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Current Medical Science 2024年第2期44卷 426-434页

作者： Bi-xin XI Si-ying LIU Yu-ting XU De-dong ZHANG Qun hu Ai-guo LIU Department of Pediatrics Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

Objective:Glucose-6-phosphate isomerase(GPI)deficiency is a rare hereditary nonspherocytic hemolytic anemia caused by GPI gene *** disorder exhibits wide heterogeneity in its clinical manifestations and molecular characteristics,often posing challenges for precise diagnoses using conventional *** this end,this study aimed to identify the novel variants responsible for GPI deficiency in a Chinese ***:The clinical manifestations of the patient were summarized and analyzed for GPI deficiency phenotype *** compound heterozygous variants of the GPI gene,c.174C>A(***58Lys)and c.1538G>T(***513Leu),were identified using whole-exome and Sanger *** AlphaFold program and Chimera software were used to analyze the effects of compound heterozygous variants on GPI ***:By characterizing 53 GPI missense/nonsense variants from previous literature and two novel missense variants identified in this study,we found that most variants were located in exons 3,4,12,and 18,with a few localized in exons 8,9,and *** study identified novel compound heterozygous variants associated with GPI *** pathogenic variants disrupt hydrogen bonds formed by highly conserved GPI amino ***:Early family-based sequencing analyses,especially for patients with congenital anemia,can help increase diagnostic accuracy for GPI deficiency,improve child healthcare,and enable genetic counseling.

关键词： glucose-6-phosphate isomerase deficiency whole-exome sequencing compound heterozygous variants genetic characterization hydrogen bond

Effects of Lactobacillus paracasei N1115 on gut microbial imbalance and liver function in patients with hepatitis B-related cirrhosis

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World Journal of Gastroenterology 2024年第11期30卷 1556-1571页

作者： Yan-Chao hu Xiang-chun Ding hui-Juan Liu Wan-Long Ma Xue-Yan Feng Li-Na Ma Department of Infectious Disease General Hospital of Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina Infectious Disease Clinical Research Center of Ningxia Yinchuan 750004Ningxia Hui Autonomous RegionChina

BACKGROUND Hepatitis B cirrhosis(HBC)is a chronic disease characterized by irreversible diffuse liver damage and aggravated by intestinal microbial imbalance and metabolic *** the relationship between certain single probiotics and HBC has been explored,the impact of the complex ready-to-eat Lactobacillus paracasei N1115(LP N1115)supplement on patients with HBC has not been *** To compare the changes in the microbiota,inflammatory factor levels,and liver function before and after probiotic treatment in HBC *** This study included 160 HBC patients diagnosed at the General Hospital of Ningxia Medical University between October 2018 and December *** were randomly divided into an intervention group that received LP N1115 supplementation and routine treatment and a control group that received routine treatment *** samples were collected at the onset and conclusion of the 12-wk intervention *** structure of the intestinal microbiota and the levels of serological indicators,such as liver function and inflammatory factors,were *** Following LP N1115 intervention,the intestinal microbial diversity significantly increased in the intervention group(P<0.05),and the structure of the intestinal microbiota was characterized by an increase in the proportions of probiotic microbes and a reduction in harmful ***,the intervention group demonstrated notable improvements in liver function indices and significantly lower levels of inflammatory factors(P<0.05).CONCLUSION LP N1115 is a promising treatment for ameliorating intestinal microbial imbalance in HBC patients by modulating the structure of the intestinal microbiota,improving liver function,and reducing inflammatory factor levels.

关键词： Hepatitis B cirrhosis N1115 ready-to-eat lactobacillus Inflammation Liver function Lachnospiraceae incertae sedis Probiotic

Clinical Analysis and Mental Health Survey of Hemophilia Carriers:a Cross-sectional Study

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Current Medical Science 2024年第2期44卷 435-440页

作者： Wen WANG Li-juan JIANG dong-yan CUI Ai ZHANG Xiong WANG Ai-guo LIU Qun hu Department of Pediatrics Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Laboratory Medicine Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

Objective:Hemophilia carriers(HCs),who are heterozygous for mutations in the clotting factor VIII/clotting factor IX gene(F8 or F9),may have a wide range of clotting factor levels,from very low,similar to afflicted males,to the upper limit of normal,and may experience mental health *** purpose of this study was to provide genetic information on mothers of hemophilia patients and to understand the clotting factor activity and phenotype of ***,we aimed to investigate the mental health status of HCs in ***:A total of 127 hemophilia mothers,including 93 hemophilia A(HA)mothers and 34 hemophilia B(HB)mothers,were enrolled in this *** distance PCR,multiplex PCR,and Sanger sequencing were used to analyze mutations in F8 or *** factor activity was detected by a one-stage clotting *** Symptom Checklist 90(SCL-90,China/Mandarin version)was given to HCs at the same time to assess their mental ***:A total of 90.6%of hemophilia mothers were diagnosed genetically as carriers,with inversion in intron 22 and missense mutations being the most common mutation types in HA and HB carriers,*** median clotting factor level in carriers was 0.74 IU/mL(ranging from 0.09 to 1.74 IU/mL)compared with 1.49 IU/mL(ranging from 0.93 to 1.89 IU/mL)in noncarriers,of which 14.3%of HCs had clotting factor levels of 0.40 IU/mL or below.A total of 53.8%(7/13)of HA carriers with low clotting factor levels(less than 0.50 IU/mL)had a history of bleeding,while none of the HB carriers displayed a bleeding *** total mean score and the global severity index of the SCL-90 for surveyed HCs were 171.00(±60.37)and 1.78(±0.59),respectively.A total of 67.7%of the respondents had psychological symptoms,with obsessive-compulsive disorder being the most prevalent and *** pooled estimates of all nine factors were significantly higher than those in the general population(P<0.05).Conclusions:The detection rate of gene mutations

关键词： hemophilia A hemophilia B mutation carrier mental health

Geometric based apple suction strategy for robotic packaging

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International Journal of Agricultural and Biological Engineering 2024年第3期17卷 12-20页

作者： Zhong Wang Qingyu Wang Mingzhao Lou Fan Wu Yaonan Zhu dong hu Mingchuan Zhou Yibin Ying College of Optical Mechanical and Electrical EngineeringZhejiang A&F UniversityHangzhou 311300China College of Biosystems Engineering and Food Science Zhejiang UniversityHangzhou 310058China Key Laboratory of Intelligent Equipment and Robotics for Agriculture of Zhejiang Province Zhejiang UniversityHangzhou 310058China Department of Micro-Nona Mechanical Science and Engineering Nagoya UniversityFuro-choChikusa-kuNagoya 464-8601Japan

Packaging is one of the least automated steps among all the fruit postharvest processes,which is time-consuming and ***,a robust suction strategy for robotic manipulation needs to be *** this research,a geometric-based apple suction strategy for robotic packaging was studied,including suction cup design,optimal suction region selection algorithm,and robot system *** the first place,on the basis of the geometric features of the spheroid fruit,the structure of the suction cups was designed to provide reliable suction ***,suction force measurement experiments on both acrylic balls and apples were *** on the results,the parameters of the suction cup were finally *** results also indicated that the curvature radius of the suction region is supposed to larger than that of the suction ***,a robust suction region selection algorithm was developed,which involves four steps:RGB-D information acquisition,object detection and point cloud generation,spherical fitting,and suction region ***,the above methods were integrated into a robotic packaging *** addition,on the basis of spatial-frequency domain imaging(SFDI)technology,early stage bruise was detected for *** results showed that,the proposed suction strategy and system is potential for robust robotic apple packaging.

关键词： apple suction cup robotic packaging robotic manipulation point cloud

Maximum initial primary wave model for low-Froude-number reservoir landslides based on wave theory

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Journal of Mountain Science 2024年第8期21卷 2664-2680页

作者： LI Yang huANG Bolin QIN Zhen dong Xingchen hu Lei National Field Observation and Research Station of Landslides in Three Gorges Reservoir Area of Yangtze River Yichang 443002China College of Civil Engineering&Architecture China Three Gorges UniversityYichang 443002China

The impulse waves induced by large-reservoir landslides can be characterized by a low Froude ***,systematic research on predictive models specifically targeting the initial primary wave is *** the Shuipingzi 1#landslide that occurred in the Baihetan Reservoir area of the Jinsha River in China as an engineering example,this study established a large-scale physical model(with dimensions of 30 m×29 m×3.5 m at a scale of 1:150)and conducted scaled experiments on 3D landslide-induced impulse *** the process in which a sliding mass displaced and compressed a body of water to generate waves,the maximum initial wave amplitude was found to be positively correlated with the sliding velocity and the volume of the *** the increase in the water depth,the wave amplitude initially increased and then *** duration of pressure exertion by the sliding mass at its maximum velocity directly correlated with an elevated wave *** on the theories of low-amplitude waves and energy conservation,while considering the energy conversion efficiency,a predictive model for the initial wave amplitude was *** model could fit and validate the functions of wavelength and wave *** accuracy of the initial wave amplitude was verified using physical experiment data,with a prediction accuracy for the maximum initial wave amplitude reaching 90%.The conversion efficiency(η)directly determined the accuracy of the estimation *** clear conditions for landslide-induced impulse wave generation,estimating the value ofηthrough analogy cases was *** study has derived the landslide-induced impulse waves amplitude prediction formula from the standpoints of wave theory and energy conservation,with greater consideration given to the intrinsic characteristics in the formation process of landslide-induced impulse waves,thereby enhancing the applicability and extensibility of the *** can facilitate the development

关键词： Three-dimensional physical model experiments Reservoir-landslide-induced impulse wave Energy conversion efficiency Landslide-induced impulse wave prediction model Shuipingzi 1#landslide

Lower synaptic density and its association with cognitive dysfunction in patients with obsessive-compulsive disorder

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General Psychiatry 2024年第3期37卷 422-430页

作者： Qian Xiao Jiale Hou Ling Xiao Ming Zhou Zhiyou He huixi dong Shuo hu Mental Health Center Xiangya HospitalCentral South UniversityChangshaHunanChina Department of Nuclear Medicine Xiangya HospitalCentral South UniversityChangshaHunanChina Key Laboratory of Biological Nanotechnology National Health CommissionChangshaHunanChina National Clinical Research Center Geriatric Disorders(Xiangya)ChangshaHunanChina

Background Understanding synaptic alteration in obsessive-compulsive disorder(OCD)is crucial for elucidating its pathological mechanisms,but in vivo research on this topic remains *** This study aimed to identify the synaptic density indicators in OCD and explore the relationship between cognitive dysfunction and synaptic density changes in *** This study enrolled 28 drug-naive adults with OCD aged 18-40 years and 16 healthy controls(HCs).Three-dimensional T1-weighted structural magnetic resonance imaging and 18F-SynVesT-1 positron emission tomography were *** function was assessed using the Wisconsin Cart Sorting Test(WCST)in patients with OCD and *** analysis was performed to examine the association between synaptic density reduction and cognitive *** Compared with HCs,patients with OCD showed reduced synaptic density in regions of the cortico-striatothalamo-cortical circuit such as the bilateral putamen,left caudate,left parahippocampal gyrus,left insula,left parahippocampal gyrus and left middle occipital lobe(voxel p<0.001,uncorrected,with cluster level above 50 contiguous voxels).The per cent conceptual-level responses of WCST were positively associated with the synaptic density reduction in the left middle occipital gyrus(R^(2)=0.1690,p=0.030),left parahippocampal gyrus(R^(2)=0.1464,p=0.045)and left putamen(R^(2)=0.1967,p=0.018)in patients with *** Adults with OCD demonstrated lower 18Flabelled difluoro analogue of 18F-SynVesT-1 compared with HCs,indicating potentially lower synaptic *** is the first study to explore the synaptic density in patients with OCD and provides insights into potential biological targets for cognitive dysfunctions in OCD.

关键词： patients dysfunction Lower

MicroRNA-451a is a candidate biomarker and therapeutic target for major depressive disorder

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General Psychiatry 2024年第1期37卷 151-162页

作者： Panpan hu Qiuchen Cao hu Feng Yun Liu Yan Chen Jingfan Xu Weixi Feng huaiqing Sun huachen Ding chun Wang Junying Gao Ming Xiao Jiangsu Key Laboratory of Neurodegeneration Nanjing Medical UniversityNanjingJiangsuChina Department of Neurology The First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsuChina Nanjing Brain Hospital Affliated to Nanjing Medical University NanjingJiangsuChina Functional Brain Imaging Institute of Nanjing Medical University NanjingJiangsuChina

Background Increasing evidence supports the role of microRNAs(miRNAs)in major depressive disorder(MDD),but the pathophysiological mechanism remains *** To explore the mechanism of microRNA-451a(miR-451a)in the pathology and behaviours of *** Abnormal miRNAs such as miR-451a reported previously in the serum of patients with MDD were screened and then confirmed in a mouse model of depression induced by chronic restraint stress(CRS).Eight-week-old male C57BL/6 mice had miR-451a overexpression in the medial prefrontal cortex(mPFC)via adeno-associated virus serotype 9 vectors encoding a pri-mmu-miR-451a-GFP fusion protein followed by behavioural and pathological ***,molecular biological experiments were conducted to investigate the potential mechanism of miR-451a against *** The serum levels of miRNA-451awere significantly lower in patients with MDD,with a negative correlation with the Hamilton Depression Scale ***,a negative association between serum miR-451a and behavioural despair or anhedonia was observed in CRS ***,miR-451a expression was significantly downregulated in the mPFC of CRS-susceptible *** miR-451a in the mPFC reversed the loss of dendritic spines and the depression-like phenotype of CRS ***,miR-451a could inhibit CRS-induced corticotropin-releasing factor receptor 1 expression via targeting transcription factor 2,subsequently protecting dendritic spine *** Together,these results highlighted miR-451a as a candidate biomarker and therapeutic target for MDD.

关键词： therapeutic medial behaviour

Machine learning for carbonate formation drilling: Mud loss prediction using seismic attributes and mud loss records

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Petroleum Science 2024年第2期21卷 1241-1256页

作者： hui-Wen Pang Han-Qing Wang Yi-Tian Xiao Yan Jin Yun-hu Lu Yong-dong Fan Zhen Nie National Key Laboratory of Petroleum Resources and Engineering China University of Petroleum(Beijing)Beijing102249China College of Science China University of Petroleum-BeijingBeijing102249China Petroleum Exploration and Production Research Institute SINOPECBeijing102206China College of Petroleum Engineering China University of Petroleum-BeijingBeijing102249China Research Institute of Petroleum Exploration and Development CNPCBeijing100083China

Due to the complexity and variability of carbonate formation leakage zones, lost circulation prediction and control is one of the major challenges of carbonate drilling. It raises well-control risks and production expenses. This research utilizes the H oilfield as an example, employs seismic features to analyze mud loss prediction, and produces a complete set of pre-drilling mud loss prediction solutions. Firstly, 16seismic attributes are calculated based on the post-stack seismic data, and the mud loss rate per unit footage is specified. The sample set is constructed by extracting each attribute from the seismic trace surrounding 15 typical wells, with a ratio of 8:2 between the training set and the test set. With the calibration results for mud loss rate per unit footage, the nonlinear mapping relationship between seismic attributes and mud loss rate per unit size is established using the mixed density network ***, the influence of the number of sub-Gausses and the uncertainty coefficient on the model's prediction is evaluated. Finally, the model is used in conjunction with downhole drilling conditions to assess the risk of mud loss in various layers and along the wellbore trajectory. The study demonstrates that the mean relative errors of the model for training data and test data are 6.9% and 7.5%, respectively, and that R2is 90% and 88%, respectively, for training data and test data. The accuracy and efficacy of mud loss prediction may be greatly enhanced by combining 16 seismic attributes with the mud loss rate per unit footage and applying machine learning methods. The mud loss prediction model based on the MDN model can not only predict the mud loss rate but also objectively evaluate the prediction based on the quality of the data and the model.

关键词： Lost circulation Risk prediction Machine learning Seismic attributes Mud loss records

Ground settlement and tunnel response due to twin-curved shield tunnelling in soft ground with small clear distance

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第8期16卷 3122-3135页

作者： Yao hu Haoran Tang Yinggang Xu huayang Lei Peng Zeng Kai Yao Yabo dong State Key Laboratory of Geohazard Prevention and Geoenvironment Protection Chengdu University of TechnologyChengdu610059China Research Center of Tunneling and Underground Engineering of Ministry of Education Beijing Jiaotong UniversityBeijing100044China College of Environment and Civil Engineering Chengdu University of TechnologyChengdu610059China School of Civil Engineering Tianjin UniversityTianjin300350China School of Qilu Transportation Shandong UniversityJinan250002China Power China Sinohydro Bureau 7 Co. Ltd.Chengdu610213China

Twin curved tunnels are often encountered in shield tunnelling,where significant complexities in densely exploited underground space are *** this study,the ground settlement and tunnel deformation due to twin-curved shield tunnelling in soft ground were investigated using numerical simulation and field *** curvature radii of twin curved tunnels and subsequent effects of tunnel construction were considered to reveal the tunnelling effect on ground surface settlement and tunnel *** results show that the settlement trough yields one offset towards inside of curved shield *** location of settlement trough and maximum settlement were affected by curvature radius but except for the shape and width of settlement *** parallel twin-curved shield tunnelling could increase the offset of existing settlement trough and maximum ***,an empirical prediction of surface settlement trough due to twin-curved shield tunnelling with same tunnel diameters in soft clay was proposed,which was applicable to curvature radius less than 800 ***,a minimum radius of 600 m of curvature tunnel was proposed in terms of allowable convergence deformation of *** result could provide guidance on safety evaluation for twin curved shield tunnelling construction.

关键词： Shield tunnelling Curvature radius Ground settlement Tunnel deformation Numerical simulation

Effectiveness of Histopathological Examination of Ultrasound-guided Puncture Biopsy Samples for Diagnosis of Extrapulmonary Tuberculosis

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Biomedical and Environmental Sciences 2024年第2期37卷 170-177页

作者： GU Wen Fei SHI Xia MA Xin YU Jun Lei XU Jin Chuan QIAN Cheng Cheng hu Zhi dong ZHANG hui Shanghai Public Health Clinical Center Fudan UniversityShanghai 201508China School of Laboratory Medicine and Life Science Wenzhou Medical UniversityWenzhou 325000ZhejiangChina Department of Laboratory Medicine Zhejiang Putuo HospitalZhoushan 316100ZhejiangChina Zhongshan Hospital Fudan UniversityShanghai 200032China

Objective To evaluate the diagnostic value of histopathological examination of ultrasound-guided puncture biopsy samples in extrapulmonary tuberculosis(EPTB).Methods This study was conducted at the Shanghai Public Health Clinical Center.A total of 115patients underwent ultrasound-guided puncture biopsy,followed by MGIT 960 culture(culture),smear,Gene Xpert MTB/RIF(Xpert),and histopathological *** assays were performed to evaluate their effectiveness in diagnosing EPTB in comparison to two different diagnostic criteria:liquid culture and composite reference standard(CRS).Results When CRS was used as the reference standard,the sensitivity and specificity of culture,smear,Xpert,and histopathological examination were(44.83%,89.29%),(51.72%,89.29%),(70.11%,96.43%),and(85.06%,82.14%),*** on liquid culture tests,the sensitivity and specificity of smear,Xpert,and pathological examination were(66.67%,72.60%),(83.33%,63.01%),and(92.86%,45.21%),*** examination showed the highest sensitivity but lowest ***,we found that the combination of Xpert and histopathological examination showed a sensitivity of 90.80%and a specificity of 89.29%.Conclusion Ultrasound-guided puncture sampling is safe and effective for the diagnosis of *** with culture,smear,and Xpert,histopathological examination showed higher sensitivity but lower *** combination of histopathology with Xpert showed the best performance characteristics.

关键词： Extrapulmonary tuberculosis Diagnosis Biopsy Histopathological examination Puncture samples