scheduling and multi-resource allocation joint mechanism significantly improves the cloud system＇s resource utilization, yet with a substantial reduction of job completion times. We show through experiments and case studies the superior performance of the algorithms in practice.

关键词： job scheduling resource allocation cloud computing dominant resource fairness

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基于FMEA的质量风险管理模式在医疗机构外用溶液剂共线生产中的实践

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中国药学杂志 2024年第13期59卷 1267-1272页

作者：张春歌倪瑶柴煜莹陆振强韩强吴憩苏州大学附属第一医院江苏苏州215000

目的建立基于失效模式与效应分析(failure mode and effect analysis,FMEA)的质量风险管理模式,探讨其在外用溶液剂共线生产中的实施效果。方法对外用溶液剂共线生产的各个环节进行FMEA,根据优先风险数值(risk priority number,RPN)识... 详细信息

目的建立基于失效模式与效应分析(failure mode and effect analysis,FMEA)的质量风险管理模式,探讨其在外用溶液剂共线生产中的实施效果。方法对外用溶液剂共线生产的各个环节进行FMEA,根据优先风险数值(risk priority number,RPN)识别出中、高风险的失效模式,整理分析其失效原因,制定并实施改进措施。评估实施控制措施前后的风险等级、清洁验证持续确认效果、比较应用质量风险管理模式前后的设备故障发生率、首次清场合格率、质控达标率及偏差处理频率,评价改进效果。结果外用溶液剂共线生产各环节共识别出21项失效模式,其中高风险4项,中风险11项,低风险6项。通过持续改进污染和交叉污染控制措施,持续开展共线生产风险控制措施的监督和研究、持续进行设备清洁效果确认等措施,中、高风险失效模式均降级为低风险。各项清洁验证指标均控制在限度范围之内。并且,实施共线生产质量风险管理模式后,设备故障发生率及偏差处理频率明显降低,首次清场合格率和质控达标率显著上升,且差异均具有统计学意义(P<0.05)。结论将质量风险管理模式应用于外用溶液剂共线生产的全过程,能显著降低混淆、污染与交叉污染发生的风险,确保外用溶液剂的质量,提高质量管理体系的运行水平。

关键词：共线生产质量风险管理失效模式效应分析混淆交叉污染

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Isolation and characterization of Akabane virus Ib substrain and its pathogenesis in sulking mice

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Virologica Sinica 2023年第6期38卷 966-970页

作者： Xiaohui Zan Shirong Wang Tianqi zhang Ying Li chunge zhang Cun Fu Jialei Wang Youzhi Wu Yanhua Ma Zhifei Li Yan Wang Hao Wang Yuhai Bi Wei Wang State Key Laboratory of Reproductive Regulation&Breeding of Grassland Livestock College of Life SciencesInner Mongolia UniversityHohhot010070China CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of MicrobiologyCenter for Influenza Research and Early-warning(CASCIRE)CAS-TWAS Center of Excellence for Emerging Infectious Diseases(CEEID)Chinese Academy of SciencesBeijing100101China Inner Mongolia Mengwei Biotech Co.Ltd Hohhot012000China University of Chinese Academy of Sciences Beijing100049China College of Basic Medicine Inner Mongolia Medical UniversityHohhot010080China

Dear Editor,Akabane disease is an arthropod-borne viral disease caused by the Akabane virus(AKAV)that can affect cattle,sheep,and *** infections in adults can lead months later to abortions,stillbirths,congenital defects,and death in newborns(Kurogi et al.,1976).Wild ruminants can also be affected,but abnormalities of the offspring in these species have not been *** report suggests that this virus can also cause clinical signs in pigs(Yanase et al.,2018).

关键词： Wild strain characterization

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Three Novel Avastroviruses Identified in Dead Wild Crows

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Virologica Sinica 2021年第6期36卷 1673-1677页

作者： chunge zhang Yongchun Yang Tao Hu Hong Zhou Cheng zhang Jian Cao Juan Li Peihan Wang Gary Wong Xiaodu Wang Houhui Song George FGao Weifeng Shi Yuhai Bi Key Laboratory of Applied Technology on Green-Eco-Healthy Animal Husbandry of Zhejiang Province College of Animal Science and Technology and College of Veterinary Medicine of ZhejiangA&F UniversityLin'an 311300China CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of MicrobiologyCenter for Influenza Research and Early-Warning(CASCIRE)CAS-TWAS Center of Excellence for Emerging Infectious Diseases(CEEID)Chinese Academy of SciencesBeijing 100101China Key Laboratory of Etiology and Epidemiology of Emerging Infectious Diseases in Universities of Shandong School of Public HealthShandong First Medical University and Shandong Academy of Medical SciencesTaian 271016China Institut Pasteur of Shanghai Chinese Academy of SciencesShanghai 200031China Département de microbiologie-infectiologie et d'immunologie UniversitéLavalQuébec City G1V 0A6Canada University of Chinese Academy of Sciences Beijing 100049China

Dear Editor,Astroviruses(AstVs)are non-enveloped,single-stranded RNA viruses with a diameter of approximately 35 nm(Madeley and Cosgrove 1975).The genomes of AstVs range in size from 6.8 to 7.9 kb(De Benedictis et al.2011),consisting of a 5'-untranslated region(UTR),three open reading frames(ORFs),a 3'-UTR,and a poly-adenylated(polyA)tail(Pantin-Jackwood et al.2006).In 1975,AstVs were first discovered in faeces of infants(Madeley and Cosgrove 1975).Until now,a variety of animal species,including cows,sheep,pigs,dogs,deer,rats,bats,chickens,ducks,turkeys,sea lions and seals have been reported to be infected with AstVs(Tzipori et al.1981;Cattoli et al.2007;Chu et al.2008,2010;Atkins et al.2009;Toffan et al.2009;Rivera et al.2010;Guix et al.2013;Kang et al.2012;Reuter et al.2012a,2012b;Li et al.2021).Currently,AstVs comprise two genera,Mamastrovirus(MAstV)and Avastrovirus(AAstV).Herein,we describe three novel AAstVs identified from dead crow *** our knowledge,this is the first report for identification of AstVs in crows.

关键词： viruses frames sheep

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Synergistic mechanisms of AMF and biochar driving rhizosphere fungal community in shallot in barren soil

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Horticultural Plant Journal 2024年第5期10卷 1252-1256页

作者： Zishan Li Yingyue Li Qing zhang Zihua zhang Jiaqing Jiang Tao Huang chunge Mei Fulang Wu Beijiu Cheng Xiaoyu Li Jin Chen National Engineering Laboratory of Crop Stress Resistance Breeding Schools of Life SciencesAnhui Agricultural UniversityHefeiAnhui 230036China

The addition of biochar(BC)or Arbuscular mycorrhizal fungi(AMF)alone has been reported to promote plant growth,while their synergistic effects on Allium schoenoprasum root morphology and rhizosphere fungal community in barren soil is still *** this study,we investigated the effects of BC and AMF(Funneliformis mosseae)on plant growth and root morphology in barren soil and revealed the structure of soil fungal communities Therefore,a greenhouse pot trial consisting of five treatments was *** results showed that the combination of biochar and AMF significantly improved plant biomass,nutrient uptake,mycorrhizal colonization rates and soil properties and significantly impacted rhizosphere fungal community composition and *** significantly increased the fungal community stability and enhanced their positive correlation with *** findings indicated that the combination of AMF and biochar play synergic role for plant growth and rhizosphere fungal community in barren soil.

关键词： soil rhizosphere barren

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Bt杀虫基因专利保护现状与趋势

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植物保护 2011年第3期37卷 1-6,11页

作者：张杰束长龙张春鸽中国农业科学院植物保护研究所植物病虫害生物学国家重点实验室北京100193

苏云金芽胞杆菌(Bacillus thuringiensis,Bt)能产生多种对昆虫有特异活性的杀虫晶体蛋白,这些毒蛋白由cry或cyt基因编码。目前Bt杀虫基因已经广泛应用于转基因抗虫作物并且取得了巨大的经济、社会和生态效益。Bt杀虫基因的巨大市场价值... 详细信息

苏云金芽胞杆菌(Bacillus thuringiensis,Bt)能产生多种对昆虫有特异活性的杀虫晶体蛋白,这些毒蛋白由cry或cyt基因编码。目前Bt杀虫基因已经广泛应用于转基因抗虫作物并且取得了巨大的经济、社会和生态效益。Bt杀虫基因的巨大市场价值引起国内外相关研究机构和企业的高度关注,并且利用知识产权将这些基因和技术转化为自己独占的权利。本文主要分析Bt杀虫基因的克隆命名情况,并对其中受专利保护的基因进行统计分析,借此为我国在转基因技术研发、产业化应用过程中,合理有效地规避知识产权陷阱,有效利用Bt资源提供决策参考。

关键词： Bt杀虫基因克隆专利

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Co-existence and co-infection of influenza A viruses and coronaviruses: Public health challenges

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The Innovation 2022年第5期3卷 38-47页

作者： Jing Yang Yuhuan Gong chunge zhang Ju Sun Gary Wong Weifeng Shi Wenjun Liu George FGao Yuhai Bi CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of MicrobiologyCenter for Influenza Research and Early-warning(CASCIRE)CAS-TWAS Center of Excellence for Emerging Infectious Diseases(CEEID)Chinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Institut Pasteur of Shanghai Chinese Academy of SciencesShanghai 200031China Key Laboratory of Etiology and Epidemiology of Emerging Infectious Diseases in Universities of Shandong Shandong First Medical University&Shandong Academy of Medical SciencesTaian 271016China

Since the 20th century,humans have lived through five pandemics caused by influenza A viruses(IAVs)(H1N1/1918,H2N2/1957,H3N2/1968,and H1N1/2009)and the coronavirus(CoV)severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).IAVs and CoVs both have broad host ranges and share multiple *** co-circulation and even co-infections facilitate genetic reassortment among IAVs and recombination among CoVs,further altering virus evolution dynamics and generating novel variants with increased cross-species transmission ***,SARS-CoV-2 may maintain longterm circulation in humans as seasonal ***-existence and co-infection of both viruses in humans could alter disease transmission patterns and aggravate disease ***,we demonstrate how virus-host ecology correlates with the co-existence and co-infection of IAVs and/or CoVs,further affecting virus evolution and disease dynamics and burden,calling for active virus surveillance and countermeasures for future public health challenges.

关键词： infection maintain generating

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浅谈当代大学生理性精神的培养

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广西教育学院学报 2005年第2期 13-16页

作者：张春歌江苏技术师范学院江苏常州213001

受社会等各种不良因素的影响,大学生的精神状态中普遍缺乏一种理性精神的指引,这对他们未来的发展不利。必须重视当代大学生理性精神的培养,在教学实践中切实关注他们的生活,使他们能为自身的存在寻求一种价值性的支撑,并使理性精神真... 详细信息

受社会等各种不良因素的影响,大学生的精神状态中普遍缺乏一种理性精神的指引,这对他们未来的发展不利。必须重视当代大学生理性精神的培养,在教学实践中切实关注他们的生活,使他们能为自身的存在寻求一种价值性的支撑,并使理性精神真正内化成一种优秀的品质。

关键词：理性理性精神

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