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Percutaneous transhepatic cholangioscopy-assisted biliary polypectomy for local palliative treatment of intraductal papillary neoplasm of the bile duct

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 1821-1832页

作者： Xu Ren Yong-Ping Qu chun-lan zhu Xiao-Hong Xu Hong Jiang Yi-Xia Lu Hong-Peng Xue Digestive Disease Hospital of Heilongjiang Provincial Hospital Heilongjiang Provincial Clinical Medical Research Center for Minimally Invasive Diagnosis and Treatment of Pancreaticobiliary DiseasesHarbin 150001Heilongjiang ProvinceChina Digestive Endoscopy Center of Heilongjiang Provincial Hospital Heilongjiang Provincial Clinical Medical Research Center for Minimally Invasive Diagnosis and Treatment of Pancreaticobiliary DiseasesHarbin 150001Heilongjiang ProvinceChina Second Department of Gastroenterology Digestive Disease Hospital of Heilongjiang Provincial Hospitaland Heilongjiang Provincial Clinical Medical Research Center for Minimally Invasive Diagnosis and Treatment of Pancreaticobiliary DiseasesHarbin 150001Heilongjiang ProvinceChina Department of Pathology Heilongjiang Provincial HospitalHarbin 150001Heilongjiang ProvinceChina

BACKGROUND Intraductal papillary neoplasm of the bile duct(IPNB)is a premalignant biliarytype epithelial neoplasm with intraductal papillary or villous *** reported local palliative therapeutic modalities,including endoscopic nasobiliary drainage,stenting and biliary curettage,endoscopic biliary polypectomy,percutaneous biliary drainage,laser ablation,argon plasma coagulation,photodynamic therapy,and radiofrequency ablation to relieve mechanical obstruction are limited with weaknesses and *** have applied percutaneous transhepatic cholangioscopy(PTCS)-assisted biliary polypectomy(PTCS-BP)technique for the management of IPNB including mucin-hypersecreting cast-like and polypoid type tumors since *** To assess the technical feasibility,efficacy,and safety of PTCS-BP for local palliative treatment of *** Patients with mucin-hypersecreting cast-like or polypoid type IPNB and receiving PTCS-BP between September 2010 and December 2019 were ***-BP was performed by using a half-moon type snare with a soft stainless-steel wire,and the tumor was snared and resected with *** primary outcome was its feasibility,indicated by technical *** secondary outcomes were efficacy,including therapeutic success,curative resection,and clinical success,and *** Five patients(four with mucin-hypersecreting cast-like type and one with polypoid type IPNB)were ***-and high-grade intraepithelial neoplasia(HGIN)and recurrent IPNB with invasive carcinoma were observed in one,two,and two patients,*** cholangitis and/or obstructive jaundice were presented in all four patients with mucin-hypersecreting cast-like type *** five patients achieved technical success of *** patients(three with mucin-hypersecreting cast-like type and one with polypoid type IPNB)obtained therapeutic success;one with mucin-hypersecreting cast-like type tumors in the intrahepatic small bile duct and HGIN h

关键词： Intraductal papillary neoplasm of the bile duct Percutaneous transhepatic cholangioscopy Biliary polypectomy Feasibility Efficacy

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A multiscale adaptive framework based on convolutional neural network: Application to fluid catalytic cracking product yield prediction

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Petroleum Science 2024年第4期21卷 2849-2869页

作者： Nan Liu chun-Meng zhu Meng-Xuan Zhang Xing-Ying lan State Key Laboratory of Heavy Oil Processing China University of Petroleum (Beijing) College of Artificial Intelligence China University of Petroleum (Beijing)

Since chemical processes are highly non-linear and multiscale, it is vital to deeply mine the multiscale coupling relationships embedded in the massive process data for the prediction and anomaly tracing of crucial process parameters and production indicators. While the integrated method of adaptive signal decomposition combined with time series models could effectively predict process variables, it does have limitations in capturing the high-frequency detail of the operation state when applied to complex chemical processes. In light of this, a novel Multiscale Multi-radius Multi-step Convolutional Neural Network(Msrt Net) is proposed for mining spatiotemporal multiscale information. First, the industrial data from the Fluid Catalytic Cracking(FCC) process decomposition using Complete Ensemble Empirical Mode Decomposition with Adaptive Noise(CEEMDAN) extract the multi-energy scale information of the feature subset. Then, convolution kernels with varying stride and padding structures are established to decouple the long-period operation process information encapsulated within the multi-energy scale data. Finally, a reconciliation network is trained to reconstruct the multiscale prediction results and obtain the final output. Msrt Net is initially assessed for its capability to untangle the spatiotemporal multiscale relationships among variables in the Tennessee Eastman Process(TEP). Subsequently, the performance of Msrt Net is evaluated in predicting product yield for a 2.80 × 10～6 t/a FCC unit, taking diesel and gasoline yield as examples. In conclusion, Msrt Net can decouple and effectively extract spatiotemporal multiscale information from chemical process data and achieve a approximately reduction of 30% in prediction error compared to other time-series models. Furthermore, its robustness and transferability underscore its promising potential for broader applications.

关键词： Fluid catalytic cracking Product yield Data-driven modeling Multiscale prediction Data decomposition Convolution neural network

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Co-occurrence of IPMN and malignant IPNB complicated by a pancreatobiliary fistula: A case report and review of the literature

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World Journal of Clinical Cases 2019年第1期7卷 102-108页

作者： Xu Ren chun-lan zhu Xu-Fu Qin Hong Jiang Tian Xia Yong-Ping Qu Digestive Disease Hospital of Heilongjiang Provincial Hospital The Second Digestive Department Digestive Disease Hospital of Heilongjiang Provincial Hospital Department of Pathology of Heilongjiang Provincial Hospital Digestive Endoscopy Center Digestive Disease Hospital of Heilongjiang Provincial Hospital

BACKGROUND Intraductal papillary neoplasm of the bile duct(IPNB) is pathologically similar to intraductal papillary mucinous neoplasm(IPMN). However, there are several significant differences between them. The rate of IPMN associated with extrapancreatic malignancies has been reported to range from 10%-40%, and it may occasionally be complicated with the presence of fistulas. IPMN associated with malignant IPNB is extremely rare and only nine cases have been reported in the *** SUMMARY We report a 52-year-old man who presented with recurrent cholangitis for nine months. Computed tomography and magnetic resonance cholangiopancreatography showed the common bile duct stricture with dilated pancreatobiliary duct without other abnormal findings. The underlying pathogenesis could not be identified based on the radiologic images. Endoscopic retrograde cholangiopancreatography revealed a pancreatobiliary fistula with dilated main pancreatic duct, biliary stricture with dilated biliary tree, and mucus discharge from the enlarged orifice of the major papilla. The patient underwent SpyGlass cholangiopancreatoscopy due to a suspected mucin-producing biliary neoplasm and indeterminate main pancreatic duct dilatation. Multiple papillary growing neoplasms with vascular images, with the extent of lesions spreading in the biliopancreatic ductal lumens, were identified by SpyGlass. In addition, the presence of a pancreatobiliary fistula was also identified. The patient was diagnosed as having benign IPMN and malignant IPNB with focal invasion by postoperative pathology. Furthermore, varying histological subtypes were present in both IPMN and IPNB. Pylorus-preserving pancreaticoduodenectomy was performed on the patient with excellent results during the 52 month followup *** We deemed that pancreatography and SpyGlass allowed for an efficient diagnosis of IPMN with pancreatobiliary fistula, whereas the etiology could not be identified by radiologic imaging.

关键词： Intraductal papillary mucinous neoplasm of the pancreas Intraductal papillary neoplasm of the bile duct Extrapancreatic malignancies Co-occurrence Pancreatobiliary fistula SpyGlass cholangiopancreatoscopy Endoscopic retrograde cholangiopancreatography Case report

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Constructing highly safe and long-life calcium ion batteries based on hydratedvanadium oxide cathodes featuring a pillar structure

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Rare Metals 2024年第6期43卷 2597-2612页

作者： chun-Fang Wang Shi-Wei Zhang lan Huang Yuan-Min zhu Feng Liu Jian-Chuan Wang Li-Ming Tan chun-Yi Zhi Cui-Ping Han Powder Metallurgy Research Institute Central South UniversityChangsha410083China Songshan Lake Materials Laboratory Dongguan 523808China Research Institute of Interdisciplinary Science and School of Materials Science and Engineering Dongguan University of TechnologyDongguan 523808China Department of Materials Science and Engineering City University of Hong KongHong Kong 999077China Faculty of Materials Science and Energy Engineering/Institute of Technology for Carbon Neutrality Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China

Calcium-ion batteries(CIBs)have generated intense interest due to the growing demand for safer,cheaper,and large-scale energy storage ***,their development is still in its infancy,owing to the lack of suitable cathodes for sustaining reversiblc Ca^(2+)intercalation/***,layered H_(2)V_(3)O_(8)(HVO)with Zn^(2+)pre-insertion(ZHVO)is reported as a high-rate and highly durable cathode material for *** existence of Zn^(2+)and H_(2)O pillars could expand the interlayer spacing up to 1.8 nm,which is favorable for the diffusion of bulky Ca^(2+).The formation of Zn-O bonds facilitates electron transfer and enhances electrical ***,the ZHVO cathode achieves superior capacity performance(213.9 mAh·g^(-1)at 0.2 A·g^(-1))and long lifespan(78.3%for 1,000 cycles at 5 A·g^(-1))compared to pristine *** functional theory(DFT)calculations revealed that Zn^(2+)moved during Ca^(2+)intercalation,thereby reducing the diffusion energy barrier and facilitating Ca^(2+)***,a safe aqueous calcium ion cell was successfully assembled.

关键词： Multivalent batteries Calcium-ion batteries Layered structure Vanadium oxide Cathode materials

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Piezoelectricity activates persulfate for water treatment:A perspective

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Environmental Science and Ecotechnology 2024年第2期18卷 7-12页

作者： Zhi Li Shenyu lan Mingshan zhu Guangdong Key Laboratory of Environmental Pollution and Health School of EnvironmentJinan UniversityGuangzhou511443China Department of Environmental Science and Engineering Xi'an Jiaotong UniversityXi'an710049China

Advanced oxidation processes(AOPs)utilizing persulfate(PS)offer great potential for wastewater ***,the dependency on energy and chemical-intensive activation techniques,such as ultraviolet radiation and transition metal ions,constrains their widespread *** this limitation,researchers are turning towards the piezoelectric effectda novel,energy-efficient method for PS activation that capitalizes on the innate piezoelectric characteristics of ***,this method taps into weak renewable mechanical forces omnipresent in nature,ranging from wind,tides,water flow,sound,and atmospheric *** this perspective,we delve into the burgeoning realm of piezoelectric/PS-AOPs,elucidating its fundamental principles,the refinement of piezoelectric materials,potential mechanical force sources,and pertinent application *** emerging technology harbors significant potential as a pivotal element in wastewater pretreatment and may spearhead innovations in future water pollution control engineering.

关键词： Piezoelectric charge Persulfate Piezoelectric activation Water treatment

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An Imbalanced Data Classification Method Based on Hybrid Resampling and Fine Cost Sensitive Support Vector Machine

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Computers, Materials & Continua 2024年第6期79卷 3977-3999页

作者： Bo zhu Xiaona Jing lan Qiu Runbo Li College of Mechanical and Electrical Engineering Kunming University of Science&TechnologyKunming650500China

When building a classification model,the scenario where the samples of one class are significantly more than those of the other class is called data *** imbalance causes the trained classification model to be in favor of the majority class(usually defined as the negative class),which may do harm to the accuracy of the minority class(usually defined as the positive class),and then lead to poor overall performance of the model.A method called MSHR-FCSSVM for solving imbalanced data classification is proposed in this article,which is based on a new hybrid resampling approach(MSHR)and a new fine cost-sensitive support vector machine(CS-SVM)classifier(FCSSVM).The MSHR measures the separability of each negative sample through its Silhouette value calculated by Mahalanobis distance between samples,based on which,the so-called pseudo-negative samples are screened out to generate new positive samples(over-sampling step)through linear interpolation and are deleted finally(under-sampling step).This approach replaces pseudo-negative samples with generated new positive samples one by one to clear up the inter-class overlap on the borderline,without changing the overall scale of the *** FCSSVM is an improved version of the traditional *** considers influences of both the imbalance of sample number and the class distribution on classification simultaneously,and through finely tuning the class cost weights by using the efficient optimization algorithm based on the physical phenomenon of rime-ice(RIME)algorithm with cross-validation accuracy as the fitness function to accurately adjust the classification *** verify the effectiveness of the proposed method,a series of experiments are carried out based on 20 imbalanced datasets including both mildly and extremely imbalanced *** experimental results show that the MSHR-FCSSVM method performs better than the methods for comparison in most cases,and both the MSHR and the FCSSVM played significan

关键词： Imbalanced data classification Silhouette value Mahalanobis distance RIME algorithm CS-SVM

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Animal models of hepatitis E infection: Advances and challenges

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Hepatobiliary & Pancreatic Diseases International 2024年第2期23卷 171-180页

作者： Ze Xiang Xiang-Lin He Chuan-Wu zhu Jia-Jia Yang lan Huang chun Jiang Jian Wu Chinese Consortium for the Study of Hepatitis E(CCSHE) Zhejiang University School of Medicine Hangzhou 310030China Department of Infectious Diseases The Fifth People’s Hospital of SuzhouSuzhou 215007China Department of Infection Management The Affiliated Suzhou Hospital of Nanjing Medical UniversitySuzhou Municipal HospitalGusu SchoolNanjing Medical UniversitySuzhou 215008China Department of Clinical Laboratory The Affiliated Suzhou Hospital of Nanjing Medical UniversitySuzhou Municipal HospitalGusu SchoolNanjing Medical UniversitySuzhou 215008China 不详

Hepatitis E virus(HEV)is one of the leading causes of acute viral hepatitis *** most of HEV infections are asymptomatic,some patients will develop the symptoms,especially pregnant women,the elderly,and patients with preexisting liver diseases,who often experience anorexia,nausea,vom-iting,malaise,abdominal pain,and *** infection may become chronic in immunosuppressed *** addition,HEV infection can also cause several extrahepatic *** exists in a wide range of hosts in nature and can be transmitted across ***,animals susceptible to HEV can be used as *** establishment of animal models is of great significance for studying HEV transmission,clinical symptoms,extrahepatic manifestations,and therapeutic strategies,which will help us understand the pathogenesis,prevention,and treatment of hepatitis *** review summarized the animal models of HEV,including pigs,monkeys,rabbits,mice,rats,and other *** each animal species,we provided a concise summary of the HEV genotypes that they can be infected with,the cross-species transmission pathways,as well as their role in studying extrahepatic manifestations,prevention,and treatment of HEV *** advantages and disadvantages of these animal models were also *** review offers new perspectives to enhance the current understanding of the research landscape surrounding HEV animal models.

关键词： Hepatitis E virus Animal models Pathogenesis Prevention Treatment

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High-entropy design boosts dielectric energy storage

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Rare Metals 2024年第8期43卷 4013-4015页

作者： Qiu-Ying Xia He zhu Si lan Yang Ren Herbert Gleiter Institute of Nanoscience School of Materials Science and EngineeringNanjing University of Science and TechnologyNanjing 210094China Department of Physics City University of Hong KongHong Kong999077China

Dielectric capacitors are vital for advanced electronic and electrical power systems due to their impressive power density and ***,a persistent challenge has been enhancing their energy densities while maintaining high *** in Science,a novel high-entropy design for relaxor ferroelectric materials has been proposed,promising significant improvements in both energy density and efficiency for multilayer dielectric ceramic *** the crucial role of high-entropy design in energy storage materials and devices,this highlight focuses on interpreting the progress and significance of this innovative work.

关键词： ceramic dielectric energy

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Application of Bionic Technology in Marine Cruise Equipment:Research Progress and Development Trends

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Journal of Bionic Engineering 2024年第3期21卷 1117-1155页

作者： Kunhui Luo lan Yan Zhiyi zhu Zhongqiu Wang Hongru Wang Feng Jiang School of Electromechanical and Automation Huaqiao UniversityXiamen36102China National Local Joint Engineering Research Center for Intelligent Manufacturing Technology of Brittle Material Products Xiamen361021China Institute of Oceanographic Instrumentation Shandong Academy of SciencesQilu University of Technology(Shandong Academy of Sciences)Qingdao266100China Shandong Provincial Key Laboratory of Marine Monitoring Instrument Equipment Technology Qingdao266100China National Engineering and Technological Research Center of Marine Monitoring Equipment Qingdao266100China Institute of Manufacturing Engineering Huaqiao UniversityXiamen361021China

This article provides an overview of the application of bionic technology in marine cruising equipment,discussing its research progress and future development *** cruising is a crucial means of gaining insights into the marine environment and conducting scientific ***,conventional marine cruising equipment faces numerous challenges when dealing with complex and ever-changing marine *** technology,as a means of drawing inspiration from the structure and functions of living organisms,offers new approaches and methods to address the challenges faced by marine cruising equipment and has found widespread *** article primarily focuses on the applications and historical developments of bionic technology in propulsion methods,drag reduction,and surface *** summarizes the design principles,manufacturing techniques,and optimization methods for marine biomimetic cruising ***,this paper analyzes the achievements,challenges,and future directions of bionic technology in marine cruising *** application of bionic technology in marine cruising equipment holds vast potential for development,enabling us to better confront the challenges of marine exploration and research by drawing wisdom from nature and driving advancements in marine science.

关键词： Marine cruising equipment Bionic technology Propulsion methods Drag reduction Surface antifouling

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Allosteric modulation of G protein-coupled receptors as a novel therapeutic strategy in neuropathic pain

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Acta Pharmaceutica Sinica B 2024年第1期14卷 67-86页

作者： chunhao zhu Xiaobing lan Zhiqiang Wei Jianqiang Yu Jian Zhang School of Pharmacy Ningxia Medical UniversityYinchuan 750004China Medicinal Chemistry and Bioinformatics Center Shanghai Jiao Tong University School of MedicineShanghai 200025China School of Basic Medical Science Ningxia Medical UniversityYinchuan 750004China Medicinal Chemistry and Bioinformatics Center Ocean University of ChinaQingdao 266100China State Key Laboratory of Pharmaceutical Biotechnology Nanjing UniversityNanjing 210023China

Neuropathic pain is a debilitating pathological condition that presents significant therapeutic challenges in clinical ***,current pharmacological treatments for neuropathic pain lack clinical efficacy and often lead to harmful adverse *** G protein-coupled receptors(GPCRs)are widely distributed throughout the body,including the pain transmission pathway and descending inhibition pathway,the development of novel neuropathic pain treatments based on GPCRs allosteric modulation theory is gaining *** research has shown that allosteric modulators targeting GPCRs on the pain pathway can effectively alleviate symptoms of neuropathic pain while reducing or eliminating adverse *** review aims to provide a comprehensive summary of the progress made in GPCRs allosteric modulators in the treatment of neuropathic pain,and discuss the potential benefits and adverse factors of this *** will also concentrate on the development of biased agonists of GPCRs,and based on important examples of biased agonist development in recent years,we will describe universal strategies for designing structure-based biased *** is foreseeable that,with the continuous improvement of GPCRs allosteric modulation and biased agonist theory,effective GPCRs allosteric drugs will eventually be available for the treatment of neuropathic pain with acceptable safety.

关键词： Neuropathic pain Allosteric modulators G protein-coupled receptors Analgesia

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