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Level of proinsulin in association with cardiovascular risk factors and sleep snoring

World Journal of Gastroenterology 2005年第32期11卷 5047-5052页

作者： En-Zhi Jia Zhi-Jian Yang Shi-Wei Chen Guang-Yao Qi chun-fa you Jian-Feng Ma Jing-Xin Zhang Zhen-Zhen Wang Wei-Chong Qian Hai-Yan Wang Wen-Zhu Ma Department of Cardiovascular Medicine The First Affiliated Hospital of Nanjing Medical University Nanjing 210029 Jiangsu Province China The Disease Control Center of Pizhou City Pizhou 221300 Jiangsu Province China Department of Central Clinical Laboratory The First Affiliated Hospital of Nanjing Medical University Nanjing 210029 Jiangsu Province China Department of Nuclear Medicine The First Affiliated Hospital of Nanjing Medical University Nanjing 210029 Jiangsu Province China

AIM: To explore the relationship between the level of proinsulin with cardiovascular risk factors and sleep ***: Based on the random stratified sampling principle, 1 193 Chinese residents in Pizhou City, Jiangsu Province (530 males and 663 females, aged 35-59 years with an average age of 46.69 years) were recruited. Their sleep snoring habits were investigated. Biotin-avidin based double mAbs ELISA was used to detect specific insulin and proinsulin, and a risk factor score was established to evaluate the individuals according to the number of their risk ***: The results of Spearman correlation analysis and covariate ANOVA analysis after age and sex were controlled, indicated that not only the level of proinsulin (r = 0.156, P = 0.000, F= 5.980 P = 0.000), but also cardiovascular risk factors score (r = 0.194, P = 0.000,F= 11.135, P = 0.000) significantly associated with the frequency of sleep snoring, and the significant relationship between true insulin and frequency of sleep snoring was only shown in the covariate ANOVA analysis (F = 2.868,P = 0.022). The result of multivariate stepwise logistic regression after age, sex, body mass index, waist circumference and true insulin were controlled showed that proinsulin (division by interval of quartile) was an independent risk factor for sleep snoring (OR = 1.220,95%CI: 1.085-1.373, P = 0.001).CONCLUSION: The interaction of cardiovascular risk factors clustering, high proinsulin level and sleep breathing disorder may be a syndrome, which has not been recognized in human beings so far.

关键词： True insulin Proinsulin Snoring Epidemiology

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Numerical Study on the Effect of Gap Diffraction on the Hydrodynamic Performance of A Floating Breakwater

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China Ocean Engineering 2024年第4期38卷 663-675页

作者： BIAN Xiang-qian JI chun-yan XU Sheng GUO Jian-ting HUO fa-li School of Naval Architecture and Ocean Engineering Jiangsu University of Science and TechnologyZhenjiang 212100China

Two-dimensional(2D)flume experiments are useful in investigating the performances of floating breakwaters(FBs),including hydrodynamic performances,motion responses,and mooring *** a reasonable gap between the flume wall and the FBs is a critical step in 2D flume ***,research on the effect of the gap on the accuracy of 2D FB experimental results is *** address this issue,a numerical wave tank is developed using CFD to estimate the wave-FB interaction of a moored dual-cylindrical FB,and the results are compared to experimental data from a previously published *** is good agreement between them,indicating that the numerical model is sufficiently *** numerical model is then applied to explore the effect of gap diffraction on the performance of FBs in2D *** was discovered that the nondimensional gap length L_(Gap)/W_(Pool)should be smaller than 7.5%to ensure that the relative error of the transmission coefficient is smaller than 3%.The influence of the gap is also related to the entering wave properties,such as the wave height and period.

关键词： floating breakwater diffraction effect gap hydrodynamic performance model experiments CFD numerical simulation

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Shuxuening Injection Inhibits Apoptosis and Reduces Myocardial Ischemia-Reperfusion Injury in Rats through PI3K/AKT Pathway

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Chinese Journal of Integrative Medicine 2024年第5期30卷 421-432页

作者： YUE Tong-tong CAO Ying-jie CAO Ya-xuan LI Wei-xia WANG Xiao-yan SI chun-ying XIA Han ZHU Ming-jun TANG Jin-fa WANG He The First Clinical Medical College of Henan University of Chinese Medicine Zhengzhou 450046China Department of Pharmacy the First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou 451200China Department of Cardiovascular Diseases the First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou 451200China

Objective: To investigate the main components and potential mechanism of Shuxuening Injection(SXNI) in the treatment of myocardial ischemia-reperfusion injury(MIRI) through network pharmacology and in vivo research. Methods: The Traditional Chinese Medicine Systems Pharmacology(TCMSP) and Pharm Mapper databases were used to extract and evaluate the effective components of Ginkgo biloba leaves, the main component of SXNI. The Online Mendelian Inheritance in Man(OMIM) and Gene Cards databases were searched for disease targets and obtain the drug target and disease target intersections. The active ingredient-target network was built using Cytoscape 3.9.1 software. The STRING database, Metascape online platform, and R language were used to obtain the key targets and signaling pathways of the anti-MIRI effects of SXNI. In order to verify the therapeutic effect of different concentrations of SXNI on MIRI in rats, 60 rats were first divided into 5 groups according to random number table method: the sham operation group, the model group, SXNI low-dose(3.68 mg/kg), medium-dose(7.35 mg/kg), and high-dose(14.7 mg/kg) groups, with 12 rats in each group. Then, another 60 rats were randomly divided into 5 groups: the sham operation group, the model group, SXNI group(14.7 mg/kg), SXNI+LY294002 group,and LY294002 group, with 12 rats in each group. The drug was then administered intraperitoneally at body weight for 14 days. The main biological processes were validated using in vivo testing. Evans blue/triphenyltetrazolium chloride(TTC) double staining, hematoxylin-eosin(HE) staining, terminal deoxynucleotidyl transferase d UTP nick end labeling(TUNEL) assay, enzyme-linked immunosorbent assay(ELISA), and Western blot analysis were used to investigate the efficacy and mechanism of SXNI in MIRI rats. Results: Eleven core targets and 30 Kyoto Encyclopedia of Genes and Genomes(KEGG) pathways were selected. Among these, the phosphoinositide 3-kinase(PI3K)/protein kinase B(AKT) pathway was

关键词： myocardial ischemia reperfusion injury PI3K/AKT signaling pathway Shuxuening Injection apoptosis Ginkgo biloba leaves

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Variation Characteristics of Root Traits of Different Alfalfa Cultivars under Saline-Alkaline Stress and their Relationship with Soil Environmental factors

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Phyton-International Journal of Experimental Botany 2024年第1期93卷 29-43页

作者： Tian-Jiao Wei Guang Li Yan-Ru Cui Jiao Xie Xing-Ai Gao Xing Teng Xin-Ying Zhao fa-chun Guan Zheng-Wei Liang Northeast Agricultural Research Center of China Jilin Academy of Agricultural SciencesChangchun130033China Northeast Institute of Geography and Agroecology Chinese Academy of SciencesChangchun130102China

Soil salinization is the main factor that threatens the growth and development of plants and limits the increase of *** is of great significance to study the key soil environmental factors affecting plant root traits to reveal the adaptation strategies of plants to saline-alkaline-stressed soil *** this study,the root biomass,root morphological parameters and root mineral nutrient content of two alfalfa cultivars with different sensitivities to alkaline stress were analyzed with black soil as the control group and the mixed saline-alkaline soil with a ratio of 7:3 between black soil and saline-alkaline soil as the saline-alkaline treatment *** the same time,the correlation analysis of soil salinity indexes,soil nutrient indexes and the activities of key enzymes involved in soil carbon,nitrogen and phosphorus cycles was carried *** results showed that compared with the control group,the pH,EC,and urease(URE)of the soil surrounding the roots of two alfalfa cultivars were significantly increased,while soil total nitrogen(TN),total phosphorus(TP),organic carbon(SOC),andα-glucosidase activity(AGC)were significantly decreased under saline-alkaline *** was no significant difference in root biomass and root morphological parameters of saline-alkaline tolerant cultivar GN under saline-alkaline *** number of root tips(RT),root surface area(RS)and root volume(RV)of AG were reduced by 61.16%,44.54%,and 45.31%,respectively,compared with control *** ratios of K^(+)/Na^(+),Ca^(2+)/Na^(+)and Mg^(2+)/Na^(+)of GN were significantly higher than those of AG(pfalfa were positively regulated by soil SOC and TN,but negatively regulated by soil pH,EC,and URE(p<0.01).Root Ca^(2+)/Na+ratio was significantly positively correlated with soil TN,TP and SOC(p<0.01).The absorption of Mg and Ca ions in roots is significantly negatively regulated by soilβ-glucosidase ac

关键词： Saline-alkaline stress alfalfa root traits soil environmental factors correlation analysis

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Characterization of a pangolin SARS-CoV-2-related virus isolate that uses the human ACE2 receptor

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Science China(Life Sciences) 2024年第7期67卷 1502-1513页

作者： Luo-Yuan Xia Xue-Feng Wang Xiao-Ming Cui Yi-Ming Zhang Zhen-Fei Wang En-Tao Li Chang-fa fan Ke Song Yuan-Guo Li Run-Ze Ye fang-Xu Li Dai-Yun Zhu Jie Zhang Zhuang-Zhuang Shi Ming-Zhu Zhang Liang-Jing Li Shi-Jing Shen Song Jin Ya-Wei Zhang Wei-Guang Fu Lin Zhao Wen-Hao Wang Tie-Cheng Wang you-chun Wang Jia-Fu Jiang Yan-Ling Hu Na Jia Yu-Wei Gao Wu-chun Cao Institute of EcoHealth School of Public HealthCheeloo College of MedicineShandong UniversityJinan 250012China Changchun Veterinary Research Institute Changchun 130122China State Key Laboratory of Pathogen and Biosecurity Beijing Institute of Microbiology and EpidemiologyBeijing 100071China Division of Animal Model Research Institute for Laboratory Animal ResourcesNational Institutes for Food and Drug ControlBeijing 102629China National Institutes for Food and Drug Control Beijing 102629China Life Sciences Institute Guangxi Medical UniversityNanning 530020China College of Life Sciences Shandong Normal UniversityJinan 250014China Research Unit of Discovery and Tracing of Natural Focus Diseases Chinese Academy of Medical SciencesBeijing 100071China

Various SARS-CoV-2-related coronaviruses have been increasingly identified in pangolins,showing a potential threat to *** we report the infectivity and pathogenicity of the SARS-CoV-2-related virus,PCoV-GX/P2V,which was isolated from a Malayan pangolin(Manis javanica).PCoV-GX/P2V could grow in human hepatoma,colorectal adenocarcinoma cells,and human primary nasal epithelial *** replicated more efficiently in cells expressing human angiotensin-converting enzyme 2(hACE2)as SARS-CoV-2 *** intranasal inoculation to the hACE2-transgenic mice,PCoV-GX/P2V not only replicated in nasal turbinate and lungs,but also caused interstitial pneumonia,characterized by infiltration of mixed inflammatory cells and multifocal alveolar *** population immunity established by SARS-CoV-2 infection and vaccination may not protect people from PCoV-GX/P2V *** findings further verify the hACE2 utility of PCoV-GX/P2V by in vivo experiments using authentic viruses and highlight the importance for intensive surveillance to prevent possible cross-species transmission.

关键词： pangolin SARS-CoV-2-related virus infectivity pathogenicity human cell lines human ACE2 receptor hACE2-transgenic mice

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Mechanically driven assembly of biomimetic 2D-material microtextures with bioinspired multifunctionality

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Nano Research 2024年第2期17卷 663-678页

作者： Yang Li Lin Jing Joshua M.Little Haochen Yang Tsai-chun chung Po-Yen Chen Department of Chemical and Biomolecular Engineering University of MarylandCollege ParkMD 20740USA Maryland Robotics Center University of MarylandCollege ParkMD 20742USA School of Materials Science and Engineering Nanyang Technological University50 Nanyang AvenueSingapore 639798Singapore

Nature provides a wealth of bio-inspiration for advanced material *** various nanomaterials into biomimetic microtextures with bioinspired functionalities has spurred increasing research interests and facilitated technological advances in various *** recent years,two-dimensional materials(2DMs)have emerged as important building block units in the biomimicry field due to their distinct chemical,physical,electrical,electrochemical,and catalytic *** this review article,various mechanically driven assembly approaches are summarized to fabricate various genealogies of biomimetic 2DM microtextures with bio-inspired ***,sequential deformation strategies are discussed to programmably construct higher dimensional 2DM microtextures,ranging from wrinkles/crumples(one-time deformation)to multiscale hierarchies(multiple deformations).Next,the current progress using higher dimensional 2DM microtextures to imitate different biological structures and/or induce bio-inspired multifunctionality is systematically *** showcases of bio-inspiration and biomimicry using different 2DM nanosheets are highlighted:(1)wrinkle patterns of an earthworm that spur the design of strain sensors with programmable working ranges and sensitivities,(2)wrinkle appearance of a Shar-Pei dog that motivates the fabrication of stretchable energy storage devices,(3)hierarchical scale textures of a desert lizard that inspire cation-induced gelation platforms for 2DM aerogels,and(4)wrinkle skin of an elephant that influences the development of 2DM protective skin for soft ***,challenges and future opportunities of adopting 2DM nanosheets to assemble biomimetic microstructures with synergistic functionalities are discussed.

关键词： two-dimensional(2D)materials mechanically driven assembly biomimetic microtextures functional nanocomposite bio-inspired multifunctionality

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数字普惠金融的民生福祉效应:“红利”与“鸿沟”

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西北人口 2024年第3期45卷 25-38页

作者：谭远发朱春霞西南财经大学社会发展学院成都611130 西南财经大学经济学院成都611130

数字普惠金融比传统金融具有更好的地理穿透性,为增进民生福祉,破解“胡焕庸线魔咒”提供了可能,但较少有文献对此进行系统研究。论文基于中国民生发展指数和数字普惠金融指数,利用空间统计与计量方法,从市级层面系统考察了数字普惠金... 详细信息

数字普惠金融比传统金融具有更好的地理穿透性,为增进民生福祉,破解“胡焕庸线魔咒”提供了可能,但较少有文献对此进行系统研究。论文基于中国民生发展指数和数字普惠金融指数,利用空间统计与计量方法,从市级层面系统考察了数字普惠金融的民生福祉效应,并分析了以胡焕庸线为界的区域异质性特征。研究发现:数字普惠金融指数和民生福祉指数具有明显的空间分布异质性特点,呈现“高值向东南集聚、低值向西北集聚”的趋势。数字普惠金融与民生福祉皆存在显著的空间关联性,空间集聚特征明显且呈两极分化格局,胡焕庸线仍是两者的重要空间分界线;高-高集聚主要分布在胡焕庸线东南侧的沿海城市,低-低集聚主要分布在靠近胡焕庸线两侧的城市。数字普惠金融显著增进了民生福祉,发挥出“数字红利”的普惠作用;该作用在胡焕庸线东南侧城市显著高于西北侧城市,但两侧差距在缩小,这说明区域“鸿沟”在缩小,“胡焕庸线魔咒”有望破解。此外,研究还显示数字普惠金融的覆盖广度和使用深度是增进民生福祉的主要驱动力,而且后者的作用大于前者。因此,要加快西部地区数字基础设施与相关技术发展,提升胡焕庸线西北侧城市数字普惠金融的覆盖广度与使用深度,以增进区域民生福祉均衡性和可及性。

关键词：数字普惠金融民生福祉胡焕庸线莫兰指数空间滞后模型

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西沙群岛鹦嘴鱼科耳石形态学物种鉴定的可行性研究

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水生生物学报 2024年第3期48卷 469-478页

作者：康志鹏李纯厚李纯然王腾赵金发石娟刘永中国水产科学研究院南海水产研究所农业农村部南海渔业资源开发利用重点实验室广东珠江口生态系统野外科学观测研究站广东省渔业生态环境重点实验室广州510300 西沙岛礁渔业生态系统海南省野外科学观测研究站/海南省深远海渔业资源高效利用与加工重点实验室/三亚热带水产研究院三亚572018 华中农业大学武汉430070

研究于2018—2021年在西沙群岛海域采集鹦嘴鱼样本,通过传统形态测量法选取的19个耳石形态指标和椭圆傅里叶分析法选取的77个椭圆傅里叶系数对其进行鉴别分析,探究耳石形态在鹦嘴鱼科物种鉴别中的可行性。结果表明,仅使用耳石形态指标... 详细信息

研究于2018—2021年在西沙群岛海域采集鹦嘴鱼样本,通过传统形态测量法选取的19个耳石形态指标和椭圆傅里叶分析法选取的77个椭圆傅里叶系数对其进行鉴别分析,探究耳石形态在鹦嘴鱼科物种鉴别中的可行性。结果表明,仅使用耳石形态指标鉴别鹦嘴鱼时综合判别率为56.8%,低于仅使用椭圆傅里叶系数的63.1%和两种参数结合的75.7%;而结合两种参数对其4个属的综合判别率为88.6%,其中绚鹦嘴鱼属的判别率达到100%;15种鹦嘴鱼的耳石形态聚类结果与已有研究的进化树结果基本一致,特别是属层面的聚类,呈现高度一致,证实了耳石形态具有遗传的属性,也说明了耳石形态学用于鱼类物种鉴定的可行性。研究结果将为西沙群岛鹦嘴鱼的基础研究提供科学资料,为鹦嘴鱼资源的保护与开发提供理论依据。

关键词：耳石形态传统形态测量法椭圆傅里叶分析法鹦嘴鱼

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贲门失迟缓导致儿童喘息发作1例报告

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中国实用儿科杂志 2024年第2期39卷 157-160页

作者：翁静毛春发胡春英徐慧芳董丽君王颖硕浙江大学医学院附属儿童医院呼吸内科浙江杭州310052 浙江大学医学院附属第二医院兰溪分院儿科浙江金华321100

回顾性分析2021年6月浙江大学医学院附属第二医院兰溪分院收治的1例由贲门失迟缓导致的喘息发作患儿的临床资料,并检索相关文献资料复习。患儿,男,5岁,因咳嗽、喘息入院,经对症治疗后效果不佳。患儿既往有贲门失迟缓并行球囊扩张术,考... 详细信息

回顾性分析2021年6月浙江大学医学院附属第二医院兰溪分院收治的1例由贲门失迟缓导致的喘息发作患儿的临床资料,并检索相关文献资料复习。患儿,男,5岁,因咳嗽、喘息入院,经对症治疗后效果不佳。患儿既往有贲门失迟缓并行球囊扩张术,考虑咳嗽、喘息与贲门失迟缓有关,终经内镜下贲门括约肌切开术,咳嗽、喘息消失。儿童喘息主要病因有感染、支气管哮喘等,贲门失迟缓也是导致儿童喘息的病因之一。

关键词：儿童喘息贲门失迟缓

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中东欧地区隧道施工OHS风险控制差异性研究

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公路 2024年第2期69卷 200-204页

作者：朱刚雷严少发于春生中交一公局集团有限公司北京市100024

针对中国企业在中东欧基建市场隧道工程的不断增多,以黑山南北高速公路项目为工程背景,基于菲迪克条款定义下的EPC合同条件,探讨隧道施工活动中出现的各类因素对职业健康安全目标的影响和解决措施,研究中东欧地区高速公路隧道施工中OHS... 详细信息

针对中国企业在中东欧基建市场隧道工程的不断增多,以黑山南北高速公路项目为工程背景,基于菲迪克条款定义下的EPC合同条件,探讨隧道施工活动中出现的各类因素对职业健康安全目标的影响和解决措施,研究中东欧地区高速公路隧道施工中OHS风险控制区别于国内施工的重难点,提出可行的施工建议,为同类工程施工及管理提供有益借鉴。

关键词：隧道施工 OHS风险控制菲迪克条款差异性

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