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Influence of operation number on arc erosion behavior of Ag/Ni electrical contact materials

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Transactions of Nonferrous Metals Society of China 2022年第8期32卷 2681-2695页

作者： Run-zhang HUANG Guo-fu XU Qiong wu Meng YUAN chun-ping wu School of Materials Science and Engineering Central South UniversityChangsha 410083China Key Laboratory of Nonferrous Materials Science and Engineering of Ministry of Education Central South UniversityChangsha 410083China

Arc erosion behavior of Ag/Ni materials with different operation numbers was investigated by OM,3DOP and *** results indicated that the arc erosion of Ag/10Ni electrical contact material fabricated by sintering−extrusion technology was more and more serious with the operation numbers increasing from 1000 to *** the same operation numbers,the arc erosion on anode was more serious than that on ***,the pores preferred to emerge around the arc effect spot during the first 10000 *** the morphology of the molten silver on cathode and anode was different due to the action of gravity and arc ***,the relationships among arc energy,arc time,welding force,electric resistivity,temperature and mass change on contacts were discussed,which indicated that the mass loss on cathode was mainly caused by the fracture of molten bridge.

关键词： Ag/Ni electrical contact material operation number arc erosion arc parameter

PRELIMINARY STUDY ON HERBICIDAL ACTIVITY OF FRUIT JUICE OF SOLANUM NIGR UM L.

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PRELIMINARY STUDY ON HERBICIDAL ACTIVITY OF FRUIT JUICE OF S...

Influence of alloy components on arc erosion morphology of Ag/MeO electrical contact materials

中国第三届植物化感作用学术研讨会、第八届全国杂草科学大会、联合国粮农组织——中国“水稻化感作用论坛”

作者： Fu-li HE,chun-he QU,chun-xiu YAN,ping wu,Xin-xin ZHOU,Chang-shan ZHAO College of Agronomy,Northeast Agricultural University,Harbinl 50030,China

The herbicidal activity of fruit juice of Solanum nigrum *** determinde by the seeds germination of Solanum nigrum *** Amaranthus retroflexus L..The test showed that the herbicidal activitve materials content are very high in fruit juice of Solanum nigrum L.,the materials kept herbicidal activity after heated 0.5h under 150℃,and the effect on Solanum,

关键词： the fruit juice of Solarium nigrum L herbicidal activity bioassay

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Transactions of Nonferrous Metals Society of China 2016年第1期26卷 185-195页

作者：吴春萍易丹青翁桅李素华周孑民中南大学能源科学与工程学院长沙410083 中南大学材料科学与工程学院有色金属材料科学与工程教育部重点实验室长沙410083 福达合金材料股份有限公司温州325025

Arc erosion morphologies of Ag/MeO（10） electrical contact materials after 50000 operations under direct current of 19 V and 20 A and resistive load conditions were investigated using scanning electron microscope（SEM） and a 3D optical profiler（3DOP）. The results indicated that 3DOP could supply clearer and more detailed arc erosion morphology information. Arc erosion resistance of Ag/SnO_2（10） electrical contact material was the best and that of Ag/CuO（10） was the worst. Arc erosion morphology of Ag/MeO（10） electrical contact materials mainly included three different types. Arc erosion morphologies of Ag/ZnO（10） and Ag/SnO_2（10） electrical contact materials were mainly liquid splash and evaporation, and those of Ag/CuO（10） and Ag/CdO（10） were mainly material transfer from anode to cathode. Arc erosion morphology of Ag/SnO_2（6）In_2O_3（4） electrical contact materials included both liquid splash, evaporation and material transfer. In addition, the formation process and mechanism on arc erosion morphology of Ag/MeO（10） electrical contact materials were discussed.

关键词： Ag/MeO electrical contact material alloy component arc erosion morphology three-dimensional optical profiler

Single-cell transcriptomic profiling reveals ZEB1-mediated regulation in microglial subtypes and the impact of exercise on neuroinflammatory responses

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Traditional Medicine Research 2025年第2期10卷 55-64页

作者： Jin-Fang wu Yi-Sheng Chen Yu-chun Xie Department of Rehabilitation Medicine Jiangsu Province Geriatric HospitalNanjing 210024China Fujian Key Laboratory of Toxicant and Drug Toxicology Medical CollegeNingde Normal UniversityNingde 352100China Central Laboratory Jiangsu Province Geriatric HospitalNanjing 210024China

Background:This study aims to identify distinct cellular subtypes within brain tissue using single-cell transcriptomic analysis,focusing on specific biomarkers that differentiate cell types and the effects of traditional and exercise ***:Four samples were analyzed:older control(OC),older exercise(OE),younger control(YC),and younger exercise(YE).Single-cell RNA sequencing was used to distinguish cellular subtypes through their biomarker *** visualization included violin and t-SNE plots to illustrate biomarker expression across cell clusters such as oligodendrocytes,microglia,and ***,BV2 cells were exposed to amyloid-beta fragments to simulate Alzheimer’s disease,assessing the impact of exercise-induced cellular ***:Distinct cellular subtypes were identified:oligodendrocytes(MBP,St18),microglia(Dock8),and astrocytes(Aqp4,Gpc5).Sample OE was predominantly oligodendrocytes,while YE had more astrocytes,inhibitory neurons,and Canal-Retzius *** showed a significant presence of Olfm3+ganglion ***1 gene knockout revealed changes in SMAD family gene expression,which regulate *** stress levels were also ***:This profiling enhances our understanding of brain cellular functions and interactions,potentially informing targeted therapies in neurological *** may influence brain cell immune responses and cell death pathways by regulating specific gene expressions,offering new insights for treating neuroinflammation and degeneration.

关键词： single-cell transcriptomics brain tissue cellular subtypes biomarker expression neuronal diversity

Homozygous phytosterolemia and a literature review:A case report

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World Journal of Clinical Cases 2025年第10期13卷 46-52页

作者： chun-Xin Jiang Guang Yang Lian-ping Shi Peng-Yu Su Department of Cardiovascular North China University of Science and Technology Affiliated HospitalTangshan 063000Hebei ProvinceChina

BACKGROUND Phytosterolemia,also known as sitosterolemia,is a rare autosomal recessive disease characterized by elevated plasma plant sterol levels and xanthomata,which is easily misdiagnosed as familial *** with homozygous phytosterolemia often have severe clinical manifestations,with xanthomata in childhood and premature *** patient had a milder clinical *** SUMMARY This report describes a patient with homozygous phytosterolemia who presented with only elevated cholesterol and low-density lipoprotein cholesterol(LDL-C)without xanthomata,arteriosclerosis,or hematological *** mutation of ABCG5 which encodes an ATP-binding cassette transporter,was detected by whole exome sequencing and diagnosed as *** of the patient’s plasma plant sterol levels detected significant elevations in stigmasterol,rapeseed oil-derived plant sterol,andβ-glutaminol *** was started and a low plant sterol diet was *** patient’s blood lipid profile was reexamined one month later and showed significant decreases in total cholesterol and LDL-C *** has similar clinical features as familial hypercholesterolemia,is highly susceptible to misdiagnosis,and has a very low incidence,and therefore clinicians need to consider a genetic diagnosis of a definitively hyperlipidemic disorder when statin drugs fail to lower lipid *** Phytosterolemia is easily misdiagnosed as familial hypercholesterolaemia and can be treated by dietary modification and cholesterol absorption inhibitors to lower blood lipids.

关键词： Hypercholesterolemia Cholesterol Low-density lipoprotein Phytosterolemia Liquid chromatography ABCG5/ABCG8 Sitosterolemia

高寒森林溪流对凋落叶分解过程中木质素降解的影响

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植物生态学报 2016年第9期40卷 893-901页

作者：岳楷杨万勤彭艳黄春萍张川吴福忠四川农业大学生态林业研究所林业生态工程省级重点实验室高山森林生态系统定位研究站成都611130 长江上游生态安全协同创新中心成都611130 四川师范大学生命科学学院成都610101

溪流广泛分布于高寒森林地表,凋落于其中的林木凋落物的分解是整个森林生态系统物质循环的重要环节,水体流动过程中的冲刷和淋洗作用及其他独特的环境条件可能显著影响凋落物中木质素的降解。该研究采用凋落袋法对比研究了岷江上游高寒... 详细信息

溪流广泛分布于高寒森林地表,凋落于其中的林木凋落物的分解是整个森林生态系统物质循环的重要环节,水体流动过程中的冲刷和淋洗作用及其他独特的环境条件可能显著影响凋落物中木质素的降解。该研究采用凋落袋法对比研究了岷江上游高寒森林4种典型且初始质量差异显著的凋落叶,即康定柳(Salix paraplesia)、高山杜鹃(Rhododendron lapponicum)、方枝柏(Sabina saltuaria)和四川红杉(Larix mastersiana),在不同生境(林下、溪流和河岸带)下分解过程中木质素残留质量和浓度(质量百分率)的动态变化特征。经过两年的分解,发现溪流显著促进了凋落叶中木质素的降解;同一物种凋落叶在不同生境下木质素残留质量差异显著(p<0.05),整体表现为溪流<河岸带<林下;在凋落叶分解的初期木质素有明显的降解,其浓度表现为先降低后升高,但不同物种之间存在显著(p<0.05)的差异;在整个分解过程中,木质素残留质量总体呈现出了降低的趋势。此外,生境类型、分解时期和区域性环境因子(温度、p H值和营养元素的有效性)能显著影响木质素的降解率。这些结果表明,传统上认为木质素在凋落叶分解初期相对稳定的观点可能并不准确,其浓度很可能是先下降后升高,这也与有关木质素动态的最新研究结果相一致。另一方面,在不同分解时期和不同生境下,凋落叶木质素降解率表现出了显著差异,表明区域性环境因子在凋落叶分解和木质素降解过程中具有重要的作用。

关键词：碳循环林下溪流河岸带降解率物种环境因子

BIBR1532 inhibits proliferation and metastasis of esophageal squamous cancer cells by inducing telomere dysregulation

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 214-225页

作者： Qin Wang Qing-Rong Li Lei Xu Zi-chun Yuan Xiao Liu Mao-Ju Tang Man Luo Xiao-wu Zhong Qiang Ma Xiao-Lan Guo Department of Clinical Laboratory Affiliated Hospital of North Sichuan Medical CollegeNanchong 637000Sichuan ProvinceChina School of Laboratory Medicine&Translational Medicine Research Center North Sichuan Medical CollegeNanchong 637000Sichuan ProvinceChina

BACKGROUND Esophageal squamous cell carcinoma(ESCC)is a malignant tumor with high morbidity and mortality,and easy to develop resistance to chemotherapeutic *** are DNA-protein complexes located at the termini of chro-mosomes in eukaryotic cells,which are unreplaceable in maintaining the stability and integrity of ***,an RNA-dependent DNA polymerase,play vital role in telomere length maintain,targeting telomerase is a promising therapeutic strategy for ***150 and KYSE410 cells were cultured and exposed to various concentrations of *** viability was assessed at 48 hours and 72 hours to determine the IC50 *** effects of BIBR1532 on ESCC cell proliferation,migration,and cellular senescence were evaluated using the cell counting kit-8 assay,plate colony formation assay,scratch assay,transwell assay,andβ-galactosidase staining,*** blotting was performed to detect the expression of RESULTS The IC50 values for KYSE150 and KYSE410 cells after 48 hours of BIBR1532 exposure were 48.53μM and 39.59μM,*** values decreased to 37.22μM and 22.71μM,respectively,following a longer exposure of 72 ***1532 exhibited dose-dependent effects on KYSE150 and KYSE410 cells,including decreased hTERT expression,inhibition of proliferation and metastasis,and induction of cellular ***,BIBR1532 upregulated the expression of the DDR protein,γ-H2AX,and activated the ataxia telangiectasia and Rad3-related protein(ATR)/check point kinase 1(CHK-1)and ataxia-telangiectasia mutated gene(ATM)/CHK2 ***1532 downregulated the expression of telomere-binding proteins,including telomeric-repeat binding factor 1(TRF1),TRF2,protection of telomeres 1,and TIN2-interacting protein *** a nude mouse xenograft model,BIBR1532 significantly suppressed tumor growth,reduced hTERT expression,and increasedγ-H2AX protein *** and eosin staining of various organs,including the heart,liver,s

关键词： Esophageal squamous cell carcinoma BIBR1532 Human telomerase reverse transcriptase DNA damage response Telomere-binding proteins

Superbond粘结系统作为牙周夹板对牙周组织影响的临床研究

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牙体牙髓牙周病学杂志 2012年第1期22卷 45-48页

作者：谭葆春肖健平吴文蕾南京大学口腔医学院.南京市口腔医院牙周科江苏南京210008

目的:观察Superbond粘结系统作为牙周夹板固定重度牙周炎导致的松动前牙后对牙周组织的影响。方法:选择重度牙周炎导致的前牙松动病人64例,随机分为实验组(Superbond固定组)和对照组(钢丝结扎加树脂组),每组32例。牙周基础治疗后1个月... 详细信息

目的:观察Superbond粘结系统作为牙周夹板固定重度牙周炎导致的松动前牙后对牙周组织的影响。方法:选择重度牙周炎导致的前牙松动病人64例,随机分为实验组(Superbond固定组)和对照组(钢丝结扎加树脂组),每组32例。牙周基础治疗后1个月牙周炎症得到控制,消除咬合创伤后固定。每3个月复查维护,观察12个月。比较固定前后所观察位点的牙周探诊深度(PD)、附着丧失(CAL)、龈沟出血指数(SBI)、菌斑指数(PLI)、牙龈指数(GI),并记录两种固定方法的美观性和舒适性。结果:实验组29例有效;对照组28例有效。实验组PD变浅(P0.05)。实验组美观性和舒适性调查满意度高于对照组。结论:在选择合适病例的前提下,Superbond粘结系统作为牙周夹板固定松动前牙美观、舒适,可提高咀嚼力,对牙周组织影响小,不妨碍菌斑控制。

关键词： Superbond粘结系统牙周夹板松动前牙牙周组织

The cGAS-STING-interferon regulatory factor 7 pathway regulates neuroinflammation in Parkinson's disease

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Neural Regeneration Research 2025年第8期20卷 2361-2372页

作者： Shengyang Zhou Ting Li Wei Zhang Jian wu Hui Hong Wei Quan Xinyu Qiao chun Cui Chenmeng Qiao Weijiang Zhao Yanqin Shen Laboratory of Neurodegenerative and Neuroinjury Diseases Wuxi Medicine SchoolJiangnan UniversityWuxiJiangsu ProvinceChina

Interferon regulatory factor 7 plays a crucial role in the innate immune ***,whether interferon regulatory factor 7-mediated signaling contributes to Parkinson's disease remains *** we report that interferon regulatory factor 7 is markedly up-regulated in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of Parkinson's disease and co-localizes with microglial *** the selective cyclic guanosine monophosphate adenosine monophosphate synthase inhibitor RU.521 and the stimulator of interferon genes inhibitor H151 effectively suppressed interferon regulatory factor 7 activation in BV2 microglia exposed to 1-methyl-4-phenylpyridinium and inhibited transformation of mouse BV2 microglia into the neurotoxic M1 *** addition,si RNA-mediated knockdown of interferon regulatory factor 7 expression in BV2 microglia reduced the expression of inducible nitric oxide synthase,tumor necrosis factorα,CD16,CD32,and CD86 and increased the expression of the anti-inflammatory markers ARG1 and *** together,our findings indicate that the cyclic guanosine monophosphate adenosine monophosphate synthase-stimulator of interferon genes-interferon regulatory factor 7 pathway plays a crucial role in the pathogenesis of Parkinson's disease.

关键词： cyclic guanosine monophosphate adenosine monophosphate synthase H151 interferon regulatory factor 7 M1 phenotype neurodegenerative disease neuroinflammation Parkinson’s disease RU521 STING type I interferon