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Dimension of marriage and adultery in The scarlet letter

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Sino-US English Teaching 2007年第9期4卷 62-64页

作者： ZHA O zhao-xia Department of Foreign Language Teaching and Research Hebei University of Economics and Business Shijiazhuang 050061 China

The story The scarlet letter happened in the later seventeenth century by Hawthorn, when the Puritans had declined in morality. Hawthorne points out that the suffering and agony of the characters in The scarlet letter is due to an ill-conceived marriage. At the same time Hawthorne lightens the story in that he invents his own moral dimension of marriage and adultery and suggests that marriage should be based on the communion of the souls.

关键词： dimension marriage adultery

烧结助剂Li_(2)CO_(3)对钽酸钇激光透明陶瓷热—力—光学性质的影响

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现代技术陶瓷 2024年第3期45卷 268-278页

作者：利建雨李家麒马猛葛春宇赵子樊冯晶昆明理工大学材料科学与工程学院昆明650093 佳木斯大学材料科学与工程学院黑龙江佳木斯154007

以五氧化二钽和氧化钇为原料,Li_(2)CO_(3)为烧结助剂,通过高温固相反应烧结法制备了钽酸钇(YTaO_(4))透明陶瓷,并系统研究了Li_(2)CO_(3)对钽酸钇陶瓷热—力—光学性质的影响。结果表明:在1530℃烧结可获得致密透明陶瓷,并且物相中含... 详细信息

以五氧化二钽和氧化钇为原料,Li_(2)CO_(3)为烧结助剂,通过高温固相反应烧结法制备了钽酸钇(YTaO_(4))透明陶瓷,并系统研究了Li_(2)CO_(3)对钽酸钇陶瓷热—力—光学性质的影响。结果表明:在1530℃烧结可获得致密透明陶瓷,并且物相中含有第二相Li_(3)TaO_(4);随着烧结助剂量增加,样品中第二相含量呈上升趋势;所制备的透明陶瓷试样具有稳定的热膨胀系数,其范围在8.28.6×10^(-6)K^(-1)之间(常温-900℃);试样的杨氏模量和硬度均随着掺入烧结助剂量的增加而减小;掺入6%的烧结助剂时,YTaO_(4)陶瓷的透光率可以稳定保持在80%以上,表明YTaO_(4)陶瓷具有优越的光学性质,在激光透明陶瓷领域具有良好的应用前景。

关键词：透明陶瓷低温烧结热膨胀系数杨氏模量透射率

基于高光谱成像的主成分分析和波谱角分类技术的天麻粉质量标志物及相关成分可视化快速检测

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食品安全质量检测学报 2024年第8期15卷 173-183页

作者：胡爽王海瑞赵春琦刘婧影张巍白雪媛长春中医药大学东北亚中医药研究院长春130021 长春中医药大学药学院长春130021

目的利用高光谱成像(hyperspectral imaging,HSI)技术,通过一种原位质量标志物评估方法,与高效液相色谱含量测定相结合,建立预测模型对不同来源的天麻粉进行可视化评价。方法采用高效液相色谱法测定不同产地、不同晾干方式天麻粉中6种... 详细信息

目的利用高光谱成像(hyperspectral imaging,HSI)技术,通过一种原位质量标志物评估方法,与高效液相色谱含量测定相结合,建立预测模型对不同来源的天麻粉进行可视化评价。方法采用高效液相色谱法测定不同产地、不同晾干方式天麻粉中6种质量标志物含量并作为金标准;苯酚-硫酸法测定天麻多糖含量、水分测定仪测定含水量,两者作为辅助评价指标。HSI选用可见近红外(visible near-infrared,VNIR)和短波红外(short wave infrared,SWIR)双波段光谱进行分析比较。结果以鲜品切块晾干方式制备的天麻粉的质量标志物对羟基苯甲醇、多糖和水分含量均增加,同时天麻素和巴利森苷含量显著减少甚至消失。根据高光谱图像主成分分析(principal component analysis,PCA)预处理特征,基于波谱角(spectral angle mapper,SAM)的监督分类算法对不同产地和加工方式制备的天麻粉进行了原位、无损分类,其建立的线性回归模型实现了质量标志物含量的反演预测。结论通过高效液相色谱含量测定的准确性和高光谱原位预测的无损性相结合的方式进行现场可视化评价和预测,可以为不同产地、不同加工方式的天麻粉质量标志物快速检测提供技术参考。

关键词：天麻粉产地加工高光谱质量标志物

Projections from Infralimbic Cortex to Paraventricular Thalamus Mediate Fear Extinction Retrieval

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Neuroscience Bulletin 2021年第2期37卷 229-241页

作者： Yan Tao Cheng-Yun Cai Jia-Yun xian xiao-Lin Kou Yu-Hui Lin Cheng Qin Hai-Yin Wu Lei Chang chun-xia Luo Dong-Ya Zhu Department of Pharmacology School of PharmacyNanjing Medical UniversityNanjing 211166China Institution of Stem Cells and Neuroregeneration Nanjing Medical UniversityNanjing 211166China Guangdong-Hong Kong Greater Bay Area Center for Brain Science and Brain-Inspired Intelligence-MacaoGuangzhou 510000China

The paraventricular nucleus of the thalamus(PVT),which serves as a hub,receives dense projections from the medial prefrontal cortex(mPFC)and projects to the lateral division of central amygdala(CeL).The infralimbic(IL)cortex plays a crucial role in encoding and recalling fear extinction ***,we found that neurons in the PVT and IL were strongly activated during fear extinction *** PVT neurons inhibited extinction retrieval at recent time point(24 h after extinction),while activating them promoted extinction retrieval at remote time point(7 d after extinction),suggesting a critical role of the PVT in extinction *** the mPFC-PVT circuit,projections from IL rather than prelimbic cortex to the PVT were dominant,and disrupting the IL-PVT projection suppressed extinction ***,the axons of PVT neurons preferentially projected to the *** the PVT-CeL circuit also suppressed extinction ***,our findings reveal a new neural circuit for fear extinction retrieval outside the classical IL-amygdala circuit.

关键词： Paraventricular thalamus Infralimbic cortex Medial prefrontal cortex Amygdala Fear extinction retrieval Neural circuit Post-traumatic stress disorder

血浆cfDNA甲基化联合检测在肝癌诊断中的价值

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河南医学研究 2024年第11期33卷 1921-1925页

作者：夏娜梅赵言腾杨乾坤董兰兰张玮黄月臧文巧郑州大学基础医学院河南郑州450000 郑州大学第一附属医院输血科河南郑州450000 武汉艾米森生命科技有限公司研发部湖北武汉430000

目的探讨血浆循环游离DNA(cfDNA)中GNB4、TCF24、Riplet、ACP1和TSPYL5基因甲基化对肝癌诊断的临床价值。方法利用滑动窗口技术在公共数据库中筛选肝癌和正常组织间的差异甲基化标志物并分析其甲基化水平。从郑州大学第一附属医院收... 详细信息

目的探讨血浆循环游离DNA(cfDNA)中GNB4、TCF24、Riplet、ACP1和TSPYL5基因甲基化对肝癌诊断的临床价值。方法利用滑动窗口技术在公共数据库中筛选肝癌和正常组织间的差异甲基化标志物并分析其甲基化水平。从郑州大学第一附属医院收集肝癌、肝硬化组织和健康人白细胞样本,Sanger测序检测筛选出的标志物的甲基化水平,选出敏感度和特异度较好的标志物。收集24例肝癌、23例肝硬化和99例健康人血浆,通过甲基化特异性PCR检测上述标志物单独和组合时对肝癌的诊断性能。结果 5个标志物(GNB4、TCF24、Riplet、ACP1和TSPYL5)在肝癌样本中显著高甲基化。组织测序结果显示除TCF24外,其他标志物在肝硬化组织中的甲基化阴性率均大于80.0%。在血浆样本验证中,GNB4单独诊断肝癌的曲线下面积(AUC)最大,为0.765,敏感度为66.7%,特异度为91.8%。在多基因组合中,GNB4+TSPYL5的诊断性能最佳,AUC值为0.893,敏感度为83.3%,特异度为90.2%。结论 GNB4、Riplet、ACP1和TSPYL5甲基化可用于肝癌诊断,且联合诊断性能优于单一基因。

关键词：肝癌循环游离DNA 甲基化血浆诊断

Extractum trametes robiniophila murr protects murine podocyte via actin cytoskeleton stabilization

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Journal of Chinese Pharmaceutical Sciences 2021年第3期30卷 230-238页

作者： Xuan Luo Qing Du Haiyan zhao Wenhai Fan Xin Gao xia Gao Department of Pediatric People’s Hospital of Gansu provinceLanzhouGansu 730000China Department of Intensive care center People’s Hospital of Gansu provinceLanzhouGansu 730000China Nephrology department Guangzhou Women and Children’s Medical CenterGuangzhou city 510623China

The Chinese medicine Extractum trametes robiniophila murr(ETRM)is the extract of a type of *** studies have suggested that ETRM efficiently improves the effacement of podocyte foot processes in adriamycin(ADR)-induced nephrotic *** the present study,we aimed to assess whether ETRM modulated the actin rearrangements of podocytes and involved signaling molecules,includingα-actinin-4 and *** were treated with ADR(0.5μmol/L),ADR(0.5μmol/L)+dexamethasone(Dex)(1μmol/L),ADR(0.5μmol/L)+ETRM(10 mg/mL).The F-actin in the podocytes was stained by fluorescent phallotoxins and observed by confocal *** expression levels ofα-actinin-4 and nephrin were tested by real-time PCR and Western blotting *** administration of ETRM could significantly prevent ADR-treated podocytes from actin *** ETRM and Dex could stabilize podocyte actin ***,α-actinin-4 might act as a potential target for ETRM functionality in podocyte actin ***,pretreatment with ETRM could not inhibit the up-regulation of nephrin as a result of ADR *** could improve the cytoskeleton stability in ADR-induced actin rearrangement of podocytes via regulatingα-actinin-4 expression.

关键词： Actin rearrangements Extractum trametes robiniophila murr Foot processes Adriamycin

Detection of Antibody to Hepatitis Delta Virus in Human Serum by Double Antigen Sandwich ELISA

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Virologica Sinica 2009年第1期24卷 45-51页

作者： Li XIE De-zhuang HUANG Li-xiang HE zhao-xia LUO Yu-sen ZHOU xiao-dong WU Beijing You-An Hospital Capital University of Medical Science Beijing 100069 China Beijing Institute ofMicrobiology and Epidemiology Beijing 100071 China Department of Biology Graduate University ofChinese Academy of Sciences Beijing 100049 China

A simple rapid detection of antibody to hepatitis delta virus (anti-HDV) in human serum was developed by using double antigen sandwich ELISA. HDV gene fragment encoding HDAg was isolated from a Chinese patient infected with HDV by RT-PCR, and a high-efficient expression HD-PQE31 strain was constructed with the fragment. We obtained high titer and good quality hepatitis delta virus protein purified by Ni-NTA metal-affinity chromatography, which was identified by Western blot and ELISA, then we set up the double antigen sandwich ELISA for detection of anti-HDV in human serum, and the performance of the sandwich ELISA was evaluated in terms of specificity and sensitivity. Results were: 1) The purified HDAg protein’s purity was 90%, and its ELISA titer was 1/100 000. 2) 42 anti-HDV positive sera were detected and showed that the sensitivity of sandwich ELISA was higher than that of competitive ELISA (t=2.44, p<0.01). 3) The inhibitory rates for 2 anti-HDV positive sera by the specific HDAg were 74% and 93% respectively. 4) For the assay of specificity, all 60 samples infected by other hepatitis viruses and 30 normal samples were negative for anti-HDV. These results suggested that the double antigen sandwich ELISA with purified recombinant HDAg showed higher specificity and sensitivity, It can be used in routine laboratories to diagnose the HDV infection.

关键词： Hepatitis delta virus Hepatitis delta virus antigen Anti-HDV Sandwich ELISA

Endoscopic nasojejunal feeding tube placement in patients with severe hepatopancreatobiliary diseases:a retrospective study of 184 patients

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Hepatobiliary & Pancreatic Diseases International 2010年第1期9卷 54-59页

作者： Ji, Feng zhao, Jing-Li Jin, Xi Jiao, chun-Hua Hu, Yu-Yao Xu, Qin-Wei Chen, Wei-Xing Zhejiang Univ Sch Med Affiliated Hosp 1 Dept Gastroenterol Hangzhou 310003 Zhejiang Peoples R China

BACKGROUND: Total parenteral nutrition (TPN) has been recognized as the mainstay of nutritional support in patients with severe hepatopancreatobiliary (HPB) diseases for decades. However, recent studies advocate the utilization of endoscopic nasojejunal feeding tube placement (ENFTP), rather than the conventional approach. This study was designed to compare the clinical value of ENFTP and TPN in patients with severe HPB diseases. METHODS: Two groups of patients with severe HPB diseases were analyzed retrospectively. One group of 88 patients received ENFTP, and the other 96 received TPN. Routine blood levels, serum glucose and prealbumin, hepatic and renal function, serum lipid, and calcium were measured at baseline and after 1, 2, and 4 weeks of nutritional support. Also, complication rate, mortality, nutritional support time, mechanical ventilation time, mean length of time in intensive care unit, and duration of hospital stay were analyzed. RESULTS: After 4 weeks of nutritional support, the degree of recovery of red blood cells, prealbumin, and blood glucose was greater in the ENFTP than in the TPN group (P<0.05). Furthermore, the ENFTP group showed a lower incidence of septicemia, multiple organ dysfunction syndrome, peripancreatic infection, biliary infection, and nosocomial infection, in addition to shorter nutritional support time and hospital stay (P<0.05). CONCLUSIONS: ENFTP is much more effective than TPN in assisting patients with severe HPB diseases to recover from anemia, low prealbumin level, and high serum glucose, as well as in decreasing the rates of various infections (pulmonary infection excluded), multiple organ dysfunction syndrome rate, nutrition support time, and length of hospital stay. Therefore, ENFTP is safer and more economical for clinical application.

关键词： tube feeding, nasojejunal endoscopy parenteral nutrition, total hepatobiliary disease pancreatic disease

Structural impairment patterns in peripapillary retinal fiber layer and retinal ganglion cell layer in mitochondrial optic neuropathies

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International Journal of Ophthalmology(English edition) 2018年第10期11卷 1643-1648页

作者： Da Teng chun-xia Peng Hai-Yan Qian Li Li Wei Wang Jun-Qing Wang Bing Chen Huan-Fen Zhou Shi-Hui Wei Ophthalmology Department Chinese PLA General Hospital Department of Ophthalmology Beijing Children’s Hospital Capital Medical University Zhongshan Ophthalmic Center Sun Yat-sen University

AIM：To evaluate the structural injure patterns in peripapillary retinal fiber layer （pRNFL）, retinal ganglion cell layer （RGCL） and their correlations to visual function in various mitochondrial optic neuropathies （MON） to offer help to their differential ***：Totally 32 MON patients （60 eyes） were recruited within 6mo after clinical onsets, including 20 Leber hereditary optic neuropathy （LHON） patients （37eyes）, 12 ethambutol-induced optic neuropathy （EON）patients （23 eyes）, and 41 age-gender matched healthy controls （HC, 82 eyes）. All subjects had pRNFL and RGCL examinations with optic coherence tomography （OCT） and visual function ***：In the early stages of MON, the temporal pRNFL thickness decreased （66.09±22.57μm）, but increased in other quadrants, compared to HC （76.95±14.81μm）. The other quadrants remaining stable for LHON and EON patients besides the second hour sector of pRNFL thickness reduced and the temporal pRNFL decreased （56.78±15.87μm） for EON. Total macular thickness in MON reduced remarkably（279.25±18.90μm; P=0.015）, which mainly occurring in the inner circle （3 mm diameter of circle） and the nasal temporal sectors in the outer circle （5.5 mm diameter of circle）, in contrast to those in HC. RGCL thickness reduced in each sector of the macula （61.90±8.73μm; P≤0.001）. It strongly showed the correlationship of best corrected visual acuity （R=0.50, P=0.0003） and visual field injury （R=0.54,P=0.0002） in MON ***：OCT is a potential tool for detecting structural alterations in the optic nerves of various MON. Different types of MON may have different damage patterns.

关键词： mitochondrial optic neuropathies peripapillary retinal fiber layer retinal ganglion cell layer visual function Leber hereditary optic neuropathy ethambutol-induced optic neuropathy