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Journal of Geriatric Cardiology 2023年第12期20卷 877-879页

作者： Hao-Tien Liu Po-Cheng Chang Hui-Ling Lee chung-chuan chou Division of Cardiology Department of Internal MedicineChang Gung Memorial HospitalTaoyuan BranchTaiwanChina Division of Cardiology Department of Internal MedicineChang Gung Memorial HospitalLinkou BranchTaiwanChina School of Medicine Chang Gung University College of MedicineTaoyuanTaiwanChina Department of Anesthesia Chang Gung Memorial HospitalTaipei BranchTaiwanChina

Radiofrequency catheter ablation(RFCA)is a cornerstone treatment of atrial fibrillation(AF).Transfemoral venous approach with transseptal puncture to assess left atrium(LA)is a mainstream method for AF *** inferior vena cava(IVC)is a rare congenital vascular anomaly which complicates electrophysiologic procedures and makes conventional approach not feasible.

关键词： fibrillation atrial vena

A three-year longitudinal study of the relation between left atrial diameter remodeling and atrial fibrillation ablation outcome

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Journal of Geriatric Cardiology 2018年第7期15卷 496-501页

作者： Hui-Ling Lee Yi-Ting Hwang Po-Cheng Chang Ming-Shien Wen chung-chuan chou Department of Anesthesia Chang Gung Memorial Hospital Taipei Taiwan China Department of Statistics National Taipei University Taipei Taiwan China Division of Cardiology Department of Internal Medicine Chang Gung Memorial Hospital Taipei Taiwan China Chang Gung University College of Medicine Taoyuan Taiwan China

Background The long-term prognostic influence of left atrial diameter （LAD） remodeling on the status of post-radiofrequency catheter ablation （RI CA） atrial fibrillation （AF） is unclear. This study employed a two-stage model from 3-year echocardiographic data to ascertain whether the two-stage model predicts RFCA outcome more favorably than models using the baseline LAD. Methods Data were retrospectively collected from 263 consecutive patients with drug-refractory AF undergoing RFCA. Regular echocardiographic measurements of LAD were performed at baseline, 1, 3, 6, and 12 months and then every 6 months after RFCA. Sex, age, type of AF, number of RFCA, and AF status were recorded. We obtain the actual （predicted） 3-year LAD using a longitudinal linear mixed model （1st stage）. Logistic regression models based on the baseline LAD （Model 1）, actual （predicted） 3-year LAD （Model 2）（2nd stage）, and observed 3-year LAD （Model 3） were constructed to predict RFCA outcome. The area under the receiver operating characteristic curve （AUC） were used to assess the performance of models. Results The lowess smoothed curve indicated that the LAD declined over the first three months and remained stable up to 36 months after RFCA. The degree of LAD reduction was significantly influenced by the baseline LAD. Non-paroxysmal AF, large LAD and female gender were significant predictors of AF recurrence. Model 2 had the largest AUC among the three models. Conclusions This longitudinal study-based two-stage model outperforms the original logistic model using the baseline LAD. Non-paroxysmal AF, larger LAD and female gender are significant predictors of RFCA failure.

关键词： Atrial fibrillation Left atrial diameter Longitudinal data Radiofrequency catheter ablation Two-stage model

Radiofrequency catheter ablation of ventricular tachycardia in a patient with dermatomyositis

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Journal of Geriatric Cardiology 2016年第11期13卷 927-929页

作者： Peter Carlo M Nierras Aida P Maranian Ming-Shien Wen chung-chuan chou Division of Cardiology Department of Medicine Chang Gung Memorial Hospital Linkou Taiwan China Section of Cardiology Department of Medicine Philippine General Hospital Manila Philippines Section of Cardiology Department of Medicine Southern Philippines Medical Center Davao City Philippines Chang Gung University College of Medicine Taoyuan Taiwan China

A 51-year old male who presented at our hospital for recurrent palpitation for several months was diagnosed dermatomyositis ten years ago and had interstitial lung disease since two years ago. Recently, he was admitte... 详细信息

关键词： Dermatomyositis Radiofrequency ablation Ventricular tachycardia

Half-precessional cycle revealed by environment magnetism of stalagmite in Shizhu Cave from southwestern China during the Last Glacial

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Journal of Earth Science 2024年

作者： Huihui Yang Yu-Min chou Xiuyang Jiang Wenyue Xia Hai Li Yi Zhong Jingyu Zhang Yaoqi He Tsai-Luen Yu Qingsong Liu chuan-chou Shen College of Tourism and Air Service， Guizhou Minzu University Research Center for Future Earth， Taiwan University Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou) School of Environment， Harbin Institute of Technology High-Precision Mass Spectrometry and Environment Change Laboratory (HISPEC)， Department of Geosciences， Taiwan University Key Laboratory of Humid Subtropical Eco-Geographical Processes， College of Geography Science， Fujian Normal University Center for Marine Magnetism (CM2)， Department of Ocean Science and Engineering， Southern University of Science and Technology

The environmental magnetic proxies of stalagmites hold significant potential for reconstructing regional hydroclimate changes by revealing the content and grain size of magnetic particles within stalagmites. In this study， we present the contents and grain sizes of magnetic particles within a stalagmite SZ-1， from Shizhu Cave in southwestern China from 70.4 to 22.3 thousand years ago (ka) during the last glacial period. Specifically， the parameters IRMsoft， soil-derived magnetic minerals， and ARM/SIRM (anhysteretic remanent magnetization/saturation isothermal remanent magnetization)， the ratio of fine magnetic particles to total ferrimagnetic particles preserved in stalagmite SZ-1， indicate the fluctuation of regional precipitation. Obvious half-precessional cycles are evident in these two proxies， indicating that hydroclimatic variations in southwestern China may predominantly arise from the heat and moisture transported from tropical oceans. These variations are likely influenced by shifts in the Intertropical Convergence Zone and fluctuations in the Asian summer monsoon.

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Targeting NAD Metabolism for the Therapy of Age-Related Neurodegenerative Diseases

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Neuroscience Bulletin 2024年第2期40卷 218-240页

作者： Feifei Li chou Wu Gelin Wang School of Pharmaceutical Sciences Ministry of Education Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical BiologyTsinghua UniversityBeijing 100084China Tsinghua-Peking Joint Center for Life Sciences Tsinghua UniversityBeijing 100084China

As the aging population continues to grow rapidly, age-related diseases are becoming an increasing burden on the healthcare system and a major concern for the well-being of elderly individuals. While aging is an inevitable process for all humans, it can be slowed down and age-related diseases can be treated or alleviated. Nicotinamide adenine dinucleotide (NAD) is a critical coenzyme or cofactor that plays a central role in metabolism and is involved in various cellular processes including the maintenance of metabolic homeostasis, post-translational protein modifications, DNA repair, and immune responses. As individuals age, their NAD levels decline, and this decrease has been suggested to be a contributing factor to the development of numerous age-related diseases, such as cancer, diabetes, cardiovascular diseases, and neurodegenerative diseases. In pursuit of healthy aging, researchers have investigated approaches to boost or maintain NAD levels. Here, we provide an overview of NAD metabolism and the role of NAD in age-related diseases and summarize recent progress in the development of strategies that target NAD metabolism for the treatment of age-related diseases, particularly neurodegenerative diseases.

关键词： Ageing Neuroprotection NAD metabolism Therapeutic strategy Neurodegenerative diseases

Regional Climate Damage Quantification and Its Impacts on Future Emission Pathways Using the RICE Model

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Advances in Atmospheric Sciences 2024年第9期41卷 1843-1852页

作者： Shili YANG Wenjie DONG Jieming chou Yong ZHANG Weixing ZHAO Beijing Meteorological Observation Centre Beijing Meteorological BureauBeijing 100089China School of Atmospheric Sciences Sun Yat-sen UniversityZhuhai 519082China Southern Marine Science and Engineering Guangdong Laboratory Zhuhai 519082China Beijing Normal University Beijing 100101China CMA Institute for Development and Programme Design Beijing 100081China

This study quantified the regional damages resulting from temperature and sea level changes using the Regional Integrated of Climate and Economy(RICE)model,as well as the effects of enabling and disabling the climate impact module on future emission *** highlight varied damages depending on regional economic development and ***,China and Africa could suffer the most serious comprehensive damages caused by temperature change and sea level rise,followed by India,other developing Asian countries(OthAsia),and other high-income countries(OHI).The comprehensive damage fractions for China and Africa are projected to be 15.1%and 12.5%of gross domestic product(GDP)in 2195,with corresponding cumulative damages of 124.0 trillion and 87.3 trillion United States dollars(USD)from 2005 to 2195,***,the comprehensive damage fractions in Japan,Eurasia,and Russia are smaller and projected to be lower than 5.6%of GDP in 2195,with cumulative damages of 6.8 trillion,4.2 trillion,and 3.3 trillion USD,***,coastal regions like Africa,the European Union(EU),and OHI show comparable damages for sea level rise and temperature *** China,however,sea level-induced damages are projected to exceed those from temperature ***,this study indicates that switching the damage modules on or off affects the regional and global emission trajectories,but the magnitude is relatively *** 2195,global emissions under the experiments with all of the damage modules switched off,only the sea level damage module switched on,and only the temperature damage module switched on,were 3.5%,2.3%and 1.2%higher than those with all of the damage modules switched on,respectively.

关键词： climate damage integrated assessment model carbon emissions sea level rise temperature change

Data-Driven Modeling of Partially Observed Biological Systems

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Communications on Applied Mathematics and Computation 2024年第1期6卷 739-754页

作者： Wei-Hung Su Ching-Shan chou Dongbin Xiu Department of Mathematics The Ohio State UniversityColumbusOH43221USA

We present a numerical approach for modeling unknown dynamical systems using partially observed data,with a focus on biological systems with(relatively)complex dynamical *** an extension of the recently developed deep neural network(DNN)learning methods,our approach is particularly suitable for practical situations when(i)measurement data are available for only a subset of the state variables,and(ii)the system parameters cannot be observed or measured at *** demonstrate that,with a properly designed DNN structure with memory terms,effective DNN models can be learned from such partially observed data containing hidden *** learned DNN model serves as an accurate predictive tool for system *** a few representative biological problems,we demonstrate that such DNN models can capture qualitative dynamical behavior changes in the system,such as bifurcations,even when the parameters controlling such behavior changes are completely unknown throughout not only the model learning process but also the system prediction *** learned DNN model effectively creates a“closed”model involving only the observables when such a closed-form model does not exist mathematically.

关键词： Deep neural network(DNN) Governing equation discovery Biological system Partial observation

A Vertex Network Model of Arabidopsis Leaf Growth

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Communications on Applied Mathematics and Computation 2024年第1期6卷 454-488页

作者： Luke Andrejek Janet Best Ching-Shan chou Aman Husbands Department of Mathematics The Ohio State UniversityColumbusOHUSA Department of Biology The University of PennsylvaniaPhiladelphiaPAUSA

Biology provides many examples of complex systems whose properties allow organisms to develop in a highly reproducible,or robust,*** such system is the growth and development of flat leaves in Arabidopsis *** mechanistically challenging process results from multiple inputs including gene interactions,cellular geometry,growth rates,and coordinated cell *** better understand how this complex genetic and cellular information controls leaf growth,we developed a mathematical model of flat leaf *** two-dimensional model describes the gene interactions in a vertex network of cells which grow and divide according to physical forces and genetic ***,the model predicts the presence of an unknown additional factor required for the formation of biologically realistic gene expression domains and iterative cell *** two-dimensional model will form the basis for future studies into robustness of adaxial-abaxial patterning.

关键词： Robustness Adaxial-abaxial patterning Mathematical modeling Gene regulatory networks(GRNs) Transcription factors Small RNAs

Catalytic behavior of Mo-Bi-Fe-Co-K-M-O(M=Ce,Gd,CeGd)catalysts for selective oxidation of isobutene

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Journal of Rare Earths 2024年第1期42卷 84-93,I0003页

作者： Qinghui Li Huahua Zhao Jian Yang Jun Zhao Liang Yan Huanling Song Lingjun chou State Key Laboratory for Oxo Synthesis and Selective Oxidation Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhou730000China University of Chinese Academy of Sciences Beijing100049China

The further improvement of methacrolein(MAL)selectivity from isobutene(IB)oxidation is crucial and *** this study,based on the typical Mo-Bi-Fe-Co-K-O mixed metal oxide,the rare earth element Gd-doped,Ce-doped and CeGd co-doped catalysts were prepared by co-precipitation strategy to increase the selectivity of MAL from 47.9%to 49.8%,64.2% and 68.6%,*** order to elucidate in-depth the promoting effect of Ce and/or Gd,various characterizations were utilized including X-ray diffraction patterns(XRD),Raman,X-ray fluorescence spectrometry(XRF),X-ray photoelectron spectroscopy(XPS),O_(2)-temperature programmed desorption(O_(2)-TPD),H2-temperature programmed reduction(H2-TPR),CO_(2)-temperature programmed desorption(CO_(2)-TPD),IB-temperature programmed desorption(i-C4-TPD)and in-situ IB-Fourier transform infrared spectroscopy(IB-FTIR).Both Ce and Gd finely regulate the bulk and surface structure of the catalyst,thus altering the redox ability,oxygen mobility and storage ability and *** with Ce,Gd addition slightly regulates the variation of Co^(2+)/Co^(3+)redox couples,greatly enhances the interaction among the components on the catalyst,thus only increases the content of surface oxygen species and has little effect on their *** Cecontaining catalyst performs stronger oxygen storage and migration ability,thus leading to the overproduction of surface Odefectspecies,which are proposed to be the active sites for the production of MAL and *** CeGd co-doped catalyst possesses the proper content of surface Odefectspecies,thus exhibits much higher MAL ***,the promoting mechanism of Ce and/or Gd over IB oxidation is ***,this work is helpful for understanding the influence of rare earth elements on the structure of mixed metal oxides and the olefin selective oxidation reaction.

关键词： Mixed metal oxide catalyst Rare earth element Isobutene Selective oxidation Methacrolein

Acquiring Weak Annotations for Tumor Localization in Temporal and Volumetric Data

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Machine Intelligence Research 2024年第2期21卷 318-330页

作者： Yu-Cheng chou Bowen Li Deng-Ping Fan Alan Yuille Zongwei Zhou Department of Computer Science Johns Hopkins UniversityBaltimore 21218USA Computer Vision Lab ETH ZurichZurich 8001Switzerland

Creating large-scale and well-annotated datasets to train AI algorithms is crucial for automated tumor detection and ***,with limited resources,it is challenging to determine the best type of annotations when annotating massive amounts of unlabeled *** address this issue,we focus on polyps in colonoscopy videos and pancreatic tumors in abdominal CT scans;Both applications require significant effort and time for pixel-wise annotation due to the high dimensional nature of the data,involving either temporary or spatial *** this paper,we develop a new annotation strategy,termed Drag&Drop,which simplifies the annotation process to drag and *** annotation strategy is more efficient,particularly for temporal and volumetric imaging,than other types of weak annotations,such as per-pixel,bounding boxes,scribbles,ellipses and ***,to exploit our Drag&Drop annotations,we develop a novel weakly supervised learning method based on the watershed *** results show that our method achieves better detection and localization performance than alternative weak annotations and,more importantly,achieves similar performance to that trained on detailed per-pixel ***,we find that,with limited resources,allocating weak annotations from a diverse patient population can foster models more robust to unseen images than allocating per-pixel annotations for a small set of *** summary,this research proposes an efficient annotation strategy for tumor detection and localization that is less accurate than per-pixel annotations but useful for creating large-scale datasets for screening tumors in various medical modalities.

关键词： Weak annotation detection localization segmentation colonoscopy abdomen