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Dynamic spatial reorganization of BSK1 complexes in the plasma membrane underpins signal-specific activation for growth and immunity

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Molecular Plant 2021年第4期14卷 588-603页

作者： Bodan su Xi Zhang Li Li Sammar Abbas Meng Yu Yaning Cui Frantisek Baluska Inhwan hwang Xiaoyi Shan Jinxing Lin Beijing Advanced Innovation Center for Tree Breeding by Molecular Design Beijing Forestry UniversityBeijing 100083China College of Biological Sciences&Biotechnology Beijing Forestry UniversityBeijing 100083China lnstitute of Cellular and Molecular Botany University of BonnBonn53115Germany 々Division of Integrative Biosciences and Biotechnology Pohang University of Science and TechnologyPohang37673Korea Present address:School of Life Sciences Tsinghua UniversityBeijing 100084China

Growth and immunity are opposing processes that compete for cellular resources,and proper resource allocation is crucial for plant ***1 plays a key role in the regulation of both growth and immunity by associating with BRI1 and FLS2,***,it remains unclear how two antagonistic signals co-opt BSK1 to induce signal-specific *** we show that the dynamic spatial reorganiization of BSK1 within the plasma membrane underlies the mechanism of signal-specific activation for growth or *** BSK1 localizes to membrane rafts as *** BSK1-associated FLS2 and BRI1,flg22 or exogenous brassinosteroid(BR)treatment did not decrease BSK1 levels at the plasma membrane(PM)but rather induced BSK1 multimerization and dissociation from FLS2/BSK1 or BRI1/BSK1,***,flg22-activated BSK1 translocated from membrane rafts to non-membrane-raft regions,whereas BR-activated BSK1 remained in membrane *** applied together with flg22,BR suppressed various flg22-induced BSK1 activities such as BSK1 dissociation from FLS2/BSK1,BSK1 interaction with MAPKKK5,and BSK translocation together with *** together,this study provides a unique insight into how the precise control of BSK1 spatiotemporal organization regulates the signaling specificity to balance plant growth and immunity.

关键词： BSK1 dynamic spatiotemporal organization membrane rafts growth and immunity

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Indeterminate pulmonary nodules in colorectal cancer

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World Journal of Gastroenterology 2015年第10期21卷 2967-2972页

作者： Eun-Joo Jung su-Ran Kim Chun-Geun Ryu Jin Hee Paik Jeong Geun Yi Dae-Yong hwang Department of surgery Colorectal Cancer Center Konkuk University Medical Center Konkuk University School of Medicine Department of Radiology Konkuk University Medical Center Konkuk University School of Medicine

AIM:To investigate the clinicopathologic parameters of pulmonary metastasis in colorectal cancer(CRC) patients after lung operation of indeterminate pulmonary nodules(IPNs).METHODS:From a prospective database of CRCpatients,40 cases that underwent lung operation between November 2008 and December 2012 for suspicious metastatic pulmonary nodules on chest computed tomography(CT)were *** decision to perform a lung operation was made if the patient met the following criteria:(1)completely resected or resectable primary CRC;(2)completely resectable IPNs;(3)controlled or controllable extrapulmonary metastasis;and(4)adequate general condition and pulmonary function to tolerate pulmonary *** operation was performed by a thoracic surgeon without CT-guided biopsy for pathologic ***:A total of 40 cases of lung resection was performed in 29 *** patients underwent repeated lung *** final pathology result showed metastasis from the CRC in 30 cases(75%)and benign pathology in 10 cases(25%).The primary tumor site was the rectum in 26/30(86.6%)cases with pulmonary metastasis,but only 3/10(30%)cases in the benign group had a primary rectal cancer(P=0.001).Positron emission tomography(PET)-CT was performed for 22/30(73.4%)patients in the lung metastasis group and for 6/10(60.0%)patients in the benign ***-CT revealed hot uptake of18fluorine 2-fluoro-2-deoxy-D-glucose with all IPNs in both *** group with pulmonary metastasis had a higher incidence of primary rectal cancer(P=0.001),a more advanced tumor stage(P=0.011),and more frequent lymphatic invasion of tumor cells(P=0.005).Six cases with previous liver metastasectomy were present in the lung metastasis *** carcinoembryonic antigen levels before lung operation were not elevated in any of the ***:The stage and location of the primary tumor and tumor cell infiltration of lymphatics provide useful indicators for deciding on lung resection of IP

关键词： Colorectal neoplasm Lung neoplasm Indeterminate pu

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Creating unconventional geometric phase gate using squeeze-like operator assisted by strong driving field

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Chinese Physics B 2007年第6期16卷 1559-1565页

作者：朱爱东张寿 Yeon Kyu-hwang Yu Seong-Cho Um chung-In Center for the Condensed-Matter Science and Technology Harbin Institute of Technology Harbin 150001 China Department of Physics College of Science Yanbian University Yanji 133002 China Department of Physics & BK21 Program for Device Physics College of Natural Science Chungbuk National University Cheonju Chungbuk 361-763 Republic of Korea Department of Physics College of Science Korea University Seoul 136-701 Republic of Korea

Based on the idea that a squeezing process can be thought of as a total cumulative effect of a large number of tiny squeezing processes, we define a squeeze-like operator with a time-dependent squeeze parameter. Applying this operator to and combining with a system which includes a two-photon interaction between two atoms and an initial vacuum cavity field, and resorting to a resonant strong driving classical field, we obtain an unconventional geometric phase gate with a shorter gating time.

关键词： squeeze-like operator quantum phase gate strong driving field

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Mechanical properties of graphene oxide?silk fibroin bionanofilms via nanoindentation experiments and finite element analysis

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Friction 2022年第2期10卷 282-295页

作者： Hyeonho CHO Joonho LEE Hyundo hwang Woonbong hwang Jin-Gyun KIM sunghan KIM School of Mechanical Engineering Chung-Ang UniversitySeoul 06974Republic of Korea Department of Mechanical Engineering(Integrated Engineering) Kyung Hee UniversityGyeonggi 17104Republic of Korea Department of Mechanical Engineering POSTECHPohang 37673Republic of Korea Department of Robotics&Mechatronics.Korea Institute of Machinery&Materials Daejeon 34103Republic of Korea

Understanding the mechanical properties of bionanofilms is important in terms of identifying their *** primary focus of this study is to examine the effect of water vapor annealed silk fibroin on the indentation modulus and hardness of graphene oxide-silk fibroin(GO-SF)bionanofilms through nanoindentation experiments and finite element analysis(FEA).The GO-SF bionanofilms were fabricated using the layer-by-layer *** water vapor annealing process was employed to enhance the interfacial properties between the GO and SF layers,and the mechanical properties of the GO-SF bionanofilms were found to be affected by this *** employing water vapor annealing,the indentation modulus and hardness of the GO-SF bionanofilms can be ***,the FEA models of the GO-SF bionanofilms were developed to simulate the details of the mechanical behaviors of the GO-SF *** difference in the stress and strain distribution inside the GO-SF bionanofilms before and after annealing was *** addition,the load-displacement curves that were obtained by the developed FEA model conformed well with the results from the nanoindentation *** summary,this study presents the mechanism of improving the indentation modulus and hardness of the GO-SF bionanofilms through the water vapor annealing process,which is established with the FEA simulation models.

关键词： graphene oxide silk fibroin layer-by-layer(LbL) nanoindentation finite element analysis(FEA)

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L^(p)Boundedness of Fourier Integral Operators in the Class S_(1,0)

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Acta Mathematica Sinica,English Series 2023年第1期39卷 37-98页

作者： Ing-Lung hwang Department of Mathematics “National Chung Cheng University of Taiwan”Chiayi County 621003China

We prove the following properties:(1)Let a∈Λ_(1,0,k,k’)^(m0)(R^(n)×R^(n))with m0=-1|1/p-1/2|(n-1),n≥2(1 n/p,k’>0;2≤p≤∞,k>n/2,k’>0 respectively).suppose the phase function S is positively homogeneous inξ-variables,non-degenerate and satisfies certain *** the Fourier integral operator T is L^(p)-*** the method of(1),we can obtain the L^(p)-boundedness of the Fourier integral operator if(2)the symbol a∈Λ_(1,δ,k,k’)^(m0),0≤δ≤1,with m0,k,k’and S given as in(1).Also,the method of(1)gives:(3)a∈Λ_(1,δ,k,k’),0≤δ<1 and k,k’given as in(1),then the L^(p)-boundedness of the pseudo-differential operators holds,1

关键词： Fourier integral operator L^(p)-boundedness

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A New Efficient Synthetic Method for 3-1odothyronamine and Its Potent Hypothermic Efficacy

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Chinese Journal of Chemistry 2011年第10期29卷 2205-2208页

作者： Kim, Joong-Gon Song, Young-Kyu Jeon, su-Yeon Lim, Ye-Ji Ju, Hyunwo Choi, Inho chung, Chan-Moon Biotechnology Division Hanwha Chemical R＆D Center Daejeon 305-345 Korea Department of Chemistry and Medical Chemistry Yonsei University Wonju Gangwon-do 220- 710 Korea Department of Biological Science and Technology Yonsei University Wonju Gangwon-do 220-710 Korea

We developed a new efficient synthetic method for a 3-iodothyronamine （TjAM） that has advantages of less synthetic steps and much higher overall yield compared to those in the conventional method. Our animal study s... 详细信息

关键词： 3-iodothyronamine hibernation-like state ICR mouse

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Inverse correlation between gastroesophageal reflux disease and atrophic gastritis assessed by endoscopy and serology

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World Journal of Gastroenterology 2022年第8期28卷 853-867页

作者： Yoo Min Han su Jin chung Seokha Yoo Jong In Yang Ji Min Choi Jooyoung Lee Joo sung Kim Department of Internal Medicine and Healthcare Research Institute Seoul National University Hospital Healthcare System Gangnam CenterSeoul 06236South Korea Department of Anesthesiology and Pain Medicine Seoul National University College of MedicineSeoul 03080South Korea Department of Internal Medicine and Liver Research Institute Seoul National University College of MedicineSeoul 03080South Korea

BACKGROUND Helicobacter pylori(***)infection is known to prevent the occurrence of gastroesophageal reflux disease(GERD)by inducing gastric mucosal ***,little is known about the relationship between atrophic gastritis(AG)and *** To confirm the inverse correlation between AG and the occurrence and severity of *** Individuals receiving health checkups who underwent upper gastrointestinal endoscopy at Seoul National University Healthcare System Gangnam Center were *** grade of reflux esophagitis was evaluated according to the Los Angeles *** AG(EAG)was categorized into six *** AG(SAG)was defined as pepsinogen I≤70 ng/m L and pepsinogen I/II ratio≤*** association between the extent of EAG and SAG and the occurrence and severity of GERD was evaluated using multivariate logistic regression *** In total,4684 individuals with GERD were compared with 21901 healthy *** multivariate logistic regression analysis,advanced age,male sex,body mass index>23 kg/m2,presence of metabolic syndrome,current smoking,and alcohol consumption were associated with an increased risk of *** for *** immunoglobulin G antibodies was associated with a decreased risk of *** was an inverse correlation between the extent of EAG and occurrence of GERD:Odds ratio(OR),1.01[95%confidence interval(CI):0.90-1.14]in C1,0.87(0.78-0.97)in C2,0.71(0.62-0.80)in C3,0.52(0.44-0.61)in O1,0.37(0.29-0.48)in O2,and 0.28(0.18-0.43)in ***,the extent of EAG showed an inverse correlation with the severity of *** presence of SAG was correlated with a reduced risk of GERD(OR=0.49,95%CI:0.28-0.87,P=0.014).CONCLUSION The extent of EAG and SAG exhibited strong inverse relationships with the occurrence and severity of *** followed by *** infection may be independently protect against GERD.

关键词： Gastroesophageal reflux disease Reflux esophagitis Helicobacter pylori Atrophic gastritis Pepsinogen

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SOCA-DOM:A Mobile System-on-Chip Array System for Analyzing Big Data on the Move

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Journal of Computer Science & Technology 2022年第6期37卷 1271-1289页

作者： Le-Le Li Jiang-Yi Liu Jian-Ping Fan Xue-Hai Qian Kai hwang Yeh-Ching chung Zhi-Bin Yu Center for Heterogeneous and Intelligent Computing Shenzhen Institutes of Advanced Technology Chinese Academy of SciencesShenzhen 518055China School of Science and Engineering The Chinese University of Hong KongShenzhenShenzhen 518172China Center for High Performance Computing Shenzhen Institutes of Advanced TechnologyChinese Academy of Sciences Shenzhen 518055China Ming Hsieh Department of Electrical and Computer Engineering University of Southern CaliforniaLos Angeles CA 90089-0001U.S.A. Department of Computer Science University of Southern CaliforniaLos AngelesCA 90089-0001U.S.A. School of Data and Science The Chinese University of Hong KongShenzhenShenzhen 518172China

Recently,analyzing big data on the move is *** requires that the hardware resource should be low volume,low power,light in weight,high-performance,and highly scalable whereas the management software should be flexible and consume little hardware *** meet these requirements,we present a system named SOCA-DOM that encompasses a mobile system-on-chip array architecture and a two-tier“software-defined”resource manager named ***,we design an Ethernet communication board to support an array of mobile ***,we propose a two-tier software architecture for Chameleon to make it ***,we devise data,configuration,and control planes for Chameleon to make it“software-defined”and in turn consume hardware resources on ***,we design an accurate synthetic metric that represents the computational power of a computing *** employ 12 Apache Spark benchmarks to evaluate ***,SOCA-DOM consumes up to 9.4x less CPU resources and 13.5x less memory than Mesos which is an existing resource *** addition,we show that a 16-node SOCA-DOM consumes up to 4x less energy than two standard Xeon *** on the results,we conclude that an array architecture with fine-grained hardware resources and a software-defined resource manager works well for analyzing big data on the move.

关键词： edge computing mobile architecture resource management big data analytics software-defined systems

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Entacapone promotes hippocampal neurogenesis in mice

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Neural Regeneration Research 2021年第6期16卷 1005-1010页

作者： Dae Young Yoo Hyo Young Jung Woosuk Kim Kyu Ri Hahn Hyun Jung Kwon sung Min Nam Jin Young chung Yeo sung Yoon Dae Won Kim In Koo hwang Department of Anatomy and Cell Biology College of Veterinary Medicineand Research Institute for Veterinary ScienceSeoul National UniversitySeoulSouth Korea Department of Anatomy College of MedicineSoonchunhyang UniversityCheonanSouth Korea Department of Biomedical Sciences and Research Institute for Bioscience and BiotechnologyHallym UniversityChuncheonSouth Korea Department of Biochemistry and Molecular Biology Research Institute of Oral SciencesCollege of DentistryGangneung-Wonju National UniversityGangneungSouth Korea Department of Anatomy College of Veterinary MedicineKonkuk UniversitySeoulSouth Korea Department of Veterinary Internal Medicine and Geriatrics College of Veterinary MedicineKangwon National UniversityChuncheonSouth Korea

Entacapone,a catechol-O-methyltransferase inhibitor,can strengthen the therapeutic effects of levodopa on the treatment of Parkinson’s ***,few studies are reported on whether entacapone can affect hippocampal neurogenesis in *** investigate the effects of entacapone,a modulator of dopamine,on proliferating cells and immature neurons in the mouse hippocampal dentate gyrus,60 mice(7 weeks old)were randomly divided into a vehicle-treated group and the groups treated with 10,50,or 200 mg/kg *** results showed that 50 and 200 mg/kg entacapone increased the exploration time for novel object *** staining results revealed that after entacapone treatment,the numbers of Ki67-positive proliferating cells,doublecortin-positive immature neurons,and phosphorylated cAMP response element-binding protein(pCREB)-positive cells were significantly *** blot analysis results revealed that treatment with tyrosine kinase receptor B(TrkB)receptor antagonist significantly decreased the exploration time for novel object recognition and inhibited the expression of phosphorylated TrkB and brain-derived neurotrophic factor(BDNF).Entacapone treatment antagonized the effects of TrkB receptor *** results suggest that entacapone treatment promoted hippocampal neurogenesis and improved memory function through activating the BDNF-TrkB-pCREB *** study was approved by the Institutional Animal Care and Use Committee of Seoul National University(approval ***-130730-1)on February 24,2014.

关键词： brain-derived neurotrophic factor entacapone hippocampus neurogenesis neurotrophic factor phosphorylated cAMP response element-binding protein tyrosine kinase receptor B receptor

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Dendritic cell-based immunotherapy for colon cancer using an HLA-A＊0201-restricted cytotoxic T-lymphocyte epitope from tumor-associated antigen 90K

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Cellular & Molecular Immunology 2013年第3期10卷 275-282页

作者： Ji Hee Lee Myong-suk Park Jun-Eul hwang Sang-Hee Cho Woo-Kyun Bae Hyun-Jeong Shim Dae-Eun Kim Ik-Joo chung Department of Hematology-Oncology Chonnam National University Medical School Gwangju Korea The Brain Korea 21 Project Center for Biomedical Human Resources at Chonnam National University Gwangiu Korea

Tumor-associated antigen 90K is implicated in cell-cell and cell-extracellular matrix adhesion through its interaction with galectin-3 and integrin-β 1 and is highly expressed in malignant tissues, making it a novel target for the development of new immunotherapies. We investigated a potential immunotherapy treatment for colon cancer using 90K-specific cytotoxic T lymphocytes induced by autologous dendritic cells and pulsed with 90K peptides. We selected three peptides （90K3s1, 90K5 and 90K523） that bind to HLA-A＊0201 molecules on the basis of their binding affinity, as determined by a peptide-T2 binding assay. Dendritic cells pulsed with 90K peptides resulted in the efficient generation of mature dendritic cells and exhibited enhanced T-cell stimulation and polarization of naive T cells toward Thl. Dendritic cells pulsed with 90K peptides generated potent cytotoxic T-lymphocytes that lysed T2 cells loaded with each 90K peptide, and 90K＋/HLA-A2＋ colon cancer cell lines, including HCT116 and SW480, in a dose-dependent and HLA-A＊O2Ol-restricted manner. No killing was observed in 90K＋/HLA-A2- DLD1 or 90K-/HLA-A2- K562 cells. Therefore, we believe that cytotoxic T-lymphocytes stimulated by 90K peptide-pulsed dendritic cells naturally recognize the 90K peptide presented by colon cancer cells in the context of HLA-A2, and kill 90K-positive tumor cells. Dendritic cells pulsed with 90K peptides led to the induction of granzyme B and perforin positive CD8＋ T cells against HCT116 and SW480 cells, but not DLD1 cells. In conclusion, 90K-specific cytotoxic T lymphocytes, generated by stimulating T cells with 90K peptide-pulsed dendritic cells, could be useful effector cells for the immunotherapv treatment of colon cancer.

关键词： 9OK colon cancer dendritic cells immunotherapy peptide

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