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Qualitative exploration of home life experiences and care needs among elderly patients with temporary intestinal stomas

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World Journal of Gastroenterology 2024年第22期30卷 2893-2901页

作者： Si-Meng Wang Jian-Ling Jiang Rui Li Juan-Juan Wang chun-hong gu Jia Zeng Xiao-Hui Wei Mei Chen Wuxi Medical College of Jiangnan University Jiangnan UniversityWuxi 214122Jiangsu ProvinceChina Department of Gastrointestinal Surgery Tongren Hospital Shanghai Jiao Tong University School of MedicineShanghai 200335China Department of Nursing Tong Ren Hospital Shanghai Jiao Tong University School of MedicineShanghai 200335China

BACKGROUND This study employed a phenomenological research approach within qualitative research to explore the challenges encountered by elderly individuals with temporary colostomies in managing their daily lives and care *** the anus surgery combined with temporary colostomy has emerged as a prevalent treatment modality for low rectal ***,the ileostomy is susceptible to peri-stoma skin complications,as well as fluid,electrolyte,and nutritional imbalances,posing challenges to effective *** successful selfmanagement of patients is intricately linked to their adjustment to temporary colostomy;nonetheless,there remains a dearth of research examining the factors influencing self-care among temporary colostomy patients and the obstacles they *** To investigate the lived experiences,perceptions,and care requirements of temporary colostomy patients within their home environment,with the ultimate goal of formulating a standardized management *** Over the period of June to August 2023,a purposive sampling technique was utilized to select 12 patients with temporary intestinal stomas from a tertiary hospital in Shanghai,*** a phenomenological research approach,a semi-structured interview guide was developed,and qualitative interviews were conducted using in-depth interview *** acquired data underwent coding,analysis,organization,and summarization following Colaizzi’s seven-step *** The findings of this study revealed that the experiences and needs of patients with temporary intestinal stomas can be delineated into four principal themes:Firstly,Temporary colostomy patients bear various burdens and concerns about the uncertainty of disease progression;secondly,patients exhibit limited self-care capabilities and face information deficits,resulting in heightened reliance on healthcare professionals;thirdly,patients demonstrate the potential for internal motivation through proactive self-adj

关键词： Elderly Temporary intestinal stomas Life experiences Intestinal ostomy complications Qualitative study

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Neutralizing peripheral circulating IL1β slows the progression of ALS in a lentivirus-infected OPTN^(E478G)mouse model

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Animal Models and Experimental Medicine 2023年第1期6卷 18-25页

作者： Wen-Bao Hu Xin Wang Zhi-Lin Pang Ran Duan chun-gu hong Zheng-Zhao Liu Xiangya Hospital Central South UniversityChangshaChina

Background:Amyotrophic lateral sclerosis(ALS)is irreversible and fatal within 3-5 years,with limited options for *** is imperative to develop a symptom-based treatment that may increase the survival of ALS patients and improve their quality of *** status,especially elevated interleukin 1β(IL1β),has been reported to play a critical role in ALS *** study determined that neutralizing circulating IL1βslows down the progression of ALS in an ALS mouse ***:The ALS mouse model was developed by microinjection of lentivirus-carrying OPTN^(E478G)(optineurin,a mutation from ALS patients)into the intra-motor cortex of *** circulating IL1βwas neutralized by injecting anti-IL1βan-tibody into the tail ***-linked immunosorbent assay(ELISA)and real-time polymerase chain reaction(RT-PCR)were carried out to determine the protein and gene expression levels of IL1β.TUNEL assay was used to assess the neural cell *** staining of MAP2 and CASP3 was accomplished to evaluate neuronal cell *** fibrillary acidic protein staining was performed to ana-lyze the number of *** test,grip strength test,balance beam test,and footprint test were conducted to assess the locomotive function after anti-IL1β***:The model revealed that neuroinflammation contributes to ALS *** mice exhibited elevated neuroinflammation and IL1β*** anti-IL1βtreatment,ALS mice revealed decreased neural cell death and astrogliosis and gained improved muscle strength and motor ***:Blocking IL1βis a promising strategy to slow down the progression of ALS.

关键词： amyotrophic lateral sclerosis inflammation interleukin 1β neurodegeneration optineurin

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Context Processing in Contextual and Cued Fear Extinction

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Neuroscience Bulletin 2024年第6期40卷 835-839页

作者： Yimu Zhang chun Xu Yu gu State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Institutes of Brain ScienceFudan UniversityShanghai200032China Institute of Neuroscience State Key Laboratory of NeuroscienceCenter for Excellence in Brain Science and Intelligence TechnologyChinese Academy of SciencesShanghai200031China

Anxiety disorders such as post-traumatic stress disorder(PTSD)are prevalent mental disorders that disturb millions *** disorders often manifest as excessive fear,anxiety,and distress,significantly impacting daily *** fear extinction paradigms in animals were established decades ago and have been widely used in research,providing a scientific basis for exposure therapies for anxiety disorders in humans.

关键词： distress disorders traumatic

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Compressed Data Separation via ℓ_(q)-Split Analysis with ℓ_(∞)-Constraint

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Acta Mathematica Sinica,English Series 2024年第7期40卷 1655-1673页

作者： Ming Yang gu Song Li Jun hong Lin School of Mathematical Science Zhejiang UniversityHangzhou310027P.R.China Center for Data Science Zhejiang UniversityHangzhou310027P.R.China

In this paper,we study compressed data separation(CDS)problem,i.e.,sparse data separation from a few linear random *** propose the nonconvex ℓ_(q)-split analysis with ℓ_(∞)-constraint and 0 详细信息

In this paper,we study compressed data separation(CDS)problem,i.e.,sparse data separation from a few linear random *** propose the nonconvex ℓ_(q)-split analysis with ℓ_(∞)-constraint and 0

关键词： Data separation ℓ_(q)-split analysis Dantzig selector frames restricted isometry property compressed sensing

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Combining lymph node ratio to develop prognostic models for postoperative gastric neuroendocrine neoplasm patients

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World Journal of Gastrointestinal Oncology 2024年第8期16卷 3507-3520页

作者： Wen Liu hong-Yu Wu Jia-Xi Lin Shu-Ting Qu Yi-Jie gu Jin-Zhou Zhu chun-Fang Xu Department of Gastroenterology Changzhou Hospital of Traditional Chinese MedicineChangzhou 213000Jiangsu ProvinceChina Department of Gastroenterology The First Affiliated Hospital of Soochow UniversitySuzhou 215006Jiangsu ProvinceChina Department of Gastroenterology Suzhou Ninth Hospital Affiliated to Soochow UniversitySuzhou 215200Jiangsu ProvinceChina

BACKGROUND Lymph node ratio(LNR)was demonstrated to play a crucial role in the prognosis of many ***,research concerning the prognostic value of LNR in postoperative gastric neuroendocrine neoplasm(NEN)patients was *** To explore the prognostic value of LNR in postoperative gastric NEN patients and to combine LNR to develop prognostic *** A total of 286 patients from the Surveillance,Epidemiology,and End Results database were divided into the training set and validation set at a ratio of 8:2.92 patients from the First Affiliated Hospital of Soochow University in China were designated as a test *** regression analysis was used to explore the relationship between LNR and disease-specific survival(DSS)of gastric NEN *** survival forest(RSF)algorithm and Cox proportional hazards(CoxPH)analysis were applied to develop models to predict DSS respectively,and compared with the 8th edition American Joint Committee on Cancer(AJCC)tumornode-metastasis(TNM)*** Multivariate analyses indicated that LNR was an independent prognostic factor for postoperative gastric NEN patients and a higher LNR was accompanied by a higher risk of *** RSF model exhibited the best performance in predicting DSS,with the C-index in the test set being 0.769[95%confidence interval(CI):0.691-0.846]outperforming the CoxPH model(0.744,95%CI:0.665-0.822)and the 8th edition AJCC TNM staging(0.723,95%CI:0.613-0.833).The calibration curves and decision curve analysis(DCA)demonstrated the RSF model had good calibration and clinical ***,the RSF model could perform risk stratification and individual prognosis prediction *** A higher LNR indicated a lower DSS in postoperative gastric NEN *** RSF model outperformed the CoxPH model and the 8th edition AJCC TNM staging in the test set,showing potential in clinical practice.

关键词： Gastric neuroendocrine neoplasm Lymph node ratio Disease-specific survival Random survival forest Predictive model

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Electronic regulation to achieve efficient anaerobic digestion of organic fraction of municipal solid waste(OFMSW):strategies,challenges and potential solutions

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Frontiers of Environmental Science & Engineering 2024年第4期18卷 159-165页

作者： Yongdong Chen hong Wang Parisa Ghofrani-Isfahani Li gu Xiaoguang Liu Xiaohu Dai State Key Laboratory of Pollution Control and Resources Reuse College of Environmental Science and EngineeringTongji UniversityShanghai 200092China Shanghai Institute of Pollution Control and Ecological Security Tongji UniversityShanghai 200092China Department of Chemical and Biochemical Engineering Technical University of DenmarkKgs Lyngby DK-2800Denmark College of Environment and Ecology Chongqing UniversityChongqing 400045China

Anaerobic digestion(AD)of organic fraction of municipal solid waste(OFMSW)is prone to system breakdown under high organic loading rates(OLRs)condition,which subsequently reduces the efficiency of digestion process and results in substantial economic *** this perspective paper,the substances metabolisms,electrons flow,as well as microbial interaction mechanisms within AD process are comprehensively discussed,and the underlying bottleneck that causes inefficient methane production is identified,which is“electrons surplus”.Systems encountering severe electron surplus are at risk of process failure,making it crucial to proactively prevent this phenomenon through appropriate *** this basis,the present perspective proposes three potential electronic regulation strategies to prevent electrons surplus,namely,electron shunt,accelerating electron transfer and regulating methanogenic metabolism pathway,and presents specific methodologies for each ***,the potential solutions to challenges that may occur during the electronic regulation process are also presented in this *** perspective aims to provide innovative approaches to achieve the efficient and stable operation of OFMSW anaerobic digestion,especially under high OLRs condition.

关键词： Anaerobic digestion Electrons surplus Electronic regulation Electrons shunt Electron transfer Methanogenic metabolism pathway

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Two positive effects with one arrow:Modulating crystal and interfacial decoration towards high-potential cathode material

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Journal of Energy Chemistry 2024年第5期92卷 216-223页

作者： Xuexiu gu Xuan-Wen Gao Dongrun Yang Qinfen gu YSong hong Chen Tianzhen Ren Wen-Bin Luo Institute for Energy Electrochemistry and Urban Mines Metallurgy School of MetallurgyNortheastern UniversityShenyang 110819LiaoningChina Australian Synchrotron(ANSTO) 800 Blackburn RdClaytonVictoria 3168Australia School of Science and Engineering University of DundeeNethergateDundee DD14HNScotlandUK

As the primary suppliers of cyclable sodium ions,O3-type layer-structured manganese-based oxides are recognized as highly competitive cathode candidates for sodium-ion *** advance the development of high-energy sodium-ion batteries,it is crucial to explore cathode materials operating at high voltages while maintaining a stable cycling *** orbital and electronic structure of the octahedral center metal element plays a crucial role in maintaining the octahedra structural integrity and improving Na^(+)ion diffusion by introducing heterogeneous chemical *** by the abundant configuration of extra nuclear electrons and large ion radius,we employed trace amounts of tungsten in this *** obtained cathode material can promote the reversibility of oxygen redox reactions in the high-voltage region and inhibit the loss of lattice ***,the formation of a Na_(2)WO_(4) coating on the material surface can improve the interfacial stability and interface ions *** demonstrates an initial Coulombic efficiency(ICE)of 94.6%along with 168.5 mA h g^(-1 )discharge capacity within the voltage range of 1.9-4.35 *** findings contribute to the advancement of high-energy sodium-ion batteries by providing insights into the benefits of tungsten doping and Na_(2)WO_(4) coating on cathode materials.

关键词： Sodium ion battery Layer-structured manganese-based oxides Cathodematerial Surface modification Elements doping

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Cytochrome P45026A1 Contributes to the Maintenance of Neuropathic Pain

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Neuroscience Bulletin 2024年第3期40卷 293-309页

作者： De-Li Cao Ling-Jie Ma Bao-chun Jiang Qiang gu Yong-Jing Gao Institute of Pain Medicine and Special Environmental Medicine Co-innovation Center of NeuroregenerationNantong UniversityNantong226019China Nantong University Medical School Nantong226001China Department of Pain Management The Affiliated Hospital of Nantong UniversityNantong226001China

The cytochrome P450 proteins(CYP450s)have been implicated in catalyzing numerous important biological reactions and contribute to a variety of ***26A1,a member of the CYP450 family,carries out the oxidative metabolism of retinoic acid(RA),the active metabolite of vitamin *** we report that CYP26A1 was dramatically upregulated in the spinal cord after spinal nerve ligation(SNL).CYP26A1 was mainly expressed in spinal neurons and *** analysis displayed that the content of all-trans-RA(at-RA),the substrate of CYP26A1,was reduced in the spinal cord on day 7 after *** of CYP26A1 by siRNA or inhibition of CYP26A1-mediated at-RA catabolism by talarozole relieved the SNL-induced mechanical allodynia during the maintenance phase of neuropathic *** also reduced SNL-induced glial activation and proinflammatory cytokine production but increased anti-inflammatory cytokine(IL-10)*** RA receptors RARα,RXRβ,and RXRγwere expressed in spinal neurons and glial *** promoter of Il-10 has several binding sites for RA receptors,and at-RA directly increased Il-10 mRNA expression in ***,intrathecal IL-10 attenuated SNL-induced neuropathic pain and reduced the activation of astrocytes and ***,the inhibition of CYP26A1-mediated at-RA catabolism alleviates SNL-induced neuropathic pain by promoting the expression of IL-10 and suppressing glial ***26A1 may be a potential therapeutic target for the treatment of neuropathic pain.

关键词： CYP26A1 Microglia Astrocytes ERK P38 IL-10 Neuropathic pain

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Difluoromethyl phenoxathiinium salt: A new general and versatile difluoromethylating reagent with divergent ·CF_(2)H, CF_(2)H^(+), and :CF_(2) reactivities

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Science China Chemistry 2024年第3期67卷 953-962页

作者： Yuan-Qing gu hong-Xin Long Dan-Dan Zhang Mei-Feng Ruan guo-Kai Liu School of Pharmacy Shenzhen University Medical SchoolShenzhen UniversityShenzhen 518055China

Development of practical and versatile electrophilic difluoromethylating reagent is still a grand challenge so far due to its inherent instability or low ***,we report the design and synthesis of difluoromethyl phenoxathiinium tetrafluoroborate(PT-CF_(2)H^(+)BF_(4)^(-)) as a novel difluoromethylating reagent,which proves to be a bench-stable,general,powerful and versatile reagent with divergent·CF_(2)H,CF_(2)H^(+),and:CF_(2) *** use of this reagent,we demonstrated a vast array of difluoromethyl radical transfer reactions via diverse pathways involving photocatalyst-free visible-light induction,visible-light photoredox catalysis and visible-light mediation single electron transfer of EDA ***,the green and highly effective CF_(2)H^(+) and:CF_(2) transfer reactions were also readily accomplished.

关键词： difluoromethyl phenoxathiinium salt versatile difluoromethylating reagent difluoromethyl radical difluoromthyl cation difluorocarbene

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Layer Hall effect induced by hidden Berry curvature in antiferromagnetic insulators

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National Science Review 2024年第2期11卷 15-23页

作者： Rui Chen Hai-Peng Sun Mingqiang gu chun-Bo Hua Qihang Liu Hai-Zhou Lu X.C.Xie Shenzhen Institute for Quantum Science and Engineering and Department of Physics Southern University of Science and Technology(SUSTech) International Quantum Academy Institute for Theoretical Physics and Astrophysics University of Würzburg School of Electronic and Information Engineering Hubei University of Science and Technology guangdong Provincial Key Laboratory of Computational Science and Material Design Southern University of Science and Technology Shenzhen Key Laboratory of Quantum Science and Engineering International Center for Quantum Materials School of PhysicsPeking University Collaborative Innovation Center of Quantum Matter CAS Center for Excellence in Topological Quantum Computation University of Chinese Academy of Sciences

The layer Hall effect describes electrons spontaneously deflected to opposite sides at different layers, which has been experimentally reported in the MnBi2Te4thin films under perpendicular electric fields. Here, we reveal a universal origin of the layer Hall effect in terms of the so-called hidden Berry curvature, as well as material design principles. Hence, it gives rise to zero Berry curvature in momentum space but non-zero layer-locked hidden Berry curvature in real space. We show that, compared to that of a trivial insulator, the layer Hall effect is significantly enhanced in antiferromagnetic topological insulators. Our universal picture provides a paradigm for revealing the hidden physics as a result of the interplay between the global and local symmetries, and can be generalized in various scenarios.

关键词： layerHall effect hidden Berry curvature antiferromagnetic insulator axion insulator, quantum transport

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