检索结果-南通市图书馆

Increased N6-methyladenosine is related to the promotion of the methyltransferase METTL14 in ovarian aging

在线全文

学校读者我要写书评

暂无评论

Genes & Diseases 2024年第3期11卷 151-154页

作者： chunfeng Qian Zhenxing liu Yonghong Qian Jie Ding Rulei Chen Han Su Minghong Shen Hong Li Boxian Huang State Key Laboratory of Reproductive Medicine and Offspring Health Suzhou Affliated Hospital of Nanjing Medicine and Offspring HealthSuzhou Affiliated Hospital of Nanjing Medical UniversitySuzhouMunicipal HospitalGusu SchoolNanjing Medical UniversitySuzhouJiangsu 215002China Department of Gynecology Affliated Suzhou Hospital of Nanjing Medical UniversitySuzhou Municipal HospitalGusu School of Nanjing Medical UniversitySuzhouJiangsu 215002China Department of Pathology Affiliated Suzhou Hospital of Nanjing Medical UniversitySuzhou Municipal HospitalGusu School of Nanjing Medical UniversitySuzhouJiangsu 215002China

The ovary is a vital female reproductive organ that functions to produce oocyte gametes and cyclically expressed sex hormones to maintain reproductive capacity and hormone homeostasis.Ovarian aging,characterized by declines in follicle quantity and oocyte quality,leads to premature ovarian failure,premature ovarian insufficiency,or diminished ovarian reserve,thus contributing to female infertility.Distinct gene-expression signatures from RNA transcriptional level and post-transcriptional regulation are relative to oocyte quality and reproductive age.

关键词： promotion signature maintain

A 1-bp deletion in the MC04g1399 is highly associated with failure to produce fruit wart in bitter gourd

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Horticultural Plant Journal 2024年第1期10卷 171-180页

作者： Jia liu Junjie Cui Jichi Dong Jian Zhong chunfeng Zhong Fanchong Yuan Wendong Guan Fang Hu Jiaowen Cheng Kailin Hu College of Horticulture South China Agricultural UniversityGuangzhouGuangdong 510642China Key Laboratory of Biology and Genetic Improvement of Horticultural Crops(South China) Ministry of Agriculture and Rural AffairsGuangzhouGuangdong 510642China Guangdong Vegetables Engineering Research Center GuangzhouGuangdong 510642China Department of Horticulture Foshan UniversityFoshanGuangdong 528225China Henry Fok School of Biology and Agricultural Shaoguan UniversityShaoguanGuangdong 512023China

Fruit wart is an important appearance trait influencing consumer preferences of bitter gourd(Momordica charantia L.).The molecular genetic mechanisms underlying fruit wart formation in bitter gourd are largely unknown.In this study,genetic analysis based on four generations showed that fruit wart formation in bitter gourd was controlled by a single dominant locus named as Fwa.The Fwa locus was initially mapped into a 4.82 Mb region on pseudochromosome 4 by BSA-seq analysis and subsequently narrowed down to a 286.30 kb region by linkage analysis.A large F2population consisting of 2360 individuals was used to screen recombinants,and the Fwa locus was finally fine mapped into a 22.70 kb region harboring four protein-coding genes through recombination analysis.MC04g1399,encoding an epidermal patterning factor 2-like protein,was proposed as the best candidate gene for Fwa via sequence variation and expression analysis.In addition,a 1-bp insertion and deletion(InDel)variation within MC04g1399 was converted to a cleaved amplified polymorphic sequence(CAPS)marker that could precisely distinguish between the warty and non-warty types with an accuracy rate of 100%among a wide panel of 126 bitter gourd germplasm resources.Our results not only provide a scientific basis for deciphering the molecular mechanisms underlying fruit wart formation but also provide a powerful tool for efficient genetic improvement of fruit wart via marker-assisted selection.

关键词： Bitter gourd Fruit wart Bulk segregant analysis Fine-mapping Candidate gene

Seasonal variations of nonmotor symptoms in patients with Parkinson's disease in Southeast China

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2023年第4期136卷 415-422页

作者： Jingyi Wang Kangping Xiong Jingyuan Chao Sheng Zhuang Jie Li chunfeng liu Department of Neurology and Clinical Research Center of Neurological Disease The Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu 215004China Sleep Center The Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu 215004China Institute of Neuroscience Soochow UniversitySuzhouJiangsu 215123China

Background:Studies suggest seasonal fluctuations of symptoms in Parkinson’s disease(PD)patients in Western countries.However,the association between seasonal change and variation in nonmotor symptoms(NMS)in Chinese PD patients is unclear.Here,we studied whether there is a change rule with annual cycle with severity of NMS for patients with PD in Southeast China.Methods:We studied 1005 PD patients between April 2008 and October 2020.Patients were classified into four seasons according to the 24 Chinese solar terms,based on assessment date.We compared comprehensive NMS scales and polysomnography parameters among groups and conducted further analysis of disease severity.Results:Among the 1005 patients studied,the mean age was 64.2±9.7 years and 569(56.6%)of them were men.Relative to the summer group,patients assessed during winter had higher Scales for Outcomes in Parkinson’s disease-Autonomic Dysfunction(SCOPA-AUT)scores(P=0.045).The sleep efficiency factor scores of Pittsburgh Sleep Quality Index in patients were higher during spring than summer(P=0.009).Among patients who completed polysomnography during the same period(n=135),compared with summer follow-ups,we observed a higher percentage of NREMS1 in winter and spring follow-ups(P=0.042,P=0.011),a higher NREMS1 time in spring follow-ups(P=0.0024),a lower NREMS2 time in winter follow-ups(P=0.007),and a higher percentage of phasic rapid eye movement(REM)-sleep without atonia in autumn and winter follow-ups(P=0.026 and P=0.020,respectively).In a subset of patients with PD and REM sleep behavior disorder(RBD;n=182),those visited during winter had higher scores for RBD questionnaire-Hong Kong and its factor 1(dream-related sub-score)than those visited during summer(P=0.034,P=0.020).We observed similar findings for SCOPA-AUT and sleep efficiency factor scores in early stage patients in subgroup analysis.Conclusions:PD patients assessed for follow-up during summer showed less severe symptoms of autonomic dysfunction and RBD symptoms than those assessed in winter,and l

关键词： Nonmotor symptoms Parkinson’s disease Seasonal variations

Effect of salt reduction on nutritional,functional and sensory aspects of Anhui‑style doubanjiang,a traditional Chinese broad bean paste

在线全文

学校读者我要写书评

暂无评论

Systems Microbiology and Biomanufacturing 2023年第2期3卷 262-272页

作者： Chengtuo Niu Xianlei Xing Feiyun Zheng chunfeng liu Jinjing Wang Qi Li Key Laboratory of Industrial Biotechnology Ministry of EducationSchool of BiotechnologyJiangnan UniversityWuxi 214122China Lab of Brewing Science and Technology School of BiotechnologyJiangnan UniversityWuxi 214122China School of Biotechnology Jiangnan University1800 Lihu AvenueWuxi 214122JiangsuChina

This study aimed to reveal the effect of salt reduction on the nutritional,functional and sensory aspects of doubanjiang through preparing three sets of doubanjiang fermentation(Sample H,Sample M and Sample L)with different salt concentrations.The results showed that fermentation with lower salt concentration led to significantly higher amino acids concentrations in doubanjiang,while the organic acids concentrations were also slightly increased.For biologically active compounds,the concentrations of total flavonoids,total phenols and five monomer isoflavones in Sample L were all significantly higher than those in Sample M and Sample H.Moreover,better anti-oxidant ability was observed in doubanjiang samples fermented with lower salt concentration.Bacillus and Millerozyma genus were found to be closely related to the formation of amino acids and biologically active compounds in doubanjiang,while organic acids were highly correlated with Cronobacter,Erwinia,Trabulsiella,Enterobacter and Millerozyma genus.Through sensory evaluation and electric tongue,unsatisfactory sensory characteristics,such as lighter color,strong acid taste and off-flavor,were found in lower salt fermented doubanjiang samples.This indicated that lower salt concentration favored the nutrition and function of doubanjiang while negatively influenced doubanjiang flavor.This study deepened our understanding of the roles of salt concentration on doubanjiang fermentation and provided guidance for the further development of low-salt doubanjiang.

关键词： Doubanjiang Salt concentration Nutritional compounds Anti-oxidant ability Biologically active compounds Sensory evaluation

Inflammation-associated peripheral blood cells and serum lipid levels are associated with Parkinson’s disease

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Medical Journal 2023年第5期136卷 621-622页

作者： Hong Jin Lanxiang Wang Yun Shen Chengjie Mao Jing Chen chunfeng liu Department of Neurology The Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu 215123China Department of Neurology Suqian First HospitalSuqianJiangsu 223800China Jiangsu Key Laboratory of Neuropsychiatric Diseases and Institute of Neuroscience Soochow UniversitySuzhouJiangsu 215123China.

To the Editor:Parkinson’s disease(PD)is one of the most common neurodegenerative disorders and the most common movement disorder worldwide.PD pathogenesis has been demonstrated to be associated with neuroinflammation and intestinal inflammation.Increased C-reactive protein(CRP)levels were related to freezing of gait and rapid PD progression,particularly in elderly patients.Recent research indicates that immune cells in peripheral blood might also contribute to PD pathogenesis,providing further insight into the relationship between inflammation and PD.

关键词： inflammation pathogenesis blood

Stabilization of Uncertain Systems With Markovian Modes of Time Delay and Quantization Density

在线全文

学校读者我要写书评

暂无评论

IEEE/CAA Journal of Automatica Sinica 2018年第2期5卷 463-470页

作者： Jufeng Wang chunfeng liu Department of Information and Computing China Jiliang University Hangzhou 310018 China Hangzhou Dianzi University Hangzhou 310018 China

This work studies the stabilization of a class of control systems that use communication networks as signal transmission medium. The lateral motion of independently actuated four-wheel vehicle is modeled as an uncertain-linear system. Time delay and quantization density are modeled as Markov chains.The networked control systems(NCSs) with plants being lateral motion are first transformed to switched linear systems with uncertain parameters. Sufficient and necessary conditions for the stochastic stability of closed-loop networked control systems are then established. By solving the matrix inequalities, this work presents an output-feedback controller that depends on the modes of time delay and quantization density. The controller performance is illustrated via a vehicular lateral motion system.

关键词： Networked control system(NCS) quantization stabilization time delay vehicle lateral motion

Different dosages of methylprednisolone therapy for acute necrotizing encephalopathy of childhood:a 6-year multicenter retrospective study

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2023年第6期136卷 743-745页

作者： Kechun Li Lijie Wang Gang liu Ping Jin Chaonan Fan Tao Zhang Meixian Xu Tao Zhou Chunyi liu Yeqing Wang chunfeng liu Suyun Qian Department of Pediatric Intensive Care Unit Beijing Children’s HospitalCapital Medical UniversityNational Center for Children’s HealthBeijing 100045China Department of Pediatrics Shengjing Hospital of China Medical UniversityLiaoningShenyang 110004China Department of Pediatric Intensive Care Unit Hebei Children’s HospitalHebei Medical UniversityShijiazhuangHebei 050031China Department of Pediatric Intensive Care Unit Bao’an Maternity and Child Health HospitalShenzhenGuangdong 518133China

To the Editor:Acute necrotizing encephalopathy(ANE)is a rare but often devastating neurologic disorder in children.[1]Hereditary susceptibility and cytokine storm play important roles in ANE pathogenesis,[2,3]but the ... 详细信息

关键词： dosage necrotizing Acute

在线全文

学校读者我要写书评

暂无评论

镇痛镇静治疗从舒适到器官功能保护

中华儿科杂志 2024年第3期62卷 193-195页

作者：许峰刘春峰钱素云重庆医科大学附属儿童医院重症医学科重庆400014 中国医科大学附属盛京医院儿科重症监护病房沈阳110004 首都医科大学附属北京儿童医院重症医学科北京100045

镇痛镇静治疗是儿童重症监护病房患儿的基本治疗措施,而器官功能支持与保护是镇痛镇静治疗的核心目的。镇痛镇静治疗与血流动力学支持、机械通气、持续肾脏替代治疗等具有同样的临床地位,已成为脑保护、肺保护、休克治疗以及器官功能衰... 详细信息

镇痛镇静治疗是儿童重症监护病房患儿的基本治疗措施,而器官功能支持与保护是镇痛镇静治疗的核心目的。镇痛镇静治疗与血流动力学支持、机械通气、持续肾脏替代治疗等具有同样的临床地位,已成为脑保护、肺保护、休克治疗以及器官功能衰竭防治的重要手段。

关键词：儿童重症监护病房持续肾脏替代治疗镇痛镇静治疗器官功能衰竭肺保护血流动力学基本治疗措施临床地位

Therapeutic potential of bright light therapy for the non-motor symptoms in Parkinson's disease

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2022年第2期135卷 243-244页

作者： Yun Shen Siyi Gong Yulu liu Jie Li Kangping Xiong Chengjie Mao Yali Wang Dan Li Fen Wang Hua Hu chunfeng liu Department of Neurology Suzhou Clinical Research Center of Neurological DiseaseThe Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu 215004China Jiangsu Key Laboratory of Neuropsychiatric Diseases Institute of NeuroscienceSoochow UniversitySuzhouJiangsu 215123China Department of Neurology Suzhou Municipal Hospital of Nanjing Medical UniversitySuzhouJiangsu 215008China Department of Neurology Suqian First HospitalSuqianJiangsu 223899China

To the Editor:Alterations of circadian rhythms seem to be the casual contribution to sleep disturbances,depression,and other non-motor symptoms in Parkinson's disease(PD).[1,2]By restoring the circadian rhythm,bright light therapy(BLT)might be a potentially new treatment option for PD.However,no studies have conclusively demonstrated the effects of BLT on the non-motor symptoms in PD.

关键词： symptoms therapy Therapeutic