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PI3K/AKT signaling and neuroprotection in ischemic stroke:molecular mechanisms and therapeutic perspectives

Neural Regeneration Research 2025年第10期20卷 2758-2775页

作者： Tianlong liu Xiaolin Li Xiaowei Zhou Wei Chen Aidong wen Minna liu Yi Ding Department of Pharmacy Xijing HospitalFourth Military Medical UniversityXi’anShaanxi ProvinceChina Department of Pharmacy The 940 Hospital of Joint Logistics Support Forces of Chinese PLALanzhouGansu ProvinceChina Department of Pharmacy The 944 Hospital of Joint Logistics Support Forces of Chinese PLAJiuquanGansu ProvinceChina Department of Nephrology The 940 Hospital of Joint Logistics Support Forces of Chinese PLALanzhouGansu ProvinceChina

It has been reported that the PI3K/AKT signaling pathway plays a key role in the pathogenesis of ischemic *** a result,the development of drugs targeting the PI3K/AKT signaling pathway has attracted increasing attention from *** article reviews the pathological mechanisms and advancements in research related to the signaling pathways in ischemic stroke,with a focus on the PI3K/AKT signaling *** key findings include the following:(1)The complex pathological mechanisms of ischemic stroke can be categorized into five major types:excitatory amino acid toxicity,Ca^(2+)overload,inflammatory response,oxidative stress,and apoptosis.(2)The PI3K/AKT-mediated signaling pathway is closely associated with the occurrence and progression of ischemic stroke,which primarily involves the NF-κB,NRF2,BCL-2,mTOR,and endothelial NOS signaling pathways.(3)Natural products,including flavonoids,quinones,alkaloids,phenylpropanoids,phenols,terpenoids,and iridoids,show great potential as candidate substances for the development of innovative anti-stroke medications.(4)Recently,novel therapeutic techniques,such as electroacupuncture and mesenchymal stem cell therapy,have demonstrated the potential to improve stroke outcomes by activating the PI3K/AKT signaling pathway,providing new possibilities for the treatment and rehabilitation of patients with ischemic *** investigations should focus on the direct regulatory mechanisms of drugs targeting the PI3K/AKT signaling pathway and their clinical translation to develop innovative treatment strategies for ischemic stroke.

关键词： apoptosis autophagy inflammation ischemic stroke neuroprotection oxidative stress pathogenesis phosphatidylinositol 3-kinase protein kinase B therapeutics

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Engineered Cancer Nanovaccines:A New Frontier in Cancer Therapy

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Nano-Micro Letters 2025年第2期17卷 134-168页

作者： Yijie Wang Congrui liu Chao Fang Qiuxia Peng wen Qin Xuebing Yan Kun Zhang Central Laboratory and Department of Medical Ultrasound Sichuan Academy of Medical SciencesSichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaNo.32West Second SectionFirst Ring RoadChengdu 610072People’s Republic of China Department of Stomatology and Central Laboratory School of MedicineShanghai Tenth People’s HospitalTongji UniversityNO.301 Yan‑Chang‑Zhong RoadShanghai 200072People’s Republic of China Jiangsu Provincial Innovation and Practice Base for Postdoctors Suining People’s HospitalAffiliated Hospital of Xuzhou Medical UniversityNo.2Bayi West RoadSuiningXu Zhou 221000Jiangsu ProvincePeople’s Republic of China

Vaccinations are essential for preventing and treating disease,especially cancer nanovaccines,which have gained considerable interest recently for their strong anti-tumor immune *** can prompt the immune system to generate antibodies and activate various immune cells,leading to a response against tumor tissues and reducing the negative effects and recurrence risks of traditional chemotherapy and *** enhance the flexibility and targeting of vaccines,nanovaccines utilize nanotechnology to encapsulate or carry antigens at the nanoscale level,enabling more controlled and precise drug delivery to enhance immune *** nanovaccines function by encapsulating tumor-specific antigens or tumor-associated antigens within *** small size of these nanomaterials allows for precise targeting of T cells,dendritic cells,or cancer cells,thereby eliciting a more potent anti-tumor *** this paper,we focus on the classification of carriers for cancer nanovaccines,the roles of different target cells,and clinically tested cancer nanovaccines,discussing strategies for effectively inducing cytotoxic T lymphocytes responses and optimizing antigen presentation,while also looking ahead to the translational challenges of moving from animal experiments to clinical trials.

关键词： Cancer nanovaccines Immunotherapy Nanobiotechnology Immune targets Signaling pathway

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Broadband and perfect terahertz absorber based on multilayer metamaterial with cross-ring patterned structures

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Optoelectronics Letters 2025年第1期21卷 1-6页

作者： wen Jin liu Zhanzhi WU Zhengwei PAN Yu ZHANG Ying School of Science Xi'an Shiyou University Shaanxi Key Laboratory of Measurement and Control Technology for Oil and Gas Wells

Broadband and perfect terahertz absorber based on multilayer metamaterial using cross-ring patterned structures is proposed and investigated. The structure of the absorber is double absorption layers consisting of a chromium cross ring and eight isosceles right triangles. The unique structure of the double absorbing layers excites the electric dipole multimode resonance, giving rise to high absorption performance. Meanwhile, the influence of construal parameters on absorber behavior is also discussed. The numerical results show that the absorption achieves over 90% ranging from 2.45 THz to 6.25 THz and 99% absorption in the range of 3.7—5.3 THz. The realization of broadband and perfect absorber is described using the impedance matching principle. It is obviously found that the absorber is insensitive to the high angle of incidence for both transverse electric(TE) and transverse magnetic(TM) polarizations. Compared with the former reports, this absorber has remarkable improved absorption efficiency and smaller period. The terahertz absorber may be found applications in the fields of energy capture and thermal detection.

关键词： Metamaterials

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利用金属废液以化学共沉法合成镍铜锌铁氧磁体

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过程工程学报 2006年第Z2期6卷 202-204页

作者：刘忠文傅彦培林正雄吴凤技术学院化工系台湾嘉义62153 东华大学材料与工程系台湾花莲97401

利用钢板酸洗废液、镍电镀废液、铜电镀废液及锌电镀废液,以适量各废液调配,以ICP-AES检测其浓度,经化学共沉法而获得镍铜锌铁氧磁粉,热处理使晶粒长大,增大模具成型生胚密度,经烧结得环状体,测量其性质,经XRD,SEM,TEM及VSM等检测分析,... 详细信息

利用钢板酸洗废液、镍电镀废液、铜电镀废液及锌电镀废液,以适量各废液调配,以ICP-AES检测其浓度,经化学共沉法而获得镍铜锌铁氧磁粉,热处理使晶粒长大,增大模具成型生胚密度,经烧结得环状体,测量其性质,经XRD,SEM,TEM及VSM等检测分析,实验结果显示镍铜锌铁氧磁粉晶体为尖晶石立方结构,晶粒大小为8～20nm,饱和磁束密度为31.6emu/g,经过750℃热处理饱和磁束密度为52.3emu/g.烧结环状体晶粒大小为1～3μm,饱和磁束密度为60.7emu/g(3670 Gauss).

关键词：化学共沉法镍铜锌铁氧磁粉尖晶石立方结构

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Gatekeepers of The Guardian:Insights Into p53 Activation by MDM2 and MDM4 Revealed by Mouse Models and In Vitro Studies

Gatekeepers of The Guardian:Insights Into p53 Activation by ...

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第四届中国肿瘤学术大会暨第五届海峡两岸肿瘤学术会议

作者： Geoffrey M. Wahl Kurt Krummel Crystal Lee chung-wen liu Luo-Wei Rodewald Franck Toledo Mark Wade Ee-Tsin Wong The Salk Institute for Biological Studies The Salk Institute for Biological Studies The Salk Institute for Biological Studies The Salk Institute for Biological Studies and Institut Pasteur Unité d’Expression Génétique et Maladies The Salk Institute for Biological Studies The Salk Institute for Biological Studies

＜正＞Background: The p53 tumor suppressor has been called the "Guardian of the Genome" since it prevents cells that have irrepairable DNA damage from proliferating. p53 is a stress responsive transcriptional regulator that is activated by many adverse conditions that impinge on developing tumor cells to prevent them from dividing. This ensures genetic stability, and prevents the emergence of genetically variant clones. Conversely, loss of p53 allows cells to proliferate under challenging, potentially genotoxic conditions. Thus, loss of p53 function is highly selected during tumor progres-

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机械合金/固态反应法制备高性能铁芯

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过程工程学报 2006年第z2期6卷 205-208页

作者：刘忠文初文明傅彦培林正雄吴凤技术学院化工系台湾嘉义62153 吴凤技术学院光机电研究所台湾嘉义62153 东华大学材料与工程系台湾花莲97401

铁硅铝及铁镍钼合金具有低磁伸缩系数、低磁异方性常数及比纯金属高的电阻系数,非常适合于制作高性能铁芯.此铁芯通常以合金粉末为原料,由粉末冶金法制成.由于合金粉末通常采用喷雾法或化学还原法制作,需要庞大的设备及先进的技术,一般... 详细信息

铁硅铝及铁镍钼合金具有低磁伸缩系数、低磁异方性常数及比纯金属高的电阻系数,非常适合于制作高性能铁芯.此铁芯通常以合金粉末为原料,由粉末冶金法制成.由于合金粉末通常采用喷雾法或化学还原法制作,需要庞大的设备及先进的技术,一般铁芯制造工厂不易自行制造,铁硅铝及铁镍钼合金粉末属特殊规格,国际上也不容易购得,限制了金属质铁芯工业的发展.为解决此一问题,拟以机械合金/固态反应法,以纯金属粉末为原料,制作此铁芯,其制作过程把纯金属粉末经混合及研磨数十多小时,制成半机械合金粉末,粉末表面经绝缘处理后,再经过成型及氢气炉烧结,制成铁芯.在烧结过程中,未完全反应的粉末继续反应成合金.所拟开发的技术尚属首创,其优点为不需投资喷雾法或化学还原法的制粉设备,以现成的研磨罐即可制作机械合金,设备简单,原料便宜.另一优点为半机械合金粉末比全合金粉末软,可以压成高密度及高强度的胚体,烧结后的铁芯磁性较佳.如果成功,将根本改变铁芯的制作技术,改变数十亿铁芯市场的制作成本及成品质量.

关键词：机械合金/固态反应法铁硅铝合金铁芯铁镍钼合金铁芯

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Differential distribution of PINK1 and Parkin in the primate brain implies distinct roles

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Neural Regeneration Research 2025年第4期20卷 1124-1134页

作者： Yanting liu Wei Huang Jiayi wen Xin Xiong Ting Xu Qi Wang Xiusheng Chen Xianxian Zhao Shihua Li Xiaojiang Li Weili Yang Guangdong Key Laboratory of Non-human Primate Research Key Laboratory of CNS Regeneration(Ministry of Education)Guangdong-Hongkong-Macao CNS Regeneration Institute of Jinan UniversityJinan UniversityGuangzhouGuangdong ProvinceChina

The vast majority of in vitro studies have demonstrated that PINK1 phosphorylates Parkin to work together in mitophagy to protect against neuronal ***,it remains largely unclear how PINK1 and Parkin are expressed in mammalian *** has been difficult to address because of the intrinsically low levels of PINK1 and undetectable levels of phosphorylated Parkin in small *** this issue is critical for elucidating the in vivo roles of PINK1 and ***,we showed that the PINK1 kinase is selectively expressed as a truncated form(PINK1–55)in the primate *** the present study,we used multiple antibodies,including our recently developed monoclonal anti-PINK1,to validate the selective expression of PINK1 in the primate *** found that PINK1 was stably expressed in the monkey brain at postnatal and adulthood stages,which is consistent with the findings that depleting PINK1 can cause neuronal loss in developing and adult monkey ***1 was enriched in the membrane-bound fractionations,whereas Parkin was soluble with a distinguishable *** double staining experiments showed that PINK1 and Parkin did not colocalize under physiological conditions in cultured monkey astrocytes,though they did colocalize on mitochondria when the cells were exposed to mitochondrial *** findings suggest that PINK1 and Parkin may have distinct roles beyond their well-known function in mitophagy during mitochondrial damage.

关键词： neurodegeneration Parkin Parkinson’s disease PINK1 subcellular distribution

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Efficient large-area flexible organic photovoltaic modules on transparent thin silver electrodes

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Science China Chemistry 2025年

作者： Cong Xie Zedong Xiong Xinlu liu wen Wang Yang liu Xueshi Jiang Xin Lu Lulu Sun Yinhua Zhou Wuhan National Laboratory for Optoelectronics Huazhong University of Science and Technology Kunming Institute of Physics

Large-area flexible organic photovoltaic（OPV） modules are challenging to achieve high power conversion efficiency（PCE）.Electrical shunts or shortages generally occur in large-area OPV modules due to the ultrathin（100–200 nm） and soft active layers. Improving the surface smoothness of bottom transparent electrode will be able to suppress the shunts and shortages. In this work, we report a method to fabricate smooth and flexible transparent electrodes based on thin silver film, and further to fabricate efficient large-area flexible OPV modules. The fabricated thin silver transparent electrodes simultaneously have high conductivity, high optical transmittance, good mechanical flexibility and low surface roughness. Humidity exposure（h.e.）treatment on MoO3effectively facilitates the continuous growth of the thin transparent silver electrode. 6 nm silver film on MoO3（h.e.） on plastic substrate shows a transmittance up to 89%, a sheet resistance of 15 Ω/sq, and a low surface roughness with a rootmean-square value of 0.276 nm. Furthermore, 52-cm2flexible organic solar modules（15 subcells） showed a certified PCE of12.66%. Furthermore, a 1350 cm2flexible component assembled by 25 pieces of 52–55 cm2modules showed certified PCE of12.10% with an open-circuit voltage of 62.85 V.

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Visualization of the protective role of estrogen against female liver fibrosis via an ER viscosity NIR fluorescent probe

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Science China Chemistry 2025年第1期 360-368页

作者： Zheng liu Changyu Zhang Zipeng Li Wanying Ma Jia liu Xiang Xia Ning Xu wen Sun Jianjun Du Jiangli Fan Xiaojun Peng State Key Laboratory of Fine Chemicals Dalian University of Technology Ningbo Institute of Dalian University of Technology

Endoplasmic reticulum(ER) viscosity has emerged as a new potential biomarker for hepatic fibrosis(HF). Herein, we report the first ER-targeting viscosity-responsive near-infrared(NIR) fluorescent probe HBT-PP for investigations of HF *** twisted intramolecular charge transfer(TICT) and the excited state intramolecular proton transfer(ESIPT) are combined to endow HBT-PP with the selective response towards viscosity(～62-fold) and a super large stokes shift(～320 nm). HBT-PP mainly targets organelle ER and is able to image the drug-or alcohol-induced viscosity elevation in living cells. Significantly,HBT-PP was successfully applied to visualize the gender difference in HF and the protective role of estrogen in restraining HF progression. Of note, after 10 min of stain with HBT-PP, HF lesions showed a stage-based response, indicating the potential of this probe in fast and early diagnosis of HF. These results clearly demonstrated the promising application of HBT-PP as a new tool for exploring ER viscosity-involved physiological and pathological processes.

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Rational modulation of fluorophosphate cathode by anionic groups to reduce the polarization behavior for fast-charging sodium-ion batteries

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Journal of Energy Chemistry 2025年第1期100卷 509-521页

作者： Xinyuan Wang Fan Zhang Xingyu Zhou Qian Wang Changyu liu Yangyang liu Hui Wang Xiaojie liu Key Laboratory of Synthetic and Natural Functional Molecule of the Ministry of Education College of Chemistry & Materials Science Northwest University

Na3V2（PO4）2O2F （VP） is recognized as a promising cathode material for sodium-ion batteries due to its stable structural framework and high specific *** functional theory （DFT） and finite element simulations show that incorporating SO42-into VP decreases its band gap,lowers the migration energy barrier,and ensures a uniform Na+concentration gradient and stress distribution during charge and discharge ***,the average Na+diffusion coefficient of Na3V2（PO4）1.95（SO4）0.05O2F（VPS-1） is roughly double that of VP,leading to enhanced rate capability (80 C,75.5 mAh g-1) and cycling stability (111.0 mAh g-1capacity after 1000 cycles at 10 C current density) for ***-1 exhibits outstanding fast-charging capabilities,achieving an 80%state of charge in just 8.1 *** assembled VPS-1//SbSn/NPC full cell demonstrated stable cycling over 200 cycles at a high 5 C current,maintaining an average coulombic efficiency of 95.35%.

关键词： Anionic group modulation Polarization behavior Fast-charging Sodium-ion battery Fluorophosphate Cathode

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