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Mechanisms inactivating the gene for E-cadherin in sporadic gastric carcinomas

World Journal of Gastroenterology 2006年第14期12卷 2168-2173页

作者： Yao-Chi Liu Chen-Yang Shen Hurng-Sheng Wu Tsai-Yuan Hsieh De-Chuan Chan Cheng-Jueng Chen Jyh-Cherng Yu Cheng-Ping Yu Horng-Jyh Harn Peng-Jen Chen chung-Bao Hsieh Teng-Wei Chen Huan-Mieng hsu Division of General Surgery Department of Surgery Tri-Service General Hospital National Defense Medical Center Taipei Taiwan China Division of Gastroenterology Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan China Department of Pathology Tri-Scrvice General Hospital National Defense Medical Center Taipei Taiwan China Department of Pathology Buddhist Tzu-Chi General Hospital Hualien Taiwan China Department of Surgery Show Chwan Memorial Hospital Changhua Taiwan China Institute of Biomedical Sciences Academia Sinica Taipei Taiwan China

AIM： To study the role of CDH1/E-cadherin （E-cad） gene alteration profiles including mutation, loss of heterozygosity （LOH）, promoter polymorphism and hypermethylation in mechanisms of CDH1 inactivation in gastric carcinoma （GC）. METHODS： Specimens were collected surgically from 70 patients with GC. Allelotyping PCR and detection of LOH, denaturing high pressure liquid chromatography and DNA sequencing, restriction fragment length polymorphism analysis, methylation specific PCR, and immunohistochemical staining were used. RESULTS： Promoter polymorphism was not a major mechanism of E-cad inactivation. Only one truncating mutation was found in a diffuse type tumor （3%）. Both LOH and promoter hypermethylation were major mechanisms of E-cad inactivation, but interestingly, there was a negative association between the fraction of allelic loss （LOH） in tumors and hypermethylation of CDH1. Therefore LOH and hypermethylation were two different tumorigenic pathways involved in GC. CONCLUSION： Given the findings that somatic mutation was extremely low and the relationship between LOH and hypermethylation was inverse, any two combinations of these three factors cannot fulfill the classical two-hit hypothesis of CDH1 inactivation. Thus, other mechanisms operating at the transcriptional level or at the post-translational level might be required to induce E-cadherin inactivation.

关键词： Gastric carcinoma E-cadherin gene alteration profiles Inactivation of E-cadherin

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MOBILE INFORMATION SYSTEMS

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中国通信：英文版 2015年第12期12卷 I0002-I0003页

作者： WANG Shangguang Ching-Hsien hsu David Taniar Patrick Hung Beijing University of Posts and Telecommunications department of computer science and information engineering at chung Hua University Taiwan China the Faculty of Information Technology Monash UniversityAustralia University of Ontario Institute of Technology Canada the IEEE Transactions on Services Computing International Journal of Web Services Research and International Journal of Business Process and Integration Management the Information Systems Frontiers by Springer

With the popularity of mobile infrastructures providing higher bandwidth and constant connection to the network from virtually anytime and everywhere,the way people use information resources is radically *** can use mobile devices such as mobile phones,pocket PCs,laptops,etc.,to obtain services/applications which are based on the mobile

关键词：移动信息系统管理信息系统信息资源笔记本电脑基础设施移动设备掌上电脑应用程序

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Study on the complex-formation reaction of yttrium with para-methyl-chlorophosphonazo(CPApM)

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Chinese Journal of Chemistry 1991年第3期9卷 199-204页

作者： DU,Ying-Xiang Division of Analytical Chemistry,China Pharmaceutical University,Nanjing 210009XU,Zhong-Jun(hsu,chung-Gin) PAN,Jiao-Mai Department of Chemistry,East China Normal University,Shanghai 200062 Division of Analytical Chemistry China Pharmaceutical University Nanjing 210009 Department of Chemistry East China Normal University Shanghai 200062

Yttrium forms with CPApM a 1:2 α-complex instantaneously in acidic *** pH～ (buffer solution),the α-complex is transformed to a β-complex with an absorption peak at 755 nm after *** transformation reaction is a first-order *** rate constant and the apparent activation energy were found to be 9.67×10^(-) min^(-1) and 52.3 kJ·mol^(-1) *** mechanism of the reaction shows that the β-complex(Y:CPApM=2:4)is formed by combining two molecules of α-complex with the liberation of one proton.

关键词： PM Study on the complex-formation reaction of yttrium with para-methyl-chlorophosphonazo

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The Suitability of Typhoon Disaster Reconstruction Work Planning—A Case of Meizuolyu Stream in Taitung County

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Engineering（科研） 2015年第5期7卷 237-247页

作者： Shu-Tzu Chen Hung-Ming Shu Shin-Yi Dai Jie-Ming Huang chung-Li hsu Department of Civil Engineering National Pingtung University of Science and Tehnology Pingtung Chinese Taipei Department of Soil and Water Conservation National Pingtung University of Science and Tehnology Pingtung Chinese Taipei

Due to effects of succession typhoons and heavy rainfall, central government often invests the funds within shortest time of contingency promptly after disaster occurring to handle the planning and design project of taking precautions against natural disaster. Because the time limit of design project operating so generally were planned without many detail investigations, it was necessary to probe into the project effect and reconstruction security behind constructed. In this study, we choose the Meizuolyu stream watershed in Taitung County of eastern Taiwan as the research area to realize the situation and effect of setting up the control work reconstructions by inspecting, surveying and according to hydrology analysis and topography measured, and combined to carry on hydrology mathematical calculations. We adopted HEC-RAS software to make hydrology mathematical calculations, used the result to examine whether the position of each construction was proper, and finally submitted the complete of mend suggestion. The study concluded that no matter how urgent governance was, application of appropriate scientific tools to checklist designed could avoid the mistakes of the generation.

关键词： Typhoon Disaster Reconstruction Hydrology Analysis

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Spatial and Temporal Features of Regional Variations in Mean Sea Level around Taiwan

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Open Journal of Marine Science 2012年第2期2卷 58-65页

作者： Li-chung Wu Chia Chuen Kao Tai-Wen hsu Yi-Fung Wang Jong-Hao Wang Coastal Ocean Monitoring Center National Cheng Kung University Tainan Chinese Taipei Department of Hydraulic and Ocean Engineering National Cheng Kung University Tainan Chinese Taipei Water Resources Agency Ministry of Economic Affairs Taipei Chinese Taipei

Satellite altimeter and in-situ tide gauge records are probably the most common means to obtain observational data for the study of changes in mean sea level. In this study, we employed these data to discuss the spatial and temporal features of regional variations in mean sea level around Taiwan. The results showed that most of the regional mean sea surface heights (SSH) around Taiwan are higher than the global mean sea surface heights. Most of the sea level trends are greater than the global mean sea level trend as well. We obtained diverse distribution results from the altimeter sea level records in neighboring areas by distributions fit, and the altimeter sea level records showed obvious inhomogene- ity. In addition, periodic fluctuations in the records regarding mean sea level were revealed in our study, based on Fourier spectra and wavelet scalograms.

关键词： Sea Level Variations Tide-Gauge Altimeter

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亚洲沙尘的长途运送:一个综合性模型研究(英文)

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干旱区资源与环境 2004年第S1期18卷 104-105页

作者： Neng-huei Lin Department of Atmospheric Sciences National Central University chung-Li Taiwan.

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Full-color micro-LED display with high color stability using semipolar(20-21) InGaN LEDs and quantum-dot photoresist

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Photonics Research 2020年第5期8卷 630-636页

作者： SUNG-WEN HUANG CHEN YU-MING HUANG KONTHOUJAM JAMES SINGH YU-CHIEN hsu FANG-JYUN LIOU JIE SONG JOOWON CHOI PO-TSUNG LEE CHIEN-chung LIN ZHONG CHEN JUNG HAN TINGZHU WU HAO-chung KUO Department of Photonics&Graduate Institute of Electro-Optical Engineering College of Electrical and Computer EngineeringTaiwan Chiao Tung UniversityHsinchu 30010China Institute of Photonic System Taiwan Chiao Tung UniversityTainan 71150China Saphlux Inc. BranfordConnecticut 06405USA Departm ent of Electronic Science Fujian Engineering Research Center for Solid-State LightingXiamen UniversityXiamen 361005China Departm ent of Electrical Engineering Yale UniversityNew HavenConnecticut 06520USA

Red-green-blue(RGB)full-color micro light-emitting diodes(μ-LEDs)fabricated from semipolar(20-21)wafers,with a quantum-dot photoresist color-conversion layer,were *** semipolar(20-21)In Ga N/Ga Nμ-LEDs were fabricated on large(4 in.)patterned sapphire substrates by orientation-controlled *** semipolarμ-LEDs showed a 3.2 nm peak wavelength shift and a 14.7%efficiency droop under 200 A∕cm2injected current density,indicating significant amelioration of the quantum-confined Stark *** of the semipolarμ-LEDs’emission-wavelength stability,the RGB pixel showed little color shift with current density and achieved a wide color gamut(114.4%NTSC space and 85.4%Rec.2020).

关键词： LEDs photoresist sapphire

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Perspective and Strategy in Stroke Drug Discovery from Traditional Chinese Medicine

Perspective and Strategy in Stroke Drug Discovery from Tradi...

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第十四届全国中药和天然药物学术研讨会

作者： Zhiyan Xiao Yu Zhao chung Y.hsu Kuo-Hsiung Lee University of North Carolina Chapel HillNorth Carolina Chinese Academy of Medical Sciences and Peking Union Medical College China Medical University Healthcare System China Medical University and Hospital

＜正＞Stroke is the third most common cause of *** one drug,tissue plasminogen activator（TPA）,has been approved by US FDA to treat *** than 100 traditional Chinese Medicine（TCM）,including Scutellaria baicalensis,Bupleurum Chinese,Gentiana macrophylla,Ligusticum chuanxiong,Salvia miltiorrhiza,and Gastrodia elata,have been used for stroke

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Characteristics of PM2.5 mass and water-soluble ions during Background and biomass burning periods observed at *** in Taiwan from 2003 to 2009

Characteristics of PM2.5 mass and water-soluble ions during ...

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第七届海峡两岸气胶技术研讨会暨第二届空气污染技术研讨会

作者： chung-Te Lee Ming-Tung Chuang Neng-huei Lin Guey-Rong Sheu Shuenn-Chin Chang Sheng-Hsiang Wang Hill Huang Horng-Wen Chen Guo-Hau Weng Hsin-YoLai Shao-Peng hsu Graduate Institute of Environmental Engineering National Central University Department of Atmospheric Sciences National Central University

＜正＞This paper analyzes six years’ PM2.5 mass and water-soluble ions collected at Mt. Lulin （2,862 m a.s.l.） from April 2003 to April 2009. Among global high-elevation sites,Mt. Lulin site is the only observatory that receives aerosol from Southeast Asia in the West Pacific region. Based on a six-year observation,the most active biomass

关键词： Biomass burning PM2.5 Water-soluble ions Long-range transport High-elevation site

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THE HISTOPATHOLOGY OF KALA-AZAR IN SQUIRRELS

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中华医学杂志(英文版) 1933年第11期47卷 1142-1145+1034-1036页

作者： huei-LAN chung K. Y. CH'IN Parasitic Diseases Laboratory Department of Medicine and Department of Pathology Peiping Union Medical College Peiping.

The histopathological changes of kala-azar in squirrels are described. These changes are similar to those found in hamsters and monkeys and comparable to those in man. The changes in the bone marrow are the most striking and may adequately explain the leucopenia and anemia seen in these animals when they are infected with the disease.

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