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有机化学 2004年第z1期24卷 21-22页

作者： SONG,chun-lian wang,Dao-Lin IMAFUKU,Kimiaki Jixi University Jixi 158100 China School of Chemical Engineering & Environment Beijing Institute of Technology Beijing 100081 China Department of Chemistry Kumamoto University Kumamoto 860 Japan

　　Thiazole derivatives have attracted a great deal of interest owing to their physiological activities. In addition, thiazoles are also useful in dye and photographic industry.[1] In the present paper we report the ...

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Primary shunt hyperbilirubinaemia in a large four-generation family confirming autosomai dominant genetic disorder

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World Journal of Gastroenterology 2006年第19期12卷 3123-3125页

作者： chun-lian wang Xiao-Wei Liu Fang-Gen Lu Xiao-Ping Wu chun-Hui Ouyang Dong-Ye Yang Department of Gastroenterology the Second Xiangya Hospital Central South University Changsha 410011 Hunan Province China

AIM： To describe the pattern of inheritance and confirm the diagnostic criteda of primary shunt hyperbilirubinaemia （PSH）. METHODS： Forty members of a family pedigree across four generations were included in this study. All family members were interviewed and investigated by physical examination, hematology and liver function test and the pattern of inheritance was analyzed. RESULTS： Nine of the forty family members suffered primary shunt hyperbilirubinaemia. The mature erythrocytes of the propositus were irregular in shape and size. The pedigree showed transmission of the trait through four generations with equal distribution in male and female. No individual with a primary shunt hyperbilirubinaemia was born to unaffected parents. The penetrance was complete in adult. CONCLUSION： The pattern of inheritance is autosomal dominant. The abnormality of erythrocytes and decrease in white blood cell could be supplemented in the diagnosis of PSH. The PSH is a genetic disorder and could by renamed as hereditary shunt hyperbilirubinaemia.

关键词： Hyperbilirubinaemia Hereditary Shunt

Palynology and stratigraphy of the thick evaporate-bearing Shashi Formation in Jiangling Depression,Jianghan Basin of South China,and its paleoclimate change

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China Geology 2020年第2期3卷 283-291页

作者： chun-lian wang Cheng-lin Liu Jiu-yi wang Xiao-can Yu Kai Yan Ministry of Natural Resources Key Laboratory of Metallogeny and Mineral Assessment Institute of Mineral ResourcesChinese Academy of Geological SciencesBeijing 100037China

In the greater inland Jianghan Basin of South China,three salt depressions are lacking accurate geological times,of which Jiangling Depression is the *** are important records of paleoclimate,however,the geological ages of evaporates are very difficult to be determined because often evaporates have scare macrofossils and *** Cretaceous to Tertiary halite deposits interbedded with mudstones are widely distributed in ***-Eocene Thermal Maximum had very high temperatures and attracted strong interests of geologists because these times can be compared with future climate change because of global ***,previous studies focused on marine sediments found that during the Paleocene-Early Eocene,massive evaporate deposits formed in Jiangling depression of the Jianghan *** this paper,the authors show that the Shashi Formation halite deposits formed in the Paleocene according to *** of these palynology fossils are arid types,so the massive evaporites in the Jiangling depression could be closely related to the hot Paleocene *** temperatures during the Paleocene contributed to the formation of the massive evaporates in the Jiangling Depression,until sylvite was the result.

关键词： Palynology Geological age of evaporate Sylvite Paleocene Paleoclimate Shashi Formation Mineral exploration engineering South China

Lactobacillus crispatus M206119 exacerbates murine DSS-colitis by interfering with inflammatory responses

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World Journal of Gastroenterology 2012年第19期18卷 2344-2356页

作者： Fu-Xi Zhou Lu Chen Xiao-Wei Liu chun-Hui Ouyang Xiao-Ping Wu Xue-Hong wang chun-lian wang Fang-Gen Lu Division of Digestive Disease Xiangya Second-HospitalCentral South UniversityChangsha 410011Hunan ProvinceChina

AIM： TO investigate the role of Lactobacillus crispatus （L. crispatus） strain China Center for Type Culture Col- lection （CCTCC） M206119 in intestinal inflammation.METHODS： Forty 8-wk-old Balb/c mice （20± 2 g） were divided into four groups of 10 mice each. Three groups that had received dextran sulfate sodium （DSS） were administered normal saline, sulfasalazine or CCTCC M206119 strain, and the fourth group received none of these. We assessed the severity of colitis using a disease activity index, measured the colon length and weight, collected stools and mesenteric lymph nodes for bacterial microflora analysis. One centimeter of the proximal colon, middle colon and distal colon were collected and fixed in 10% buffered formalin, dehydrated in ethanol, and embedded in paraffin. Interleukin （IL）- 1β, IL-6 and tumor necrosis factor （TNF）-α expression was detected using reverse transcription polymerase chain reaction. Protective factors zonula occludens （ZO）-1 and β-defensin 2 were detected by immunoblot-ting. The features of CCTCC M206119 strain were identified based on morphology, biochemical profile, and 16S RNA sequencing.RESULTS： DSS-colitis animals treated with CCTCC M206119 had markedly more severe disease, with greater weight loss, diarrhea, fecal bleeding, and shortened colon length. In addition, the CCTCC-M206119- treated group had comparatively higher histologi- cal scores and more neutrophil infiltration than the controls. Expression of protective factors ZO-1 and β-defensin 2 was downregulated due to destruction of the mucosal barrier after CCTCC M206119 strain treatment. An in vitro assay demonstrated that CCTCC M206119 strain increased the nuclear translocation of nuclear factor-κB in epithelial cells. Intestinal proinflam- matory or anti-inflammatory cytokine responses were evaluated. Proinflammatory colonic cytokine （IL-Iβ, IL-6 and TNF-α） levels were clearly increased in CCTCC- M206119-treated animals, whereas anti-inflammatory colonic cytokine （IL-

关键词： Colitis Lactobacillus crispatus Intestine Dextra sodium sulfate Mice

First report of TSR origin minerals filled in anhydrite dissolved pores in southeastern Ordos Basin

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China Geology 2019年第2期2卷 245-247页

作者： Li-hong Liu chun-lian wang Xing-min Zhao Oil & Gas Survey China Geological SurveyMinistry of Natural Resources Beijing 100083China School of Earth and Space Sciences Peking University/Institute of Oil & GasPeking UniversityBeijing 100871China MLR Key Laboratory of Metallogeny and Mineral Assessment Institute of Mineral ResourcesChinese Academy of Geological SciencesBeijing 100037China

*** Yican 1 well, drilled in Southeastern Ordos Basin by Oil & Gas Survey, China Geological Survey in 2014 produced 3.7×104 m3 natural gas daily, which is the most productive well in the area by far. However, the reservoir quality is poor compared with those of Jingbian gas field in the middle of the Basin, which is mainly caused by the pores filling in karst reservoir.

关键词： TSR anhydrite dissolved pores southeastern Ordos Basin

AN X-RAY INVESTIGATION OF A SMECTIG, CYCLOTETRASILOXANE LIQUID CRYSTALV

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Chinese Chemical Letters 1994年第4期5卷 349-350页

作者： Zhao Hui LUO Ren Xi ZHUO Xian liang ZHANG(Chemistry Department, Wuhan University, Wuhan 430072)chun Lin wang, lian Xin CAO(Auatysis & Test Center, Wuhan University, Wutan 430072)

X-ray diffraction has been used to investigate a tiquid crystattine cyctotetrasiloxane mith combination of a mesogen pendant on the siloxane ring. The change of Bragg spacings in solid state and SA phase of the samples with different thermat treatments was detected. It is assumed that the aggregate structure of this sample agrees mith bundte structure arranged in interdigitating layers, and the stloxane ring planes are parallet to the long axes of the molecutes in the mesophase and crystat state.

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儿童艾滋病15例临床特点分析

中华儿科杂志 2009年第5期47卷 389-390页

作者：杨燕王春连盛燕王静莫鑫首都医科大学附属北京儿童医院中医科 100045

艾滋病是指感染人类免疫缺陷病毒（HIV）后，免疫功能受抑制到一定程度时出现的临床疾病，对人类健康和社会发展造成严重的危害。据世界卫生组织及世界艾滋病规划署联合公布：至2005年全球的4030万例艾滋病病毒感染者中，15岁以下儿童已... 详细信息

艾滋病是指感染人类免疫缺陷病毒（HIV）后，免疫功能受抑制到一定程度时出现的临床疾病，对人类健康和社会发展造成严重的危害。据世界卫生组织及世界艾滋病规划署联合公布：至2005年全球的4030万例艾滋病病毒感染者中，15岁以下儿童已达230万例。为探讨儿童艾滋病的临床发病特点，提高对该病的认识，我们对1999至2006年经我院确诊的15例儿童艾滋病患儿进行临床资料分析，报告如下。

关键词：艾滋病病毒感染者临床特点儿童人类免疫缺陷病毒世界卫生组织免疫功能受抑临床疾病人类健康

幽门螺杆菌致病机制及益生菌防治作用的研究进展

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世界华人消化杂志 2007年第25期15卷 2690-2697页

作者：陈云华汪春莲谢云中南大学湘雅二医院湖南省长沙市410005 长沙市卫生学校湖南省长沙市410100

幽门螺杆菌(H pylori)己被确认与慢性胃炎、消化性溃疡、胃黏膜相关淋巴样组织淋巴瘤和胃癌密切相关,目前多种抗生素联合治疗仍是抗H pylori感染的主要方法,但是由于细菌抗药性的出现、以及长期不合理应用抗生素可引起不良反应,因此近... 详细信息

幽门螺杆菌(H pylori)己被确认与慢性胃炎、消化性溃疡、胃黏膜相关淋巴样组织淋巴瘤和胃癌密切相关,目前多种抗生素联合治疗仍是抗H pylori感染的主要方法,但是由于细菌抗药性的出现、以及长期不合理应用抗生素可引起不良反应,因此近年提出了抗H pylori感染一些新方法,其中益生菌在提高H pylori根除率及减少药物不良反应方面尤显优势,而且还具有维持胃肠道微生态的稳定、减轻黏膜炎症反应等多种作用,本文就H pylori的致病机制及益生菌治疗H pylori感染的研究进展作一综述.

关键词：幽门螺杆菌致病机制益生菌治疗

Return to work in young and middle-aged colorectal cancer survivors:Factors influencing self-efficacy,fear,resilience,and financial toxicity

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World Journal of Gastroenterology 2025年第1期31卷 79-92页

作者： Dan Hu Yue Li Hua Zhang lian-lian wang Wen-Wen Liu Xin Yang Ming-Zhao Xiao Hao-Ling Zhang Juan Li Department of Nursing The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Nursing National Clinical Research Center for Child Health and DisordersMinistry of Education Key Laboratory of Child Development and DisordersChildren’s Hospital of Chongqing Medical UniversityChongqing 400014China Department of Gastrointestinal Surgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Biomedical Science Advanced Medical and Dental InstituteUniversity Sains MalaysiaPenang 13200Malaysia Academic Affairs Office The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China

BACKGROUND Return to work(RTW)serves as an indication for young and middle-aged colorectal cancer(CRC)survivors to resume their normal social ***,these survivors encounter significant challenges during their RTW ***,scientific research is necessary to explore the barriers and facilitating factors of returning to work for young and middle-aged CRC *** To examine the current RTW status among young and middle-aged CRC survivors and to analyze the impact of RTW self-efficacy(RTW-SE),fear of progression(FoP),eHealth literacy(eHL),family resilience(FR),and financial toxicity(FT)on their RTW *** A cross-sectional investigation was adopted in this *** September 2022 to February 2023,a total of 209 participants were recruited through a convenience sampling method from the gastrointestinal surgery department of a class A tertiary hospital in *** investigation utilized a general information questionnaire alongside scales assessing RTW-SE,FoP,eHL,FR,and *** analyze the factors that influence RTW outcomes among young and middle-aged CRC survivors,Cox regression modeling and Kaplan-Meier survival analysis were *** A total of 43.54%of the participants successfully returned to work,with an average RTW time of 100 *** regression univariate analysis revealed that RTW-SE,FoP,eHL,FR,and FT were significantly different between the non-RTW and RTW groups(P<0.05).Furthermore,Cox regression multivariate analysis identified per capita family monthly income,job type,RTW-SE,and FR as independent influencing factors for RTW(P<0.05).CONCLUSION The RTW rate requires further *** levels of RTW-SE and FR were found to significantly increase RTW among young and middle-aged CRC *** professionals should focus on modifiable factors,such as RTW-SE and FR,to design targeted RTW support programs,thereby facilitating their timely reintegration into mainstream society.

关键词： Return to work Colorectal neoplasms Return-to-work self-efficacy Fear of progression Family resilience Financial toxicity

Homozygous phytosterolemia and a literature review:A case report

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World Journal of Clinical Cases 2025年第10期13卷 46-52页

作者： chun-Xin Jiang Guang Yang lian-Ping Shi Peng-Yu Su Department of Cardiovascular North China University of Science and Technology Affiliated HospitalTangshan 063000Hebei ProvinceChina

BACKGROUND Phytosterolemia,also known as sitosterolemia,is a rare autosomal recessive disease characterized by elevated plasma plant sterol levels and xanthomata,which is easily misdiagnosed as familial *** with homozygous phytosterolemia often have severe clinical manifestations,with xanthomata in childhood and premature *** patient had a milder clinical *** SUMMARY This report describes a patient with homozygous phytosterolemia who presented with only elevated cholesterol and low-density lipoprotein cholesterol(LDL-C)without xanthomata,arteriosclerosis,or hematological *** mutation of ABCG5 which encodes an ATP-binding cassette transporter,was detected by whole exome sequencing and diagnosed as *** of the patient’s plasma plant sterol levels detected significant elevations in stigmasterol,rapeseed oil-derived plant sterol,andβ-glutaminol *** was started and a low plant sterol diet was *** patient’s blood lipid profile was reexamined one month later and showed significant decreases in total cholesterol and LDL-C *** has similar clinical features as familial hypercholesterolemia,is highly susceptible to misdiagnosis,and has a very low incidence,and therefore clinicians need to consider a genetic diagnosis of a definitively hyperlipidemic disorder when statin drugs fail to lower lipid *** Phytosterolemia is easily misdiagnosed as familial hypercholesterolaemia and can be treated by dietary modification and cholesterol absorption inhibitors to lower blood lipids.

关键词： Hypercholesterolemia Cholesterol Low-density lipoprotein Phytosterolemia Liquid chromatography ABCG5/ABCG8 Sitosterolemia