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Trends of alkaline phosphatase to prealbumin ratio in patients with hepatitis B linked to hepatocellular carcinoma development

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World Journal of Gastroenterology 2025年第2期31卷 42-51页

作者： wen-Chong Zhen Jing Sun Xue-Ting Bai Qian Zhang Zi-Han Li Yi-Xin Zhang Rong-Xuan Xu Wei Wu Zhi-Han Yao chun-wen pu Xiao-Feng Li School of public Health Dalian Medical UniversityDalian 116044Liaoning ProvinceChina Graduate School Dalian Medical UniversityDalian 116044Liaoning ProvinceChina Dalian public Health Clinical Center Dalian Municipal Research Institute for Public HealthDalian 116001Liaoning ProvinceChina Department of Epidemiology and Health Statistics Dalian Medical UniversityDalian 116044Liaoning ProvinceChina

BACKGROUND Chronic hepatitis B often progresses silently toward hepatocellular carcinoma(HCC),a leading cause of mortality *** detection of HCC is crucial,yet *** To investigate the role of dynamic changes in alkaline phosphatase to prealbumin ratio(APR)in hepatitis B progression to *** Data from 4843 patients with hepatitis B(January 2015 to January 2024)were *** incidence rates in males and females were compared using the log-rank *** were evaluated using Kaplan–Meier *** Linear Mixed-Effects Model was applied to track the fluctuation of APR levels over ***,Joint Modeling of Longitudinal and Survival data was employed to investigate the temporal relationship between APR and HCC *** The incidence of HCC was higher in *** ensure the model’s normality assumption,this study applied a logarithmic transformation to APR,yielding *** levels were higher in females(t=5.26,P<0.01).A 1-unit increase in ratio correlated with a 2.005-fold higher risk of HCC in males(95%CI:1.653-2.431)and a 2.273-fold higher risk in females(95%CI:1.620-3.190).CONCLUSION Males are more prone to HCC,while females have higher APR *** no baseline APR link,rising APR indicates a higher HCC risk.

关键词： Alkaline phosphatase to prealbumin ratio Chronic hepatitis B patients Hepatocellular carcinoma Retrospective cohort study Linear Mixed-Effect Mode Joint Modelling of Longitudinal and Survival data

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Clinical characteristics of patients with hepatitis and cirrhosis and the construction of a prediction model

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World Journal of Hepatology 2025年第2期17卷 54-64页

作者： Yu-Shuang Huang Wei Gao Ai-Jun Sun chun-wen pu Shuang-Shuang Xu Department of Infectious Diseases Dalian Public Health Clinical CenterDalian 116031Liaoning ProvinceChina Department of Gastroenterology The First Affiliated Hospital of Dalian Medical UniversityDalian 116011Liaoning ProvinceChina Dalian public Health Clinical Center Dalian Municipal Research Institute for Public HealthDalian 116031Liaoning ProvinceChina

BACKGROUND Hepatitis B-associated cirrhosis is an important disease burden in ***,there is a lack of effective predictors in clinical practice to drive delivery and enable early treatment to delay disease *** To analyzing the clinical characteristics of patients with hepatitis and cirrhosis,the nomogram model was established and *** The clinical data of 1070 patients with hepatitis B who were treated in our hospital from October 2015 to July 2022 were *** a 7:3 ratio,749 cases were divided into training cohorts and 321 cases were divided into validation *** addition,the training cohort and validation cohort were further divided into hepatitis group and hepatitis B-related cirrhosis group based on whether the patient progressed to *** logistic regression was used to analyze the influencing factors of hepatitis progression to cirrhosis.A roadmap prediction model was established,and the predictive effect of the model was evaluated by patientsubject receiver operating characteristic curve(ROC),and the effectiveness of the model was evaluated by decision curve *** Binary logistic regression analysis was performed using hepatitis B-related cirrhosis=1 and hepatitis=0 as dependent variables,and univariate analysis of serological indicators was used as *** results showed that glutamic oxaloacetate aminotransferase/glutamate acetone aminotransferase levels,prothrombin time activity,and hepatitis B e antigen levels were all contributing factors to the progression of hepatitis to *** area under the ROC curve was 0.693[95%confidence interval(CI):0.631 to 0.756]for the training cohort and 0.675(95%CI:0.561 to 0.790)for the validation *** addition,the decision analysis curves of the prediction models of both the training cohort and the validation cohort confirmed the effectiveness of the nomogram prediction *** Three independent factors influencing the progression

关键词： Hepatitis Hepatitis B-related cirrhosis Clinical features Influencing factors Nomogram

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Non alcoholic steatohepatitis a precursor for hepatocellular carcinoma development

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World Journal of Gastroenterology 2014年第44期20卷 16464-16473页

作者： chun-Meng Jiang chun-wen pu Ya-Hui Hou Zhe Chen Mohammed Alanazy Lionel Hebbard Department of Digestive System the Second Affiliated Hospital of Dalian Medical University Department of Liver Disease Dalian the Sixth People’s Hospital Department of General Surgery the Second Affiliated Hospital of Dalian Medical University Storr Liver Unit Westmead Millennium Institute University of Sydney

Hepatocellular carcinoma(HCC) is increasing in prevalence and is one of the most common cancers in the world. Chief amongst the risks of attaining HCC are hepatitis B and C infection, aflatoxin B1 ingestion, alcoholism and obesity. The later has been shown to promote non alcoholic fatty liver disease, which can lead to the inflammatory form non alcoholic steatohepatitis(NASH). NASH is a complex metabolic disorder that can impact greatly on hepatic function. The mechanisms by which NASH promotes HCC are only beginning to be characterized. Here in this review, we give an overview of the recent novel mechanisms published that have been associated with NASH and subsequent HCC progression. We will focus our discussion on inflammation and gut derived inflammation and how they contribute to NASH driven HCC.

关键词： Nonalcoholic steatohepatitis Hepatocellular carcinoma Inflammation Microbiome Bile acids

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Low-profile,low sidelobe array antenna with ultrawide beam coverage for UAV communication

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Chinese Journal of Aeronautics 2025年第1期38卷 444-454页

作者： Mei LI Zhiliang SHANG Lin pu Ming-chun TANG Lei ZHU School of Microelectronics and Communication Engineering Chongqing UniversityChongqing 400044China Department of Electrical and Computer Engineering University of MacaoMacao SAR 999078China

This paper presents a design method to implement an antenna array characterized by ultra-wide beam coverage,low profile,and low Sidelobe Level(SLL)for the application of Unmanned Aerial Vehicle(UAV)air-to-ground *** array consists of ten broadside-radiating,ultrawide-beamwidth elements that are cascaded by a central-symmetry series-fed network with tapered currents following Dolph-Chebyshev distribution to provide low ***,an innovative design of end-fire Huygens source antenna that is compatible with metal ground is presented.A low-profile,half-mode Microstrip Patch Antenna(MPA)is utilized to serve as the magnetic dipole and a monopole is utilized to serves as the electric dipole,constructing the compact,end-fire,grounded Huygens source ***,two opposite-oriented end-fire Huygens source antennas are seamlessly integrated into a single antenna element in the form of monopole-loaded MPA to accomplish the ultrawide,broadside-radiating *** consideration has been applied into the design of series-fed network as well as antenna element to compensate the adverse coupling effects between elements on the radiation *** indicates an ultrawide Half-Power Beamwidth(HPBW)of 161°and a low SLL of-25 dB with a high gain of 12 d Bi under a single-layer *** concurrent ultrawide beamwidth and low SLL make it particularly attractive for applications of UAV air-to-ground communication.

关键词： Array antenna Broad beam Fan beam Low sidelobe level Chebyshev synthesis UAV communication

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Perilipin2 inhibits the replication of hepatitis B virus deoxyribonucleic acid by regulating autophagy under high-fat conditions

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World Journal of Virology 2023年第5期12卷 296-308页

作者： Chuang Wang Xiao-Yun Gao Mei Han Meng-chun Jiang Xiao-Yi Shi chun-wen pu Xuan Du Graduate School Graduate School of Dalian Medical UniversityDalian 116000Liaoning ProvinceChina Department of Geriatric The Second Affiliated Hospital of Dalian Medical UniversityDalian 116023Liaoning ProvinceChina Department of Gastroenterology The Second Affiliated Hospital of Dalian Medical UniversityDalian 116023Liaoning ProvinceChina Dalian public Health Clinical Center Dalian Municipal Research Institute for Public HealthDalian 116001Liaoning ProvinceChina

BACKGROUND Chronic hepatitis B virus(HBV)infection is often associated with increased lipid deposition in ***,when combined with non-alcoholic fatty liver disease or hyperlipidemia,it tends to have a lower HBV deoxyribonucleic acid(DNA)*** relationship between lipid metabolism and HBV DNA replication and its underlying mechanisms are not well *** To investigate the relationship between lipid metabolism and HBV DNA replication and its underlying *** 1603 HBsAg-seropositive patients were included in the *** first explored the relationship between patients'lipid levels,hepatic steatosis,and HBV DNA ***,we constructed an HBV infection combined with a hepatic steatosis cell model in vitro by fatty acid stimulation of HepG2.2.15 cells to validate the effect of lipid metabolism on HBV DNA replication in *** knocking down and overexpressing Plin2,we observed whether Plin2 regulates autophagy and HBV *** inhibiting both Plin2 and cellular autophagy under high lipid stimulation,we examined whether the Plin2-autophagy pathway regulates HBV *** The results revealed that serum triglyceride levels,high-density lipoprotein levels,and hepatic steatosis ratio were significantly lower in the HBV-DNA high load *** regression analysis indicated that hepatic steatosis and serum triglyceride levels were negatively correlated with HBV-DNA *** analysis by HBeAg showed significant negative correlations between HBV-DNA load and hepatic steatosis ratio in both HBeAgpositive and HBeAg-negative *** in vitro cell model was developed by stimulating HepG2.2.15 cells with palmitic acid and oleic acid to study the relationship between HBV-DNA load and lipid *** results of the in vitro experiments suggested that fatty acid treatment increased lipid droplet deposition and decreased the expression of cell supernatant HBsAg,HBeAg,and HBV DNA *** blot and polymerase c

关键词： Lipid metabolism Chronic HBV infection Nonalcoholic fatty liver Plin2 Autophagy

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基于仿生设计的风力机塔架力学性能分析

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热能动力工程 2018年第5期33卷 126-132页

作者：孙瑞李春陈文朴上海理工大学能源与动力工程学院

为提高塔架力学性能,提出一种仿生结构塔架并研究静态和动态结构特性。建立了1.5 MW风力机塔架有限元模型,通过仿棕榈植物的结构,将传统塔架模型设计成带类维管束腹板的锥筒塔架和带类维管束腹板多段式仿生塔架,并将计算结果与传统塔架... 详细信息

为提高塔架力学性能,提出一种仿生结构塔架并研究静态和动态结构特性。建立了1.5 MW风力机塔架有限元模型,通过仿棕榈植物的结构,将传统塔架模型设计成带类维管束腹板的锥筒塔架和带类维管束腹板多段式仿生塔架,并将计算结果与传统塔架进行了对比分析。结果表明：类维管束腹板使仿生塔架具有更强的抗弯性能,可有效降低塔架的塔尖位移,较之传统塔架减小了68%;传统塔架的应力集中在塔架根部,而仿生塔架能高效地分散载荷,最大应力下降19%,起到减载作用;仿生塔架的一阶固有频率较传统塔架下降0.246 Hz,能够避开塔架的共振频率范围。

关键词：风力机塔架仿生模态分析减载力学性能

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Effects of aggregate size distribution and carbon nanotubes on the mechanical properties of cemented gangue backfill samples under true triaxial compression

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 311-324页

作者： Qian Yin Fan wen Zhigang Tao Hai pu Tianci Deng Yaoyao Meng Qingbin Meng Hongwen Jing Bo Meng Jiangyu Wu State Key Laboratory of Intelligent Construction and Healthy Operation and Maintenance of Deep Underground Engineering China University of Mining and TechnologyXuzhou 221116China State Key Laboratory of Mining Response and Disaster Prevention and Control in Deep Coal Mines Anhui University of Science and TechnologyHuainan 232001China State Key Laboratory for Geomechanics&Deep Underground Engineering China University of Mining and Technology(Beijing)Beijing 100083China Key Laboratory of Xinjiang Coal Resources Green Mining Ministry of EducationXinjiang Institute of EngineeringUrumqi 830023China

The mechanical behavior of cemented gangue backfill materials(CGBMs)is closely related to particle size distribution(PSD)of aggregates and properties of cementitious ***,the true triaxial compression tests,CT scanning,SEM,and EDS tests were conducted on cemented gangue backfill samples(CGBSs)with various carbon nanotube concentrations(P_(CNT))that satisfied fractal theory for the PSD of *** mechanical properties,energy dissipations,and failure mechanisms of the CGBSs under true triaxial compression were systematically *** results indicate that appropriate carbon nanotubes(CNTs)effectively enhance the mechanical properties and energy dissipations of CGBSs through micropore filling and microcrack bridging,and the optimal effect appears at P_(CNT)of 0.08wt%.Taking PSD fractal dimension(D)of 2.500 as an example,compared to that of CGBS without CNT,the peak strength(σ_(p)),axial peak strain(ε_(1,p)),elastic strain energy(Ue),and dissipated energy(U_(d))increased by 12.76%,29.60%,19.05%,and90.39%,***,excessive CNTs can reduce the mechanical properties of CGBSs due to CNT agglomeration,manifesting a decrease inρ_(p),ε_(1,p),and the volumetric strain increment(Δε_(v))when P_(CNT)increases from 0.08wt%to 0.12wt%.Moreover,the addition of CNTs improved the integrity of CGBS after macroscopic failure,and crack extension in CGBSs appeared in two modes:detour and pass through the ***σ_(p)and U_(d)firstly increase and then decrease with increasing D,and porosity shows the opposite ***ε_(1,p)andΔε_(v)are negatively correlated with D,and CGBS with D=2.150 has the maximum deformation parameters(ε_(1,p)=0.05079,Δε_(v)=0.01990)due to the frictional slip effect caused by coarse *** increasing D,the failure modes of CGBSs are sequentially manifested as oblique shear failure,"Y-shaped"shear failure,and conjugate shear failure.

关键词： cemented gangue backfill materials particle size distribution true triaxial compression test carbon nanotubes mechanical properties failure modes

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Self-reporting hypoxia-responsive supramolecular phototheranostic nanomaterials based on AIEgen and azocalixarene

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Science China Chemistry 2025年

作者： Xiao-wen Han Guo-Ling Zhang pu Chen Jing Zhang Guo-Gang Shan chun-Xuan Qi Ben-Zhong Tang Hai-Tao Feng AIE Research Center Shaanxi Key Laboratory of Phytochemistry College of Chemistry and Chemical Engineering Baoji University of Arts and Sciences National & Local United Engineering Laboratory for Power Batteries Department of Chemistry Northeast Normal University School of Science and Engineering Shenzhen Institute of Aggregate Science and Technology The Chinese University of Hong KongShenzhen (CUHK-Shenzhen)

Hypoxia is a significant feature in most of solid tumors. Hence, developing hypoxia-responsive phototheranostic system is still a challenge. In this contribution, a supramolecular assembly strategy based on sulfonate-functionalized azocalix[4]arene(SAC4A)and cationic aggregation-induced emission photosensitizer(namely TPA-H) was proposed for hypoxia-responsive bioimaging and photodynamic therapy(PDT). Upon supramolecular complexation of TPA-H and SAC4A through electrostatic interaction,the fluorescence and reactive oxygen species(ROS) generation of TPA-H were largely inhibited. In hypoxic tumors, the azo group of SAC4A can be reduced to aniline derivative and release the included TPA-H to recover its pristine fluorescence and ROS. Interestingly, the free TPA-H undergoes cell membrane-to-mitochondria translocation during cell imaging, achieving a real-time self-reporting PDT system. In vivo tumor imaging and therapy reveal that this as-prepared supramolecular complexes have good biosafety and efficient antitumor activity under hypoxia. Such hypoxia-responsive supramolecular photosensitizer system will enrich image-guided photodynamic therapy.

关键词： Hypoxia is a significant feature in most of solid tumors. Hence, developing hypoxia-responsive phototheranostic system is still a challenge. In this contribution, a supramolecular assembly strategy based on sulfonate-functionalized azocalixarene(SAC4A)and cationic aggregation-induced emission photosensitizer(namely TPA-H) was proposed for hypoxia-responsive bioimaging and photodynamic therapy(PDT). Upon supramolecular complexation of TPA-H and SAC4A through electrostatic interaction,the fluorescence and reactive oxygen species(ROS) generation of TPA-H were largely inhibited. In hypoxic tumors, the azo group of SAC4A can be reduced to aniline derivative and release the included TPA-H to recover its pristine fluorescence and ROS. Interestingly, the free TPA-H undergoes cell membrane-to-mitochondria translocation during cell imaging, achieving a real-time self-reporting PDT system. In vivo tumor imaging and therapy reveal that this as-prepared supramolecular complexes have good biosafety and efficient antitumor activity under hypoxia. Such hypoxia-responsive supramolecular photosensitizer system will enrich image-guided photodynamic therapy.

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Chiral phosphoramidite ligand-modulated palladium auto-tandem catalysis for asymmetric dehydrogenative dienylation of imines with α-alkenes

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Science China Chemistry 2025年

作者： Zhong-Sheng Nong Hao-Fan Qian Ying-chun Chen pu-Sheng Wang Liu-Zhu Gong Hefei National Research Center for Physical Sciences at the Microscale and Department of Chemistry University of Science and Technology of China Key Laboratory of Drug Targeting and Drug Delivery System (Sichuan University) Ministry of Education and Sichuan Research Center for Drug Precision Industrial Technology West China School of Pharmacy Sichuan University School of Materials and Chemistry Southwest University of Science and Technology

The development of efficient processes allowing rapid access to complex chiral molecules from easily available alkenes is a long-term pursuit in the synthetic chemistry community. Transition metal-catalyzed asymmetric functionalization of allylic C–H bond represents a unique alternative toward this goal. However, enantioselective dehydrogenative transformation of olefins to value-added optically enriched molecules remains yet to be discovered. Here, we report a highly enantioselective dehydrogenative dienylation of imines with unactivated α-alkenes driven by the synergistic action of palladium complex and carboxylic acid. Chiral phosphoramidite ligands turned out to be superior in modulating the performance of palladium autotandem catalysis and allowed a broad range of α-alkenes and imines to be transformed into chiral dienylamines. Mechanistic studies suggest that the dienes could be in situ generated from α-alkenes through a palladium(0)-mediated dehydrogenative process in the presence of excess benzoquinone oxidants, and then participated in the Pd-chiral phosphoramidite-catalyzed intermolecular vinylogous-type addition to the imines activated by the carboxylic acid co-catalyst. Notably, the second β-H elimination occurring in the dienylation event might be the turnover-limiting step.

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变工况下高低齿迷宫密封泄漏特性及结构优化

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热能动力工程 2018年第5期33卷 33-39页

作者：张尧张万福李春陈文朴上海理工大学能源与动力工程学院

高低齿迷宫密封是透平机械中抑制流体泄漏的关键部件。以某机组隔板密封为对象建立高低齿迷宫的计算流体力学（CFD）模型,研究由变工况引起的转子轴向偏移对密封泄漏特性的影响,并通过调整转子凸台宽度和密封腔高度对密封结构进行优化... 详细信息

高低齿迷宫密封是透平机械中抑制流体泄漏的关键部件。以某机组隔板密封为对象建立高低齿迷宫的计算流体力学（CFD）模型,研究由变工况引起的转子轴向偏移对密封泄漏特性的影响,并通过调整转子凸台宽度和密封腔高度对密封结构进行优化。结果表明：原始结构设计下,转子轴向偏移±3 mm内,泄漏量并未发生大幅度的上升;在-2-1.5 mm范围内泄漏量有所下降,说明在工况变动不大时,密封性能有所提高,但超出±3 mm的范围,泄漏量呈突增趋势;泄漏量分别随转子凸台宽度和密封腔高度呈二次非线性变化,存在一个最佳值使泄漏量达到最小,最佳凸台宽度和密封腔高度分别为5.13和7.5 mm;结构优化后密封泄漏量在正常工况及变工况下均小于原始结构,密封性能得到提高。

关键词：迷宫密封轴向偏移泄漏特性变工况 CFD

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