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亚太热带医药杂志：英文版 2017年第2期10卷 127-133页

作者： Yu-Hao Wang Yu-Chieh Wang Pi-Hsiung Wu Lan hsu chung-Yang Wang chung-Ren Jan Hsing-Hao Su Department of Microbiology and Immunology University of Rochester Department of Biology Wake Forest University Department of Otorhinolaryngology Head and Neck SurgeryKaohsiung Veterans General Hospital Department of Dermatology Kaohsiung Veterans General Hospital Anshing Clinic Department of Medical Education and Research Kaohsiung Veterans General Hospital

Objective:To discuss the effect of lesser-known potential risk factors,such as bedroom showers,on the prevalence of allergic ***:A cross-sectional,population-based study was performed using both survey and fungal culturing in southern *** were 998 participants enrolled in the survey,and 513 sets of fungal culture *** score for allergic rhinitis(SFAR) more than 7,the patient was defined to have allergic *** of allergic rhinitis were calculated as odds ratios for various predicted risk factors by logistic *** between predicted risk factors and fungal level were examined with linear ***:The adjusted odds ratio of frequently using bedroom shower to having allergic rhinitis was 1.572(95% confidence interval:1.090-2.265),and 0.962 for people with older age to have AR(95% confidence interval:0.949-0.976).As to the 24-hour fungal level,the standardized coefficient was 0.254 for frequent use of bedroom shower,and 0.106 for window open ***:Use of bedroom shower is a potential risk factor for allergic rhinitis development.

关键词： Allergic rhinitis Allergens Environment Fungi Indoor air quality

Prevalence and risk factors for Barrett’s esophagus in Taiwan

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World Journal of Gastroenterology 2019年第25期25卷 3231-3241页

作者： Yan-Hua Chen Hsien-chung Yu Kung-Hung Lin Huey-Shyan Lin Ping-I hsu Division of Gastroenterology and Hepatology Department of Internal MedicineKaohsiung Veterans General HospitalKaohsiung 81362Taiwan Health Evaluation Center Kaohsiung Veterans General HospitalKaohsiung 81362Taiwan Department of Nursing Meiho UniversityNeipu TownshipPingtung County 91202Taiwan Institute of Health Care Management Department of Business ManagementNational Sun Yat-Sen UniversityKaohsiung 80424Taiwan Department of Health-Business Administration Fooyin UniversityKaohsiung 83102Taiwan National Yang Ming University Taipei 12221Taiwan

BACKGROUND Barrett’s esophagus(BE)is a pre-malignant condition associated with the development of esophageal *** prevalence of BE in the general populations of Asian countries ranges from 0.06%to 1%.However,with lifestyle changes in Asian countries and adoption of western customs,the prevalence of BE might have *** To determine the current prevalence of BE in Taiwan,and to investigate risk factors predicting the presence of *** This retrospective study was conducted at the Health Evaluation Center of Kaohsiung Veterans General Hospital in *** January 2015 and December 2015,3385 subjects undergoing routine esophagogastroduodenoscopy examinations as part of a health check-up at the Health Evaluation Center were *** characteristics and endoscopic findings were carefully *** with endoscopic findings consistent with BE awaiting histological evaluation were judged as endoscopically suspected esophageal metaplasia(ESEM).BE was defined based on extension of the columnar epithelium≥1 cm above the gastroesophageal junction and was confirmed based on the presence of specialized intestinal metaplasia(IM)in the metaplastic esophageal *** factors of subjects with BE and subjects without BE were compared,and the risk factors predicting BE were *** A total of 3385 subjects(mean age,51.29±11.42 years;57.1%male)were included in the study,and 89 among them were confirmed to have IM and presence of goblet cells via biopsy *** majority of these individuals were classified as short segment BE(n=85).The overall prevalence of BE was 2.6%.Multivariate analysis disclosed that old age[odds ratio(OR)=1.033;95%confidence interval(CI):1.012-1.055;P=0.002],male gender(OR=2.106;95%CI:1.145-3.872;P=0.017),ingestion of tea(OR=1.695;95%CI:1.043-2.754;P=0.033),and presence of hiatal hernia(OR=3.037;95%CI:1.765-5.225;P<0.001)were significant risk factors predicting *** independent risk facto

关键词： Barrett’s esophagus Prevalence Risk factors Intestinal metaplasia Taiwan

Traditional Chinese Medicine-facilitated switch from methadone to buprenorphine-naloxone for treatment of heroin dependence: a case report

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Journal of Traditional Chinese Medicine 2019年第2期39卷 281-284页

作者： Huang Kuei-Yu Yu Kai-Chiang hsu chung-Hua Yeh Yuh-Hsiang Han Kao-Ching Wei Han-Ting Department of Chinese Medicine Taipei City Hospital Linsen Chinese Medicineand Kunming Branch Institute of Traditional Medicine National Yang-Ming University Department of Nursing Taipei City Hospital Linsen Chinese Medicine and Kunming Branch Department of Psychiatry Taipei City Hospital Linsen Chinese Medicine and Kunming Branch

The switch from methadone to buprenorphine-naloxone for individuals with heroin dependence is associated with several obstacles and *** patients may experience discomfort from discontinuing methadone, precipitated withdrawal symptoms induced by buprenorphine-naloxone,and poor psychosocial adjustments such as anticipatory anxiety regarding severe opioid *** herein describe a 46-year-old man with a history of heroin dependence who underwent Traditional Chinese Medicine(TCM)-facilitated switching from methadone to buprenorphine-naloxone. No precipitated withdrawal was induced by buprenorphine-naloxone. The drug-switching process was successful and smooth. He maintained abstinence from heroin for the following year. In this case, we applied TCM for enhancement of methadone metabolism and detoxification, analgesic effects, and anxiolytic and hypnotic effects during the drug switch. We observed that TCM effectively facilitated the switch from methadone to buprenorphine-naloxone in our case. Further studies regarding TCM-facilitated treatment for heroin dependence should be conducted.

关键词： Heroin dependence Opioid Methadone Buprenorphine Medicine,Chinese traditional

Consumption of purple sweet potato leaves modulates human immune response: T-lymphocyte functions, lytic activity of natural killer cell and antibody production

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World Journal of Gastroenterology 2005年第37期11卷 5777-5781页

作者： Chiao-Ming Chen Sing-chung Li Ya-Ling Lin Ching-Yun hsu Ming-Jer Shieh Jen-Fang Liu Graduate Institute of Pharmacy Graduate Institute of Nutrition and Health Sciences Taipei Medical University Department of Dietetics Taipei Medical University Hospital Taipei Taiwan China School of Nutrition and Health Sciences Taipei Medical University Taipei Taiwan China Chang-Gung Institute of Technology TaoyuanTaiwan Graduate Institute of Pharmacy Taipei Medical University Taipei Taiwan China

AIM： To study the immunological effects of physiologica doses of purple sweet potato leaves （PSPL）. METHODS： The randomized crossover study （two periods, each lasting for 2 wk） involved 16 healthy non-smoking adults of normal weight. The 6-wk study consisted of a run-in （wk 1） PSPL diet （daily consumption of 200 g PSPL） or a control diet （low polyphenols, with the amount of carotenoids adjusted to the same level as that of PSPL）（wk 2-3）, washout diet （wk 4）, and switched diet （wk 5-6）. Fasting blood was collected weekly in the morning. T-lymphocyte function was assessed via the proliferation and secretion of immunoreactive cytokines. Salivary IgA secretion and the specific cytotoxic activities of cytotoxic T lymphocytes and natural killer （NK） cells were determined. RESULTS： The plasma 13-carotene level increased with time in both groups, while the plasma polyphenol level decreased in the control group, and no significant difference was detected between the two groups. Although p^asma polyphenol levels did not significantly increase in the PSPL group at the end of the study, they were significantly elevated in urine. PSPL consumption produced a significant increase in proliferation responsiveness of peripheral blood mononuclear cells （PBMC） and their secretion of immunoreactive IL-2 and IL-4. As well, lytic activity in NK cells was elevated in a time-dependent fashion. Salivary IgA secretion significantly decreased in control group after 2 wk, and returned to baseline following dietary switch to PSPL. CONCLUSION： Consumption of PSPL modulates various immune functions including increased proliferation responsiveness of PBMC, secretion of cytokines IL-2 and IL-4, and the lytic activity of NK cells. The responsible determinants of PSPL remain to be elucidated, as does the biological significance of the present observations.

关键词： Purple sweet potato leaves Polyphenol Immune function

3D culturing of human adipose-derived stem cells enhances their pluripotency and differentiation abilities

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Journal of Materials Science & Technology 2021年第4期63卷 9-17页

作者： Tzu-Cheng Sung Chao-Wen Heish Henry Hsin-chung Lee Jhe-Yu hsu Chun-Ko Wang Jia-Hua Wang Yu-Ru Zhu Shih-Hsi Jen Shih-Tien hsu Abdurahman HHirad Abdullah AAlarfaj Akon Higuchi School of Ophthalmology and Optometry Eye HospitalWenzhou Medical UniversityNo.270Xueyuan RoadWenzhouZhejiang325027China Department of Chemical and Materials Engineering National Central UniversityTaoyuan 32001Taiwan Department of Surgery Hsinchu Cathay General HospitalHsinchu 30060China Graduate Institute of Translational and Interdisciplinary Medicine National Central UniversityTaoyuan 32001Taiwan Department of Obstetrics and Gynecology Landseed HospitalTaoyuan 32405Taiwan Department of Internal Medicine Landseed HospitalTaoyuan 32405Taiwan Department of Botany and Microbiology King Saud UniversityRiyadh 11451Saudi Arabia Wenzhou Institute University of Chinse Academy of ScienceWenzhou 325001China Center for Emergent Matter Science Riken2-1 HirosawaWakoSaitama 351-0198Japan

Human mesenchymal stem cells,such as human adipose-derived stem cells(hASCs),are typically cultured on a two-dimensional(2 D)monolayer material surface,on which 2 D culturing methods are easily performed and ***,hASCs usually suffer from decreased pluripotency and differentiation ability when cultured with a 2 D monolayer culturing method compared to hASCs cultured with a three-dimensional(3 D)culturing method,such as suspension *** this study,we evaluated whether the pluripotency and differentiation ability of hASCs can be reversibly changed during sequential cultivation with 2 D and 3 D culturing *** hASCs cultivated with a 3 D culturing process after 2 D culture showed at least 2-fold enhanced pluripotency(Sox2,Nanog,and OCT4)compared with that of hASCs cultured with the 2 D culture process ***,hASCs obtained from the 3 D culture process expressed increased levels of differentiation markers of chondrocytes and osteoblasts compared with hASCs obtained from the 2 D culture process when hASCs were induced to ***,their pluripotency and differentiation ability were extensively reduced when hASCs were shifted from 3 D culture to 2 D culture and vice versa,which indicates that hASCs show reversibility in terms of their pluripotency and differentiation ability depending on their environment in 2 D and 3 D *** reversibility of pluripotency and differentiation ability were found to last for at least 5 passages in culture during the alternative and sequential culture of cells with 2 D and 3 D culturing *** study revealed the importance of the culture microenvironment in maintaining the pluripotency and differentiation ability of hASCs,which may reduce the effects of the aging process in *** discuss whether the environment of stem cell culture(i.e.,2 D or 3 D cultivation)can affect stem cell fate in terms of pluripotency and differentiation reversibility.

关键词： culture alone stem

Hole-Buffer Material Derived from Pyrene, Schiff Base and Tris to Enhance Emission Efficiency of Polymer Light-Emitting Diodes

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Journal of Materials Science and Chemical Engineering 2018年第3期6卷 31-46页

作者： Jyun-huei Liou Ping-Feng hsu Yun Chen Department of Chemical Engineering National Cheng Kung University Taiwan

Inserting a hole-buffer layer is an effective way to enhance emission efficiency of electroluminescence devices. We have successfully synthesized a new hole-buffer material PSB composed of pyrene, Schiff base and trihydroxy tert-butyl groups by the Suzuki-coupling reaction. The HOMO and LUMO lev-els were -6.33 eV and -2.55 eV, respectively, as estimated from cyclic volt-ammograms. In addition, homogeneous films (rms roughness ~2 nm) were readily obtained by spin-coating process. Multilayer polymer light-emitting diodes, ITO/PEDOT:PSS/PSB/SY/LiF/Al, have been fabricated using PSB as hole-buffer layer (HBL). Inserting PSB as HBL significantly enhances the per-formance (maximum luminance: 26,439 cd/m2, maximum current efficiency: 7.03 cd/A), compared with the one without PSB (9802 cd/m2, 2.43 cd/A). It is also superior to the device with conventional BCP as hole-blocking layer (ITO/PEDOT:PSS/SY/BCP/LiF/Al: 15,496 cd/m2, 5.56 cd/A). Current results strongly indicate that the PSB is a potential hole-buffer material for electrolu-minescent devices.

关键词： Hole-Buffer Polymer Light-Emitting Diodes Pyrene Schiff Base Spin-Coating

Federated Feature Concatenate Method for Heterogeneous Computing in Federated Learning

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计算机、材料和连续体（英文） 2023年第4期75卷 351-371页

作者： Wu-Chun chung Yung-Chin Chang Ching-Hsien hsu Chih-Hung Chang Che-Lun Hung Department of Information and Computer Engineering Chung Yuan Christian UniversityTaoyuanTaiwan Department of Computer Science and Information Engineering Asia UniversityTaichungTaiwan Department of Medical Research China Medical University HospitalChina Medical UniversityTaichungTaiwan Department of Computer Science&Communication Engineering Providence UniversityTaichungTaiwan Institute of Biomedical Informatics National Yang Ming Chiao Tung UniversityTaipeiTaiwan

Federated learning is an emerging machine learning techniquethat enables clients to collaboratively train a deep learning model withoutuploading raw data to the aggregation server. Each client may be equippedwith different computing resources for model training. The client equippedwith a lower computing capability requires more time for model training,resulting in a prolonged training time in federated learning. Moreover, it mayfail to train the entire model because of the out-of-memory issue. This studyaims to tackle these problems and propose the federated feature concatenate(FedFC) method for federated learning considering heterogeneous *** leverages the model splitting and feature concatenate for offloadinga portion of the training loads from clients to the aggregation server. Eachclient in FedFC can collaboratively train a model with different cutting ***, the specific features learned in the deeper layer of the serversidemodel are more identical for the data class classification. Accordingly,FedFC can reduce the computation loading for the resource-constrainedclient and accelerate the convergence time. The performance effectiveness isverified by considering different dataset scenarios, such as data and classimbalance for the participant clients in the experiments. The performanceimpacts of different cutting layers are evaluated during the model *** experimental results show that the co-adapted features have a criticalimpact on the adequate classification of the deep learning model. Overall,FedFC not only shortens the convergence time, but also improves the bestaccuracy by up to 5.9% and 14.5% when compared to conventional federatedlearning and splitfed, respectively. In conclusion, the proposed approach isfeasible and effective for heterogeneous clients in federated learning.

关键词： Federated learning deep learning artificial intelligence heterogeneous computing

Thermal transformation of acid compounds in high TAN crude oil

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Science China Chemistry 2013年第7期56卷 848-855页

作者： YANG BaiBing XU ChunMing ZHAO SuoQi hsu Chang Samuel chung Keng H. SHI Quan State Key Laboratory of Heavy Oil Processing China University of Petroleum

The Liaohe crude oil with high total acid number （TAN） was subjected to thermal reaction at 300 ℃ to 500℃. Reaction products were collected and analyzed by negative-ion electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry （ESI FT-ICR MS） to determine acid compounds in the crude oil. The double-bond equivalence （DBE） versus carbon number was used to characterize the oxygenated components in the feed and reaction products. The 02 class which mainly corresponds to naphthenic acids decarboxylated at 350-400℃, resulting in a sharply decrease in TAN. Phenols （O1 class） are more thermally stable than carboxylic acids. Carboxylic acids were also thermally cracked into smaller molecular size acids, evidenced by the presence of acetic acid, propanoic acid, and butyric acid in the liquid product. These small acid species are strong acids likely responsible for corrosion problems in refineries.

关键词： naphthenic acid TAN ESI FT-ICR MS thermal cracking

Clinical correlation of gallstone disease in a Chinese population in Taiwan:Experience at Cheng Hsin General Hospital

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World Journal of Gastroenterology 2006年第8期12卷 1281-1286页

作者： Chi-Ming Liu Tao-Hsin Tung Pesus Chou Victor Tze-Kai Chen chung-Te hsu Wu-Shyong Chien Yeu-Tyng Lin hsu-Feng Lu Hui-Chuan Shih Jorn-Hon Liu Community Medicine Research Center & Institute of Public Health National Yang-Ming University Cheng Hsin General Hospital Taipei Taiwan China Community Medicine Research Center & Institute of Public Health National Yang-Ming University Taipei TaiwanChina Cardinal Tien Hospital College of Medicine Fu-Jen Catholic University National Defence Medicine Center Taipei Taiwan China Department of Nursing Kaohsiung Military General Hospital Kaohsiung Taiwan China Faculty of Medicine School of Medicine National Yang-Ming University Cheng Hsin General Hospital TaipeiTaiwan China

AIM： TO explore the prevalence of gallstone disease （GSD） in Taiwan and condition-associated factors related to it. METHODS： We studied a total of 2386 healthy adults （1235 males and 1151 females） voluntarily admitted to Cheng Hsin General Hospital for a paid physical check-up between January 2002 and December 2002. Blood samples and ultrasound sonography results were collected. RESULTS： The overall prevalence of GSD among this study-population was 5.3%, including 1.7% （n=40） having a single stone, 2.3% （n = 55） having multiple stones, and 1.3% （n = 31） having cholecystectomy. The prevalence revealed a statistically significant increase with increasing age （P〈 0.0001）. Females exhibited a greater prevalence of multiple stones than did males （3.0% vs 1.7%, P= 0.04）. Using multiple logistic regression analysis, the following appeared to be significantly related to the prevalence of GSD： older age （40-49 years vs 〈40 years, OR= 1.63 [95% CI： 0.76-3.48], 50-59 years vs 〈40 years, OR=4.93 [95% CI： 2.43-9.99], 60-69 years vs 〈40 years, OR = 6.82 [95% CI： 3.19-14.60], ≥70 years vs 〈40 years, OR= 10.65 [95% CI： 4.78-23.73]）, higher BMI （≥27 kg/m^2 vs 〈24 kg/m^2, adjusted OR= 1.74 [95% CI： 1.04-2.88]）, and higher FPG （≥ 126 mg/dL vs 〈110 mg/dL, OR= 1.71, 95% CI： 1.01-2.96）. CONCLUSION： Older age （≥50 years）, obesity （BMI ≥ 27 kg/m^2）, and type 2 diabetes （FPG ≥126 mg/dL） are associated with the prevalence of GSD.

关键词： Cross-sectional study Gallstone disease Prevalence Risk factors

Prevalence and risk factors of asymptomatic peptic ulcer disease in Taiwan

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World Journal of Gastroenterology 2011年第9期17卷 1199-1203页

作者： Fu-Wei Wang Ming-Shium Tu Guang-Yuan Mar Hung-YiChuang Hsien-chung Yu Lung-Chih Cheng Ping-I hsu Department of Family Medicine Kaohsiung Veterans General Hospital Kaohsiung City 80424 Taiwan China Division of Cardiology Department of Internal Medicine Kaohsiung Veterans General Hospital KaohsiungCity 80424 Taiwan China Department of Community Medicine Kaohsiung Medcal University Hospital Kaohsiung City-80424 Taiwan ChinaHung-Yi Chuang Faculty of Public Health Kaohsiung MedicalUniversity Kaohsiung City 80424 Taiwan China Division ofGastroenterology Department of Internal Medicine KaohsiungVeterans General Hospital and National Yang-Ming UniversityKaohsiung City 80424 Taiwan China

AIM:To investigate the prevalence and risk factors of asymptomatic peptic ulcer disease(PUD)in a general Taiwan Residents population. METHODS:From January to August 2008,consecutive asymptomatic subjects undergoing a routine health check-up were evaluated by upper gastrointestinal *** mucosal breaks were carefully assessed,and a complete medical history and demographic data were obtained from each *** regression analysis was conducted to identify indepen-dent risk factors for asymptomatic PUD. RESULTS:Of the 572 asymptomatic subjects,54(9.4%) were diagnosed as having *** prevalence of gastric ulcer,duodenal ulcer and both gastric and duodenal ulcers were 4.7%,3.9%,and 0.9%,respectively. Multivariate analysis revealed that prior history of PUD [odds ratio(OR),2.0,95%CI:1.3-2.9],high body mass index[body mass index(BMI)25-30:OR,1.5,95%CI: 1.0-2.2;BMI>30 kg/m 2 :OR,3.6,95%CI:1.5-8.7] and current smoker(OR,2.6,95%CI:1.6-4.4)were independent predictors of asymptomatic *** contrast, high education level was a negative predictor of PUD (years of education 10-12:OR,0.5,95%CI:0.3-0.8; years of education>12:OR,0.6,95%CI:0.3-0.9). CONCLUSION:The prevalence of PUD in asymptomatic subjects is 9.4%in *** history of PUD, low education level,a high BMI and current smoker are independent risk factors for developing asymptomatic PUD.

关键词： Asymptomatic Endoscopy Health checkup Peptic ulcer disease