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Identification of SNP-containing regulatory motifs in the myelodysplastic syndromes model using SNP arrays and gene expression arrays

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Chinese Journal of Cancer 2013年第4期32卷 170-185页

作者： Jing Fan Jennifer G. Dy chung-che chang Xiaobo Zhou Department of Electrical and Computer Engineering Northeastern University Department of Pathology Florida Hospital University of Central Florida Department of Radiology The Methodist Hospital Research Institute Weill Medical College & Cornell University

Myelodysplastic syndromes have increased in frequency and incidence in the American population, but patient prognosis has not significantly improved over the last decade. Such improvements could be realized if biomarkers for accurate diagnosis and prognostic stratification were successfully identified. In this study, we propose a method that associates two state-of-the-art array technologies-single nucleotide polymorphism (SNP) array and gene expression array-with gene motifs considered transcription factor -binding sites (TFBS). We are particularly interested in SNP-containing motifs introduced by genetic variation and mutation as TFBS. The potential regulation of SNP-containing motifs affects only when certain mutations occur. These motifs can be identified from a group of co-expressed genes with copy number variation. Then, we used a sliding window to identify motif candidates near SNPs on gene sequences. The candidates were filtered by coarse thresholding and fine statistical testing. Using the regression-based LARS-EN algorithm and a level-wise sequence combination procedure, we identified 28 SNP-containing motifs as candidate TFBS. We confirmed 21 of the 28 motifs with ChIP-chip fragments in the TRANSFAC database. Another six motifs were validated by TRANSFAC via searching binding fragments on coregulated genes. The identified motifs and their location genes can be considered potential biomarkers for myelodysplastic syndromes. Thus, our proposed method, a novel strategy for associating two data categories, is capable of integrating information from different sources to identify reliable candidate regulatory SNP-containing motifs introduced by genetic variation and mutation.

关键词： Association study, genetic variation and mutation, transcription factor-binding sites, myelodysplastic syndromes

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Release characteristics of arsenic from sediments and its source or sink competition with phosphorus:A case of a great lake with grass-algae alternation

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Journal of Environmental Sciences 2025年第3期149卷 278-287页

作者： Shuhang Wang Yongsheng chang Wei Huang Dianhai Yang Feifei che State Key Laboratory of Pollution Control and Resource Reuse College of Environmental Science and EngineeringTongji UniversityShanghai 200092China College of Environmental Science and Engineering Donghua UniversityShanghai 201620China National Engineering Laboratory for Lake Pollution Control and Ecological Restoration Chinese Research Academy of Environmental SciencesBeijing 100012China

The arsenic(As)release from sediments in great lakes is affected by various *** this study,the characteristics of As release fromsediments was investigated,and the As sources and sinks with the strengths in sediments from different areas(grass-type,algae-type,and grass-algae alternation areas)in great shallow lakes(Taihu Lake,China)were analyzed,and the influence of P competition in the process of As release was also *** results showed that changing trend of the values of equilibrium As concentration in sediments were consistent with the regional changes(0 to 28.12μg/L),and the sediments from algaetype areas had the higher *** sediments from western lake and northwest lake bay were a strong As and a weak P source,and the north lake bay had the opposite trend of these two *** P source competition with As from the sediments occurred in algae-type *** grass-type areas had strong As and P retention capacities,indicating a sink role of sediment with high As and P sorption *** degree of As and P saturation had similar trend in sediments,and the grass-type areas had the higher values,18.3%-21.4%and 15.31%-20.34%,*** analysis results showed that most of As release contribution was from the bottom(30-50 cm)sediments,and the surface(0-10 cm)sediments from algae-type areas contributed more to the overlying water than other region.

关键词： Arsenic Phosphorus Sediment Source and sink Contribution

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Omnidirectional simulation analysis of thermomechanical coupling mechanism in inertia friction welding of Ni-based superalloy

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Chinese Journal of Aeronautics 2025年第1期38卷 202-216页

作者： chang-an LI Guoliang QIN Hao WANG School of Materials Science and Engineering Shandong UniversityJinan 250061China

The coupling between heat and pressure is the kernel of inertia friction welding(IFW)and is still not fully understood.A novel 3D fully coupled finite element model based on a plastic friction pair was developed to simulate the IFW process of a Ni-based superalloy and reveal the omnidirectional thermo-mechanical coupling mechanism of the friction *** numerical model successfully simulated the deceleration,deformation processes,and peak torsional moments in IFW and captured the evolution of temperature,contact pressure,and *** simulated results were validated through measured thermal history,optical macrography,and axial *** results indicated that interfacial friction heat was the primary heat source,and plastic deformation energy only accounted for 4%of the *** increase in initial rotational speed and friction pressure elevated the peak temperature,reaching a maximum of 1525.5K at an initial rotational speed of 2000 r/min and friction pressure of 400 *** interface heat generation could form an axial temperature gradient exceeding 320K/*** radial inhomogeneities of heat generation and temperature were manifested in a concentric ring distribution with maximum heat flux and temperature ranging from 2/5 to 2/3 *** radial inhomogeneities were caused by increasing linear velocity along the radius and an opposite distribution of contact pressure,which could reach 1.7 times the set pressure at the *** circumferential inhomogeneity of thermomechanical distribution during rotary friction welding was revealed for the first time,benefiting from the 3D *** deflection and transformation of distribution in contact pressure and Mises stress were indicators of plastic deformation and transition of quasi-steady state *** critical Mises stress was 0.5 times the friction pressure in this *** presented modeling provides a reliable insight into the thermo-mechanical coupling mechanism of IFW and lays a solid found

关键词： Inertia friction welding Thermo-mechanical coupling Inhomogeneity Numerical simulation Ni-based superalloy

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Three-dimensional line-of-sight-angle-constrained leader-following cooperative interception guidance law with prespecified impact time

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Chinese Journal of Aeronautics 2025年第1期38卷 491-506页

作者： Hao YOU Xinlong chang Jiufen ZHAO Rocket Force University of Engineering Xi’an 710025China

To address the problem of multi-missile cooperative interception against maneuvering targets at a prespecified impact time and desired Line-of-Sight(LOS)angles in ThreeDimensional(3D)space,this paper proposes a 3D leader-following cooperative interception guidance ***,in the LOS direction of the leader,an impact time-controlled guidance law is derived based on the fixed-time stability theory,which enables the leader to complete the interception task at a prespecified impact ***,in the LOS direction of the followers,by introducing a time consensus tracking error function,a fixed-time consensus tracking guidance law is investigated to guarantee the consensus tracking convergence of the ***,in the direction normal to the LOS,by combining the designed global integral sliding mode surface and the second-order Sliding Mode Control(SMC)theory,an innovative 3D LOS-angle-constrained interception guidance law is developed,which eliminates the reaching phase in the traditional sliding mode guidance laws and effectively saves energy ***,it effectively suppresses the chattering phenomenon while avoiding the singularity issue,and compensates for unknown interference caused by target maneuvering online,making it convenient for practical engineering ***,theoretical proof analysis and multiple sets of numerical simulation results verify the effectiveness,superiority,and robustness of the investigated guidance law.

关键词： Three-dimensional cooperative interception Leader-following missiles Prespecified impact time LOS-angle-constrained Fixed-time stability Global integral sliding mode

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Bound state noise-like pulses generation from composite filtering effects

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Optoelectronics Letters 2025年第3期21卷 142-148页

作者： chang Qingyu ZHANG Caishi College of Physics & Optoelectronic Engineering Jinan University Guangdong-Hong Kong-Macao Joint Laboratory for Intelligent Micro-Nano Optoelectronic Technology School of Physics and Optoelectronic EngineeringMacau University of Science and Technology School of Innovation Engineering Macau University of Science and Technology

This paper demonstrated the generation of multi-wavelength bound state noise-like pulse (BNLP) in a dispersion-managed composite-filtered fiber laser consisting of nonlinear polarization rotation (NPR) and *** the case of BNLP,the generation is caused by the interaction between two noise-like pulses (NLPs) induced by the comb-filtering effect,and bound state level can be artificially controlled in the *** work provides a new method for generating low-coherence pulses and establishes a research idea for the study of the comb-filtering effects.

关键词： A

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基于大语言模型多轮对话的推荐模型研究

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计算机科学与探索 2025年第2期19卷 385-395页

作者：常保发车超梁艳大连大学先进设计与智能计算省部共建教育部重点实验室辽宁大连116622 大连大学软件工程学院辽宁大连116622 上海建桥学院机电学院上海201306

近来结合大语言模型的推荐方法在提高推荐准确度和增强用户体验等方面展现出明显的优越性。然而这些方法存在没有充分利用用户信息、仅使用单轮对话无法学习用户多次交互的行为特征、大语言模型与推荐系统之间存在巨大的语义差异等问题... 详细信息

近来结合大语言模型的推荐方法在提高推荐准确度和增强用户体验等方面展现出明显的优越性。然而这些方法存在没有充分利用用户信息、仅使用单轮对话无法学习用户多次交互的行为特征、大语言模型与推荐系统之间存在巨大的语义差异等问题。针对这些问题,提出了一个基于大语言模型多轮对话模式的推荐模型。该模型利用矢量量化技术将用户信息转化为用户索引,并通过微调任务把大语言模型的语言语义与推荐系统的协作语义整合,不仅学习了用户特征而且缓解了语义差异问题;将用户索引与历史交互数据拼接成提示语,再经过多轮对话机制进行推荐微调,从而学习用户交互行为之间的特征。模型在亚马逊Instructions、Arts和Games三个数据集上进行实验,结果表明模型在命中率(HR)和归一化折损累计增益(NDCG)两个评价指标上优于对比基线算法,在三个数据集上与最优对比基线算法相比,HR平均提升10.53%,NDCG平均提升5.10%,证明了模型的有效性。

关键词：推荐系统序列推荐大语言模型多轮对话机制

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Data-based neural controls for an unknown continuous-time multi-input system with integral reinforcement

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Control Theory and Technology 2025年第1期23卷 118-130页

作者： Yongfeng Lv Jun Zhao Wan Zhang Huimin chang College of Electrical and Power Engineering Taiyuan University of TechnologyTaiyuanShanxi030024China College of Transportation Shandong University of Science and TechnologyQingdao266590ShandongChina School of Mathematical Sciences Shanxi UniversityTaiyuan030006ShanxiChina

Integral reinforcement learning(IRL)is an effective tool for solving optimal control problems of nonlinear systems,and it has been widely utilized in optimal controller design for solving discrete-time ***,solving the Hamilton-Jacobi-Bellman(HJB)equations for nonlinear systems requires precise and complicated ***,the research and application of IRL in continuous-time(CT)systems must be further *** develop the IRL of a CT nonlinear system,a data-based adaptive neural dynamic programming(ANDP)method is proposed to investigate the optimal control problem of uncertain CT multi-input systems such that the knowledge of the dynamics in the HJB equation is ***,the multi-input model is approximated using a neural network(NN),which can be utilized to design an integral reinforcement ***,two criterion networks and one action network are constructed based on the integral reinforcement signal.A nonzero-sum Nash equilibrium can be reached by learning the optimal strategies of the multi-input *** this scheme,the NN weights are constantly updated using an adaptive *** weight convergence and the system stability are analyzed in *** optimal control problem of a multi-input nonlinear CT system is effectively solved using the ANDP scheme,and the results are verified by a simulation study.

关键词： Adaptive dynamic programming Integral reinforcement Neural networks Heuristic dynamic programming Multi-input system

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Utilizing BP neural networks to accurately reconstruct the tritium depth profile in materials for BIXS

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Nuclear Science and Techniques 2025年第1期36卷 103-114页

作者： chen Zhao Wei Jin Yan Shi chang-An chen Yi-Ying Zhao Institute of Materials China Academy of Engineering PhysicsJiangyou 621908China

β-ray-induced X-ray spectroscopy(BIXS)is a promising method for tritium detection in solid materials because of its unique advantages,such as large detection depth,nondestructive testing capabilities,and low requirements for sample ***,high-accuracy reconstruction of the tritium depth profile remains a significant challenge for this *** this study,a novel reconstruction method based on a backpropagation(BP)neural network algorithm that demonstrates high accuracy,broad applicability,and robust noise resistance is *** average reconstruction error calculated using the BP network(8.0%)was much lower than that obtained using traditional numerical methods(26.5%).In addition,the BP method can accurately reconstruct BIX spectra of samples with an unknown range of tritium and exhibits wide applicability to spectra with various tritium ***,the BP network demonstrates superior accuracy and stability compared to numerical methods when reconstructing the spectra,with a relative uncertainty ranging from 0 to 10%.This study highlights the advantages of BP networks in accurately reconstructing the tritium depth profile from BIXS and promotes their further application in tritium detection.

关键词： β-ray-induced X-ray spectroscopy Tritium detection BP network Ridge regression Reconstruction problem

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Long-duration aqueous Zn-ion batteries achieved by dual-salt highly-concentrated electrolyte with low water activity

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Journal of Energy chemistry 2025年第2期101卷 778-785页

作者： Lvzhang Jiang Lingbo Yao Gege Wang chang Liu Xiaowei Chi Yu Liu Shanghai Institute of Ceramics Chinese Academy of Sciences University of Chinese Academy of Sciences

Aqueous Zn-ion batteries have attracted much attention due to their unique high safety and low-cost ***,their practical applications are at a slow pace due to their short cycle life,which fundamentally results from the instability of the positive/negative electrode interface in the traditional dilute aqueous electrolytes with high water *** highly concentrated electrolyte（HCE）has been considered as an effective *** previous studies of single salt-based HCE（SSHCE）,herein,a new dual-salt HCE（15 m ZnCl2+10 m NH4NH2SO3DS-HCE） was proposed for the first ***-HCE was proven to simultaneously possess higher conductivity than traditional dilute electrolytes and ultralow water activity of SS-HCE by the regulation of dual high-concentration salts on the solvation structure,which renders the Zn‖Zn symmetric cell the record-long cycling life of 2200 h compared with those with SS-HCE（30 m ZnCl2,300 h） and other reported ***,the Zn‖NH4V4O10full cell with DS-HCE demonstrated impressed rate capability within a wide-range current densities from 0.1 to 10 A ***,at the high current density of 5 A g-1,the full cell shows almost100% capacity retention after 4000 cycles,which indicates the promising future of the DS-HCE system for long-duration aqueous Zn-ion batteries.

关键词： Ammonium vanadate Aqueous zinc battery Cycling stability Electrolyte

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Understanding amorphous PrO_(x)-based N-doped carbon catalyst as an efficient electrocatalyst for oxygen reduction reaction

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Journal of Rare Earths 2025年第1期43卷 73-80,I0003页

作者： Xiao Man Ying chang Shaohong Guo Meilin Jia Jingchun Jia Inner Mongolia Key Laboratory of Green Catalysis and Inner Mongolia Collaborative Innovation Center for Water Environment Safety College of Chemistry and Environmental ScienceInner Mongolia Normal UniversityHohhot010022China

The development of an e fficacious and easily prepared no nprecious metal electrocatalyst is crucial for the oxygen reduction reaction(ORR).This work used a dual template method to prepare the amorphous rare earth-based catalyst PrO_(x)-NC,and optimized the calcination temperature and *** PrO_(x)-NC-900 catalyst has high durability and activity and exhibits superior ORR performance in alkaline electrolytes with an onset potential(E_(0))of 0.96 V and a half-wave potential(E_(1/2))of 0.85 *** research results indicate that the ORR performance of rare earth oxide composite carbon catalysts can be improved by adjusting oxygen vacancies(Ov).In addition,high specific surface area,N rich defect *** oxygen vacancies,and the synergistic effect of oxygen vacancies and N-doped carbon interfacial layer play a significant part in the enhancement of *** performance of the zinc air battery assembled with PrO_(x)-NC-900 is significantly improved,and rare earth oxides and carbon frameworks originating from metal organic frameworks(MOFs)contribute to the oxygen electrocatalyst and electron transfer rate of the zinc air *** catalyst provides promising information for the development of rare earth metal oxide nanostructures as potential candidate materials for ORR in alkaline media.

关键词： Rare earths Metal-organic framework Oxygen reduction reaction Zn-air batteries

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