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中国现代医学杂志 2011年第3期21卷 348-353页

作者： Hai-xia Tong Qiu-shi Wang chun-wei lu Mei-yan lu Department of Blood Transfusion Shengjing Hospital China Medical University Shenyang Liaoning 110022 P.R.China Section of Health Testing College of Public Health China Medical University Shenyang Liaoning 110001 P.R.China Section of Oral Technology College of Oral Medicine Medical University of Dalian Dalian Liaoning 116027 P.R.China

Objective To study the changes of lymphocyte subsets and regulatory T cells in peripheral blood of patients with acute leukemia(AL) and its clinical *** The different levels of peripheral blood lymphocyte subsets and regulatory T cells of 60 AL patients and 40 normal controls were detected with flow *** Compared with the normal controls,the percentages of CD3+ T cells,CD4+ T cells,CD16+CD56+ NK cells and the ratio of CD4+ /CD8+ obviously decreased in newly diagnosed AL group(P lusion Cellular immune function is significantly abnormal in patients with *** with AML patients,ALL patients had poorer cellular immune *** increased CD4 + CD25high Treg cells might be one of the important reasons of immunosuppression in *** of lymphocyte subsets and regulatory T cells is of clinical value on the evaluation of therapeutic effect and prognosis in AL patients.

关键词： acute leukemia lymphocyte subset regulatory T cell

COMBINATION OF γ-INTERFERON WITH TRAIL AND CISPLATIN OR ETOPOSIDE INDUCES APOPTOSIS IN HUMAN NEUROBLASTOMA CELL LINE SH-SY5Y

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Chinese Medical Sciences Journal 2007年第1期22卷 38-43页

作者： Hai-xia Tong chun-wei lu Ji-hong Zhang Li Ma Jin-hua Zhang Laboratory of Hematology Shengjing Hospital China Medical University Shenyang 110004 Section of Health Testing College of Public Health China Medical University Shenyang 110001 Department of Infectious Diseases Shengjing Hospital China Medical University Shenyang 110004

Objective To study the effect of γ-interferon （IFNγ）, tumor necrosis factor related apoptosis inducing ligand （TRAIL）, and cisplatin or etoposide induced apoptosis in human neuroblastoma cell line SH-SY5Y and its possible molecular mechanisms. Methods The expressions of Caspase 8 mRNA and protein were detected with RT-PCR and Western blot analysis. The effects of IFNγ, TRAIL, IFNγ ＋ TRAIL, IFNγ ＋ Caspase 8 inhibitor ＋ TRAIL, IFNγ ＋ cisplatin ＋ TRAIL, and IFNγ ＋ etoposide ＋ TRAIL on the growth and apoptosis of SH-SY5Y cells were detected with the methods of MTT and flow cytometry. The relative Caspase 8 activity was measured with colorimetric assay. Results Caspase 8 was undetectable in SH-SY5Y cells but an increased expression of Caspase 8 mRNA and protein was found after treatment with IFNγ. SH-SY5Y ceils themselves were not sensitive to TRAIL, but those expressing Caspase 8 after treatment with IFNγ were. The killing effect of TRAIL on SH-SY5Y cells expressing Caspase 8 was depressed by Caspase 8 inhibitor. Cisplatin and etoposide could enhance the sensitivity of TRAIL on SH-SY5Y cells. The relative Caspase 8 activity of SH-SY5Y cells in IFNγ ＋ TRAIL group was significantly higher than those of control group, IFNγ group, TRAIL group, and inhibitor group （ P 〈 0. 01 ）. There was no significant difference among IFNγ ＋ TRAIL group, IFNγ ＋ cisplatin ＋ TRAIL group, and IFNγ ＋ etoposide ＋ TRAIL group. Conclusions IFNγ could sensitize SH-SY5Y cells to TRAIL-induced apoptosis and this may be realized by the up-regulation of Caspase 8. Cisplatin and etoposide could enhance the killing effect of TRAIL on SH-SY5Y cells.

关键词： neuroblastoma apoptosis tumor necrosis factor related apoptosis inducing ligand γ-interferon

Studies on the Synthesis,Characterization and Properties of the Reactive Thermotropic Liquid Crystalline Polymer

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复旦学报（自然科学版） 2007年第5期46卷 812-814页

作者： chun wei, Chi-hua lu, Deng Xu, Yong-yang Gong, wei-zhong lu, Ming Zeng (Key Laboratory of New Processing Technology for Nonferrous Metals and Materials, Ministry of Education, Guilin University of Technology, Guilin 541004, China) Guilin University of Technology Key Laboratory of New Processing Technology for Non ferrous Metals and MaterialsMinistry of Education Guilin 541004

1 Introduction Four species of reactive thermotropic liquid crystalline polymer (LCMC) with different relative molecular weight were synthesized in this work (see scheme 1, n=2, 6, 10, ∞.n means number of repeat structure unit). Their structure, morphology and properties were investigated systemically by differential scanning calorimetry (DSC), Thermogravimetric analysis (TGA), Fourier transform infrared spectroscopy (FTIR), Wide-angle X-ray diffraction (WAXD), polarizing opticalmicroscopy (POM) and ubb...

关键词： thermotropic liquid crystalline polymer relative molecular weight synthesis

The Progression of Atrophic Gastritis to Gastric Cancer: A Retrospective Study in 61,810 Cases

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Journal of Cancer Therapy 2017年第6期8卷 553-560页

作者： Yi-Ren Hu Ying Yu Jian-Xin Li wei-chun lu Qi-Jin Shu Ying-Cong Yu Wenzhou People’s Hospital the Third Clinical Institute Affiliated to Wenzhou Medical University Wenzhou China The First Affiliated Hospital of Zhejiang Chinese Medical University Hangzhou China

Background and Aim: Chronic atrophic gastritis is a known precancerous lesion for gastric cancer, with an overall 5-year survival less than 20%. However, there is few new data describing the progression rate from atrophic gastritis (AG) to gastric cancer in China. We retrospectively analyzed the risk of gastric cancer among patients with AG and aimed to determine the accuracy of endoscopy diagnosis of AG in China. Methods: Clinical features and endoscopic profiles of chronic atrophic gastritis patients from Wenzhou People’s Hospital between January 2006 and December 2016 were analyzed retrospectively. Results: There were 61,810 cases analyzed retrospectively. 3641 cases of atopic gastritis were diagnosed by endoscopy, in which 1704 cases were confirmed by pathological biopsy;the diagnostic coincidence rate was 46.80%;2631 cases were diagnosed as atrophic gastritis by pathological biopsy, in which 927 cases were ignored by endoscopy;the miss diagnosis rate was 35.23%. The progression rate from chronic atrophic gastritis and non-atrophic gastritis to gastric cancer respectively was 0.79% and 0.43%. The rate of intestinal metaplasia in mild AG, moderate AG and severe AG respectively was 75.63%, 86.18% and 90.32%, 3.42%, 6.27% and 5.16% about dysplasia in three different degree atrophic gastritis. Conclusions: Endoscopy diagnosis and pathology diagnosis of AG were statistically different. Patients with atrophic gastritis have higher risk of developing into gastric cancer, but it needs further investigation. Different degrees of atrophic gastritis have the different proportions of intestinal metaplasia and dysplasia.

关键词： Atrophic Gastritis Stomach Neoplasms Disease Progression Endoscopy Diagnosis

黑格尔的艺术类型理论与艺术史观——反思贡布里希对黑格尔的批判

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美育学刊 2020年第1期11卷 51-57页

作者：魏春露复旦大学中文系

黑格尔从其整个哲学体系出发,对美的理念和艺术类型进行一种形而上思考。贡布里希对黑格尔的这种艺术分类理论和艺术史观提出了猛烈批评。因此,在反思贡布里希对黑格尔的批判的基础上,结合黑格尔思想产生的时代,重新考察黑格尔艺术类型... 详细信息

黑格尔从其整个哲学体系出发,对美的理念和艺术类型进行一种形而上思考。贡布里希对黑格尔的这种艺术分类理论和艺术史观提出了猛烈批评。因此,在反思贡布里希对黑格尔的批判的基础上,结合黑格尔思想产生的时代,重新考察黑格尔艺术类型理论和艺术史观的贡献和局限性,对当代艺术史和美学研究都有一定的现实意义。

关键词：黑格尔美的理念艺术史观贡布里希

基于VMS的交通信息服务系统管理问题研究——以长春市为例

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政法学刊 2018年第6期35卷 122-125页

作者：魏春璐吉林警察学院交通管理系吉林长春130117

可变信息情报板是交通信息服务系统的重要组成部分。随着大数据、人工智能等新兴技术的发展,交通信息服务系统已经成为我国交通管理的重要途径。长春市交通信息服务系统管理现状存在配套基础设施建设滞后,VMS发布内容不规范,停车诱导系... 详细信息

可变信息情报板是交通信息服务系统的重要组成部分。随着大数据、人工智能等新兴技术的发展,交通信息服务系统已经成为我国交通管理的重要途径。长春市交通信息服务系统管理现状存在配套基础设施建设滞后,VMS发布内容不规范,停车诱导系统和路径诱导系统有待优化四点问题。针对以长春市为代表的中小型城市交通信息服务系统建设中存在的问题,可以通过合理增加VMS建设数量、科学优化VMS区域分布,制定VMS发布文字字数上限规则;完善交通流诱导信息实时更新技术;发展个性化路径诱导系统等措施来解决。

关键词： VMS 交通诱导长春市

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钢管拱桥防腐涂装设计与施工

江苏建筑 2020年第S1期 38-40页

作者：韦春陆南京市市政设计研究院有限责任公司江苏南京210008

通过对老桥主拱涂装失效的病害分析,采用了抗腐蚀性能更为优越的氟碳漆作为面漆材料,提高钢结构的涂层抗腐蚀能力及主拱结构的耐久性。结合桥梁交通运营要求,选择满堂支架及移动吊篮的施工方案,确保主拱涂装顺利施工。涂层厚度检测采用... 详细信息

通过对老桥主拱涂装失效的病害分析,采用了抗腐蚀性能更为优越的氟碳漆作为面漆材料,提高钢结构的涂层抗腐蚀能力及主拱结构的耐久性。结合桥梁交通运营要求,选择满堂支架及移动吊篮的施工方案,确保主拱涂装顺利施工。涂层厚度检测采用涂料用量控制法保证涂层的厚度,结合湿膜测试法控制涂膜的均匀性,有效的保证了涂层的质量。

关键词：钢管拱桥涂装体系防腐涂层检测

The Citron homology domain of MAP4Ks improves outcomes of traumatic brain injury

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Neural Regeneration Research 2025年第11期20卷 3233-3244页

作者： Xiaoling Zhong Wenjiao Tai Meng-lu Liu Shuaipeng Ma Tianjin Shen Yuhua Zou chun-Li Zhang Department of Molecular Biology University of Texas Southwestern Medical CenterDallasTXUSA Hamon Center for Regenerative Science and Medicine University of Texas Southwestern Medical CenterDallasTXUSA Peter O’Donnell Jr.Brain Institute University of Texas Southwestern Medical CenterDallasTXUSA

The mitogen-activated protein kinase kinase kinase kinases(MAP4Ks)signaling pathway plays a pivotal role in axonal regrowth and neuronal degeneration following *** targeting this pathway is beneficial to brain injury remains *** this study,we showed that adeno-associated virus-delivery of the Citron homology domain of MAP4Ks effectively reduces traumatic brain injury-induced reactive gliosis,tauopathy,lesion size,and behavioral *** inhibition of MAP4Ks replicated the ameliorative effects observed with expression of the Citron homology ***,the Citron homology domain acted as a dominant-negative mutant,impeding MAP4K-mediated phosphorylation of the dishevelled proteins and thereby controlling the Wnt/β-catenin *** findings implicate a therapeutic potential of targeting MAP4Ks to alleviate the detrimental effects of traumatic brain injury.

关键词： adeno-associated virus Citron homology Citron homology domain gene therapy mitogen-activated protein kinase kinase kinase kinases traumatic brain injury

The cGAS-STING-interferon regulatory factor 7 pathway regulates neuroinflammation in Parkinson's disease

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Neural Regeneration Research 2025年第8期20卷 2361-2372页

作者： Shengyang Zhou Ting Li wei Zhang Jian Wu Hui Hong wei Quan Xinyu Qiao chun Cui Chenmeng Qiao weijiang Zhao Yanqin Shen Laboratory of Neurodegenerative and Neuroinjury Diseases Wuxi Medicine SchoolJiangnan UniversityWuxiJiangsu ProvinceChina

Interferon regulatory factor 7 plays a crucial role in the innate immune ***,whether interferon regulatory factor 7-mediated signaling contributes to Parkinson's disease remains *** we report that interferon regulatory factor 7 is markedly up-regulated in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of Parkinson's disease and co-localizes with microglial *** the selective cyclic guanosine monophosphate adenosine monophosphate synthase inhibitor RU.521 and the stimulator of interferon genes inhibitor H151 effectively suppressed interferon regulatory factor 7 activation in BV2 microglia exposed to 1-methyl-4-phenylpyridinium and inhibited transformation of mouse BV2 microglia into the neurotoxic M1 *** addition,si RNA-mediated knockdown of interferon regulatory factor 7 expression in BV2 microglia reduced the expression of inducible nitric oxide synthase,tumor necrosis factorα,CD16,CD32,and CD86 and increased the expression of the anti-inflammatory markers ARG1 and *** together,our findings indicate that the cyclic guanosine monophosphate adenosine monophosphate synthase-stimulator of interferon genes-interferon regulatory factor 7 pathway plays a crucial role in the pathogenesis of Parkinson's disease.

关键词： cyclic guanosine monophosphate adenosine monophosphate synthase H151 interferon regulatory factor 7 M1 phenotype neurodegenerative disease neuroinflammation Parkinson’s disease RU521 STING type I interferon

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栖霞大桥病害分析及加固处理

江苏建筑 2009年第2期 40-43页

作者：纪诚韦春陆南京市市政设计研究院有限责任公司江苏南京210008

栖霞大桥为南京地区第一座下承式系杆拱桥,运营10年来出现了较严重的病害,文章通过分析病害原因及其对结构的影响,提出了消险加固措施,具有较强的实用性。

关键词：桥梁工程系杆拱病害分析加固处理