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Early extrahepatic recurrence as a pivotal factor for survival after hepatocellular carcinoma resection:A 15-year observational study

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World Journal of Gastroenterology 2022年第36期28卷 5351-5363页

作者： Jae Hyun Yoon Sung Kyu Choi Sung Bum Cho Hee Joon Kim Yang Seok Ko chung hwan jun Department of Gastroenterology and Hepatology Chonnam National University Hospital and College of MedicineGwangju 61469South Korea Department of Gastroenterology and Hepatology Hwasun Chonnam National University Hospital and College of MedicineHwasun 58128South Korea Department of Surgery Chonnam National University Hospital and College of MedicineGwangju 61469South Korea Department of Surgery Hwasun Chonnam National University Hospital and College of MedicineHwasun 58128South Korea Department of Internal Medicine Mokpo Hankook HospitalMokpo 58643South Korea

BACKGROUND Surgical resection is one of the most widely used modalities for the treatment of hepatocellular carcinoma(HCC).Early extrahepatic recurrence(EHR)of HCC after surgical resection is considered to be closely associated with poor ***,data regarding risk factors and survival outcomes of early EHR after surgical resection remain *** To investigate the clinical features and risk factors of early EHR and elucidate its association with survival *** From January 2004 to December 2019,we enrolled treatment-naïve patients who were≥18 years and underwent surgical resection for HCC in two tertiary academic *** excluding patients with tumor types other than HCC and/or ineligible data,this retrospective study finally included 779 *** resection of HCC was performed according to the physicians’decisions and the EHR was diagnosed based on contrast-enhanced computed tomography or magnetic resonance imaging,and pathologic confirmation was performed in selected *** Cox regression analysis was performed to identify the variables associated with *** Early EHR within 2 years after surgery was diagnosed in 9.5%of patients during a median followup period of 4.4 *** recurrence-free survival period was 5.2 mo,and the median time to EHR was 8.8 mo in patients with early *** 52.7%of patients with early EHR,EHR occurred as the first recurrence of HCC after surgical *** multivariate analysis,serum albumin100 U/L,surgical margin involvement,venous and/or lymphatic involvement,satellite nodules,tumor necrosis detected by pathology,tumor size≥7 cm,and macrovascular invasion were determined as risk factors associated with early *** sub-categorizing the patients according to the number of risk factors,the rates of both EHR and survival showed a significant correlation with the risk of early ***,multivariate analysis revealed that early E

关键词： Early extrahepatic recurrence Hepatocellular carcinoma Prognosis Surgery Survival

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Self-expandable metal stents for choledocholithiasis in Billroth II gastrectomy patients

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Hepatobiliary & Pancreatic Diseases International 2018年第6期17卷 546-552页

作者： Min-Gui Han Eunae Cho Chang-hwan Park chung-hwan jun Seon-Young Park Division of Gastroenterology Department of Internal MedicineChonnam National University Hospital42Jaebong-roDong-KuGwangju 61482Korea

Background: Efficient ampullary intervention is essential for endoscopic retrograde cholangiopancreatography(ERCP) in patients with a prior Billroth II gastrectomy. We retrospectively evaluated the safety and effectiveness of ampullary intervention using fully covered self-expandable metal stents(FCSEMSs) for the management of common bile duct(CBD) stones in a subset of patients with a history of Billroth II gastrectomy. Methods: This retrospective analysis involved patients with a prior Billroth II gastrectomy who underwent ampullary intervention with FCSEMSs for the management of CBD stones. The factors associated with FCSEMSs placement, treatment success, and procedural complications were analyzed. Results: A group of 15 patients(10 males; median age, 78 years) underwent biliary metal stent placement for high degree of CBD angulation(6), small or flat papilla with unclear margin(5), current use of double antiplatelet agents or an anticoagulant(2), unwanted instrumentation of the cystic duct(1), and insecure position of the scope(1). Ampullary intervention with FCSEMSs was successful in all patients. After dilating the ampulla of Vater and building a durable conduit with FCSEMSs immediately, CBD stones were removed successfully from all patients in a single session. A mild post-ERCP pancreatitis occurred in one patient, who recovered without complications. Conclusion: Ampullary intervention with FCSEMSs is safe and effective for the management of CBD stones in a subset of patients with a history of Billroth II gastrectomy.

关键词： Common bile duct stone Endoscopic retrograde cholangiopancreatography Stent placement Stone extraction

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Restoration of common bile duct diameter within 2 weeks after endoscopic stone retraction is a preventive factor for stone recurrence

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Hepatobiliary & Pancreatic Diseases International 2018年第3期17卷 251-256页

作者： Jin Jeon Sung Uk Lim Chang-hwan Park chung-hwan jun Seon-Young Park Jong-Sun Rew Department of Internal Medicine Chonnam National University Hospital Department of Internal Medicine Mokpo Hankook Hospital

Background： Little information is available about the relationship between restoration of common bileduct （CBD） diameter after endoscopic stone retraction and recurrence of CBD stones in elderly *** present study was to determine whether restoration of CBD diameter is a preventive factor for CBDstone recurrence in elderly patients who underwent endoscopic retrograde cholangiopancreatography（ERCP）.

关键词： Restoration Common bile duct Endoscopic retrograde cholangiopancreatography Common bile duct stone

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Advances in wearable and implantable bioelectronics for precision medicine

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Bio-Design and Manufacturing 2024年第4期7卷 383-387页

作者： Kaichen Xu Seung hwan Ko jun Chen State Key Laboratory of Fluid Power and Mechatronic Systems School of Mechanical EngineeringZhejiang UniversityHangzhou 310058China Applied Nano and Thermal Science Lab Department of Mechanical EngineeringSeoul National UniversitySeoul 08826Republic of Korea Department of Bioengineering University of CaliforniaLos AngelesLos AngelesCA 90095-1599USA

The continuous pursuit for a better quality of life promotes continuous advancements in intelligent *** wearable and implantable bioelectronics have emerged as an innovative complement to rigid material-based electronic devices[1-3].Due to their distinct advantages in terms of ductile,ultrathin,and biocompatible features,these elastic and soft bioelectronic devices can be seamlessly mounted onto various real or artificial tissues and organs.

关键词： wear mounted pursuit

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Endoscopic repair of delayed stomach perforation caused by penetrating trauma:A case report

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World Journal of Clinical Cases 2021年第5期9卷 1228-1236页

作者： Jae Hyun Yoon chung hwan jun Jae Pil Han Ji-Woong Yeom Seung-Ku Kang Hyun Yi Kook Sung KyuChoi Department of Gastroenterology and Hepatology Chonnam National University Hospital and College of MedicineGwangju 61469South Korea Department of Internal Medicine Mokpo Hankook HospitalMokpo 58643South Korea Department of Surgery Mokpo Hankook HospitalMokpo 58643South Korea Department of Cardiothoracic Surgery Mokpo Hankook HospitalMokpo 58643South Korea Department of Nursing Chonnam National University Hospitaland College of NursingGwangju 61469South Korea

BACKGROUND Primary endoscopic closure of a perforated gastric wall during endoscopic procedures is mostly effective and well-tolerated;however,there are very few studies on the efficacy of endoscopic management of delayed traumatic gastric ***,we report a novel case of a patient who was successfully treated for delayed traumatic stomach perforation using an alternative endoscopic *** SUMMARY A 39-year-old woman presented with multiple penetrating traumas in the back and left abdominal *** imaging studies revealed left diaphragmatic disruption and peri-splenic hemorrhage without gastric *** emergency primary repair of the disrupted diaphragm with omental reduction and suturing of the lacerated lung was performed;however,delayed free perforation of the gastric wall was noted on computed tomography after 3 *** an emergency abdominal surgery for the primary repair of the gastric wall,re-perforation was noted 15 d *** high risk associated with re-surgery prompted an endoscopic intervention using 2 endoloops and 11 endoscopic clips using a novel modified purse-string suture *** free perforated gastric wall was successfully repaired without additional surgery or *** patient was discharged after 46 d without any *** Endoscopic closure with endoloops and clips can be a useful therapeutic alternative to re-surgery for delayed traumatic gastric perforation.

关键词： Surgical endoscopy Trauma Stomach Re-perforation Endoloop Case report

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Achieving High CO_(2)Photoreduction Activity by Conductive Crosslinks of Metal–Organic Framework

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CCS Chemistry 2024年第5期6卷 1211-1221页

作者： Ning Li Gui-Qi Lai Lai-Hon chung Fei Yu jun He Ya-Qian Lan Department School of Chemical Engineering and Light Industry Guangdong University of TechnologyGuangzhouGuangdong 510006 School of Chemistry South China Normal UniversityGuangzhou 510006 School of Chemistry and Materials Science Nanjing Normal UniversityNanjing 210023

Fast photogenerated charge migration is crucial for the improvement of photocatalytic performance,but its deliberate modulation is *** work presents two Zr-based metal–organic framework catalysts,GDUT-8 and GDUT-8-Ox,for photocatalytic CO_(2)***,thiophene pendants in GDUT-8 were coupled covalently via Scholl reaction to give GDUT-8-Ox,a catalyst with at least two orders of magnitude(up to 6.1×10^(−3)S cm^(−1))enhanced conductivity and faster transport of photogenerated carriers during ***,from GDUT-8 to GDUT-8-Ox,stronger ligand-to-cluster charge transfer with pronounced light absorption extension was *** a result,GDUT-8-Ox exhibited the highest photocatalytic CO_(2)-to-HCOO−conversion rate(1725μmol g^(−1)h^(−1))to date,in the absence of photosensitizer,as well as turnover number,turnover frequency,and quantum efficiency much higher than *** work presents an unprecedented strategy to accelerate the photogenerated carrier transport of photocatalysts.

关键词： metal-organic framework Scholl reaction covalent crosslinks high conductivity CO_(2)photoreduction CO_(2)-to-HCOO−conversion

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Numerical investigation of non-uniform temperature fields for proppant and fluid phases in supercritical CO_(2)fracturing

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Particuology 2024年第7期90卷 149-163页

作者： Boyu Liu jun Yao Research Center of Multiphase Flow in Porous Media China University of Petroleum(East China)Qingdao 266000China

The non-uniform temperature distribution in supercritical CO_(2)(Sc-CO_(2))fracturing influences the density,viscosity,and volume expansion or shrinkage rate of Sc-CO_(2),impacting proppant *** study presents a coupled computational fluid dynamics-discrete element method and heat transfer model to examine the effects of proppant bed shape and the heat transfers of proppant-wall,proppant-fluid,and fluid-wall on the fluid and proppant temperature *** Sc-CO_(2)volume expansion is assessed under various temperature conditions by evaluating the volume-averaged Sc-CO_(2)*** factors,including proppant size,shape,thermal conductivity,concentration,temperature difference,and injection velocity,are carefully analyzed to elucidate their *** findings elucidate the existence of four distinct zones in the fluid temperature *** zone exhibits different magnitudes of temperature change under diverse conditions and undergoes dynamic transformations with the development of the proppant *** fluid-wall heat transfer and the fluid temperatures in Zones C and D are significantly subject to the fluid injection velocity(governing the heating duration),the temperature difference between fluid and formation(impacting the magnitude of heat flux),and the proppant bed shape(controlling the effective heating area).Additionally,the proppant-wall and proppant-fluid heat transfers determine the temperatures of both the proppant bed and the fluid within Zone B,showing a strong correlation with proppant thermal conductivity,proppant size,injection velocity,and temperature *** proposed coupled model provides valuable insights into the temperature distributions and flow behaviors of temperature-dependent fracturing fluids and proppants.

关键词： CFD-DEM Heat transfer Compressible fluid CO_(2)sequestration Proppant transport

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Geometric Error Identification of Gantry-Type CNC Machine Tool Based on Multi-Station Synchronization Laser Tracers

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Chinese Journal of Mechanical Engineering 2024年第2期37卷 150-162页

作者： jun Zha Huijie Zhang School of Mechanical Engineering Xi’an Jiaotong UniversityXi’an 710049China Xi’an Jiaotong University Suzhou Academy Suzhou 215123China

Laser tracers are a three-dimensional coordinate measurement system that are widely used in industrial *** propose a geometric error identification method based on multi-station synchronization laser tracers to enable the rapid and high-precision measurement of geometric errors for gantry-type computer numerical control(CNC)machine *** method also improves on the existing measurement efficiency issues in the single-base station measurement method and multi-base station time-sharing measurement *** consider a three-axis gantry-type CNC machine tool,and the geometric error mathematical model is derived and established based on the combination of screw theory and a topological analysis of the machine kinematic *** four-station laser tracers position and measurement points are realized based on the multi-point positioning principle.A self-calibration algorithm is proposed for the coordinate calibration process of a laser tracer using the Levenberg-Marquardt nonlinear least squares method,and the geometric error is solved using Taylor’s first-order linearization *** experimental results show that the geometric error calculated based on this modeling method is comparable to the results from the Etalon laser *** a volume of 800 mm×1000 mm×350 mm,the maximum differences of the linear,angular,and spatial position errors were 2.0μm,2.7μrad,and 12.0μm,respectively,which verifies the accuracy of the proposed *** research proposes a modeling method for the precise measurement of errors in machine tools,and the applied nature of this study also makes it relevant both to researchers and those in the industrial sector.

关键词： Multi-point positioning Multi-station synchronization CNC machine tool Geometric error Error separation

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A generalized presentation of multi-caloric effects based on exterior derivative theory and its applications

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Communications in Theoretical Physics 2024年第8期76卷 158-165页

作者： jun Yin School of Materials Science and Engineering Nankai University School of Mechanical Engineering and Automation Fuzhou University

The emerging concept of multi-caloric effects, introduced in 2010, entails the application of multiple interplay fields to a thermodynamic system. While multi-caloric effects are the main focus of experimental endeavors, theoretical considerations fall short of providing a thorough understanding. This paper introduces a comprehensive presentation on multi-caloric effects,employing the method and theory of exterior derivative formations. It addresses every aspect of thermodynamic systems, showcasing its applicability to multi-caloric materials(both singlephase and multi-phase materials), and its adaptability to different scenarios(either in single or multiple force fields). The formulation of Maxwell relationships, characterized by their generality and universality, enables a clear prediction in entropy and temperature, facilitating a distinct identification between independent and interdependent contributions from multi-caloric effects. These insights hold significant importance in designing and developing specialized thermodynamic materials, optimizing functional performances and exploring innovative mechanisms.

关键词： adiabatic temperature isothermal entropy Maxwell relations multicaloric effects

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On the Monge–Kantorovich Mass Transfer Problem in Higher Dimensions

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Acta Mathematica Sinica,English Series 2024年第8期40卷 1989-2004页

作者： Xiao jun LU School of Mathematics Southeast UniversityNanjing 210096P.R.China

This paper mainly investigates the approximation of a global maximizer of the Monge–Kantorovich mass transfer problem in higher dimensions through the approach of nonlinear partial differential equations with Dirichlet *** an approximation mechanism,the primal maximization problem can be transformed into a sequence of minimization *** applying the systematic canonical duality theory,one is able to derive a sequence of analytic solutions for the minimization *** the final analysis,the convergence of the sequence to an analytical global maximizer of the primal Monge–Kantorovich problem will be demonstrated.

关键词： Monge-Kantorovich mass transfer singular variational problem canonical duality theory

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