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Journal of Iron and Steel Research International 2024年第9期31卷 2217-2235页

作者： Ting-song Yang Tie-heng Yuan Wen-quan Sun An-rui He chun-tao qu National Engineering Research Center of Advanced Rolling and Intelligent Manufacturing University of Science and Technology BeijingBeijing100083China Institute of Aeronautical Power Machinery AECC Harbin Dongan Engine Co.Ltd.Harbin150000HeilongjiangChina

To achieve stable rolling,the influence of a tension mechanism of a large diameter ratio roll system on the rolling process of a strip flatness electromagnetic control rolling mill is *** the analysis of the rolling deformation zone,the deformation zone composition form of a large diameter ratio roll system and a calculation formula of neutral angle under tension are *** analyze the effect of front and post tensions on the rolling characteristic and the strip flatness control characteristic,a three-dimensional rolling finite element(FE)model of a large diameter ratio roll system with the function of roll profile electromagnetic control is established by FE software and verified by a strip flatness electromagnetic control rolling *** on the model,the strip thickness characteristic,metal transverse flow,strip flatness state,and adjustment range of the loaded roll gap are analyzed for different front and post tensions setting *** results show that changing the front or post tension setting values can improve the single-pass reduction rate of a large diameter ratio roll system and have little effect on the flatness control ability of the strip flatness electromagnetic control rolling mill.

关键词： Strip flatness electromagnetic control rolling mill Tension mechanism Roll profile electromagnetic control technology Rolling characteristic Strip flatness control characteristic

Inhibiting SHP2 reduces glycolysis, promotes microglial M1 polarization, and alleviates secondary inflammation following spinal cord injury in a mouse model

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Neural Regeneration Research 2025年第3期20卷 858-872页

作者： Xintian Ding chun Chen Heng Zhao Bin Dai Lei Ye tao Song Shuai Huang Jia Wang tao You Department of Orthopedics The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Department of Orthopedics Provincial Hospital Affiliated to Anhui Medical UniversityHefeiAnhui ProvinceChina

Reducing the secondary inflammatory response, which is partly mediated by microglia, is a key focus in the treatment of spinal cord injury. Src homology 2-containing protein tyrosine phosphatase 2(SHP2), encoded by PTPN11, is widely expressed in the human body and plays a role in inflammation through various mechanisms. Therefore, SHP2 is considered a potential target for the treatment of inflammation-related diseases. However, its role in secondary inflammation after spinal cord injury remains unclear. In this study, SHP2 was found to be abundantly expressed in microglia at the site of spinal cord injury. Inhibition of SHP2 expression using siRNA and SHP2 inhibitors attenuated the microglial inflammatory response in an in vitro lipopolysaccharide-induced model of inflammation. Notably, after treatment with SHP2 inhibitors, mice with spinal cord injury exhibited significantly improved hind limb locomotor function and reduced residual urine volume in the bladder. Subsequent in vitro experiments showed that, in microglia stimulated with lipopolysaccharide, inhibiting SHP2 expression promoted M2 polarization and inhibited M1 polarization. Finally, a co-culture experiment was conducted to assess the effect of microglia treated with SHP2 inhibitors on neuronal cells. The results demonstrated that inflammatory factors produced by microglia promoted neuronal apoptosis, while inhibiting SHP2 expression mitigated these effects. Collectively, our findings suggest that SHP2 enhances secondary inflammation and neuronal damage subsequent to spinal cord injury by modulating microglial phenotype. Therefore, inhibiting SHP2 alleviates the inflammatory response in mice with spinal cord injury and promotes functional recovery postinjury.

关键词： apoptosis glycolysis inflammatory response microglia neurons polarization spinal cord injury Src homology 2-containing protein tyrosine phosphatase 2

Macro-mechanics and Microstructure of Nanomaterial-modified Geopolymer Concrete: A Comprehensive Review

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 204-214页

作者： WANG tao FAN Xiangqian GAO Changsheng qu Chiyu The National Key Laboratory of Water Disaster Prevention Nanjing Hydraulic Research InstituteNanjing 210024China Southern Marine Science and Engineering Guangdong Laboratory(Guangzhou) Guangzhou 511458China School of Water Conservancy and Transportation Zhengzhou UniversityZhengzhou 450001China

We have described in detail the effects of nano-SiO_(2),nano-CaCO_(3),carbon nanotubes,and nano-Al_(2)O_(3) on geopolymer concrete from the perspectives of macro mechanics and *** existing research results show that the mechanism of nano-materials on geopolymer concrete mainly includes the filling effect,nucleation effect,and bridging effect,the appropriate amount of nano-materials can be used as fillers to reduce the porosity of geopolymer concrete,and can also react with Ca(OH)2 to produce C-S-H gel,thereby improving the mechanical properties of geopolymer *** optimum content of nano-SiO_(2) is between 1.0%and 2.0%.The optimum content of nano-CaCO_(3) is between 2.0%and 3.0%.The optimum content of carbon nanotubes is between 0.1%and 0.2%.The optimum content of nano-Al_(2)O_(3) is between 1.0%and 2.0%.The main problems existing in the research and application of nanomaterial-modified geopolymer concrete are summarized,which lays a foundation for the further application of nanomaterial in geopolymer concrete.

关键词： nanomaterials low carbon geopolymer concrete macro-mechanics microstructure

A C-type lectin with dual carbohydrate recognition domains functions in innate immune response in Asian corn borer,Ostrinia furnacalis

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Insect Science 2025年第1期32卷 172-192页

作者： Er-tao Li Jia-Yue Ji Wei-Jie Kong Dong-Xu Shen Cai Li chun-Ju An Deparment of Entomology College of Plant ProtectionChina Agricultural UniversityBejingChina Pomology Institute Shanxi Agricultural UniversityJinzhongShanxi ProvinceChina Jiangsu Key Laboratory of Sericultural Biology and Biotechnology School of BiotechnologyJiangsu University of Science and TechnologyZhenjiangJiangsu ProvinceChina

C-type lectins(CTLs)act as pattern recognition receptors(PRRs)to initiate the innate immune response in insects.A CTL with dual carbohydrate recognition domains(CRDs)(named immulectin-4[IML-4])was selected from the Ostrinia furnacalis transcriptome dataset for functional *** cloned the full-length complementary DNA of *** IML-4(OfIML-4).It encodes a 328-residue protein with a Glu-Pro-Asn(EPN)and Gln-Pro-Asp(QPD)motifs in 2 CRDs,***-4 messenger RNA levels increased significantly upon the bacterial and fungal *** OfIML-4(rIML-4)and its individual CRDs(rCRD1 and rCRD2)exhibited the binding ability to various microorganisms including Escherichia coli,Micrococcus luteus,Pichia pastoris,and Beauveria bassiana,and the cell wall components including lipopolysaccharide from ***,peptidoglycan from *** or Bacillus subtilis,and curdlan from Alcaligenes *** binding further induced the agglutination of ***,***,and *** in the presence of calcium,the phagocytosis of Staphylococcus aureus by the hemocytes,in vitro encapsulation and melanization of nickel-nitrilotriacetic acid beads,and a significant increase in phenoloxidase activity of *** addition,rIML-4 significantly enhanced the phagocytosis,nodulation,and resistance of *** to *** together,our results suggest that OfIML-4 potentially works as a PRR to recognize the invading microorganisms,and functions in the innate immune response in ***.

关键词： cellular immunity C-type lectin humoral immunity immulectin Ostrinia furnacalis pattern recognition receptor(PRR)

Spg3a promotes axon elongation and induces neuronal cell death during development

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Spg3a promotes axon elongation and induces neuronal cell dea...

Propagating subduction initiation of the Caroline Plate at the Mussau Trench

中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： Ying GAO,Hua-Ping tao,chun-Sheng qu,Yue-E ZHAO,Jia qu,Jie-Guang CHEN~* School of Optometry and Ophthalmology,Wenzhou Medical College,Wenzhou 325027,China

＜正＞Hereditary spastic paraplegia is an inherited neurological disorder manifested by progressive spasticity and weakness of the *** most common early-onset form of HSP is caused by mutations in the human gene SPG3A that results in degeneration of corticospinal projection *** early postnatal mice,spg3a is expressed in hippocampus, and enriched in the layer V of cerebral cortex,which contains long subcortical projection *** study the function of spg3a in vivo,we over expressed it in the upper layers（Ⅱ/Ⅲ） of cortex via in utero electroporation,and examined the development of callosal projection *** generation and radial migration of labeled neurons expressing spg3a were *** of spg3a did not interfere with the axons crossing corpus callosum,instead,some labeled axons elongate and reach to the contralateral of cortex earlier than those from the control *** addition,spg3a expressing neurons were clearly reduced when mice were examined 14 days after birth,suggesting that over-expression of Spg3a may induce neuronal cell *** hypothesize that Spg3a could be involved in postnatal development and maturation of cortical projection *** we are trying to determine consequences of the disease-causing mutations of SPG3A to the developmental processes when expressed in vivo.

关键词： Spg3a axon growth neuronal cell death cortex in vivo

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Science China Earth Sciences 2025年第1期68卷 253-269页

作者： chun-Feng LI Yongkang DENG tao WU Dongdong DONG Guoliang ZHANG Jiazheng ZHANG Yutao LIU Yaqing LI Fugui TANG Lulu ZHANG Department of Marine Sciences Zhejiang UniversityZhoushan316021China Laboratory of Marine Mineral Resources Laoshan LaboratoryQingdao266237China Key Lab of Marine Geology and Environment Institute of OceanologyChinese Academy of SciencesQingdao266071China Key Lab of Ocean and Marginal Sea Geology South China Sea Institute of OceanologyChinese Academy of SciencesGuangzhou510301China Science&Technology on Integrated Information System Lab Institute of SoftwareChinese Academy of SciencesBeijing100190China

New seismic imaging from the Mussau Trench confirms that,under horizontal compression on an oceanic plate boundary,it is within the young and weak oceanic plate that a trench will develop,and it is the young plate,not so long after its birth,that starts to subduct toward the old *** Mesozoic Pacific Plate cannot easily bend,under the joint horizontal compression and vertical gravity pull,even with a pre-existing weak zone in place and with a large age offset across the plate *** bending of the Caroline Plate near the northern end of the Mussau Trench started only after a long-time span of trench migration,and/or after a prolonged transition from initial compression to trench *** contrasting trench deformation and sedimentary accretion between two parallel seismic sections support an evident migration of underthrusting or significant longitudinal heterogeneity along the *** swift transition from underthrusting to non-thrusting can be explained by a counter-clockwise rotation of the Caroline *** miniature accretionary wedges develop even before the subduction initiates imply strong compression and uplifting before the underthrusting can *** of the Caroline Plate have been halted as the Mussau Trench is seismically rather quiet and the Lyra Trough to the east shows relaxational extension.

关键词： Mussau Trench Subduction initiation Seismic reflection Caroline Plate

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Prompt fission neutron uranium logging(Ⅱ):dead-time effect of the neutron time spectrum

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Nuclear Science and Techniques 2025年第2期36卷 82-94页

作者： Yan Zhang Chi Liu Shi-Liang Liu Hao-Ran Zhang Hai-tao Wang Jin-Hui qu Wen-Xing Hu Ren-Bo Wang Bin Tang National Key Laboratory of Uranium Resources Exploration-Mining and Nuclear Remote Sensing East China University of TechnologyNanchang 330013China Fundamental Science on Radioactive Geology and Exploration Technology Laboratory East China University of TechnologyNanchang 330013China

The acquisition of neutron time spectrum data plays a pivotal role in the precise quantification of uranium via prompt fission neutron uranium logging(PFNUL).However,the impact of the detector dead-time effect remains paramount in the accurate acquisition of the neutron time ***,it is imperative for neutron logging instruments to establish a dead-time correction method that is not only uncomplicated but also practical and caters to various logging *** study has formulated an innovative equation for determining dead time and introduced a dead-time correction method for the neutron time spectrum,called the“dual flux method.”Using this approach,a logging instrument captures two neutron time spectra under disparate neutron *** carefully selecting specific“windows”on the neutron time spectrum,the dead time can be accurately *** substantiate its efficacy and discern the influencing factors,experiments were conducted utilizing a deuterium-tritium(D-T)neutron source,a Helium-3(3He)detector,and polyethylene shielding to collate and analyze the neutron time spectrum under varying neutron fluxes(at high voltages).The findings underscore that the“height”and“spacing”of the two windows are the most pivotal influencing ***,the“height”(fd)should surpass 2,and the“spacing”twd should exceed 200μ*** dead time of the 3 He detector determined in the experiment was 7.35μ*** the dead-time correction,the deviation of the decay coefficients from the theoretical values for the neutron time spectrum under varying neutron fluxes decreased from 12.4%to within 5%.Similarly,for the PFNUL instrument,the deviation in the decay coefficients decreased from 22.94 to 0.49%after correcting for the dead-time *** results demonstrate the exceptional efficacy of the proposed method in ensuring precise uranium *** dual flux method was experimentally validated as a universal approach applicable to pulsed neutron logging instrumen

关键词： PFNUL Neutron time spectrum Dead time Pulsed source Correction method

Advances and global trends of precancerous lesions of gastric cancer:A bibliometric analysis

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World Journal of Gastrointestinal Oncology 2025年第3期17卷 371-384页

作者： Yuan-Ping Jia Dian-chun Liu Ting-Lan Cao Hui-Zhong Jiang tao Li Yuan Li Xia Ding Dongzhimen Hospital Beijing University of Chinese MedicineBeijing 100700China School of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijing 100029China National Institute of Traditional Chinese Medicine Constitution and Preventive Treatment of Diseases Beijing University of Chinese MedicineBeijing 100029China

BACKGROUND Precancerous lesions of gastric cancer(PLGC)represent a critical pathological stage in the development of intestinal gastric *** detection and diagnosis are key to reducing the incidence of gastric *** advancements have been made in PLGC research in recent years,making it necessary to provide updated reviews using bibliometric *** hypothesize that this review will identify emerging trends,key research areas,and gaps in PLGC research,providing insights that could guide future studies and enhance prevention *** To comprehensively review the current state of research on PLGC,examining development trends and research *** We conducted a bibliometric analysis of PLGC-related studies published between 2004 and 2023 using the Web of Science Core Collection *** employed Software,including VOSviewer,CiteSpace,R software,and SCImago Graphica,to map scientific networks and visualize knowledge trends in terms of publication volume,countries/regions,institutions,journals,authors,and *** A total of 4097 articles were included,and overall publication volume showed an increasing *** the past two decades,China published the most articles,followed by the United States,Japan,South Korea,and *** the top 10 contributors,the United States ranked highest in institutions,authors,and citations and demonstrated the strongest international *** keywords in this field were clustered into three main categories:Risk factors,pathogenesis,and diagnosis and *** and molecular biomarkers remain key areas of *** research should explore the mechanisms of gut microbiota,immune microenvironment,metabolic reprogramming,and *** technologies,including single-cell sequencing,spatially resolved analysis,multi-omics approaches,artificial intelligence,and machine learning,will likely accelerate in-depth investigations of *** PLGC research

关键词： Precancerous lesions of gastric cancer Gastric precancerous lesion Dysplasia Bibliometric Visualization

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中国百年师范教育论争

河北师范大学学报(教育科学版) 2025年第1期27卷 7-20页

作者：曲铁华姜涛东北师范大学教育学部吉林长春130024 大连理工大学高等教育研究院辽宁大连116024

在中国百年师范教育的历史沿革中,曾在不同的时期围绕不同的主题,进行过程度不一、激烈程度不等的论争。主要包括:清末时期的“要不要建立师范教育体系”之论争;20世纪初“师范教育是否独立设置”之论争;20世纪五六十年代“如何办好师... 详细信息

在中国百年师范教育的历史沿革中,曾在不同的时期围绕不同的主题,进行过程度不一、激烈程度不等的论争。主要包括:清末时期的“要不要建立师范教育体系”之论争;20世纪初“师范教育是否独立设置”之论争;20世纪五六十年代“如何办好师范教育”之论争以及“师范教育由谁来办”之论争。这些论争促使师范教育不仅在曲折前进的道路上得到了不同程度的反思与规制,也使师范教育的特点日益明晰,推动了人们对师范教育的认识和理解。中国百年师范教育论争的总体特点:一是“师范性”与“学术性”的博弈贯穿论争始终;二是“推动力”与“阻滞力”的矛盾一直共存;三是“国际化”与“本土化”的张力持续激荡;四是“调和论”主导了中国百年师范教育的演进。通过论争,使我们更清楚地认识到,在建设教育强国的历史背景下,师范教育要遵循以下原则:一是要尊重师范教育规律,这是教师教育发展的首要原则;二是要加强高质量教师队伍建设,这是教师教育发展的重要指向;三是要完善多元主体合作机制,这是教师教育发展的必要保障;四是要提高教师教育质量,这是师范教育论争的根本旨归。

关键词：中国百年师范教育教育论争师范性学术性

Functional atlastin-1 induces neuronal cell loss in cerebral cortex

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Functional atlastin-1 induces neuronal cell loss in cerebral...