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Alleviating effects and mechanisms of action of large-leaf yellow tea drinking on diabetes and diabetic nephropathy in mice

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Food science and Human Wellness 2023年第5期12卷 1660-1673页

作者： Guangshan Zhao Jianyuan Teng Ruixia Dong Qiuyan Ban Lian yang Kang Du Yifei Wang Hanlin Pu chung s.yang Zhe Ren Innovation Team of Food Nutrition and safety Control College of Food Science&TechnologyHenan Agricultural UniversityZhengzhou 450002China Biology Postdoctoral Research station Department of Cell BiologyCollege of Life Science and TechnologyJinan UniversityGuangzhou 510632China College of Horticulture Jinling Institute of TechnologyNanjing 211169China Department of Forestry and Technology Lishui Vocational and Technical CollegeLishui 323000China Department of Tea science College of HorticultureHenan Agricultural UniversityZhengzhou 450002China Guangdong Provincial Engineering Center of Topical Precise Drug Delivery system School of PharmacyGuangdong Pharmaceutical UniversityGuangzhou 510006China Department of Chemical Biology Ernest Mario School of PharmacyRutgersThe State University of New JerseyPiscataway 08901USA International Joint Research Laboratory of Tea Chemistry and Health Effects Anhui Agricultural UniversityHefei 230036China

Our previous study found that large-leaf yellow tea(LYT)had interesting hypoglycemic activity in high-fat diet-induced obese mice and highly safety in healthy mice. To study the anti-diabetic potential of LYT, the present study further investigated the preventive effects and mechanisms of action of LYT administration on diabetes and diabetic nephropathy in high-fat diet plus streptozotocin-induced diabetic mice. Results showed that LYT infusions(1/100 and 1/50, m/V)as drinking fluid for 4 weeks reduced diabetic polydipsia and polyuria, enhanced glucose tolerance and insulin sensitivity, and lowered fasting blood glucose level. The underlying mechanisms involve downregulation of gluconeogenesis(lower protein levels of TXNIP and FBP and enzyme activity of FBP), upregulation of lipid catabolism(higher protein levels of CPT-1α and PPARα), downregulation of lipogenesis(lower protein level of sREBP-1), and modification of the structure and abundance of gut microbiota to modulate metabolic homeostasis. Moreover, LYT administration prevented diabetic nephropathy, possibly due to reduced glucose-caused osmotic diuresis and lowered levels of renal PKC-β2, NLRP3 as well as membrane PKC-α, AQP2 and glycosylated AQP2 proteins. Taken together, LYT exhibits the activities in alleviating diabetic symptoms, ameliorating glucose and lipid dysmetabolism and fatty liver, and preventing diabetic nephropathy in diabetic mice. These activities may be explored for the prevention and treatment of diabetes in humans.

关键词： Diabetes Glucose and lipid metabolism Gut microbiota Diabetic nephropathy Large-leaf yellow tea

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Chinese Herbal Medicines 2023年第1期15卷 33-36页

作者： Hongjing Pan Miamoiao Le Chunnian He chung s.yang Tiejun Ling state Key Laboratory of Tea Plant Biology and Utilization Anhui Agricultural UniversityHefei 230036China Institute of Medicinal Plant Development Chinese Academy of Medicinal SciencesPeking Union Medicinal CollegeBeijing 100193China Ernest Maria school of Pharmacy Rutgers UniversityPiscatawayNJ 08854-8020USA International Joint Laboratory on Tea Chemistry and Health Effects of Ministry of Education Anhui Agricultural UniversityHefei 230036China

Tea is a famous beverage that is produced from leaves of Camellia *** the six major tea categories in China,dark tea is the only one that involves microbial fermentation in the manufacturing process,which contributes unique flavors and functions for the *** the recent decade,the reports about the biofunctions of dark teas have increased *** it may be the proper time to consider dark tea as one potential homology of medicine and *** this viewpoint,our current understanding of the chemical constituents,biological activities and possible health beneficial effects of dark teas were *** future directions and challenges to the development perspectives of dark teas were also discussed.

关键词： biological activities dark tea metabolites medicinal development perspectives

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EFFECTs OF TEA CONsUMPTION ON HEALTH

EFFECTS OF TEA CONSUMPTION ON HEALTH

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2005 International symposium on Innovation in Tea science and sustainable Development in Tea Industry

作者： chung s.yang Joshua Lambert Mousumi Bose Department of Chemical Biology Ernest Mario School of PharmacyRutgersThe State University of New JerseyPiscatawayNew Jersey 08854-8020USA Department of Chemical Biology Ernest Mario School of PharmacyRutgersThe State University of New JerseyPiscatawayNew Jersey 08854-8020USA Department of Chemical Biology Ernest Mario School of Pharmacy RutgersThe State University of New JerseyPiscatawayNew Jersey 08854-8020USA

＜正＞Tea and tea preparations have been proposed to have beneficial health effects based mostly on studies in animals and some observations or experiments in humans. The most extensively studied area is on the prevention of cancer and cardiovascular diseases. A new hot topic is on the effects of tea in weight or body fat reduction and in alleviating diabetes. Tea consumption has also been proposed to inhibit oral bacterial growth and prevent cavities, to reduce the risk of cataracts, to alleviate symptoms of arthritis, and to increase bone density. The scientific evidence for the proposed benefits is evaluated in this review based on our understanding of the chemical, biochemical, and pharmacological properties of tea constituents. It is hoped that this review will stimulate additional studies and improve our understanding of the health effects associated with tea consumption.

关键词： tea consumption health review

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Prolonger Tocopherol Diet Inhibits Chronic Lung Inflammation and Improves Lung Function in surfactant Protein-D Deficiency Mice

Prolonger Tocopherol Diet Inhibits Chronic Lung Inflammation...

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中华医学会呼吸病学年会——2013（第十四次全国呼吸病学学术会议）

作者： Jindong shi Thea Golden Chang-Jiang Guo shui-Ping Tu Mao-jung Lee chung s.yang Andrew J.Gow the Fifth Peoples Hospital of shanghai Fudan University Rutgers The State University of New JerseyUnited States of America

Backgrounds and Purpose sP-D knockout(sP-D-/-) mice exhibit an increase in the number and size of airway macrophages,peribronchiolar inflammation, increases in metalloproteinase activity,and development of *** nitric oxide metabolic is involved in the process of this *** have previously shown that disruption of iNOs-NO loop in sP-D-/- mice reverses inflammation

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Tocopherol supplementation Reduces NO Production and Pulmonary Inflammatory Response to Bleomycin

Tocopherol Supplementation Reduces NO Production and Pulmona...

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中华医学会呼吸病学年会——2013（第十四次全国呼吸病学学术会议）

作者： Jindong shi Thea Golden Chang-jiang Guo shui-ping Tu Pamela scott Mao-jung Lee chung s.yang Andrew J.Gow the Fifth Peoples Hospital of shanghai Fudan University Rutgers The state University of New Jersey United States of America

Backgrounds and purpose Bleomycin causes acute lung injury through production of reactive species and initiation of *** work has shown alteration to the production of reactive oxygen species results in attenuation of *** E,in particular Y-tocopherol,has the potential to scavenge reactive oxygen and nitrogen *** study examines the utility of dietary supplementation with tocopherols in

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人贲门癌WAF－1基因和P53肿瘤抑制基因表达的初步研究

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河南医科大学学报 1995年第2期30卷 149-152页

作者：王立东周琦高珊珊杨光育 chung s.yang 河南医科大学医学实验中心癌症研究室河南省肿瘤病理学重点实验室美国新泽西州立大学癌症研究室

采用免疫组织化学方法，初步观察３４例手术切除后的贲门癌组织ＷＡＦ－１基因蛋白（Ｐ２１）的表达状况并与Ｐ５３肿瘤抑制基因蛋白的免疫组化结果进行比较。贲门癌组织Ｐ２１免疫组化阳性率为７４％；癌细胞Ｐ２１免疫反应强度与正常... 详细信息

采用免疫组织化学方法，初步观察３４例手术切除后的贲门癌组织ＷＡＦ－１基因蛋白（Ｐ２１）的表达状况并与Ｐ５３肿瘤抑制基因蛋白的免疫组化结果进行比较。贲门癌组织Ｐ２１免疫组化阳性率为７４％；癌细胞Ｐ２１免疫反应强度与正常细胞相似。

关键词：贲门肿瘤 P53基因 WAF-1基因基因表达

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Naturally Crosslinked Biocompatible Carbonaceous Liquid Metal Aqueous Ink Printing Wearable Electronics for Multi-sensing and Energy Harvesting

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Nano-Micro Letters 2024年第8期16卷 148-168页

作者： King Yan chung Bingang Xu Di Tan Qingjun yang Zihua Li Hong Fu Nanotechnology Center School of Fashion and TextilesThe Hong Kong Polytechnic UniversityHong Kong 999077People’s Republic of China Department of Mathematics and Information Technology The Education University of Hong KongHong KongPeople’s Republic of China

Achieving flexible electronics with comfort and durability comparable to traditional textiles is one of the ultimate pursuits of smart *** printing is desirable for e-textile development using a simple and inexpensive ***,fabricating high-performance atop textiles with good dispersity,stability,biocompatibility,and wearability for high-resolution,large-scale manufacturing,and practical applications has remained ***,waterbased multi-walled carbon nanotubes(MWCNTs)-decorated liquid metal(LM)inks are proposed with carbonaceous gallium–indium *** the assistance of biopolymers,the sodium alginate-encapsulated LM droplets contain high carboxyl groups which non-covalently crosslink with silk sericin-mediated MWCNTs.E-textile can be prepared subsequently via printing technique and natural waterproof triboelectric coating,enabling good flexibility,hydrophilicity,breathability,wearability,biocompatibility,conductivity,stability,and excellent versatility,without any artificial *** obtained e-textile can be used in various applications with designable patterns and ***-sensing applications of recognizing complex human motions,breathing,phonation,and pressure distribution are demonstrated with repeatable and reliable ***-powered and energy-harvesting capabilities are also presented by driving electronic devices and lighting *** proof of concept,this work provides new opportunities in a scalable and sustainable way to develop novel wearable electronics and smart clothing for future commercial applications.

关键词： Biocompatible Conductive ink Biopolymer E-textile Carbonaceous liquid metal

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茶叶对甲基苄基亚硝胺诱发的大鼠食管癌变的影响

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河南医科大学学报 1995年第2期30卷 108-111页

作者：王立东刘保池周琦王志远裘宋良 chung s.yang 河南医科大学医学实验中心癌症研究室河南省肿瘤病理学重点实验室河南医科大学第一附属医院外科

观察了红茶和绿茶对亚硝胺诱发的ＳｐｒａｇｕｅＤａｗｌｅｙ大鼠食管癌变的影响。实验１，雄性ＳｐｒａｇｕｅＤａｗｌｅｙ大鼠，甲基苄基亚硝胺（Ｎ－ｎｉｔｒｏｓｏｍｅｔｈｙｌｂｅｎｚｙｌａｍｉｎｅ，ＮＭＢｚＡ）连续处理５周（... 详细信息

观察了红茶和绿茶对亚硝胺诱发的ＳｐｒａｇｕｅＤａｗｌｅｙ大鼠食管癌变的影响。实验１，雄性ＳｐｒａｇｕｅＤａｗｌｅｙ大鼠，甲基苄基亚硝胺（Ｎ－ｎｉｔｒｏｓｏｍｅｔｈｙｌｂｅｎｚｙｌａｍｉｎｅ，ＮＭＢｚＡ）连续处理５周（２．５ｍｇ／ｋｇ，ｓ．ｃ每周２次）；３９周时，肿瘤发生率为６５％。在ＮＭＢＺＡ处理中饮０．６％的脱咖啡因绿茶和红茶，食管乳头瘤发生率分别降低７４％和６３％。ＮＭＢｚＡ处理后给绿茶或红茶，乳头瘤发生率降低５４％和６６％。实验２，提高ＮＭＢｚＡ到３．５ｍｇ／ｋｇ，１６周时，乳头瘤发生率为７５％，鳞癌发生率４０％。ＮＭＢｚＡ处理后饮０．９％普通绿茶或脱咖啡因绿茶，食管乳头瘤的形成受到明显抑制。结果提示口服绿茶或红茶可预防ＮＭＢｚＡ诱发的大鼠食管癌变。

关键词：食管肿瘤甲基苄基亚硝胺大鼠红茶绿茶

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Mechanism of Primary Frequency Regulation for Battery Hybridization in Hydropower Plant

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CsEE Journal of Power and Energy systems 2024年第5期10卷 2127-2137页

作者： Yiwen Liao Weijia yang Zhecheng Wang Yifan Huang C.Y.chung state Key Laboratory of Water Resources and Hydropower Engineering science Wuhan UniversityWuhan 430072China Department of Electrical Engineering The Hong Kong Polytechnic UniversityHong KongChina

Battery hybridization in hydropower plants is a hydropower flexibility enhancement technology innovation that can potentially expand hydropower’s contributions to the grid,but its fundamental characteristics and influencing mechanisms are still *** this paper,primary frequency regulation(PFR)performance and the mechanism of this new technology are studied.A battery hybridized hydropower plant(BH-HPP)model,based on a field-measured-data-based hydropower plant(HPP)model and a verified battery simplified model,is *** of system stability and dynamics is undertaken for three different battery control strategies by root locus and participation factor *** to conventional HPPs,analysis results theoretically reveal BH-HPP can not only accelerate system regulation rapidity but also effectively enlarge HPP stability region during PFR *** domain simulation verifies the results and further shows synthetic control has better performance among introduced ***,initial design ranges of control parameters considering battery capacity and a renewable energy source scenario case are also *** work could provide theoretical support for flexibility enhancement solutions for hydropower systems.

关键词： Battery hybridization dynamic response hydropower plant primary frequency regulation stability

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Accelerating Oxygen Electrocatalysis Kinetics on Metal-Organic Frameworks via Bond Length Optimization

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Nano-Micro Letters 2024年第9期16卷 279-290页

作者： Fan He Yingnan Liu Xiaoxuan yang Yaqi Chen Cheng‑Chieh yang chung‑Li Dong Qinggang He Bin yang Zhongjian Li Yongbo Kuang Lecheng Lei Liming Dai yang Hou Key Laboratory of Biomass Chemical Engineering of Ministry of Education College of Chemical and Biological EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China Institute of Zhejiang University-Quzhou Quzhou 324000People’s Republic of China Ningbo Institute of Materials Technology and Engineering Chinese Academy of SciencesNingbo 315201People’s Republic of China school of Biological and Chemical Engineering NingboTech UniversityNingbo 315100People’s Republic of China Department of Physics Tamkang UniversityNew Taipei 25137TaiwanPeople’s Republic of China Australian Carbon Materials Centre(A‑CMC) School of Chemical EngineeringUniversity of New South WalesSydneyNSW 2051Australia

Metal-organic frameworks(MOFs)have been developed as an ideal platform for exploration of the relationship between intrinsic structure and catalytic activity,but the limited catalytic activity and stability has hampered their practical use in water ***,we develop a bond length adjustment strategy for optimizing naphthalene-based MOFs that synthesized by acid etching Co-naphthalenedicarboxylic acid-based MOFs(donated as AE-CoNDA)to serve as efficient catalyst for water ***-CoNDA exhibits a low overpotential of 260 mV to reach 10 mA cm^(−2)and a small Tafel slope of 62 mV dec^(−1)with excellent stability over 100 *** integrated AE-CoNDA onto BiVO_(4),photocurrent density of 4.3 mA cm^(−2)is achieved at 1.23 *** investigations demonstrate that the stretched Co-O bond length was found to optimize the orbitals hybridization of Co 3d and O 2p,which accounts for the fast kinetics and high *** calculations reveal that the stretched Co-O bond length strengthens the adsorption of oxygen-contained intermediates at the Co active sites for highly efficient water splitting.

关键词： Metal-organic frameworks Bond length adjustment spin state transition Orbitals hybridization Water splitting

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