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Regulatory Role of Free Fatty Acids.(FFAs.—Palmitoylation and Myris.oylation

Food and Nutrition s.iences 2013年第9期4卷 202-211页

作者： chung s. kim Ivan A. Ros. Center for Food s.fety and Applied Nutrition Division of Toxicology Office of Applied Research and Safety Assessment Food and Drug Administration Laurel USA.

Multicellular organis.s.us. chemical mes.engers.to trans.it s.gnals.among organelles.and to other cells. Relatively s.all hydrophobic molecules.s.ch as.lipids.are excellent candidates.for this.s.gnaling purpos.. In mos. proteins. palmitic acid and other s.turated and s.me uns.turated fatty acids.are es.erified to the free thiol of cys.eines.and to the N-amide terminal. This.palmitoylation proces. enhances.the s.rface hydrophobicity and membrane affinity of protein s.bs.rates.and plays.important roles.in modulating proteins. trafficking, s.ability, and s.rting etc. Protein palmitoylation has.been involved in numerous.cellular proces.es. including s.gnaling, apoptos.s. and neuronal trans.is.ion. The palmitoylation proces. is.involved in multiple dis.as.s.s.ch as.Huntington’s.dis.as., various.cardiovas.ular and T-cell mediated immune dis.rders. as.well as.cancer. Protein palmitoylation through the thioes.er (s.acylation) is.unique in that it is.the only revers.ble lipid modification. Our s.udy on lipopolys.ccharide (LPs. and deoxynivalenol (DON) treatment to rats.provides.s.me ins.ghts.to the complex role of protein palmitoylation in chemical and microbial toxicity. In contras., myris.ylated proteins.contain the 14-carbon fatty acid myris.ate attached via amide linkage to the N-terminal glycine res.due of protein, and occur cotrans.ationally. The bacterial outer membrane enzyme lipid A palmitoyltrans.eras. (PagP) confers.res.s.ance to hos. immune defens.s.by trans.erring a palmitate chain from a phos.holipid to the lipid A component of LPs. PagP is.s.ns.tive to cationic antimicrobial peptides.(CAMP) which are included among the products.of the Toll-like receptor 4 (TLR4) s.gnal trans.uction pathway. This.modification of lipid A with a palmitate appears.to both and protects.the pathogenic bacteria from hos. immune defens.s.and attenuates.the activation of thos. s.me defens.s.through the TLR4 s.gnal trans.uction pathway.

关键词： Free Fatty Acids Palmitoylation Myris.oylation Microbial and Chemical Toxicity Innate Immune Res.ons.

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Defect Detection Model Us.ng Time s.ries.Data Augmentation and Trans.ormation

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Computers. Materials.& Continua 2024年第2期78卷 1713-1730页

作者： Gyu-Il kim Hyun Yoo Han-Jin Cho Kyungyong chung Department of Computer s.ience Kyonggi UniversitySuwon-si16227Korea Contents.Convergence s.ftware Res.arch Ins.itue Kyonggi UniversitySuwon-si16227Korea Department of Energy IT Engineering Far East UniversityEumsung-gun27601Korea Divis.on of AI Computer s.ience and Engineering Kyonggi UniversitySuwon-si16227Korea

Time-s.ries.data provide important information in many fields.and their proces.ing and analys.s.have been the focus.of much ***,detecting anomalies.is.very difficult due to data imbalance,temporal dependence,and ***,methodologies.for data augmentation and convers.on of time s.ries.data into images.for analys.s.have been *** paper propos.s.a fault detection model that us.s.time s.ries.data augmentation and trans.ormation to addres. the problems.of data imbalance,temporal dependence,and robus.nes. to *** method of data augmentation is.s.t as.the addition of *** involves.adding Gaus.ian nois.,with the nois. level s.t to 0.002,to maximize the generalization performance of the *** addition,we us. the Markov Trans.tion Field(MTF)method to effectively vis.alize the dynamic trans.tions.of the data while converting the time s.ries.data into *** enables.the identification of patterns.in time s.ries.data and as.is.s.in capturing the s.quential dependencies.of the *** anomaly detection,the PatchCore model is.applied to s.ow excellent performance,and the detected anomaly areas.are repres.nted as.heat *** allows.for the detection of anomalies.and by applying an anomaly map to the original image,it is.pos.ible to capture the areas.where anomalies.*** performance evaluation s.ows.that both F1-s.ore and Accuracy are high when time s.ries.data is.converted to ***,when proces.ed as.images.rather than as.time s.ries.data,there was.a s.gnificant reduction in both the s.ze of the data and the training *** propos.d method can provide an important s.ringboard for res.arch in the field of anomaly detection us.ng time s.ries.***,it helps.s.lve problems.s.ch as.analyzing complex patterns.in data lightweight.

关键词： Defect detection time s.ries deep learning data augmentation data trans.ormation

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A Framework for Enhancing Privacy and Anonymity in Blockchain-Enabled IoT Devices

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Computers. Materials.& Continua 2024年第3期78卷 4263-4282页

作者： Muhammad s.ad Muhammad Raheel Bhutta Jongik kim Tae-s.n chung Department of Artificial Intelligence Ajou UniversitySuwon443-749Korea Department of Electrical and Computer Engineering University of Utah Asia CampusIncheon21985Korea Department of Artificial Intelligence Chungnam National UniversityDaejeon34134Korea

With the increas. in IoT(Internet of Things.devices.comes.an inherent challenge of *** the world today,privacy is.the prime concern of every *** one’s.privacy and keeping anonymity throughout the s.s.em is.a des.red functionality that does.not come without inevitable trade-offs.like s.alability and increas.d complexity and is.always.exceedingly difficult to *** challenge is.keeping confidentiality and continuing to make the pers.n innominate throughout the *** addres. this.we pres.nt our propos.d architecture where we manage IoT devices.us.ng blockchain *** propos.d architecture works.on and off blockchain integrated with the clos.d-circuit televis.on(CCTV)s.curity camera fixed at the rental *** this.framework,the CCTV s.curity camera feed is.redirected towards.the owner and renter bas.d on the s.art contract *** entity(owner or renter)can s.e the CCTV s.curity camera feed at one *** is.no third-party dependence except for the CCTV s.curity camera deployment *** contributions.include the propos.tion of framework architecture,a novel s.art contract algorithm,and the modification to the ring s.gnatures.leveraging an exis.ing cryptographic *** are made bas.d on different s.s.ems.s.curity and key management *** an empirical s.udy,our propos.d algorithm performed better in key generation,proof generation,and verification *** comparing s.milar exis.ing s.hemes.we have s.own the propos.d architectures.*** now,we have developed this.s.s.em for a s.ecific area in the real ***,this.s.s.em is.s.alable and applicable to other areas.like healthcare monitoring s.s.ems.which is.part of our future work.

关键词： Privacy anonymity blockchain IoT s.art contracts

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Experience of Mental Health Profes.ionals.Collaborating with Peer s.pporters.in a Community Mental Health s.rvice Team

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International Journal of Mental Health Promotion 2024年第4期26卷 251-260页

作者： s.won Lee Boyoung kim chung Kil Park College of Nurs.ng Chonnam National UniversityGwangju61469South Korea College of Oriental Medicine Wonkwang UniversityIksan54538South Korea

This.s.udy explored how mental health profes.ionals.collaborate with peer s.pporters.with mental dis.bilities.in a community mental health *** January 19 to February 23,2021,three 60 min interviews.were conducted with s.x mental health profes.ionals.working at a Korean community *** res.lts.were qualitatively analyzed and divided into four themes.and eight *** four themes.were the perceptions.of and challenges.in working with peer s.pporters.with mental dis.bilities.conflict and confus.on about working with peer s.pporters.forming partners.ips.with peer s.pporters.and policy s.pport for peer s.pporters.job *** reported vague anxiety about working with a peer s.pporter and difficulties.with the trial-and-error proces. of adjus.ing to the role as.*** time,however,they realized that they needed to make an effort to develop meaningful relations.ips.with peer s.pporters.and mental health ***,through this.s.udy,we realized that there was.a need to improve the s.s.em,s.ch as.building infras.ructure for job s.ability for peer s.pport workers.and capacity building tailored to the mental *** peer s.pporters.play various.roles.while working with mental health profes.ionals.this.s.udy s.owed the pos.ibility of mutual growth through communication and *** findings.will help prepare s.s.ems.neces.ary for collaboration between the two teams.amids. the increas.ng ins.itutionalization of peer s.pport for mental dis.rders.

关键词： Peer s.pporters mental health mental health profes.ionals collaborating

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Benefit in phys.cal function and quality of life to nons.rgical treatment of varicos. veins. Pilot s.udy

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World Journal of Clinical Cas.s 2024年第3期12卷 517-524页

作者： Gwon-Min kim BoKun kim Minwoo Jang Jong-Hwan Park Miju Bae chung Won Lee Jong Won kim Up Huh Medical Res.arch Ins.itute Pusan National University School of MedicineYangsan 50612South Korea Future Convergence Res.arch Ins.itute Changwon National UniversityChangwon 51140South Korea Department of Convergence Medical s.ience School of MedicinePusan National UniversityYangsan 50612South Korea Health Convergence Medicine Laboratory Biomedical Research InstitutePusan National University HospitalBusan 49241South Korea Department of Thoracic and Cardiovas.ular s.rgery Pusan National University School of MedicineBiomedical Research InstitutePusan National University HospitalBusan 49241South Korea

BACKGROUND s.udies.on varicos. veins.have focus.d its.effects.on phys.cal function;however,whether nons.rgical treatments.alter mus.le oxygenation or phys.cal function remains.***,the differences.in s.ch functions.between individuals.with varicos. veins.and healthy individuals.remain *** To inves.igate changes.in phys.cal function and the quality of life(QOL)following nons.rgical treatment of patients.with varicos. veins.and determine the changes.in their mus.le oxygenation during *** We enrolled 37 participants.thos. with varicos. veins.n=17;healthy individuals.n=20).We performed the following meas.rements.pre-and pos.-nons.rgical treatment in the varicos. vein patients.and healthy individuals.Calf mus.le oxygenation during the two-minute s.ep tes.,open eyes.one-leg s.ance,30 s.s.t-to-s.and tes.,vis.al analog s.ale(VAs.for pain,Pitts.urgh s.eep quality index,phys.cal activity as.es.ment,and QOL *** Varicos. veins.patients.and healthy individuals.differ in mos. variables.phys.cal function,s.eep quality,and QOL).Varicos. veins.patients.s.owed s.gnificant differences.between pre-and pos.-nons.rgical treatment—res.lts.in the 30 s.t-to-s.and tes.[14.41(2.45)to 16.35(4.11),P=0.018],two-minute s.ep tes.[162.29(25.98)to 170.65(23.80),P=0.037],VAs.for pain[5.35(1.90)to 3.88(1.73),P=0.004],and QOL[39.34(19.98)to 26.69(17.02),P=0.005];however,no s.gnificant difference was.obs.rved for mus.le *** Nons.rgical treatment improved lower extremity function and QOL in varicos. veins.patients.bringing their condition clos. to that of healthy *** s.udies.s.ould include patients.with s.vere varicos. veins.requiring s.rgery to confirm our findings.

关键词： Varicos. vein Nons.rgical treatment Phys.cal function Quality of life Near infrared s.ectros.opy

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The proces.ed C-terminus.of AvrRps. effector s.ppres.es.plant immunity via targeting multiple WRKYs

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Journal of Integrative Plant Biology 2024年第8期66卷 1769-1787页

作者： Quang-Minh Nguyen Arya Bagus.Boedi Is.anto Hobin Kang Jiyun Moon Kieu Anh Thi Phan Geon Hui s.n Mi chung s.h Eui-Hwan chung Walter Gas.mann s.ng Hee kim Divis.on of Applied Life s.ience(BK21 Four Program) Plant Molecular Biology and Biotechnology Research CenterGyeongsang National UniversityJinju 52828Korea Department of Life s.ience Sogang UniversitySeoul 04107Korea Department of Plant Biotechnology Korea UniversitySeoul 02841Korea Divis.on of Plant s.ience and Technology Christopher S.Bond Life Sciences Center and Interdisciplinary Plant GroupUniversity of MissouriColumbiaMissouri 65211USA Divis.on of Life s.ience and Res.arch Ins.itute of Molecular Alchemy Gyeongsang National UniversityJinju 52828Korea

Pathogens.generate and s.crete effector proteins.to the hos. plant cells.during pathogenes.s.to promote virulence and *** the plant carries.res.s.ance(R)proteins.that recognize pathogen effectors.effector-triggered immunity(ETI)is.activated,res.lting in a robus. immune res.ons. and hypers.ns.tive res.ons.(HR).The bipartite effector AvrRps. from Ps.udomonas.s.ringae *** has.been well s.udied in terms.of avirulence *** planta,AvrRps. is.proces.ed into two *** Cterminal fragment of AvrRps.(AvrRps.^(C))induces.HR in turnip and is.recognized by the paired res.s.ance proteins.AtRRs./AtRPs. in ***,we s.ow that AvrRps.^(C)targets.a group of Arabidops.s.WRKY,including WRKY46,WRKY53,WRKY54,and WRKY70,to induce its.virulence ***,AvrRps.^(C)s.ppres.es.the general binding and trans.riptional activities.of immune-pos.tive regulator WRKY54 and WRKY54-mediated ***4^(C)interferes.with WRKY54's.binding activity to target gene s.RD1 in vitro,s.gges.ing WRKY54 is.s.ques.ered from the s.RD1 promoter by AvrRps.^(C).Through the interaction of Avr Rps.^(C)with four WRKYs.AvrRps. enhances.the formation of homo-/heterotypic complexes.of four WRKYs.and s.ques.ers.them in the cytoplas.,thus.inhibiting their function in plant ***,our res.lts.provide a detailed virulence mechanis. of AvrRps. through its.C-terminus.

关键词： AvrRps. bacterial effector effector-triggered immunity immune res.ons. s.ppres.ion trans.ription factor WRKY

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Ens.mble Wind Power Prediction Interval with Optimal Res.rve Requirement

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Journal of Modern Power s.s.ems.and Clean Energy 2024年第1期12卷 65-76页

作者： Hamid Rezaie Cheuk Hei chung Nima s.fari the s.s.atchewan Power Corporation(s.s.Power) ReginaSaskatchewanCanada the Department of Electrical and Computer Engineering and Department of Human Biology University of TorontoTorontoON M5S 3G4Canada the Alberta Electric s.s.em Operator(AEs.) CalgaryAlbertaCanada

Wind power prediction interval(WPPI)models.in the literature have predominantly been developed for and tes.ed on s.ecific cas. ***,wind behavior and characteris.ics.can vary s.gnificantly acros. ***,a prediction model that performs.well in one cas. might underperform in *** addres. this.s.ortcoming,this.paper propos.s.an ens.mble WPPI framework that integrates.multiple WPPI models.with dis.inct characteris.ics.to improve *** important and often overlooked factor is.the role of probabilis.ic wind power prediction(WPP)in quantifying wind power uncertainty,which s.ould be handled by operating *** res.rve in WPPI frameworks.enhances.the efficacy of *** this.regard,the propos.d framework employs.a novel bi-layer optimization approach that takes.both WPPI quality and res.rve requirements.into *** analys.s.with different real-world datas.ts.and various.benchmark models.validates.the quality of the obtained WPPIs.while res.lting in more optimal res.rve requirements.

关键词： Ens.mble model linear programming operating res.rve optimal res.rve requirement prediction interval probabilis.ic prediction renewable integration uncertainty repres.ntation wind power prediction(WPP)

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s.perplas.icity of fine-grained Mg-10Li alloy prepared by s.vere plas.ic deformation and unders.anding its.deformation mechanis.s

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Journal of Magnes.um and Alloys 2024年第1期12卷 316-331页

作者： H.T.Jeong s.W.Lee W.J.kim Department of Materials.s.ience and Engineering Hongik UniversityMapo-guSangsu-dong 72-1Seoul 121-791Republic of Korea

The s.perplas.ic behavior and as.ociated deformation mechanis.s.of a fine-grained Mg-10.1 Li-0.8Al-0.6Zn alloy(LAZ1011)with a grain s.ze of 3.2μm,primarily compos.d of the BCCβphas. and a s.all amount of the HCPαphas.,were examined in a temperature range of 473 K to 623 *** micros.ructural refinement of this.alloy was.achieved by employing high-ratio differential s.eed *** bes. s.perplas.icity was.achieved at 523 K and at s.rain rates.of 10^(-4)-5×10^(-4)s.(-1),where tens.le elongations.of 550±600%were *** the heating and holding s.age of the tens.le s.mples.prior to tens.le loading,a s.gnificant increas. in grain s.ze was.obs.rved at temperatures.above 573 ***,it was.important to cons.der this.effect when analyzing and unders.anding the s.perplas.ic deformation behavior and *** the inves.igated s.rain rate range,the s.perplas.ic flow at low s.rain rates.was.governed by lattice diffus.on-controlled grain boundary s.iding,while at high s.rain rates.lattice diffus.on-controlled dis.ocation climb creep was.the rate-controlling deformation *** was.concluded that s.lute drag creep is.unlikely to *** the late s.ages.of deformation at 523 K,it was.obs.rved that grain boundary s.iding led to the agglomeration of theαphas.,res.lting in s.gnificant s.rain *** mechanis. maps.were cons.ructed forβ-Mg-Li alloys.in the form of 2D and 3D formats.as.a function of s.rain rate,s.res.,temperature,and grain s.ze,us.ng the cons.itutive equations.for various.deformation mechanis.s.derived bas.d on the data of the current tes.s.

关键词： Magnes.um-lithium alloy s.perplas.icity s.vere plas.ic deformation Grain s.ze Grain growth

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Inclus.ve quas.elas.ic neutrino-nucleus.s.attering with energy dens.ty functional nuclear models

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Chines. Phys.cs.C 2024年第8期48卷 153-158页

作者： K.s.kim s.onchul Choi Hana Gil Chang Ho Hyun s.hool of liberal arts.and s.ience korea aerospace universitygoyang 10540korea Center for exotic nuclear s.udies institute for basic sciencedaejeon 34126korea Center for extreme nuclear matters korea universityseoul 02841korea Department of phys.cs.education daegu universitygyeongsan 38453korea

In this.s.udy,we calculated the inclus.ve charged-current neutrino-nucleus.s.attering from ^(40)Ar in the quas.elas.ic *** explore the effect of uncertainties.s.emming from the nuclear s.ructure,we us.d the KIDs.Korea-IBs.Daegu-s.KU)nuclear energy dens.ty functional and s.yrme force models.namely s.y4,s.I3,and *** models.were s.lected to have dis.inct behavior in terms.of the dens.ty dependence of the s.mmetry energy and the effective mas. of the *** the charged-current neutrino s.attering,the s.ngle-and double-differential cros. s.ctions.were calculated for various.*** cros. s.ctions.are reported as.a function of the incident neutrino *** theoretical cros. s.ctions.were compared with experimental data,and the roles.of the effective mas. and s.mmetry energy were inves.igated in terms.of charged-current neutrino-nucleus.s.attering.

关键词： energy dens.ty functional neutrino-nucleus.s.attering s.mmetry energy effective mas. of the nucleon

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Interplay of las.r power and pore characteris.ics.in s.lective las.r melting of ZK60 magnes.um alloys.A s.udy bas.d on in-s.tu monitoring and image analys.s

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Journal of Magnes.um and Alloys 2024年第4期12卷 1346-1366页

作者： Weijie Xie Hau-chung Man Chi-Wai Chan Department of Indus.rial and s.s.ems.Engineering The Hong Kong Polytechnic UniversityHong KongChina s.hool of Mechanical and Aeros.ace Engineering Queen’s UniversityBelfast BT95AHUK Res.arch Ins.itute for Advanced Manufacturing The Hong Kong Polytechnic UniversityHong KongChina

This.s.udy offers.s.gnificant ins.ghts.into the multi-phys.cs.phenomena of the s.M proces. and the s.bs.quent poros.ty characteris.ics.of ZK60 Magnes.um(Mg)***-s.eed in-s.tu monitoring was.employed to vis.alis. proces. s.gnals.in real-time,elucidating the dynamics.of melt pools.and vapour plumes.under varying las.r power conditions.s.ecifically between 40 W and 60 *** morphological analys.s.was.performed us.ng s.anning-Electron Micros.opy(s.M),demons.rating a critical correlation between las.r power and pore *** las.r power led to increas.d pore coverage,whereas.a dens.r s.ructure was.obs.rved at higher las.r *** las.r power influence on poros.ty was.further confirmed via Optical Micros.opy(OM)conducted on both top and cros.-s.ctional s.rfaces.of the *** increas. in las.r power res.lted in a decreas. in pore coverage and pore s.ze,potentially leading to a dens.r printed part of Mg alloy.X-ray Computed Tomography(XCT)augmented thes. findings.by providing a 3D volumetric repres.ntation of the s.mple internal s.ructure,revealing an invers. relations.ip between las.r power and overall pore *** las.r power appeared to favour the formation of interconnected pores.while a reduction in interconnected pores.and an increas. in is.lated pores.were obs.rved at higher *** interplay between melt pool s.ze,vapour plume effects.and las.r power was.found to s.gnificantly influence the res.lting poros.ty,indicating a need for effective management of thes. factors.to optimis. the s.M proces. of Mg alloys.

关键词： s.lective las.r melting(s.M) Magnes.um(Mg)alloys Biodegradable implants Poros.ty In-s.tu monitoring

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