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Appendiceal intussusception complicated by adenocarcinoma of the cecum:A case report

World Journal of Clinical Cases 2024年第8期12卷 1461-1466页

作者： Yu Long Yi-Ning Xiang Fei Huang Lei xu Xiao-yun Li yun-Huan Zhen Department of Colorectal Surgery The Affiliated Hospital of Guizhou Medical UniversityGuiyang 550001Guzihou ProvinceChina Department of Colorectal Surgery Guizhou Medical UniversityGuiyang 550001Guizhou ProvinceChina Department of Pathology The Affiliated Hospital of Guizhou Medical UniversityGuiyang 550001Guizhou ProvinceChina

BACKGROUND Appendiceal intussusception is a pathological condition in which the appendix is inverted into the cecum,which may cause symptoms that resemble those of other gastrointestinal disorders and may induce intestinal *** rarity of this case presentation is the co-occurrence of appendiceal intussusception and cecal adenocarcinoma,a combination that to our knowledge has not previously been reported in the medical *** case provides new insights into the complexities of diagnosing and managing overlapping *** SUMMARY A 25-year-old woman presented with persistent periumbilical pain and bloody *** initial biopsy showed cecal cancer;however,subsequent colonoscopy and computed tomography findings raised the suspicion of appendiceal intussus-ception,which was later confirmed *** unique case was charac-terized by a combination of intussusception and adenocarcinoma of the *** intervention included a laparoscopic right hemicolectomy,which led to the histopathological diagnosis of mucinous adenocarcinoma with appendiceal *** patient recovered well postoperatively and was advised to initiate adjuvant *** case highlights not only the importance of considering appendiceal intussusception in the differential diagnosis,but also the possibility of appendicitis and the atypical presentation of neoplastic *** Physicians should consider the possibility of appendiceal intussusception in cases of atypical appendicitis,particularly when associated with neoplastic presentation.

关键词： Appendiceal intussusception Appendicitis Cecal cancer Target signs Misdiagnosis Case report

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The Largest Chinese Cohort Study Indicates Homologous Recombination Pathway Gene Mutations as Another Major Genetic Risk Factor for Colorectal Cancer with Heterogeneous Clinical Phenotypes

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Research 2024年第3期6卷 191-203页

作者： yun xu Kai Liu Cong Li Minghan Li Fangqi Liu Xiaoyan Zhou Menghong Sun Megha Ranganathan Liying Zhang Sheng Wang Xin Hu Ye xu Department of Colorectal Surgery Fudan University Shanghai Cancer CenterShanghaiP.R.China Department of Pathology Fudan University Shanghai Cancer CenterShanghaiP.R.China Department of Pathology Tissue BankFudan University Shanghai Cancer CenterShanghaiP.R.China Department of Medicine Memorial Sloan Kettering Cancer CenterNew YorkNYUSA Department of Pathology and Laboratory Medicine David Geffen School of MedicineUniversity of CaliforniaLos AngelesCAUSA Precision Cancer Medical Center Fudan University Shanghai Cancer CenterShanghaiP.R.China

While genetic factors were associated with over 30% of colorectal cancer (CRC) patients, mutations in CRC-susceptibility genes were identified in only 5% to 10% of these patients. Besides, previous studies on hereditary CRC were largely designed to analyze germline mutations in patients with single genetic high-risk factor, which limited understanding of the association between genotype and phenotypes. From January 2015 to December 2018, we retrospectively enrolled 2,181 patients from 8,270 consecutive CRC cases, covering 5 categories of genetic high-risk factors. Leukocyte genomic DNA was analyzed for germline mutations in cancer predisposition genes. The germline mutations under each category were detected and analyzed in association with CRC susceptibility, clinical phenotypes, and prognoses. A total of 462 pathogenic variants were detected in 19.3% of enrolled CRC patients. Mismatch repair gene mutation was identified in 9.1% of patients, most prevalent across all high-risk groups. Homologous recombination (HR) gene mutations were detected in 6.5% of cases, penetrated in early-onset and extra-colonic cancer risk groups. Mutations in HR genes, including BARD1, RAD50, and ATM, were found to increase CRC risk with odds ratios of 2.8-, 3.1-, and 3.1-fold, respectively. CRC patients with distinct germline mutations manifested heterogeneous phenotypes in clinicopathology and long-term prognoses. Thus, germline mutation screenings should be performed for CRC patients with any of those genetic risk factors. This study also reveals that HR gene mutations may be another major driver for increased CRC risk.

关键词： susceptibility category Major

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Identification of male schizophrenia patients using brain morphology based on machine learning algorithms

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World Journal of Psychiatry 2024年第6期14卷 804-811页

作者： Tao Yu Wen-Zhi Pei chun-Yuan xu Chen-Chen Deng xu-Lai Zhang Department of Clinical Nutrition Hefei Fourth People’s HospitalHefei 230032Anhui ProvinceChina Department of Psychiatry Hefei Fourth People’s HospitalHefei 230032Anhui ProvinceChina Department of Gynaecology Anhui Maternal and Child Health HospitalHefei 230032Anhui ProvinceChina

BACKGROUND Schizophrenia is a severe psychiatric disease,and its prevalence is ***,diagnosis of early-stage schizophrenia is still considered a challenging *** To employ brain morphological features and machine learning method to differentiate male individuals with schizophrenia from healthy *** The least absolute shrinkage and selection operator and t tests were applied to select important features from structural magnetic resonance images as input features for *** commonly used machine learning algorithms,the general linear model,random forest(RF),k-nearest neighbors,and support vector machine algorithms,were used to develop the classification *** performance of the classification models was evaluated according to the area under the receiver operating characteristic curve(AUC).RESULTS A total of 8 important features with significant differences between groups were considered as input features for the establishment of classification models based on the four machine learning *** to other machine learning algorithms,RF yielded better performance in the discrimination of male schizophrenic individuals from healthy controls,with an AUC of *** Our research suggests that brain morphological features can be used to improve the early diagnosis of schizophrenia in male patients.

关键词： Schizophrenia Machine learning Classification Structure Magnetic Resonance imaging

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Effects of water extract from Cornus controversa on the expression levels of DiSOC1-b and DiCCoAOMT1 genes related with the growth of dove tree seedlings

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Journal of Plant Ecology 2024年第2期17卷 62-73页

作者： Xiaoyan Chen Zhengchuan Liang yun Long Jihong Pan Tingfa Dong Qinsong Liu Xiao xu College of Life Science China West Normal UniversityNanchongSichuan 637009China Key Laboratory of Southwest China Wildlife Resources Conservation(China West Normal University) Ministry of EducationNanchongSichuan 637009China Academy of Agricultural Sciences Liangshan Yi Autonomous PrefectureXichangSichuan 615000China

Although characterization of plant interactions has become a research hotspot to assess the adaptability of endangered plants,the underlying molecular basis remains *** tree(Davidia involucrata)seedlings were watered with distilled water(CK),leaf water extract(0.025 g mL^(-1))and branch water extract(0.1 g mL^(-1))from Cornus controversa,***,the morphology,biomass and gene expression levels of DiSOC1-b and DiCCoAOMT1 were *** results showed that morphological traits and biomass accumulation of *** seedlings were decreased by the addition of leaf water extracts,and increased by branch water ***,the gene expression level of DiSOC1-b was signifcantly down-regulated,while the gene expression level of DiCCoAOMT1 was signifcantly up-regulated in the stems and roots of *** upon treatment with leaf water extracts of *** contrast,the gene expression level of DiSOC1-b was signifcantly up-regulated in the leaves and stems,while the gene expression level of DiCCoAOMT1 was signifcantly down-regulated in the roots of *** upon treatment with branch water extracts of *** addition,the expression level of DiSOC1-b was positively correlated with most of morphological traits and total biomass(P<0.05),while DiCCoAOMT1 was negatively correlated with the majority of morphological traits in *** seedlings(P<0.05).Taken together,these results suggest that water extracts from the leaves and branches of the *** exhibit opposite allelopathic effects and affect the expression levels of genes related to growth(DiSOC1-b)and environmental adaptability(DiCCoAOMT1)in *** seedlings.

关键词： allelopathy Davidia involucrata DiCCoAOMT1 DiSOC1-b water extract

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MiRNA-145-5p inhibits gastric cancer progression via the serpin family E member 1-extracellular signal-regulated kinase-1/2 axis

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 2123-2140页

作者： Hong-Xia Bai xue-Mei Qiu chun-Hong xu Jian-Qiang Guo Department of Gastroenterology The Second Hospital of Shandong UniversityJinan 250000Shandong ProvinceChina Department of Gastroenterology Liaocheng People’s HospitalLiaocheng 252000Shandong ProvinceChina Department of Reproductive Center Zaozhuang Maternal and Child Health Care HospitalZaozhuang 277000Shandong ProvinceChina

BACKGROUND MicroRNAs(miRNAs)regulate gene expression and play a critical role in cancer ***,there is still a limited understanding of the function and regulatory mechanism of miRNAs in gastric cancer(GC).AIM To investigate the role and molecular mechanism of miRNA-145-5p(miR145-5p)in the progression of *** Real-time polymerase chain reaction(RT-PCR)was used to detect miRNA expression in human GC tissues and *** ability of cancer cells to migrate and invade was assessed using wound-healing and transwell assays,*** proliferation was measured using cell counting kit-8 and colony formation assays,and apoptosis was evaluated using flow *** of the epithelial-mesenchymal transition(EMT)-associated protein was determined by Western *** of miR-145-5p were predicated using bioinformatics analysis and verified using a dual-luciferase reporter *** family E member 1(SERPINE1)expression in GC tissues and cells was evaluated using RT-PCR and immunohistochemical *** correlation between SERPINE1 expression and overall patient survival was determined using Kaplan-Meier plot *** association between SERPINE1 and GC progression was also tested.A rescue experiment of SERPINE1 overexpression was conducted to verify the relationship between this protein and *** mechanism by which miR-145-5p influences GC progression was further explored by assessing tumor formation in nude *** GC tissues and cells had reduced miR-145-5p expression and SERPINE1 was identified as a direct target of this *** of miR-145-5p was associated with decreased GC cell proliferation,invasion,migration,and EMT,and these effects were reversed by forcing SERPINE1 ***-Meier plot analysis revealed that patients with higher SERPINE1 expression had a shorter survival rate than those with lower SERPINE1 *** mouse tumorigenesis experiments confirmed that miR-145-5p target

关键词： Gastric cancer MicroRNA-145-5p Serpin family E member 1 Epithelial-mesenchymal transition Proliferation Extracellular signal-regulated kinase-1/2

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Improved Flexible Triboelectric Nanogenerator Based on Tile-Nanostructure for Wireless Human Health Monitor

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Energy & Environmental Materials 2024年第4期7卷 386-395页

作者： Huamin Chen Shujun Guo Shaochun Zhang Yu Xiao Wei Yang Zhaoyang Sun xu Cai Run Fang Huining Wang yun xu Jun Wang Zhou Li Fujian Key Laboratory of Functional Marine Sensing Materials Minjiang University Beijing Institute of Nanoenergy and Nanosystems Chinese Academy of Sciences Institute of Semiconductors Chinese Academy of Sciences Beijing Key Laboratory of Inorganic Stretchable and Flexible Information Technology Faculty of Science and Engineering The University of Nottingham Ningbo China

Triboelectric nanogenerators (TENCs) have emerged as promising candidates for integrating with flexible electronics as self-powered systems owing to their intrinsic flexibility,biocompatibility,and *** this study,an improved flexible TENC with a tile-nanostructured MXene/polymethyl methacrylate (PMMA) composite electrode (MP-TENC) is proposed for use in wireless human health monitor.

关键词： flexible electrode MXene tile nanostructure triboelectric nanogenerator wireless monitor

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Status quo and factors of depression and anxiety in patients with non-muscle invasive bladder cancer after plasma electrocision

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World Journal of Psychiatry 2024年第6期14卷 822-828页

作者： Bing Lu Meng Ding Hong-Bo xu chun-Yin Yan Department of Urology Suzhou Dushu Lake HospitalSuzhou 215000Jiangsu ProvinceChina Department of Urology The First Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina

BACKGROUND Bladder cancer is a type of cancer with a high incidence in *** electrosurgery(PES)is often used in the treatment of bladder *** complications often cause depression and anxiety in patients after *** To investigate the current state of depression and anxiety after PES in patients with non-muscle-invasive bladder cancer and analyze the factors affecting *** A retrospective study was conducted to compare the baseline data of patients by collecting their medical history and grouping them according to their mental status into negative and normal *** regression analysis was used to explore the risk factors affecting the occurrence of anxiety and depression after surgery in patients with bladder *** Comparative analyses of baseline differences showed that the patients in the negative and normal groups differed in terms of their first surgery,economic status,educational level,and marital status.A logistic regression analysis showed that it affected the occurrence of anxiety in patients with bladder cancer,and the results showed that whether the risk factors were whether or not it was the first surgery,monthly income between 3000 and 3000-6000,secondary or junior high school education level,single,divorced,and widowed *** The risk factors affecting the onset of anxiety and depression in bladder cancer patients after PES are the number of surgeries,economic status,level of education,and marital *** study provides a reference for the clinical treatment and prognosis of bladder cancer patients in the future.

关键词： Bladder cancer Anxiety Depression Analysis of influencing factors Plasma electrocision

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2017年四川九寨沟M_s7.0地震前区域重力场变化

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地球物理学报 2017年第10期60卷 4124-4131页

作者：祝意青梁伟锋赵云峰刘芳隗寿春徐云马中国地震局第二监测中心西安710054

利用南北地震带2014-2017年期间的流动重力观测资料,系统分析了区域重力场变化及其与2017年8月8日四川九寨沟7.0级地震发生的关系.结果表明:①区域重力场异常变化与北西西向塔藏断裂和南北向岷江断裂带在空间上关系密切,反映了沿控震断... 详细信息

利用南北地震带2014-2017年期间的流动重力观测资料,系统分析了区域重力场变化及其与2017年8月8日四川九寨沟7.0级地震发生的关系.结果表明:①区域重力场异常变化与北西西向塔藏断裂和南北向岷江断裂带在空间上关系密切,反映了沿控震断裂在2013-2017年期间发生了引起地表重力变化效应的地壳变形和构造活动.②九寨沟地震前,测区内出现了大空间范围的区域性重力异常,而震源区附近产生了局部重力异常,沿塔藏断裂带形成了重力变化高梯度带,其中,甘肃玛曲、迭部、青海河南蒙古族自治县、四川若尔盖、九寨沟一带重力差异变化达100×10^(-8)m·s^(-2)以上;这些可能反映九寨沟地震前,区域及震源区附近均产生与该地震孕育、发生有关的构造运动或应力增强作用.③九寨沟地震震中位于重力差异运动剧烈的鞍部等值线附近,与断裂走向基本一致的重力变化高梯度带零值线上,这一观测事实进一步佐证了重力场动态变化图像对强震地点预测具有重要的指示意义.

关键词：南北地震带重力观测重力变化九寨沟地震中期前兆

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Advanced oxidation via the synergy of C-defective/C-O band modified ultrathin porous g-C3N4 and PMS for efficient photothermal degradation of bisphenol pollutants and lignin derivatives

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Green Energy & Environment 2024年第7期9卷 1159-1170页

作者： Liquan Jing Meng Xie Yuanguo xu chun Tong Xia Du Heng Zhao Na Zhong Huaming Li Jinguang Hu School of Chemistry and Chemical Engineering Jiangsu University Department of Chemical and Petroleum Engineering University of Calgary School of Pharmacy Jiangsu University School of Material Science & Chemical Engineering Harbin University of Science and Technology Institute for Energy Research Jiangsu University

This work uses thermal polymerization of urea nitrate, oxyacetic acid and urea as the raw material to prepare ultra-thin porous carbon nitride with carbon defects and C-O band（OA-UN-CN）. Density functional theory（DFT） calculations showed OA-UN-CN had narrower band gap,faster electron transport and a new internal construction electric field. Additionally, the prepared OA-UN-CN significantly enhanced photocatalytic activation of peroxymonosulfate（PMS） due to enhanced light absorption performance and faster electron overflow. As the result, the OA-UN-CN/PMS could entirely degrade bisphenol A（BPA） within 30 min, where the photodegradation rate was 81.8 and 7.9 times higher than that of g-C3N4and OA-UN-CN, respectively. Beyond, the OA-UN-CN/PMS could likewise degrade other bisphenol pollutants and sodium lignosulfonate efficiently. We suggested possible photocatalytic degradation pathways accordingly and explored the toxicity of its degradation products. This work provides a new idea on the development of advanced photocatalytic oxidation processes for the treatment of bisphenol pollutants and lignin derivatives, via a metal-free photothermal-catalyst.

关键词： Photothermal-catalytic G-C 3 N 4 Peroxymonosulfate Bisphenol Sodium lignosulfonate

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Recent advances in Pt catalysts and membrane electrode assemblies fabrication for proton exchange membrane fuel cells

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Rare Metals 2024年第9期43卷 4198-4221页

作者： Miao Ma Li-Xiao Shen Jing Liu Bin xu yun-Long Zhang Lei Zhao Zhen-Bo Wang School of Chemistry and Chemical Engineering Harbin Institute of TechnologyHarbin 150001China College of Environmental and Chemical Engineering Yanshan UniversityQinhuangdao 066004China Unipower Hydrogen Technology(Jiangsu)Corporation Changzhou 213176China

Proton exchange membrane fuel cells(PEMFCs)have been identified as a highly promising means of achieving sustainable energy conversion.A crucial factor in enhancing the performance of PEMFCs for further potential energy applications is the advancement in the field of catalyst engineering that has led to remarkable performance enhancement in facilitating the oxygen reduction reaction(ORR).Subsequently,it is important to acknowledge that the techniques used in preparation of membrane electrode assemblies(MEAs),the vital constituents of PEMFCs,also possess direct and critical influence on exhibiting the full catalytic activity of meticulously crafted ***,a succinct summary of the most recent advancements in Pt catalysts for ORR was offered and their underly catalytic mechanism were ***,both laboratory-scale and industrial-scale MEA fabrication techniques of Pt catalysts were ***,a detailed analysis of the connections between materials,process,and performance in MEA fabrication was presented in order to facilitate the development of optimal catalyst layers.

关键词： Pt catalysts Oxygen reduction reaction Membrane electrode assemblies MEA fabrication techniques

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