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Cancer Biology & Medicine 2018年第S1期15卷 17-18页

作者： Kun Chen Yanmei Wang Hong zhao Zhiyuan Wu Xinyu Bi Jianguo Zhou Dongmei Wang Jianqiang Cai chunfeng Qu Department of Immunology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Hepatobiliary Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina State Key Laboratory of Molecular Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

Objective:To induce potent CD8^+T-cells against glypican-3(GPC3),which is overexpressed in hepatocellular carcinoma(HCC),to suspend tumor ***:Since the chemokine receptor XCR1 is selectively expressed on professional ... 详细信息

关键词： XCL1/Glypican-3 fusion protein

Efficacy and safety of rasagiline in Chinese patients with early Parkinson’s disease:a randomized, double-blind,parallel,placebo-controlled,fixed-dose study

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Translational Neurodegeneration 2018年第1期7卷 352-360页

作者： Zhenxin Zhang Jian Wang Shengdi Chen chunfeng Liu Baorong Zhang Rong Peng Shenggang Sun Xiangru Sun Gang zhao Qiumin Qu Yansheng Li Suiqiang Zhu Xiaoping Pan Ming Shao Yanping Wang Peking Union Medical College Hospital BeijingChina Huashan Hospital Fudan UniversityShanghaiChina Ruijin Hospital Shanghai Jiaotong University School of MedicineShanghaiChina The Second Affiliated Hospital of Soochow University SuzhouChina The Second Affiliated Hospital School of MedicineZhejiang UniversityZhejiangHangzhouChina West China Hospital Sichuan UniversityChengduChina Tongji Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology WuhanChina Peking University First Hospital BeijingChina Xijing Hospital The First Affiliated Hospital of The Fourth Military Medical UniversityXi’anChina The First Affiliated Hospital of Xi’an Jiaotong University Xi’anChina Renji Hospital Shanghai Jiaotong University School of MedicineShanghaiChina Tongji Hospital of Tongji Medical College Huazhong University of Science and TechnologyWuhanChina Guangzhou First People’s Hospital School of MedicineSouth China University of TechnologyGuangzhouChina The First Affiliated Hospital of Guangzhou Medical University GuangzhouChina The Second Affiliated Hospital of Guangzhou Medical University GuangzhouChina

Background:Rasagiline is a monoamine oxidase-B inhibitor used for Parkinson’s disease(PD)treatment,but its effectiveness on Chinese patients is *** study aimed to evaluate the efficacy and safety of rasagiline monotherapy in Chinese patients with early ***:A 26-weeks,randomized,double-blind,placebo-controlled study has been performed at 15 sites in China and enrolled outpatients(≥35 years old)with idiopathic PD without a history of using any dopaminergic *** were randomized 1:1 to receive rasagiline 1 mg once daily or *** primary endpoint was the change of the Unified Parkinson’s Disease Rating Scale(UPDRS)total score from baseline to 26 weeks *** endpoints included changes in UPDRS subscale scores from part Ⅰ to Ⅲ.Health status was assessed with the PD Questionnaire(PDQ)-39 and EuroQol-Five-Dimension(EQ-5D)*** profile was collected until 30 weeks after ***:A total of 130 patients(n=65/group)were recruited,and 127(rasagiline,n=64;placebo,n=63)were included in the full analysis *** characteristics were comparable between the two *** decrease in the mean UPDRS total score was greater in the rasagiline group than in the placebo group(−3.18±0.95 vs.−0.18±0.98,P=0.025),and the mean UPDRS part I non-motor symptoms score(−0.54±0.15 vs.-0.08±0.15,P=0.003)were significantly decreased in the rasagiline group compared with placebo treated *** improvement trend was observed in the active treatment group for the subscales evaluation with parts Ⅱ and Ⅲ,while the difference to placebo was not statistically *** quality assessed by the EQ-5D visual analog scale improved in the rasagiline group but worsened in placebo treated *** overall incidence of treatment-emergent adverse events(AEs)was slightly lower in the rasagiline group(41.5%)than in the placebo group(46.2%).Conclusions:Rasagiline is effective,safe,and well tolerated as monotherapy for the

关键词： Parkinson’s disease Monoamine oxidase inhibitor Rasagiline Monotherapy China

HMIBase: An Hierarchical Indexing System for Storing and Querying Big Data

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ZTE Communications 2014年第4期12卷 8-15页

作者： Shengmei Luo Di zhao Wei Ge Rong Gu chunfeng Yuan Yihua Huang ZTE Corporation Nanjing University

Relational database management systems are usually deployed on singlenode machines and have strict limitations in terms of da ta structure. This means they do not work well with big data, and NoSQL has been proposed as a solution. To make data querying more efficient, indexes and memory cache techniques are used in NoSQL databases. In this paper, we propose a hierarchical in dexing mechanism and a prototype distributed datastorage system, called HMIBase, which has hierarchical indexes for nonprima ry keys in tables and makes data querying more efficient. HMIBase uses HBase as the lower data storage and creates a memory cache for more efficient data transmission. HMIBase supports coprocessortoprocess update requests. It also provides a client with query and update APIs and a server to support RPCs from the client and finish jobs. To improve the cache hit ratio, we propose a memory cache replacement strategy, called Hot Score algorithm, in HMIBase. The experimental results show that Hot Score algo rithm is better than other cachereplacement strategies.

关键词： NoSQL In-Memory Index HMIBase Hot Score

Parameter Optimization and Precision Enhancement of Dual-Coil Eddy Current Sensor

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Journal of Shanghai Jiaotong university(Science) 2023年第5期28卷 596-603页

作者：张振宁刘强吕春峰毛义梅陶卫赵辉 Department of Instrument Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China Shandong Institute of Space Electronic Technology Yantai 264670ShandongChina College of Engineering Science and Technology Shanghai Ocean UniversityShanghai 201306China

To enhance the measurement precision of eddy current sensor in particular environments such asextreme temperature changes and limited available space in aerospace, we optimized the structural parameters ofthe traditional dual-coil eddy current sensor probe by electromagnetic field analysis and finite element simulationmodeling, and further presented the criteria for determining the optimal coil distance of the dual-coil probe. Thesimulation results are verified by setting up an experimental platform. For the extreme temperature environment,the displacement measurement error caused by the full range temperature variation of the dual-coil sensor underthe optimal distance is less than 21.0% of that of the single-coil sensor. On this basis, we analyzed and verified thethermal stability of the structurally optimized dual-coil eddy current sensor. After temperature compensation,the displacement measurement accuracy can reach 14.9 times more accurate than that of the single-coil *** method proposed in this paper can provide a design reference for the structural optimization of the axialdual-coil eddy current sensor probe.

关键词： eddy current sensor electromagnetic field analysis finite element simulation parameter optimization

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在役预应力混凝土箱梁开裂后承载力评估

同济大学学报（自然科学版） 2010年第9期38卷 1271-1275页

作者：赵煜贺拴海李春风葛耀君同济大学桥梁工程系上海200092 长安大学公路旧桥检测与加固交通行业重点实验室陕西西安710064

针对目前大量存在的在役预应力混凝土箱梁桥跨中下挠和开裂的现象,基于主要受力裂缝的外观统计特征,通过构造两类损伤单元,即正裂缝区损伤单元和斜裂缝区损伤单元,采用刚度折减和引入平面刚架模型的方法,建立了基于裂缝统计特征参数的... 详细信息

针对目前大量存在的在役预应力混凝土箱梁桥跨中下挠和开裂的现象,基于主要受力裂缝的外观统计特征,通过构造两类损伤单元,即正裂缝区损伤单元和斜裂缝区损伤单元,采用刚度折减和引入平面刚架模型的方法,建立了基于裂缝统计特征参数的损伤预应力混凝土箱梁计算模型,提出了基于截面刚度变化的预应力混凝土箱梁桥截面有效刚度折减系数和基于混凝土受压区应力变化程度的承载力折减系数,从而实现了对在役预应力混凝土结构开裂损伤后,在其使用过程中的受力性能评价.

关键词：桥梁工程预应力混凝土箱梁裂缝特征有效刚度承载力

Adjunct rasagiline to treat Parkinson’s disease with motor fluctuations:a randomized,double-blind study in China

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Translational Neurodegeneration 2018年第1期7卷 127-137页

作者： Zhenxin Zhang Ming Shao Shengdi Chen chunfeng Liu Rong Peng Yansheng Li Jian Wang Suiqiang Zhu Qiumin Qu Xiaoying Zhang Haibo Chen Xiangru Sun Yanping Wang Shenggang Sun Baorong Zhang Jimei Li Xiaoping Pan Gang zhao Department of Neurology Peking Union Medical College Hospital53 Dongdan N StDongchengBeijingChina Department of Neurology The First Affiliated Hospital of Guangzhou Medical UniversityGuangzhouChina Department of Neurology Ruijin HospitalShanghai Jiaotong University School of MedicineShanghaiChina Department of Neurology The Second Affiliated Hospital of Soochow UniversitySuzhouChina Department of Neurology West China HospitalSichuan UniversityChengduChina Department of Neurology Renji HospitalShanghai Jiaotong University School of MedicineShanghaiChina Department of Neurology Huashan HospitalFudan UniversityShanghaiChina Department of Neurology Tongji Hospital of Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Department of Neurology The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’anChina Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Department of Neurology Beijing HospitalBeijingChina Department of Neurology Peking University First HospitalBeijingChina Department of Neurology The Second Affiliated Hospital of Guangzhou Medical UniversityGuangzhouChina Department of Neurology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Department of Neurology The Second Affiliated hospital of Zhejiang University School of MedicineZhejiangHangzhouChina Department of Neurology Beijing Friendship HospitalCapital Medical UniversityBeijingChina Department of Neurology Guangzhou First People’s HospitalGuangzhouChina Department of Neurology Xijing HospitalThe First Affiliated Hospital of The Fourth Military Medical UniversityXi’anChina

Background:The use of adjunct rasagiline in levodopa-treated patients with Parkinson’s disease and motor fluctuations is supported by findings from large-scale clinical *** study is to investigate the efficacy and safety of adjunct rasagiline in Chinese patients with Parkinson’s disease,as a product registration ***:This 16-week,randomized,double-blind,parallel-group,multicenter,placebo-controlled study of rasagiline 1 mg/day included levodopa-treated patients with Parkinson’s disease and motor *** primary efficacy endpoint was mean change from baseline in total daily OFF time over 16 *** endpoints were Clinical Global Impressions–Improvement(CGI-I),and change in Unified Parkinson’s Disease Rating Scale(UPDRS)Activities of daily living(ADL)and Motor *** well-being(EQ-5D),and the frequency of adverse events were also ***:In total,324 levodopa-treated patients were randomized to rasagiline 1 mg/day(n=165)or placebo(n=159).Over 16 weeks,rasagiline statistically significantly reduced the mean[95% confidence interval]total daily OFF time versus placebo(−0.5 h[−0.92,−0.07];p=0.023).There were also statistically significant improvements versus placebo in CGI-I(−0.4 points[−0.61,−0.22];p<0.001),UPDRS-ADL OFF(−1.0 points[−1.75,−0.27];p=0.008),and UPDRS-Motor ON(−1.6 points[−3.05,−0.14];p=0.032)scores,as well as the EQ-5D utility index(p<0.05).Rasagiline was safe and well ***:In levodopa-treated Chinese patients with Parkinson’s disease and motor fluctuations,adjunct rasagiline 1 mg/day statistically significantly reduced OFF time,and improved daily function and overall well-being,versus *** with findings in other countries,adjunct rasagiline was proven efficacious and well tolerated in Chinese patients.

关键词： Parkinson’s disease Rasagiline Adjunct Motor fluctuations OFF time Quality of life China

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特定人群失眠诊断与治疗专家共识

中国临床药理学与治疗学 2024年第8期29卷 841-852页

作者：陈贵海邓丽影杜懿杰黄志力江帆金富锐李雁鹏刘春风潘集阳彭颜晖宿长军唐吉友王涛王赞吴惠涓薛蓉杨月嫦于逢春于欢詹淑琴张红菊张琳赵正卿赵忠新机构不详

不同人群的失眠存在各自不同的临床特征,诊断和治疗的过程需要依据这些特征来进行。本文就老年期失眠、女性特定生理时期失眠、儿童期失眠、阻塞性睡眠呼吸暂停患者的失眠以及肝肾功能损害患者的失眠等临床表现和治疗过程中需要关注的重... 详细信息

不同人群的失眠存在各自不同的临床特征,诊断和治疗的过程需要依据这些特征来进行。本文就老年期失眠、女性特定生理时期失眠、儿童期失眠、阻塞性睡眠呼吸暂停患者的失眠以及肝肾功能损害患者的失眠等临床表现和治疗过程中需要关注的重点,进行文献分析、交流讨论,并做出了治疗方案的推荐。期望加深临床医师对这些特定人群失眠发生机制的理解,对诊断、鉴别与治疗方法的选择,提供参考和帮助。

关键词：失眠诊断治疗共识

脓毒症抗菌药物降阶梯治疗的应用现状及其对结局的影响

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中华儿科杂志 2022年第3期60卷 203-208页

作者：赵艳杨妮刘春峰中国医科大学附属盛京医院儿科沈阳110004

目的分析儿童重症监护病房(PICU)细菌培养阳性的脓毒症患儿经验性抗菌药物治疗的恰当性,探讨抗菌药物降阶梯(ADE)治疗在PICU脓毒症患儿中的应用情况及其对结局的影响。方法回顾性分析2018年1月至2020年12月中国医科大学附属盛京医院PIC... 详细信息

目的分析儿童重症监护病房(PICU)细菌培养阳性的脓毒症患儿经验性抗菌药物治疗的恰当性,探讨抗菌药物降阶梯(ADE)治疗在PICU脓毒症患儿中的应用情况及其对结局的影响。方法回顾性分析2018年1月至2020年12月中国医科大学附属盛京医院PICU收治的123例脓毒症相关器官功能障碍及脓毒性休克患儿的一般情况、实验室检查、经验性抗菌药物使用及调整情况和ADE的实施率等临床资料。根据抗菌药物调整情况分为降阶梯组和非降阶梯组,比较其临床特点和结局指标。组间比较采用独立样本t检验、Mann-Whitney U检验、χ^(2)检验或Fisher确切概率法。结果123例患儿中男70例、女53例,年龄11.4(2.8,56.5)月龄,其中41例体液培养阳性,经验性抗菌药物治疗不足的有3例(7.3%),使用充足的有38例(92.7%),其中28例为抗菌药物使用过度,10例抗菌药物使用恰当。降阶梯组患儿46例、非降阶梯组患儿77例,两组间PICU全因病死率、住院花费、住院期间的机械通气时间及再次感染发生率差异均无统计学意义(均P>0.05)。对使用过针对多重耐药菌抗菌药物的101例患儿而言,降阶梯组患儿43例、非降阶梯组患儿58例,降阶梯组此类抗菌药物的使用时间比非降阶梯组短[5.0(4.0,12.0)比9.5(7.0,13.0)d,Z=-3.14,P=0.002]。结论经验性抗菌药物使用过度情况仍非常常见,但ADE的应用情况却不理想,ADE可以减少针对多重耐药菌抗菌药物的使用时间,并且对脓毒症患儿的结局无明显不良影响。

关键词：抗菌药脓毒症儿童预后

Therapeutic effect in patients with coronary heart disease based on information analysis from Traditional Chinese Medicine four diagnostic methods

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Journal of Traditional Chinese Medicine 2014年第1期34卷 34-41页

作者： Yiqin Wang Jin Xu Rui Guo Chaoxia Xu Yiming Hao chunfeng Chen Yijian Hong Xiangqun Xiao Wenjie Xu Jing Hong zhao Lei Laboratory of Information Access and Synthesis of Traditional Chinese Medicine Four Diagnostic School of Basic MedicineShanghai University of Traditional Chinese Medicine

OBJECTIVE:To study information gained by Traditional Chinese Medicine(TCM)four diagnostic methods and characteristics of syndrome development before and after treatment in patients with coronary heart disease,and to probe into assessment indexes of therapeutic effects with distinctive TCM ***:Information from the four diagnostic methods before and after treatment in 100 patients with coronary heart disease was collected using the TCM interrogation scale,a pulse condition instrument,a tongue-face diagnosis instrument,anda voice diagnosis information collection *** in the four diagnostic method results from before and after treatment were analyzed with frequency analysis and t-test ***:Before treatment,deficiency syndrome complicated with hyperactivity of pathogenic factors was most *** treatment,deficiency syndrome was most *** change from complex syndromes to single syndromes indicates disease and syndrome *** of symptoms gained by interrogation after treatment for syndrome of deficiency of heart-Qi,syndrome of deficiency of heart-Yin,and turbid phlegm syndrome were all less severe than those before *** of face color,color on all sub-regions of tongue,color of tongue fur,septic and greasy fur,and lip color after treatment all had significant *** treatment,part of the voice diagnosis parameters in the deficiency of heart-Yin and turbid phlegm syndromes had significant changes,but no significant changes were found in the deficiency of heart-Qi ***:Use of the TCM four diagnostic methods can provide an effective basis forTCM syndrome diagnosis,observation of development of state of illness,and evaluation of clinical therapeutic effects.

关键词： Medicine Chinese traditional Four di-agnostic methods Syndrome Treatment outcome Coronary disease

利用红外热像仪测量半透明体透射率的方法研究

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红外技术 2019年第6期41卷 549-554页

作者：王春峰赵小龙南京信息职业技术学院机电学院江苏南京210023 海军工程大学动力工程学院湖北武汉430033

针对E1897-97标准未给出半透明体透射率测量的理论模型,也未考虑被测材料温度变化对透射率测量结果影响问题,依据红外测温原理以及E1897-97标准的测量条件和测量方法,推导出了半透明体透射率测量的理论公式;选用了几种不同规格的半透明... 详细信息

针对E1897-97标准未给出半透明体透射率测量的理论模型,也未考虑被测材料温度变化对透射率测量结果影响问题,依据红外测温原理以及E1897-97标准的测量条件和测量方法,推导出了半透明体透射率测量的理论公式;选用了几种不同规格的半透明体双面硅进行了实验测试,将半透明体透射率实验测试值、理论计算值、出厂测量值进行分析比较,得到了在各种温度背景下半透明体的透射率测量值相对于理论计算值的误差,透射率测量值相对于出厂测量值的误差,分析了测量误差发生的原因。提出了一种减少半透明体透射率测量误差的方法,并通过实验进行了验证。实验结果与分析表明:考虑被测材料温度变化,对理论计算公式进行修正,并使用改进的半透明体透射率测量方法,透射率修正值与出厂测量值之间的误差降低到3%以下,证明了改进的透射率计算模型和透射率测量方法的正确性和可行性。

关键词：红外测温透射率半透明体