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Endostatin inhibits hypertrophic scarring in a rabbit ear model

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2013年第3期14卷 224-230页

作者： Hai-tao REN hang HU Yuan LI Hong-fei JIANG Xin-lei HU chun-mao han Department of Burns and Wound Center the Second Affiliated HospitalSchool of MedicineZhejiang University Department of Ultrasound Women's HospitalSchool of MedicineZhejiang University Assisted Reproduction Unit Department of Obstetrics and GynecologySir Run Run Shaw HospitalSchool of MedicineZhejiang University

Objective： The present study was designed to use an in vivo rabbit ear scar model to investigate the efficacy of systemic administration of endostatin in inhibiting scar formation. Methods： Eight male New Zealand white rabbits were randomly assigned to two groups. Scar model was established by making six full skin defect wounds in each ear. For the intervention group, intraperitoneal injection of endostatin was performed each day after the wound healed （about 15 d post wounding）. For the control group, equal volume of saline was injected. Thickness of scars in each group was measured by sliding caliper and the scar microcirculatory perfusion was assessed by laser Doppler flowmetry on Days 15, 21, 28, and 35 post wounding. Rabbits were euthanatized and their scars were harvested for histological and proteomic analyses on Day 35 post wounding. Results： Macroscopically, scars of the control group were thicker than those of the intervention group. Significant differences between the two groups were observed on Days 21 and 35 （p〈0.05）. Scar thickness, measured by scar elevation index （SEI） at Day 35 post wounding, was significantly reduced in the intervention group （1.09±0.19） compared with the controls （1.36±0.28）. Microvessel density （MVD） observed in the intervention group （1.73±0.94） was significantly lower than that of the control group （5.63±1.78） on Day 35. The distribution of collagen fibers in scars treated with endostatin was relatively regular, while collagen fibers in untreated controls were thicker and showed disordered alignment. Western blot analysis showed that the expressions of type I collagen and Bcl-2 were depressed by injection of endostatin. Conclusions： Our results from the rabbit ear hypertrophic scar model indicate that systemic application of endostatin could inhibit local hypertrophic scar formation, possibly through reducing scar vascularization and angiogenesis. Our results indicated that endostatin may promote the apoptosis of endothelial ce

关键词： Endostatin Hypertrophic scar Systemic administration

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Application of collagen-chitosan/fibrin glue asymmetric scaffolds in skin tissue engineering

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2010年第7期11卷 524-530页

作者： chun-mao han Li-ping ZhanG Jin-zhang SUN Hai-fei SHI Jie ZHOU Chang-you GAO Department of Burn the Second Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310009 China Department of Polymer Science and Engineering Zhejiang University Hangzhou 310027 China

To create a scaffold that is suitable for the construction of tissue-engineered skin, a novel asymmetric porous scaffold with different pore sizes on either side was prepared by combining a collagen-chitosan porous membrane with fibrin glue. Tissue-engineered skin was fabricated using this asymmetric scaffold, fibroblasts, and a human keratinocyte line (HaCaT). Epidermal cells could be seen growing easily and achieved confluence on the fibrin glue on the upper surface of the scaffold. Scanning electron microscopy showed typical shuttle-like fibroblasts adhering to the wall of the scaffold and fluorescence microscopy showed them growing in the dermal layer of the scaffold. The constructed composite skin substitute had a histological structure similar to that of normal skin tissue after three weeks of culture. The results of our study suggest that the asymmetric scaffold is a promising biologically functional material for skin tissue engineering, with prospects for clinical applications.

关键词： Collagen Chitosan Fibrin glue Scaffold Tissue-engineered skin

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Clinical guideline on topical growth factors for skin wounds

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Burns & Trauma 2020年第1期8卷 106-115页

作者： chun-mao han Biao Cheng PanWu writing group of growth factor guideline on behalf of Chinese Burn Association Department of Burns&Wound Care Center the Second Affiliated Hospital of Zhejiang University School of MedicineNo.88 Jiefang RoadHangzhou 310009China Department of Burns&Plastic Surgery General Hospital of Southern Theater CommandPLANo.111 Liuhua RoadGuangzhou 510000China 不详

An increased number of patients with skin wounds have been witnessed in the past *** the various kinds of treatments for skin wounds,topical exogenous growth factors are indispensable and have been used in many ***,whether they have reliable effects remains controversial,and their application for skin wound treatment needs to be further standardized and optimized in terms of socio-economic ***,the Chinese Burn Association developed this guideline indicating efficacy,application details,adverse reactions and precautions of five clinically common topical growth factors using the Grading of Recommendations Assessment Development and Evaluation method to promote the rational application of topical exogenous growth factors in skin wounds and to benefit more patients.

关键词： Growth factor Skin wound Wound healing GRADE method Guideline

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Elevated skin autofluorescence is strongly associated with foot ulcers in patients with diabetes: a cross-sectional, observational study of Chinese subjects

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2012年第5期13卷 372-377页

作者： hang HU chun-mao han Xin-lei HU Wan-lan YE Wen-juan HUANG Andries J.SMIT Department of Burns and Wound Center the Second Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310009China Department of Endocrine and Diabetic Center the Seeond Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310009China Departrnent of Internal Medicine University Medical Center Groningen9700 RB Groningenthe Netherlands

Objective: This study was designed to evaluate the association between skin autofluorescence (AF), an indicator of advanced glycation end-products (AGEs), and foot ulcers in subjects with diabetes. Methods: In this study, 195 Chinese diabetic subjects were examined. Their feet were examined regardless of whether an ulcer was present or not. Skin AF was measured with an AGE reader. Demographic characteristics and blood data were recorded. Results: The mean values of skin AF were 2.29±0.47 for subjects without foot ulcers, and 2.80±0.69 for those with foot ulcers, a significant difference (P<0.05). Skin AF was strongly correlated with age and duration of diabetes. After adjusting for these factors, multivariate logistic regression showed that skin AF was independently associated with foot ulcerations. Conclusions: Skin AF is independently associated with diabetic foot ulcerations. It might be a useful screening method for foot ulceration risk of diabetic patients.

关键词： Advanced glycation end-products (AGEs) Diabetic foot ulcerations Screening

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Principles of extramural hl ealth care for chronic wounds in China

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Chinese Journal of Traumatology 2023年第4期26卷 187-192页

作者： Bin Xu Xin-Gang Wang Zi-Lun Meng Ling-Ya Zhu Yu-Xiang Zhang Pan Wu chun-mao han Department of Burns&Wound Care Center The Second Affliated Hospital of Zhejiang University School of MedicineHangzhou310009China Department of Burn&Rehabilitation Affliated Rehabilitation Hospital of Zhejiang Chinese Medical UniversityHangzhou310052.China Zhejiang Key Laboratory for Diagnosis and Treatment of Severe Trauma and Burn The Second Affliated Hospital of Zhejiang University School of MedicineHangzhou310oo9China The 2nd Clinical Medical College Zhejiang Chinese Medical UniversityHangzhou310053China Intensive Care Unit Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou310020China

Development of extramural health care for chronic wounds is still in its infancy in China,and thus it is urgent and vital to establish a correct concept and practicable *** authors reviewed recent domestic and international literature and summarized the following treatment procedures and principles for extramural health care of chronic wounds.(1)The patient needs to do self-assessment of the wound by using available simple methods;(2)The patient consults with professional physicians or nurses on wound care to define the severity and etiology of the non-healing wound;(3)Professionals evaluate the existing treatment strategies;(4)Etiological treatments are given by professionals;(5)Patients buy needed dressings via the more convenient ways from pharmacies,e-commerce platform or others;(6)Professionals provide a standardized and reasonable therapeutic plan based on the patient's wound conditions;(7)Both professionals and the patient pay attention to complications to prevent adverse outcomes;(8)Professionals strengthen the public education on wound care and integrated *** review expected to provide new perspectives on the therapeutic strategies for chronic wounds in an extramural setting.

关键词： Chronic wound Extramural health care Home-based therapy Wound healing Wound management

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High Fe‑Loading Single‑Atom Catalyst Boosts ROS Production by Density Effect for Efficient Antibacterial Therapy

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Nano-Micro Letters 2025年第2期17卷 187-203页

作者： Si Chen Fang Huang Lijie mao Zhimin Zhang han Lin Qixin Yan Xiangyu Lu Jianlin Shi Department of Cardiology Shanghai Tenth People’s HospitalSchool of MedicineTongji UniversityShanghai 200092People’s Republic of China Shanghai Institute of Ceramics Chinese Academy of SciencesShanghai 200050People’s Republic of China Shanghai Frontiers Science Center of Nanocatalytic Medicine School of MedicineTongji UniversityShanghai 200092People’s Republic of China

The current single-atom catalysts(SACs)for medicine still suffer from the limited active site ***,we develop a synthetic method capable of increasing both the metal loading and mass-specific activity of SACs by exchanging zinc with *** constructed iron SACs(h^(3)-FNC)with a high metal loading of 6.27 wt%and an optimized adjacent Fe distance of~4 A exhibit excellent oxidase-like catalytic performance without significant activity decay after being stored for six months and promising antibacterial ***,a“density effect”has been found at a high-enough metal doping amount,at which individual active sites become close enough to interact with each other and alter the electronic structure,resulting in significantly boosted intrinsic activity of single-atomic iron sites in h^(3)-FNCs by 2.3 times compared to low-and medium-loading ***,the overall catalytic activity of h^(3)-FNC is highly improved,with mass activity and metal mass-specific activity that are,respectively,66 and 315 times higher than those of commercial Pt/*** addition,h^(3)-FNCs demonstrate efficiently enhanced capability in catalyzing oxygen reduction into superoxide anion(O_(2)·^(−))and glutathione(GSH)*** in vitro and in vivo assays demonstrate the superior antibacterial efficacy of h^(3)-FNCs in promoting wound *** work presents an intriguing activity-enhancement effect in catalysts and exhibits impressive therapeutic efficacy in combating bacterial infections.

关键词： Nanocatalytic medicine Single-atom catalysts Reactive oxygen species(ROS) High metal loading Oxidase catalysis

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Deciphering fungal metabolon coupling tandem inverse-electrondemand Diels-Alder reaction and semipinacol rearrangement for the biosynthesis of spiro polycyclic alkaloids

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Science China Chemistry 2025年第1期68卷 288-296页

作者： Shuai Liu Wen-Qiang Xu Ying-Tong Di Man-Cheng Tang Ding-Kang Chen Ming-Ming Cao Yao-Wen Chang Hong-Yu Tang chun-mao Yuan Jun-Bo Yang Zhi-Li Zuo han Guo Zi-Fei Xu Ying Zeng Yun-Dong Wu Xiao-Jiang Hao Key Laboratory of Phytochemistry and Natural Medicines (Chinese Academy of Sciences) Kunming Institute of Botany Chinese Academy of Sciences University of Chinese Academy of Sciences Lab of Computational Chemistry and Drug Design State Key Laboratory of Chemical Oncogenomics Peking University Shenzhen Graduate School Shenzhen Bay Laboratory State Key Laboratory of Microbial Metabolism School of Life Sciences & Biotechnology Shanghai Jiao Tong University State Key Laboratory of Functions and Applications of Medicinal Plants Guizhou Medical University Molecular Biology Experimental Center Germplasm Bank of Wild Species in Southwest China Kunming Institute of Botany Chinese Academy of Sciences Yunnan Key Laboratory for Wild Plant Resources Kunming Institute of Botany Chinese Academy of Sciences Research Unit of Chemical Biology of Natural Anti-Virus Products Chinese Academy of Medical Sciences

In the intricate process of natural product biosynthesis, a metabolon can enhance metabolic flux by associating sequential enzymes. A fungal metabolon, comprising of flavin-dependent monooxygenase Spe F and P450 monooxygenase Spe G, is identified in the biosynthesis of spiro polycyclic alkaloids(+)-notoamide B and its diastereomer(+)-versicolamide B. Using notoamide E as a substance, Spe F/Spe G metabolon can control the stereoselectivity of its 2,3-epoxidation, followed by hydrogen atom ion at C-17 to generate reactive epoxide tau-m A with dienyl iminium unit. Subsequently,(+)-notoamide B and(+)-versicolamide B are produced via tandem nonenzymatic inverse-electron-demand Diels-Alder reaction and semipinacol rearrangement. This provides the first example of metabolon in the biosynthesis of spiro-prenylated indole alkaloids.

关键词： metabolon Diels-Alder reaction semipinacol rearrangement biosynthesis notoamides spiro polycyclic alkaloids

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Improving postoperative outcomes in patients with pancreatic cancer:Inflammatory and nutritional biomarkers

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World Journal of Clinical Oncology 2025年第1期16卷 59-64页

作者： chun-han Cheng Wen-Rui Hao Tzu-Hurng Cheng Department of Medical Education Linkou Chang Gung Memorial HospitalTaoyuan 33305Taiwan Division of Cardiology Department of Internal MedicineShuang Ho HospitalMinistry of Health and WelfareTaipei Medical UniversityNew Taipei 23561Taiwan Division of Cardiology Department of Internal MedicineSchool of MedicineCollege of MedicineTaipei Medical UniversityTaipei 11002Taiwan Department of Biochemistry School of MedicineCollege of MedicineChina Medical UniversityTaichung 404328Taiwan

This editorial assesses the prognostic value of preoperative inflammatory and nutritional biomarkers in patients undergoing surgical resection for pancreatic *** et al evaluated the ability of seven biomarkers to predict postoperative recovery and long-term *** biomarkers were albumin-to-globulin ratio,prognostic nutritional index(PNI),systemic immune-inflammation index,neutrophil-to-lymphocyte ratio,platelet-to-lymphocyte ratio,nutritional risk index,and geriatric nutritional risk *** PNI was found to be a strong predictor of both overall and recurrence-free survival,underscoring its clinical relevance in managing patients with pancreatic cancer.

关键词： Pancreatic cancer Prognostic nutritional index Systemic immune-inflammation index Postoperative recovery Prognosis

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Radiomics and molecular analysis:Bridging the gap for predicting hepatocellular carcinoma prognosis

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World Journal of Clinical Cases 2025年第4期13卷 56-60页

作者： chun-han Cheng Wen-Rui Hao Tzu-Hurng Cheng Department of Medical Education Linkou Chang Gung Memorial HospitalTaoyuan 33305TaiwanChina Division of Cardiology Department of Internal MedicineShuang Ho HospitalMinistry of Health and WelfareTaipei Medical UniversityNew Taipei 23561TaiwanChina Division of Cardiology Department of Internal MedicineSchool of MedicineCollege of MedicineTaipei Medical UniversityTaipei 11002TaiwanChina Department of Biochemistry School of MedicineCollege of MedicineChina Medical UniversityTaichung 404333TaiwanChina

This editorial examines a recent study that used radiomics based on computed tomography(CT)to predict the expression of the fibroblast-related gene enhancer of zeste homolog 2(EZH2)and its correlation with the survival of patients with hepatocellular carcinoma(HCC).By integrating radiomics with molecular analysis,the study presented a strategy for accurately predicting the expression of EZH2 from CT *** findings demonstrated a strong link between the radiomics model,EZH2 expression,and patient *** noninvasive approach provides valuable insights into the therapeutic management of HCC.

关键词： Hepatocellular carcinoma Computed tomography Radiomics Enhancer of zeste homologue 2 expression Non-invasive imaging

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竞争环境下促进农产品质量改进的投资策略研究

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管理工程学报 2025年第2期39卷 190-205页

作者：何征张旭辉罗茂冯春西南交通大学交通运输与物流学院四川成都610000 攀枝花学院四川攀枝花617000

本文基于两条竞争的“公司+农户”农产品供应链,考虑质量改进具有边际收益递减和边际成本递增规律,分析投资主体、供应链竞争强度、市场价格质量敏感度、控本能力等多个因素对决策的影响,识别促进质量改进并实现供应链参与者双赢的博弈... 详细信息

本文基于两条竞争的“公司+农户”农产品供应链,考虑质量改进具有边际收益递减和边际成本递增规律,分析投资主体、供应链竞争强度、市场价格质量敏感度、控本能力等多个因素对决策的影响,识别促进质量改进并实现供应链参与者双赢的博弈均衡特征和占优均衡。研究发现:(1)在没有竞争的情况下,供应链应该通过投资改进质量;在有竞争时,供应链是否投资取决于两条供应链的控本能力差异。如果差异较大,能力弱的供应链应选择不投资。(2)当两条供应链采用不同的提质策略时,竞争强度、价格质量敏感度和提质者控本能力的增加都会扩大双方的利润差距。(3)投资主体和质量改进决策主体保持一致的决策机制能够保证投资的激励相容,促使供应链成员主动投资从而改进质量。(4)竞争能够降低供应链非合作代价,提升供应链效率。

关键词：质量改进竞争供应链订单农业供应链效率

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