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Associations between health-related fitness and patient-reported symptoms in newly diagnosed breast cancer patients

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Journal of Sport and Health Science 2024年第6期13卷 851-862页

作者： Ki-Yong An Fernanda Z.Arthuso Myriam Filion Spencer J.Allen Stephanie M.Ntoukas Gordon J.Bell Jessica McNeil Qinggang Wang Margaret L.McNeely Jeff K.Vallance lin Yang S.Nicole Culos-Reed Leanne Dickau John R.Mackey christine M.Friedenreich Kerry S.Courneya Faculty of Kinesiology Sportand RecreationCollege of Health SciencesUniversity of AlbertaEdmonton T6G 2H9Canada Department of Kinesiology School of Health and Human SciencesUniversity of North Carolina at GreensboroGreensboroNC 27412USA Department of Cancer Epidemiology and Prevention Research Cancer Care AlbertaAlberta Health ServicesCalgary T2S 3C3Canada Faculty of Rehabilitation Medicine University of AlbertaEdmonton T6G 2H9Canada Faculty of Health Disciplines Athabasca UniversityAthabasca T9S 3A3Canada Department of Oncology Cumming School of MedicineUniversity of CalgaryCalgary T2N 4N1Canada Faculty of Kinesiology University of CalgaryCalgary T2N 1N4Canada Faculty of Medicine and Dentistry University of AlbertaEdmonton T6G 2H9Canada

Background:Newly diagnosed breast cancer patients experience symptoms that may affect their quality of life,treatment outcomes,and *** and managing breast cancer-related symptoms soon after diagnosis is *** purpose of this study was to investigate the associations between health-related fitness(HRF)and patient-reported symptoms in newly diagnosed breast cancer ***:This study utilized baseline data from the Alberta Moving Beyond Breast Cancer Cohort Study that were collected within 90 days of *** measures included peak cardiopulmonary fitness(peak volume of oxygen consumption(VO_(2peak))),maximal muscular strength and endurance,flexibility,and body *** measures included depression,sleep quality,and *** multivariable logistic regression was performed for ***:Of 1458 participants,51.5%reported poor sleep quality,26.5%reported significant fatigue,and 10.4%reported moderate *** multivariable-adjusted models,lower relative VO_(2peak)was independently associated with a greater likelihood of all symptom measures,including moderate depression(pweight was independently associated with poor sleep quality in an inverted U pattern(p=0.021).Conclusion:Relative VO_(2peak)appears to be a critical HRF component associated with multiple patient-reported symptoms in newly diag

关键词： Breast cancer Fatigue Depression Sleep quality Cardiorespiratory fitness

Biomonitoring for traditional herbal medicinal products using DNA metabarcoding and single molecule, real-time sequencing

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Acta Pharmaceutica Sinica B 2018年第3期8卷 488-497页

作者： Tianyi Xin Zhichao Xu Jing Jia christine Leon Songnian Hu Yulin lin Subramanyam Ragupathy Jingyuan Song Steven G.Newmaster Key Lab of Chinese Medicine Resources Conservation State Administration of Traditional Chinese Medicine of the People's Republic of China Institute of Medicinal Plant Development Peking Union Medical College & Chinese Academy of Medical Sciences Royal Botanic Gardens Beijing Institute of Genomics Chinese Academy of Sciences NHP Research Alliance Biodiversity Institute of Ontario (BIO) University of Guelph

Global concerns have been paid to the potential hazard of traditional herbal medicinal products(THMPs). Substandard and counterfeit THMPs, including traditional Chinese patent medicine, health foods, dietary supplements, etc. are potential threats to public health. Recent marketplace studies using DNA barcoding have determined that the current quality control methods are not sufficient for ensuring the presence of authentic herbal ingredients and detection of contaminants/adulterants. An efficient biomonitoring method for THMPs is of great needed. Herein, metabarcoding and single-molecule, realtime(SMRT) sequencing were used to detect the multiple ingredients in Jiuwei Qianghuo Wan(JWQHW), a classical herbal prescription widely used in China for the last 800 years. Reference experimental mixtures and commercial JWQHW products from the marketplace were used to confirm the method. Successful SMRT sequencing results recovered 5416 and 4342 circular-consensus sequencing(CCS) reads belonging to the ITS2 and psb A-trn H regions. The results suggest that with the combination of metabarcoding and SMRT sequencing, it is repeatable, reliable, and sensitive enough to detect species in the THMPs, and the error in SMRT sequencing did not affect the ability to identify multiple prescribed species and several adulterants/contaminants. It has the potential for becoming a valuable tool for the biomonitoring of multi-ingredient THMPs.

关键词： Traditional herbal medic inal products(THMP) Species mixture Authentication DNA metabarcoding Single molecule real-time(SMRT) sequencing Circular-consensus sequencing(CCS)

电-热耦合对航空复合材料拉伸及疲劳性能的影响

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航空学报 2014年第12期35卷 3315-3323页

作者：蔺越国 Macro GIGLIOTTI Marie christine LAFARIE-FRENOT Jinbo BAI 中国民航大学航空工程学院天津300300 国立高等机械与航空技术学院材料物理与力学系巴黎中央理工学院固体力学与材料结构力学实验室

为研究碳纤维增强树脂基复合材料（CFRP）层合板的导电性能和电-热耦合效应及其对拉伸和疲劳性能的影响,主要针对2种不同铺层的试件（单向层合板（UD）[0]8和准各向异性层合板（QI）[45/90/-45/0]s）进行导电及电-热耦合实验和通电状态... 详细信息

为研究碳纤维增强树脂基复合材料（CFRP）层合板的导电性能和电-热耦合效应及其对拉伸和疲劳性能的影响,主要针对2种不同铺层的试件（单向层合板（UD）[0]8和准各向异性层合板（QI）[45/90/-45/0]s）进行导电及电-热耦合实验和通电状态下的拉伸及疲劳实验.在电-热耦合实验中分别对试件通以1～8 A的直流电和交流电,测量其温度场的分布及最高温度,以确定温度对电阻的影响.依据实验现象建立了简化后的电-热耦合分析模型,并与实验结果进行对比,发现两者吻合很好.简化后的电-热耦合模型能够很好地预测试件在达到稳态平衡时的最高温度值.在通电情况下对不同初始状态时的QI试件进行拉伸和疲劳实验,通过实验发现,在疲劳加载过程中无论是通以直流电、交流电或者是改变电流强度和电流频率,对试件的疲劳寿命影响不大,没有发现明显差异,但在实验过程中试件表面的温度会随着电流强度的增加而升高.同时,在监测试件沿着纤维方向的电阻变化时发现,在一定的疲劳载荷下,随着循环次数的增加,试件的电阻会不断增加,这表明试件内部出现了损伤,累积后直至试件断裂.依据实验现象分别建立了电阻模型-1和电阻模型-2,分析计算后发现模型-1能够较好地模拟试件变形的线性阶段（εxx≤0.4％）,而模型-2能较好地模拟非线性阶段直至试件断裂（εxx＞0.4％）.

关键词：机身蒙皮复合材料电热电阻疲劳

Medicinal plants of Chinese Pharmacopoeia and Daodi:Insights fromphylogeny and biogeography

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Chinese Herbal Medicines 2018年第3期10卷 269-278页

作者： Di Lei Jie wu christine Leon lin-fang Huang Julie A.Hawkins School of Biological Sciences University of ReadingReading RC6 6BXUnited Kingdom Institute of Chinese Materia Mediea China Academy of Chinese Medical SciencesBeijing 100700China Royol Botanic Gardens KewRichmondSurrey TW9 3ABUnited Kingdom Institute of Medicinal Plant Development Peking Union Medical College&Chinese Academy of Medical SciencesBeijing 100193China

Objective: The Chinese Pharmacopoeia(2015) includes 584 plant medicines, of which 284 also contain high quality subsets, so called "Daodi" components, where Daodi denotes superior clinical properties compared to non-Daodi counterparts despite being sourced from the same species. Commercial and clinical drivers of selection for Daodi have been described elsewhere. Our objective is to investigate the overall composition of Daodi to determine in what ways medicines with Daodi as a whole differ from the other plants of the Chinese Pharmacopoeia. A further objective is to characterise the Chinese Pharmacopoeia and Daodi in terms of the plant species including their traits and ***: We used trait analysis to identify whether Daodi species were significantly different from the remaining Chinese Pharmacopoeia plant species in any traits. We used biogeographic methods and an existing classification of Daodi into 10 regions to identify spatial patterns amongst the species. Regression and binomial analyses were used to test for over-and under-use of plant families and endemic *** for lineages were visualized using phylogenetic ***: We found that Daodi species(species with any Daodi subset) were more likely to be roots that are "hot" or "warm", and less likely to be "oxic", according to traditional Chinese medicine(TCM) concepts. Roots were over-represented in the Bei region, and whole plants over-represented in Guang. Both the Chinese Pharmacopoeia and Daodi indicated preferences for families not common in previously studied ethnopharmacopoeias, and fewer endemic species were represented than expected by ***: Using the phylogenetic and biogeographical methods, we highlighted patterns of plant use,and the biological characters of Daodi medicinal plants. Our study points towards cultural preferences in need of scientific explanation.

关键词： biogeography Chinese Pharmacopoeia Daodi phylogeny

Postpartum psychosis in a non-native language-speaking patient: A perspective on language barriers and cultural competency

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General Psychiatry 2019年第3期32卷 159-162页

作者： Tatsuhiko Naito Justin Chin Jun lin Pritesh J Shah christine M Lomiguen Primary Care Touro College of Osteopathic Medicine New York City New York USA Psychiatry Holy Name Medical Center Teaneck New Jersey USA Basic Sciences Lake Erie College of Osteopathic Medicine Erie Pennslyvannia USA

SUMMARY Postpartum psychosis is a condition characterised by rapid onset of psychotic symptoms several weeks after childbirth. Outside of its timing and descriptions of psychotic features, minimal research exists due to its relative rarity (1 to 2 per 1000 births in the USA), with greater emphasis on postpartum sadness and depression. With the existi叩 literature, cultural differences and language barriers previously have not been taken into consideration as there are no documented cases of postpartum psychosis in a non-English-speaki叩 patient. Correctly differentiating postpartum psychosis from other postpartum psychiatric disorders requires adeptly evaluating for the presence of psychotic symptoms with in-depth history taking.

关键词： Postpartum psychosis a non-native language-speaking patient cultural competency

Can Provision of Health Information Lead to Healthier, Longer Lives?

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International Journal of Clinical Medicine 2011年第5期2卷 538-543页

作者： Carl E. Bartecchi Robert W. Schrier christine Nevin-Woods lin Chang Anne Hill Cathy Dehn 不详

As health promoters, we seek ways to direct our patients and the public to those activities that will lead to a healthier and longer life. Many programs have been tried with relatively small groups of individuals, with limited or unsustained success. This study sought to evaluate the effectiveness of providing free, quality, unbiased, frequently updated, untainted, easily accessible information to an entire community (Pueblo, Colorado) of 60,000 households. The study showed that certain groups, namely the better educated, health care workers and females benefitted most from the health information provided them. Whether the population most in need of such information was effectively reached remained unanswered due to lack of feedback from this targeted group. This study provided some valuable insights into the various challenges that one faces in trying to develop a better health-informed, participating population. It also suggests the need to continue to search for an effective way to produce the desired changes in health outcomes.

关键词： Health

一种鉴定结核分枝杆菌“北京家族”菌株的新方法

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中华微生物学和免疫学杂志 2008年第2期28卷 172-175页

作者：刘敬华 christine Pourel Yolande Hauck 赵秀芹刘志广万康林中国疾病预防控制中心传染病预防控制所传染病预防控制国家重点实验室北京102206 法国巴黎XI大学微生物学与遗传学研究所

目的研究结核分枝杆菌“北京家族”菌株鉴定的新方法——RD105缺失检测的可行性。方法分别应用间隙寡核苷酸分型（Spoligotyping）和RD105缺失检测两种方法对结核分枝杆菌进行“北京家族”的鉴定，比较分析两种方法进行菌株鉴定结果的... 详细信息

目的研究结核分枝杆菌“北京家族”菌株鉴定的新方法——RD105缺失检测的可行性。方法分别应用间隙寡核苷酸分型（Spoligotyping）和RD105缺失检测两种方法对结核分枝杆菌进行“北京家族”的鉴定，比较分析两种方法进行菌株鉴定结果的差异。结果共对来自北京、福建、新疆和吉林的342株结核分枝杆菌临床分离菌株进行了鉴定，“北京家族”菌株261株，占76．32％。非“北京家族”菌株81株，占23．68％。两种方法鉴定结果的符合度达100％。结论简单、快速的新方法——RD105缺失检测可替代原始经典方法Spoligotyping用于结核分枝杆菌“北京家族”菌株的鉴定。

关键词：北京家族间隙寡核苷酸分型长片段序列多态性 RD105缺失

MLVA和Spoligotyping用于西藏地区216株结核分枝杆菌临床分离株的基因分型研究

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中华微生物学和免疫学杂志 2007年第8期27卷 711-718页

作者：石荔杨敏 christine Pourcel 董海燕尼玛彭多张嫒媛朗珍吕冰蒋毅魏淑贞范昕建万康林四川大学华西医学院西藏自治区疾病预防控制中心 Institute of Genetics and Microbiology University Paris2SubOrsayFrance 中国疾病预防控制中心传染病预防控制所传染病预防控制国家重点实验室北京102206 西藏自治区人民医院

目的评价间隔区寡核苷酸分型(Spoligotyping)及多位点可变数量串联重复序列分析(MLVA)两种分型方法在西藏地区结核病分子流行病学中的应用。方法收集西藏地区结核分枝杆菌(Mycobacterium tuberculosis)临床分离株,应用Spoligotyping及M... 详细信息

目的评价间隔区寡核苷酸分型(Spoligotyping)及多位点可变数量串联重复序列分析(MLVA)两种分型方法在西藏地区结核病分子流行病学中的应用。方法收集西藏地区结核分枝杆菌(Mycobacterium tuberculosis)临床分离株,应用Spoligotyping及MLVA两种分型方法进行比较分析。结果共在西藏地区收集到216株结核分枝杆菌临床分离株,采用Spoligotyping分型方法,216株菌可分为3个基因群13种基因型,其中最大的1个基因群即北京家族(Beijing family)含有195株菌,占90.28%。北京家族菌株中,有BCG接种史者占45.64%(89/195),无BCG接种史者占54.36%(106/ 1195),两者间的差异无统计学意义(x^2=0.059,P>0.05)。采用MLVA分型方法,216株菌可分成19个基因群108种基因型,其中80种基因型只有1株菌,占37.03%(80/216),另有136株菌表现出28种基因型,成簇数为28,占62.96%(136/216)。在20个VNTR位点的等位基因多态性发现Miru31位点的多态性最高,多态性指数(h)达到0.77,而Mtub29、Mtub12位点的多态性较差,都低于0.05。其中Mtub02位点可鉴别北京家族和非北京家族,它鉴别的北京家族与Spoligotyping鉴别的北京家族符合率达到100%。结论西藏地区结核分枝杆菌具有明显的接引多态性,其主要流行型为北京家族。北京家族菌株与BCG接种无相关性。应用Spoligotyping和MLVA两种分型方法进行结核病流行病学研究,将提高结核病的流行病学调查和病原学监测效果。

关键词：结核分枝杆菌间隔区寡核苷酸分型多位点可变数量串联重复序列分析基因分型

Mutation analysis of 13 driver genes of colorectalcancer-related pathways in Taiwan Residents patients

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World Journal of Gastroenterology 2016年第7期22卷 2314-2325页

作者： Yuli christine Chang Jan-Gowth Chang Ta-Chih Liu Chien-Yu lin Shu-Fen Yang Cheng-Mao Ho William Tzu-Liang Chen Ya-Sian Chang Graduate Institute of Medicine College of MedicineKaohsiung Medical UniversityKaohsiung 80708Taiwan Department of Laboratory Medicine Kaohsiung Medical University HospitalKaohsiung 80708Taiwan Department of Laboratory Medicine China Medical University HospitalTaichung 40447Taiwan Epigenome Research Center China Medical University HospitalTaichung 40447Taiwan School of Medicine China Medical UniversityTaichung 40402Taiwan Institute of Clinical Medicine College of MedicineKaohsiung Medical UniversityKaohsiung 80707Taiwan Division of Colorectal Surgery Department of SurgeryChina Medical University HospitalTaichung 40447Taiwan

AIM To investigate the driver gene mutations associatedwith colorectal cancer （CRC） in the Taiwan ***： In this study, 103 patients with CRCwere evaluated. The samples consisted of 66 menand 37 women with a median age of 59 years and anage range of 26-86 years. We used high-resolutionmelting analysis （HRM） and direct DNA sequencing tocharacterize the mutations in 13 driver genes of CRCrelatedpathways. The HRM assays were conductedusing the LightCycler？ 480 Instrument provided with the software LightCycler 480 Gene Scanning SoftwareVersion 1.5. We also compared the clinicopathologicaldata of CRC patients with the driver gene ***： Of the 103 patients evaluated, 73.79%had mutations in one of the 13 driver genes. Wediscovered 18 novel mutations in APC , MLH1 , MSH2 ,PMS2 , SMAD4 and TP53 that have not been previouslyreported. Additionally, we found 16 de novo mutationsin APC , BMPR1A , MLH1 , MSH2 , MSH6 , MUTYH andPMS2 in cancerous tissues previously reported in thedbSNP database; however, these mutations couldnot be detected in peripheral blood cells. The APCmutation correlates with lymph node metastasis（34.69% vs 12.96%, P = 0.009） and cancer stage（34.78% vs 14.04%, P = 0.013）. No association wasobserved between other driver gene mutations andclinicopathological features. Furthermore, having twoor more driver gene mutations correlates with thedegree of lymph node metastasis （42.86% vs 24.07%,P = 0.043）.CONCLUSION： Our findings confirm the importanceof 13 CRC-related pathway driver genes in the developmentof CRC in Taiwan Residents patients.

关键词： Colorectal cancer Driver gene Colorectalcancer-related pathway Mutation High-resolutionmelting analysis