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Effects of Bifidobacterium lactis BLa80 on fecal and mucosal flora and stem cell factor/c-kit signaling pathway in simulated microgravity rats

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World Journal of Gastroenterology 2025年第1期31卷 93-109页

作者： Ping Zhang Ying Zhu Pu Chen Tong Zhou Zhe-Yi Han jun Xiao Jian-Feng Ma Wen Ma Peng Zang Ying Chen Graduate School Hebei North UniversityZhangjiakou 075000Hebei ProvinceChina Key Laboratory of Aerospace Nutrition and Food Engineering China Astronaut Research and Training CenterBeijing 100094China Department of Gastroenterology The Air Force Medical CenterBeijing 100142China Department of Blood Transfusion Air Force Medical CenterBeijing 100142China

BACKGROUND Simulated microgravity environment can lead to gastrointestinal motility *** pathogenesis of gastrointestinal motility disorders is closely related to the stem cell factor(SCF)/c-kit signaling pathway associated with intestinal flora and Cajal stromal ***,intestinal flora can also affect the regulation of SCF/c-kit signaling pathway,thus affecting the expression of Cajal stromal *** cells are the pacemakers of gastrointestinal *** To investigate the effects of Bifidobacterium lactis(***)BLa80 on the intestinal flora of rats in simulated microgravity and on the gastrointestinal motility-related SCF/c-kit *** The internationally recognized tail suspension animal model was used to simulate the microgravity environment,and 30 rats were randomly divided into control group,tail suspension group and drug administration tail suspension group with 10 rats in each group for a total of 28 *** tail group was given *** BLa80 by intragastric administration,and the other two groups were given water intragastric administration,the concentration of intragastric administration was 0.1 g/mL,and each rat was 1 mL/***&eosin staining was used to observe the histopathological changes in each segment of the intestine of each group,and the expression levels of SCF,c-kit,extracellular signal-regulated kinase(ERK)and p-ERK in the gastric antrum of each group were detected by Western blotting and *** fecal flora and mucosal flora of rats in each group were detected by 16S *** Simulated microgravity resulted in severe exfoliation of villi of duodenum,jejunum and ileum in rats,marked damage,increased space between villi,loose arrangement,shortened columnar epithelium of colon,less folds,narrower mucosal thickness,reduced goblet cell number and crypts,and significant improvement after probiotic *** microgravity reduced the expressions of SCF and c-kit,and increased the express

关键词： Simulated microgravity Rat Intestinal flora Gastrointestinal motility Stem cell factor/c-kit signaling pathway

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InIncidence and clinical features of endoscopic ulcers developing after gastrectomy

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World Journal of Gastroenterology 2012年第25期18卷 3260-3266页

作者： Woo Chul chung Eun jung Jeon Kang-Moon Lee Chang Nyol Paik Sung Hoon jung jung hwan Oh Ji Hyun Kim Kyong-Hwa jun Hyung Min Chin Department of Internal Medicine The Catholic University of KoreaSeoul 130-709South Korea Department of Surgery The Catholic University of Korea College of MedicineSeoul 130-709South Korea

AIM： To determine the precise incidence and clinica features of endoscopic ulcers following gastrectomy. METHODS： A consecutive series of patients who un- derwent endoscopic examination following gastrectomy between 2005 and 2010 was retrospectively analyzed. A total of 78 patients with endoscopic ulcers and 759 without ulcers following gastrectomy were enrolled. We analyzed differences in patient age, sex, size of the le- sions, method of operation, indications for gastric resec- tion, and infection rates of Helicobacterpylor/（H. pylor/~ between the nonulcer and ulcer groups. RESULTS： The incidence of endoscopic ulcers after gastrectomy was 9.3% and that of marginal ulcers was 8.6%. Ulcers were more common in patients with Billroth l] anastomosis and pre-existing conditions forpeptic ulcer disease （PUD）. Infection rates of H. pylori- did not differ significantly between the two groups. The patients who underwent operations to treat PUD had lower initial levels of hemoglobin and higher rates of hospital admission. CONCLUSION： H. pylori was not an important factor in ulcerogenesis following gastrectomy. For patients who underwent surgery for PUD, clinical course of mar- ginal ulcers was more severe.

关键词： Gastrectomy Marginal ulcer Helicobacterpylori

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Asymptomatic lymphangioma involving the spleen and retroperitoneum in adults

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World Journal of Gastroenterology 2009年第44期15卷 5620-5623页

作者： Sook Hee chung Young Sook Park Yun Ju Jo Seong hwan Kim Dae Won jun Byoung Kwan Son jun Young jung Dae Hyun Baek Dong Hee Kim Yoon Young jung Won Mi Lee Department of Internal Medicine Eulji General Hospital Eulji University School of MedicineSeoul 139-711South Korea Department of General Surgery Eulji General HospitalEulji University School of MedicineSeoul 139-711 South Korea Department of Radiology Eulji General HospitalEulji University School of MedicineSeoul 139-711 South Korea Department of Pathology Eulji General Hospital Eulji University School of MedicineSeoul 139-711 South Korea

Lymphangioma, a benign neoplasm of the lymphatic system, is common in children but rare in adults. Its clinical manifestations include abdominal pain, nausea, vomiting and a palpable mass. However, abdominal sonography or abdominal computed tomography （CT） scan can also incidentally reveal lymphangioma. A larger or symptomatic lymphangioma is treated with total resection to prevent recurrence, infection, torsion and enlargement. Although lymphangioma rarely becomes malignant, its prognosis is generally good. We report a cystic lymphangioma of the spleen and retroperitoneum, which was incidentally found in a 56-year-old man who was hospitalized due to a colon mass. Physical examination showed no specific findings. Abdominal CT revealed a 5.7 cm, non-enhanced multilobulated cystic mass with multiple sepia in the spleen and a 10 cm lobulated cystic mass in the paraaortic area. Splenectomy and retroperitoneal resection of the cystic mass were conducted. The endothelium of splenic and retroperitoneal cyst was immunohistochemically stained with D2-40 antibody. The patient was finally diagnosed with splenic cystic and retroperitoneal cavernous lymphangioma.

关键词： Lymphangioma Retroperitoneum Spleen

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Delphi study for developing a checklist of adverse events associated with acupotomy

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Journal of Integrative Medicine 2024年第5期22卷 579-587页

作者： Hyungsun jun Haebeom Lee Sang-Hoon Yoon Chan-Young Kwon Damin Jeon jun-hwan Lee jungtae Leem Department of Diagnostics College of Korean MedicineWonkwang UniversityIksan 54538Republic of Korea 7Days Inc. Seoul 06247Republic of Korea chung-Yeon Korean Medicine Clinic Seoul 06224Republic of Korea Department of Oriental Neuropsychiatry Dong-Eui University College of Korean MedicineBusan 47227Republic of Korea Chonnam National University Hwasun Hospital Hwasun 58128Republic of Korea KM Science Research Division Korea Institute of Oriental MedicineDaejeon 34054Republic of Korea Department of Korean Convergence Medical Science KIOM SchoolUniversity of Science&Technology(UST)Daejeon 34054Republic of Korea Department of Physical Medicine and Rehabilitation Spaulding Rehabilitation HospitalHarvard Medical SchoolBostonMA 02115USA Research Center of Traditional Korean Medicine College of Korean MedicineWonkwang UniversityIksan 54538Republic of Korea

Background Acupotomy,a more invasive procedure than acupuncture,involves the use of a thicker needle with an integrated knife at the tip,necessitating safety *** aimed to define relevant adverse events(AEs)and create a standardized form of the ACUPOtomy-related AEs CHECKlist(ACUPOCHECK).Methods Before conducting the Delphi process,a systematic review and pilot prospective study were conducted to gather information on previously reported *** these data,pilot versions of the ACUPOCHECK and Delphi questionnaires were *** Delphi questionnaire involved selecting types of AE for inclusion,establishing separate criteria for acupotomy-related AEs,and achieving a consensus on AE *** Korean doctors with experience in acupotomy or AE research were recruited to participate in each Delphi *** was considered to have been reached if the critical value for the content validity ratio met or exceeded *** The final ACUPOCHECK was developed using four rounds of the Delphi method and one face-to-face consensus *** included 12 local AEs(pain,hemorrhage,bruise,hematoma,edema,pruritus,rash,infection,nerve damage,dysesthesia,movement impairment,and pneumothorax)and 14 systemic AEs(disease aggravation,needle fatigue,sleepiness,procedural nausea,procedural vomiting,procedural headache,procedural dizziness,sweating,procedural shock,syncope,dyspnea,procedural pain,sleep disorder,and postprocedural infection).Separate criteria were established for pain,hemorrhage and bruising:pain was defined as pain that occurrs during daily activities and persists for longer than 72 h,hemorrhage as bleeding that continues for≥3 min despite pressure application,and bruising as having a bruise with a diameter of≥3 ***-ended descriptions were allowed for AEs not covered by the checklist,and severity and causality were assessed using the Common Terminology Criteria for Adverse Events and modified World Health Organization-Uppsala Monitoring C

关键词： Acupotomy Delphi technique Patient safety Safety management Adverse event

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Observational constraints on running vacuum model

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Chinese Physics C 2019年第2期43卷 132-137页

作者： Jin-jun Zhang chung-Chi Lee Chao-Qiang Geng School of Physics and Information Engineering Shanxi Normal University DAMTP Centre for Mathematical Sciences University of Cambridge Department of Physics National Tsing Hua University National Center for Theoretical Sciences

We investigate the power spectra of the CMB temperature and matter density in the running vacuum model(RVM) with the time-dependent cosmological constant of A=3 vH^2+ Λ_0, where H is the Hubble parameter. In this model, dark energy decreases in time and decays to both matter and radiation. By using the Markov chain Monte Carlo method, we constrain the model parameter v as well as the cosmological observables. Explicitly, we obtain v ≤1.54× 10^(-4)(68% confidence level) in the RVM with the best-fit χ_(RVM)~2 =13968.8, which is slightly smaller thanχ_(ΛCDM)~2= 13969.8 in the ΛCDM model of v = 0.

关键词： matter power spectrum running vacuum model CMB temperature spectrum cosmological constant

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Single omental metastasis of renal cell carcinoma after radical nephrectomy:A case report

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World Journal of Clinical Cases 2023年第25期11卷 5994-5999页

作者： Jae-Wook chung jun-Koo Kang Eun Hye Lee So Young Chun Yun-Sok Ha jun Nyung Lee Tae-hwan Kim Tae Gyun Kwon Ghil Suk Yoon Department of Urology Kyungpook National University HospitalDaegu 41404South Korea Department of Urology School of MedicineKyungpook National UniversityDaegu 41404South Korea Biomedical Research Institute Kyungpook National UniversityDaegu 41404South Korea Joint Institute for Regenerative Medicine Kyungpook National UniversityDaegu 41404South Korea Department of Pathology Kyungpook National University HospitalDaegu 41404South Korea Department of Pathology School of MedicineKyungpook National UniversityDaegu 41404South Korea

BACKGROUND Renal cell carcinoma(RCC)is the third most common malignancy in the genitourinary *** lungs,bone,lymph nodes,liver,and brain are common metastatic sites of ***,there is limited literature on single omental metastasis of *** SUMMARY We present the case of a 44-year-old man with single omental metastasis of RCC after laparoscopic radical *** diagnosis of the resected left kidney revealed pT3a clear cell RCC(Fuhrman grade III).At 6 mo postoperatively,abdominal computed tomography revealed a 12-mm enhancing nodule in the left lower *** 7 mo after initial operation,laparoscopic removal of the left omental nodule was *** pathological results indicated metastatic clear cell ***,the patient is being treated with adjuvant *** Omental metastasis of RCC owing to laparoscopic radical nephrectomy is *** should be aware of the diverse nature of RCC.

关键词： Metastasis Omentum Renal cell carcinoma Radical nephrectomy Case report

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Fucoidan protects hepatocytes from apoptosis and inhibits invasion of hepatocellular carcinoma by up-regulating p42/44 MAPK-dependent NDRG-1/CAP43

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Acta Pharmaceutica Sinica B 2015年第6期5卷 544-553页

作者： Yuri Cho jung-hwan Yoon Jeong-ju Yoo Minjong Lee Dong Hyeon Lee Eun Ju Cho Jeong-Hoon Lee Su Jong Yu Yoon jun Kim chung Yong Kim Department of Internal Medicine and Liver Research Institute Seoul National University College of Medicine

Fucoidan is a traditional Chinese medicine suggested to possess anti-tumor *** this study the anti-metastatic effects of fucoidan were investigated in vitro in human hepatocellular carcinoma(HCC) cells(Huh-7 and SNU-761) under normoxic and hypoxic conditions and in vivo using a distant liver metastasis model involving injection of MH134 cells into spleen via the portal *** ability to protect hepatocytes against bile acid(BA)-induced apoptosis was investigated in primary *** was found to suppress the invasion of HCC cells through up-regulation of p42/44 MAPKdependent NDRG-1/CAP43 and partly,under normoxic conditions,through up-regulation of p42/44MAPK-dependent VMP-1 *** also significantly decreased liver metastasis in *** regards its hepatoprotective effect,fucoidan decreased BA-induced hepatocyte apoptosis as shown by the attenuation of caspase-8,and-7 cleavages and suppression of the mobilization of caspase-8 and Fas associated death domain(FADD) into the death-inducing signaling *** summary,fucoidandisplays inhibitory effects on proliferation of HCC cells and protective effects on *** results suggest fucoidan is a potent suppressor of tumor invasion with hepatoprotective effects.

关键词： Fucoidan Hepatocellular carcinoma Invasion Hypoxia Hepatoprotective Cultured hepatocyte NDRG-1/CAP43 VMP-1

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Expression rates of p16,p53 in head and neck cutaneous squamous cell carcinoma based on human-papillomavirus positivity

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World Journal of Clinical Cases 2025年第9期13卷 13-23页

作者： Ha-Jong Nam Heongrae Ryu Da-Woon Lee Je Yeon Byeon jun Hyuk Kim Ji Hye Lee Soomin Lim hwan jun Choi Department of Plastic and Reconstructive Surgery Soonchunhyang University Gumi HospitalGumi-si 39371South Korea Department of Plastic and Reconstructive Surgery College of MedicineSoonchunhyang UniversityCheonan-si 31151South Korea Department of Pathology Soonchunhyang University HospitalCheonan-si 31151South Korea Bachelor of Medicine and Bachelor of Surgery University College LondonMedical SchoolLondon WC1E 6DEUnited Kingdom

BACKGROUND The high prevalence of human papillomavirus(HPV)infection in oropharyngeal squamous cell carcinoma(SCC)is well established,and p16 expression is a strong ***-related tumors exhibit unique mechanisms that target p16 and p53 ***,research on HPV prevalence and the combined predictive value of p16 and p53 expression in head and neck cutaneous SCC(HNCSCC),particularly in Asian populations,remains *** retrospective study surveyed 62 patients with HNSCC(2011-2020),excluding those with facial warts or other skin *** To explore the prevalence of HPV and the predictive value of p16 and p53 expression in HNCSCC in Asian *** All patients underwent wide excision and *** staining for HPV,p16,and p53 yielded positive and negative *** relevance of each marker was investigated by categorizing the tumor locations into high-risk and middle-risk zones based on recurrence *** Of the 62 patients,20(32.26%)were male,with an average age of 82.27 years(range 26-103 years).High-risk included 19 cases(30.65%),with the eyelid and lip being the most common sites(five cases,8.06%).Middle-risk included 43 cases(69.35%),with the cheek being the most common(29 cases,46.77%).The p16 expression was detected in 24 patients(38.71%),p53 expression in 42 patients(72.58%),and HPV in five patients(8.06%).No significant association was found between p16 expression and the presence of HPV(P>0.99),with a positive predictive value of 8.33%.CONCLUSION This study revealed that p16,a surrogate HPV marker in oropharyngeal SCC,is not reliable in HNCSCC,providing valuable insights for further research in Asian populations.

关键词： Squamous cell carcinoma Oropharyngeal Non-oropharyngeal Human papillomavirus The p16 The p53

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The Spatial Effects of Antenna Configuration in a Large Area Inductively Coupled Plasma System for Flat Panel Displays

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Plasma Science and Technology 2014年第8期16卷 758-766页

作者： Seon-Geun OH Young-jun LEE Jae-Hong JEON Jong-Hyeon SEO Hee-hwan CHOE School of Electronics Telecommunication and Computer EngineeringKorea Aerospace University Department of Material Science and Engineering Korea Aerospace University

Spatial distributions of plasma parameters such as electron density, electron temperature and electric potential were investigated using a commercial simulation software （COMSOLTM） to predict the effects of antenna configuration in a large area inductively cou- pled plasma （ICP） system for flat panel displays. Nine planar antenna sets were evenly placed above a ceramic window. While the electron density was influenced by both the input current and gas pressure, the electron temperature and electric potential were dominantly affected by the gas pressure.

关键词： plasma ICP antenna configuration simulation

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Clinical applications of next-generation sequencing in colorectal cancers

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World Journal of Gastroenterology 2013年第40期19卷 6784-6793页

作者： Tae-Min Kim Sug-Hyung Lee Yeun-jun chung MRC Cancer Evolution Research Center College of MedicineThe Catholic University of KoreaSeoul 137-701South Korea Integrated Research Center for Genome Polymorphism Department of MicrobiologyCollege of MedicineThe Catholic University of KoreaSeoul 137-701South Korea Department of Pathology College of MedicineThe Catholic University of KoreaSeoul 137-701South Korea

Like other solid tumors,colorectal cancer(CRC) is a genomic disorder in which various types of genomic alterations,such as point mutations,genomic rearrangements,gene fusions,or chromosomal copy number alterations,can contribute to the initiation and progression of the disease. The advent of a new DNA sequencing technology known as next-generation sequencing(NGS) has revolutionized the speed and throughput of cataloguing such cancer-related genomic alterations. Now the challenge is how to exploit this advanced technology to better understand the underlying molecular mechanism of colorectal carcinogenesis and to identify clinically relevant genetic biomarkers for diagnosis and personalized therapeutics. In this review,we will introduce NGS-based cancer genomics studies focusing on those of CRC,including a recent large-scale report from the Cancer Genome Atlas. We will mainly discuss how NGS-based exome-,whole genome- and methylome-sequencing have extended our understanding of colorectal carcinogenesis. We will also introduce the unique genomic features of CRC discovered by NGS technologies,such as the relationship with bacterial pathogens and the massive genomic rearrangements of chromothripsis. Finally,we will discuss the necessary steps prior to development of a clinical application of NGS-related findings for the advanced management of patients with CRC.

关键词： Next-generation sequencing Cancer genomics Colorectal cancers Personalized medicine The cancer genome atlas

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