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Inhibitory Effect of PPARδAgonist GW501516 on Proliferation of Hypoxia-induced Pulmonary Arterial Smooth Muscle Cells by Regulating the mTOR Pathway

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Current Medical Science 2023年第5期43卷 979-987页

作者： Chang-gui CHEN chun-feng yi Chang-fa CHEN Li-qun TIAN Li-wei LI Li YANG Zuo-min LI Li-qun HE Department of Cardiology Wuhan No.1 HospitalWuhan Hospital of Traditional Chinese and Western MedicineWuhan 430022China Shanghai Smartide Biotechnology Co.Ltd. Shanghai 201203China

Objective This study aimed to investigate the effects of the peroxisome proliferator-activated receptorδ(PPARδ)agonist GW501516 on the proliferation of pulmonary artery smooth muscle cells(PASMCs)induced by hypoxia,in order to search for new drugs for the treatment and prevention of pulmonary vascular *** PASMCs were incubated with different concentrations of GW501516(10,30,100 nmol/L)under the hypoxic *** proliferation was determined by a CCK-8 *** cell cycle progression was analyzed by flow *** expression of PPARδ,S phase kinase-associated protein 2(Skp2),and cell cycle-dependent kinase inhibitor p27 was detected by Western *** PASMCs were treated with 100 nmol/L GW501516,100 nmol/L mammalian target of rapamycin(mTOR)inhibitor rapamycin and/or 2µmol/L mTOR activator MHY1485 to explore the molecular mechanisms by which GW501516 reduces the proliferation of *** The presented data demonstrated that hypoxia reduced the expression of PPARδin an oxygen concentration-and time-dependent manner,and GW501516 decreased the proliferation of PASMCs induced by hypoxia by blocking the progression through the G0/G1 to S phase of the cell *** accordance with these findings,GW501516 downregulated Skp2 and upregulated p27 in hypoxia-exposed *** experiments showed that rapamycin had similar effects as GW501516 in inhibiting cell proliferation,arresting the cell cycle,regulating the expression of Skp2 and p27,and inactivating mTOR in hypoxia-exposed ***,MHY1485 reversed all the beneficial effects of GW501516 on hypoxia-stimulated *** GW501516 inhibited the proliferation of PASMCs induced by hypoxia through blocking the mTOR/Skp2/p27 signaling pathway.

关键词： peroxisome proliferator-activated receptorδ GW501516 hypoxia pulmonary artery smooth muscle cells proliferation mammalian target of rapamycin

A PILOT TRIAL FOR SEVERE ,REFRACTORY SYSTEMIC AUTOIMMUNE DISEASE WITH STEM CELL TRANSPLANTATION

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Chinese Medical Sciences Journal 2005年第3期20卷 159-165页

作者： Xiao-mei Leng Yan Zhao Dao-bing Zhou Huifen Situ Tai-sheng Li Ti Shen Yong-qiang Zhao Xiao-feng Zeng feng-chun Zhang yi Dong Fu-lin Tang Department of Rheumatology Peking Union Medical College Hospital Chinese Academy of Medical Sciences ＆ Peking Union Medical College Beijing 100730

Objective To evaluate the feasibility, efficacy, and safety of high dose immunosuppressive therapy （HDIT） and autolognus hemopoietic stem cell transplantation （HSCT） with CD^34＋ cell selection in patients with severe, refractory autoim mune diseases. Methods Twenty-six patients with persistent systemic lupus erythematosus （SLE）, rheumatoid arthritis （RA）, primary Sjogren＇s syndrome （pSS）, or systemic sclerosis （SSc） who had been treated unsuccessfully with conventional treatment were enrolled in the trial in Peking Union Medical College Hospital from September 1999 to June 2004. The patients received HDIT with 200 mg/kg cyclophosphamide followed by an infusion of autologous stem cells that were CD34 selected. Disease acti- vity, adverse effect, hemopoietic and immune reconstitution, and time to recurrence of disease were monitored. Overall treatment related mortality was 7.7% （2/26） with 1 patient died of cytomegalovirus infection and an other of severe pneumonia. Relapse occurred in 3 SLE patients （17.6%） in 37, 26, and 19 months posttransplantation respectively, and 1 RA patient in 15 months posttransplantation. SLE Disease Activity Index （SLEDAI） scores of SLE survivors decreased significantly （P 〈 0.01）. RA patients recorded a drop of Disease Activity Score 28 （DAS 28）. The pSS patient remained symptoms free up to now, more than 50 months aider the transplantation. Conclusion HSCT can be performed relative safely in patients with severe autoimmune disease. Short-term effect of HSCT is promising. However treatment related mortality and relapse were observed in a subset of patients.

关键词： systemic autoimmune disease hemopoietic stem cell transplantation therapeutics

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Catalytic atroposelective synthesis of indolyl quinazolinones bearing N-N/C-C diaxes

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Science China Chemistry 2025年

作者： Ning-yi Wang Shuo Gao Zhu-Di Shu Bei-Bei Cheng chun Ma Yu-Chen Zhang feng Shi Research Center of Chiral Functional Heterocycles School of Chemistry and Materials Science Jiangsu Normal University School of Petrochemical Engineering Changzhou University School of Chemistry and Chemical Engineering Henan Normal University

The first catalytic atroposelective synthesis of indole derivatives bearing N-N/C-C diaxes has been established by the strategy of de novo ring formation. By this strategy, various indolyl quinazolinones bearing vicinal N-N/C-C diaxes were synthesized in high yields with overall good diastereoselectivities and excellent enantioselectivities via chiral phosphoric acid-catalyzed onepot asymmetric formal (5+1) cycloaddition/oxidation reaction. Moreover, such indolyl quinazolinones bearing vicinal N-N/CC diaxes have good configurational stability and could be converted into new chiral ligands with applications in asymmetric catalysis. Therefore, this work not only offered a new member for the family of diaxial atropisomers, but also provided a powerful strategy for catalytic asymmetric synthesis of atropisomers bearing N-N/C-C diaxes.

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Microplastic and nanoplastic exposure and risk of diabetes mellitus

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World Journal of Clinical Cases 2025年第3期13卷 24-29页

作者： Hui-yi Hsiao chung-yi Nien Ruei-feng Shiu Wei-chun Chin Tzung-Hai Yen Department of Biomedical Sciences College of MedicineChang Gung UniversityTaoyuan 33302TaiwanChina Center for Tissue Engineering Chang Gung Memorial HospitalLinkouTaoyuan 33305TaiwanChina Department of Life Sciences National Central UniversityZhongli 320317TaoyuanTaiwanChina Center of Excellence for The Oceans Taiwan Ocean UniversityKeelung 20224TaiwanChina Institute of Marine Environment and Ecology Taiwan Ocean UniversityKeelung 20224TaiwanChina Department of Chemical and Materials Engineering University of California MercedMercedCA 95343United States Department of Nephrology Clinical Poison CenterChang Gung Memorial HospitalLinkou 33305TaoyuanTaiwanChina School of Traditional Chinese Medicine College of MedicineChang Gung UniversityTaoyuan 33302TaiwanChina

The issue of plastic pollutants has become a growing *** microplastics(MPs)(particle size<5 mm)and nanoplastics(NPs)(particle size<1μm)can cause DNA damage,cytotoxicity,and oxidative stress in various *** primary known impacts of microplastic/nanoplastic are observed in the liver and respiratory system,leading to hepatotoxicity and chronic obstructive pulmonary *** research on the effects of MPs and NPs on diabetes is still in its early stages,there are potential *** editorial highlights the risk to diabetics from co-exposure to contaminants and MPs/NPs,supported by evidence from animal studies and the various chemical compositions of MPs/NPs.

关键词： Microplastics Nanoplastics Plastic pollution,Diabetes mellitus Insulin resistance

Effect of order–disorder transition on thermodynamic and electronic properties of σ and χ phases in W–Re alloy: the first-principles calculation

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Tungsten 2025年第1期7卷 195-213页

作者： Zhi-Peng Zhu Dian Jia William yi Wang Jun-Lei yin Xing-Yu Gao Shu-feng Yang Hai-feng Song Jin-Shan Li State Key Laboratory of Solidification Processing Northwestern Polytechnical University Laboratory of Computational Physics Institute of Applied Physics and Computational Mathematics School of Metallurgical and Ecological Engineering University of Science and Technology Beijing

The Tungsten-Rhenium(W-Re) alloys,celebrated for their high melting point,strength at elevated temperatures,electrical resistivity,and radiation resistance,have been widely utilized in high-temperature components,aerospace,electronics,and nuclear *** constituents of the topologically close-packed(TCP) phases,the sigma phase(σ) and chi phase(χ) formed within W-Re alloys wield considerable influence on the mechanical properties and the stability of the *** calculations were utilized in the present work to explore the structural,thermodynamic,and electronic properties of both ordered and disordered configurations within the σ and χ phases,culminating in a systematic elucidation of the higher phase stability exhibited by the ordered *** is found that the bulk modulus of these two phases is directly proportional to the concentration of Re in the alloy,while the equilibrium volume is inversely *** thermodynamic parameters of the σ and χ phases are calculated via the mean-field potential *** similar trends observed in the isobaric heat capacity,enthalpy increment,and entropy change curves for these two phases suggest they possess comparable thermodynamic *** is noteworthy that the contribution of ionic vibrations predominantly affects the isobaric heat capacity,while the contribution of thermal electronic excitations increases linearly with *** the structure and thermodynamic properties of TCP phases in W-Re alloys at low temperatures has profound significance for optimizing material performance,microstructures features,establishing theoretical foundations,and predicting material behavior.

关键词： First-principles calculations Phase stability TCP phases Thermodynamic properties W–Re alloy

Propagating subduction initiation of the Caroline Plate at the Mussau Trench

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Science China Earth Sciences 2025年第1期68卷 253-269页

作者： chun-feng LI Yongkang DENG Tao WU Dongdong DONG Guoliang ZHANG Jiazheng ZHANG Yutao LIU Yaqing LI Fugui TANG Lulu ZHANG Department of Marine Sciences Zhejiang University Laboratory of Marine Mineral Resources Laoshan Laboratory Key Lab of Marine Geology and Environment Institute of Oceanology Chinese Academy of Sciences Key Lab of Ocean and Marginal Sea Geology South China Sea Institute of Oceanology Chinese Academy of Sciences Science & Technology on Integrated Information System Lab Institute of Software Chinese Academy of Sciences

New seismic imaging from the Mussau Trench confirms that, under horizontal compression on an oceanic plate boundary, it is within the young and weak oceanic plate that a trench will develop, and it is the young plate, not so long after its birth, that starts to subduct toward the old plate. The Mesozoic Pacific Plate cannot easily bend, under the joint horizontal compression and vertical gravity pull, even with a pre-existing weak zone in place and with a large age offset across the plate boundary. The bending of the Caroline Plate near the northern end of the Mussau Trench started only after a long-time span of trench migration, and/or after a prolonged transition from initial compression to trench development. Highly contrasting trench deformation and sedimentary accretion between two parallel seismic sections support an evident migration of underthrusting or significant longitudinal heterogeneity along the trench. The swift transition from underthrusting to non-thrusting can be explained by a counter-clockwise rotation of the Caroline Plate. That miniature accretionary wedges develop even before the subduction initiates imply strong compression and uplifting before the underthrusting can kick-start. Rotation of the Caroline Plate have been halted as the Mussau Trench is seismically rather quiet and the Lyra Trough to the east shows relaxational extension.

关键词： Mussau Trench Subduction initiation Seismic reflection Caroline Plate

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β1- and β2-adrenergic activations enhance excitatory synaptic transmission in layerⅤ/Ⅵpyramidal neurons of the medial prefrontal cortex of rats

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β1- and β2-adrenergic activations enhance excitatory synap...

中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： Ze-Jun feng,chun-Lei ZHANG,feng yi,Xue-Han ZHANG,Bao-Ming LI~* Institute of Neurobiology,Institutes of Brain Science,Fudan University,Shanghai 200032,China

＜正＞β-Adrenoceptors（β-ARs） are widely distributed throughout the central nervous *** previous work showed thatβ-AR activation facilitates excitatory synaptic transmission in pyramidal cells of the medial prefrontal cortex （mPFC）.However,little is known about theβ1- andβ2-AR regulations of synaptic transmission in the *** present study investigatedβ1- andβ2-AR modulation of glutamate synaptic transmission in layer V/VI pyramidal cells of the rat *** results show that,（1） stimulation ofβ1-ARs does not affect the frequency or the amplitude of mEPSCs,and stimulation ofβ2-ARs increases the frequency but not amplitude of mEPSCs;（2） stimulation ofβ2-ARs suppresses the paired-pulse ratio of eEPSC,and stimulation ofβ1-ARs does not;and（3） stimulations ofβ1- andβ2-ARs both enhance the amplitude of eEPSC and non-MDA-R current and NMDA-induced *** together,these results suggest that plandβ2-AR activations both facilitate excitatory synaptic transmission in mPFC pyramidal cells.

关键词： β1-adrenoceptor β2-adrenoceptor excitatory synaptic transmission medial prefrontal cortex rat

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医疗设备维修管理信息化的研究与实践

Switching of N-methyl-D-aspartate(NMDA) receptor-favorite intracellular signal pathways from ERK1/2 to p38 MAPK leads to developmental changes in NMDA neurotoxicity

科学与信息化 2024年第2期 94-96页

作者：冯春毅新泰市人民医院山东泰安 271200

在我国社会经济和科学技术不断发展进步的时代背景下,我国的医疗事业逐渐现代化,医院中的各类医疗设备所涉及的数据越来越多,在无形中增大了医疗设备维修及管理工作的难度,传统单一的医疗设备维修管理方式已经无法满足当今医疗设备维修... 详细信息

在我国社会经济和科学技术不断发展进步的时代背景下,我国的医疗事业逐渐现代化,医院中的各类医疗设备所涉及的数据越来越多,在无形中增大了医疗设备维修及管理工作的难度,传统单一的医疗设备维修管理方式已经无法满足当今医疗设备维修及管理工作的实际需求.因此,亟须对医疗设备维修管理进行信息化处理,以提高医疗设备维修管理的有效性及准确性,最大限度地维护医疗设备的正常运行,进而全面提升医疗设备维修管理的质量与水平.本文就上述内容展开论述.

关键词：医疗设备维修管理信息化策略措施

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Switching of N-methyl-D-aspartate(NMDA) receptor-favorite in...