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Undifferentiated high-grade pleomorphic sarcoma of the common bile duct:A case report and review of literature

World Journal of Gastrointestinal Oncology 2024年第5期16卷 2253-2260页

作者： Li-Ping Zheng Wen-Yan Shen chun-dong hu chun-hua Wang Xu-Jian Chen Jing Wang Yi-Yu Shen Department of General Surgery The Second Affiliated Hospital of Jiaxing UniversityJiaxing 314000Zhejiang ProvinceChina Department of Pathology The Second Affiliated Hospital of Jiaxing UniversityJiaxing 314000Zhejiang ProvinceChina

BACKGROUND Undifferentiated pleomorphic sarcoma(UPS)is a rare malignant mesenchymal tumor with a poor *** mainly occurs in the extremities,trunk,head and neck,and retroperitoneum *** to the lack of specific clinical manifestations and imaging features,UPS diagnosis mainly depends on pathological and immunohistochemical examinations for exclusive *** we report an extremely rare case of high-grade UPS in the common bile duct(CBD).There are limited available data on such *** SUMMARY A 70-year-old woman was admitted to our department with yellow eyes and urine accompanied by upper abdominal distending pain for 2 *** laboratory data suggested significantly elevated hepatorenal function *** imaging data revealed calculous cholecystitis,intrahepatic and extrahepatic bile duct dilation with extrahepatic bile duct calculi,and a space-occupying lesion at the distal *** endoscopic biliary stenting and symptomatic support therapy,CBD exploration and biopsy were *** frozen section indicated malignant spindle cell tumor of the CBD mass,and further radical pancreaticoduodenectomy was ***,the neoplasm was diagnosed as a high-grade UPS combined with the light-microscopic morphology and immunohistochemical *** This extremely rare case highlighted the need for increasing physicians'vigilance,reducing the odds of misdiagnosis,and providing appropriate treatment strategies.

关键词： Undifferentiated pleomorphic sarcoma Soft tissue sarcoma Common bile duct Extrahepatic bile duct Immunohistochemistry Case report

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Thermodynamic analysis and simulation for gas baffle entrance collimator of EAST-NBI system based on thermo-fluid coupled method

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Nuclear Science and Techniques 2018年第1期29卷 90-95页

作者： Ling Tao chun-dong hu Yuan-Lai Xie Institute of Plasma Physics Chinese Academy of Sciences

The world's first full Experimental Advanced Superconducting Tokamak(EAST) is designed with the auxiliary heating method of neutral beam injection(NBI)system. Beam collimators are arranged on both sides of the beam channel for absorbing the divergence beam during the beam transmission process in the EAST-NBI *** gas baffle entrance collimator(GBEC) is a typical high-heat-flux component located at the entrance of gas baffle. An efficient and accurate analysis of its thermodynamic performance is of great significance to explore the working limit and to ensure safe operation of the system under a high-parameter steady-state condition. Based on the thermo-fluid coupled method, thermodynamic analysis and simulation of GBEC is performed to get the working states and corresponding operating limits at different beam extraction conditions. This study provides a theoretical guidance for the next step to achieve long pulse with highpower experimental operation and has an important reference to ensure the safe operation of the system.

关键词： Neutral beam injection High-heat-flux component Beam collimator Thermo-fluid coupled method Thermodynamic analysis

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Achieving strength–ductility synergy in novel paramagnetic Fe-based medium-entropy alloys through deep cryogenic deformation

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Rare Metals 2024年第9期43卷 4493-4507页

作者： hu-Wen Ma Yan-chun Zhao Li Feng Tian-Zeng Liu Zhi-Qi Yu Bo Jin Wang-chun Duan Peter K.Liaw dong Ma State Key Laboratory of Advanced Processing and Recycling of Non-Ferrous Metals Lanzhou University of Technology Wenzhou Pump and Valve Engineering Research Institute Lanzhou University of Technology Iron and Steel Research Institute Jiuquan Iron and Steel Corporation Lanzhou Resources and Environment Voc-Tech University Department of Materials Science and Engineering The University of Tennessee Neutron Science Center Songshan Lake Materials Laboratory

Cryogenic pre-deformation treatment has been widely used to effectively improve the comprehensive mechanical properties of steels and novel metals. However,the dislocation evolution and phase transformation induced by different degrees of deep cryogenic deformation are not yet fully elucidated. In this study, the effects of multiple cryogenic pre-treatments on the mechanical properties and deformation mechanisms of a paramagnetic Fe63.3Mn14-Si9.1Cr9.8C3.8medium-entropy alloy（MEA） were investigated, leading to the discovery of a pretreated MEA that exhibits exceptional mechanical properties, including a fracture strength of 3.0 GPa, plastic strain of 26.1% and work-hardening index of 0.57. In addition, X-ray diffraction（XRD） and transmission electron microscopy（TEM）analyses revealed that multiple cryogenic pre-deformation treatments significantly increased the dislocation density of the MEA(from 9 × 1015to 4 × 1016m-2after three pretreatments), along with a transition in the dislocation type from predominantly edge dislocations to mixed dislocations（including screw-and edge-type dislocations）. Notably, this pretreated MEA retained its paramagnetic properties（μr< 1.0200） even after fracture. Thermodynamic calculations showed that cryogenic pretreatment can significantly reduce the stacking fault energy of the MEA by a factor of approximately four(i.e., from 9.7 to2.6 m J·m-2), thereby activating the synergistic effects of transformation-induced plasticity, twinning-induced plasticity and dislocation strengthening mechanisms. These synergistic effects lead to simultaneous strength and ductility enhancement of the MEA.

关键词： Deep cryogenic transformation Dislocation evolution Iron-based medium-entropy alloys Phase transformation Stacking fault energy

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Brain abscess from oral microbiota approached by metagenomic next-generation sequencing: A case report and review of literature

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World Journal of Clinical Cases 2024年第3期12卷 616-622页

作者： Xue-Min Zhu chun-Xia dong Lei Xie Hao-Xin Liu huai-Qiang hu School of Clinical Medicine Weifang Medical UniversityWeifang 261053Shandong ProvinceChina Department of Neurology the 960th Hospital of People′s Liberation ArmyJinan 250031Shandong ProvinceChina

BACKGROUND Brain abscess is a serious and potentially fatal disease caused primarily by microbial *** progress has been made in the diagnosis and treatment of brain abscesses,the diagnostic timeliness of pathogens needs to be *** SUMMARY We report the case of a 54-year-old male with a brain abscess caused by oral *** patient recovered well after receiving a combination of metagenomic next-generation sequencing(mNGS)-assisted guided medication and *** Therefore,mNGS may be widely applied to identify the pathogenic microor-ganisms of brain abscesses and guide precision medicine.

关键词： Brain abscess Metagenomic next-generation sequencing Periodontitis Oral bacteria Precision medicine Case report

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Enhanced Fenton-like process over Cu/L(+)-ascorbic acid co-doping mesoporous silica for toxicity reduction of emerging contaminants

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Frontiers of Environmental Science & Engineering 2024年第4期18卷 49-60页

作者： Yuhang Liu Wenxuan Deng Xiaojun Wu chun hu Lai Lyu Key Laboratory for Water Quality and Conservation of the Pearl River Delta(Ministry of Education) Institute of Environmental Research at Greater BayGuangzhou UniversityGuangzhou 510006China

Effective removal of emerging contaminants(ECs)to minimize their impacts on human health and the natural environment is a global *** the removal of ECs in water,we fabricated a seaweed spherical microsphere catalyst with Cu cation-πstructures by in situ doping of Cu species and ascorbic acid in mesoporous silica(Cu-C-MSNs)via a hydrothermal *** results indicate that bisphenol A(BPA)is substantially degraded within 5 min under natural conditions,with its biological toxicity considerably ***,industrial wastewater could also be effectively purified by Cu-C-MSNs/H_(2)O_(2) *** presence of metal sites and the complexation of ECs via cation-πinteraction andπ-πstacking on the catalyst surface were directly responsible for the polarization distribution of electrons,thus activating H_(2)O_(2) and dissolved oxygen(DO).The removal of contaminants could be attributed primarily to 1)the activation of H_(2)O_(2) into ^(·)OH to attack the contaminants and 2)self-cleavage because of the transfer of electrons from the contaminants to the *** study provides an innovative solution for the effective treatment of ECs and has positive implications for easing global environmental crises.

关键词： Cation-πstructures Polarization electric field Fenton-like process Contaminants cleavage

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Efficient concentration of trace analyte with ordered hotspot construction for a robust and sensitive SERS platform

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International Journal of Extreme Manufacturing 2024年第3期6卷 532-542页

作者： Youdi hu Yanlei hu Zhenyu Wang Jiale Yong Wei Xiong dong Wu Shixiang Xu Shenzhen Key Laboratory of Micro-Nano Photonic Information Technology College of Physics and Optoelectronic EngineeringShenzhen UniversityShenzhenGuangdong 518060People’s Republic of China CAS Key Laboratory of Mechanical Behavior and Design of Materials Key Laboratory of Precision Scientific Instrumentation of Anhui Higher Education InstitutesDepartment of Precision Machinery and Precision InstrumentationUniversity of Science and Technology of ChinaHefeiAnhui 230027People’s Republic of China Wuhan National Laboratory for Optoelectronics Huazhong University of Science and TechnologyWuhanHubeiPeople’s Republic of China

Surface-enhanced Raman scattering(SERS)platform,which enables trace analyte detection,has important application *** structuring/modifying the surface of the SERSsubstrate,analyte in highly diluted solutions can be concentrated into localized active areas for highly sensitive ***,subject to the difficulty of the fabrication process,itremains challenging to balance hot-spot construction and the concentration capacity of analyte ***,preparing SERS substrates with densely ordered hot spots andefficient concentration capacity is of great significance for highly sensitive ***,we propose an Ag and fluoroalkyl-modified hierarchical armour substrate(Ag/F-HA),which has a double-layer stacking design to combine analyte concentration with hotspot *** microarmour structure is fabricated by femtosecond-laser processing to serve as asuperhydrophobic and low-adhesive surface to concentrate analyte,while the anodic aluminium oxide(AAO)template creates a nanopillar array serving as dense and ordered hot *** the synergistic action of hot spots and analyte concentration,Ag/F-HA achieves a detectionlimit down to 10^(-7)M doxorubicin(DOX)molecules with a RSD of 7.69%.Additionally,Ag/F-HA exhibits excellent robustness to resist external disturbances such as liquid splash or *** on our strategy,SERS substrates with directional analyte concentrations are further explored by patterning microcone arrays with *** work opens a way to the realistic implementation of SERS in diverse scenarios.

关键词： surface-enhanced Raman scattering anodic aluminium oxide femtosecond laser processing concentration of trace analytes mechanical robustness

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Strong invariance principle for a counterbalanced random walk

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Applied Mathematics(A Journal of Chinese Universities) 2024年第2期39卷 370-380页

作者： TAN hui-qun hu Zhi-shui dong Liang International Institute of Finance School of ManagementUniversity of Science and Technology of ChinaHefei 230026China Center for Basic Teaching and Experiment Nanjing University of Science and TechnologyJiangyin 214443China

We study a counterbalanced random walkS_(n)=X_(1)+…+X_(n),which is a discrete time non-Markovian process andX_(n) are given recursively as *** n≥2,X_(n) is a new independent sample from some fixed law̸=0 with a fixed probability p,andX_(n)=−X_(v(n))with probability 1−p,where v(n)is a uniform random variable on{1;…;n−1}.We apply martingale method to obtain a strong invariance principle forS_(n).

关键词： random walk martingale invariance principle

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Transcriptome analysis reveals immune-related genes in tissues of Vibrio anguillarum-infected turbot Scophthalmus maximus

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Journal of Oceanology and Limnology 2024年第1期42卷 332-344页

作者： Yuting SONG Maqsood Ahmed SOOMRO Xianzhi dong Guobin hu College of Marine Life Sciences Ocean University of ChinaQingdao 266003China Institute of Evolution&Marine Biodiversity Ocean University of ChinaQingdao 266003China Institute of Biophysis Chinese Academy of SciencesBeijing 100101China

Turbot Scophthalmus maximus is an important mariculture fish species with high economic ***,the bacterial diseases caused by Vibrio anguillarum infection bring huge economic losses to the turbot aquaculture *** understand the immune response of the turbot against *** infection and to explore novel immune-related genes,the transcriptome analysis of turbot spleen and gills were conducted after *** *** expressed genes(DEGs)were identified in spleen and gill of the turbot amounted to 17261 and 16436,respectively.A large number of immunerelated DEGs were enriched in cytokine-cytokine receptor interaction signaling pathway,and the others by the kyoto encyclopedia of genes and genomes(KEGG)*** gene ontology(GO)classification analysis revealed that *** infection had the greatest effect on biological processes and cellular *** immune-related DEGs were identified in the spleen(cstl.1,egfl6,lamb21,v2rx4,calcr,and gpr78a)and gills(ghra,sh3gl2a,cst12,inhbaa,cxcl8,and il-1b)by heat *** proteinprotein interaction(PPI)networks were constructed to analyze the immune *** results demonstrate that the maturation and antigen processing of major histocompatibility complex(MHC)class II molecule,and calcitonin-or adrenomedullin-regulated physiological activity were important events in the immunity of turbot against *** *** the gills,the protein interactions in TGF-βsignaling pathway,production of inflammatory factors,and endocytosis regulation were most *** research laid a foundation for discovering novel immune-related genes and enriching the knowledge of immune mechanisms of turbot against *** infection.

关键词： Scophthalmus maximus Vibrio anguillarum transcriptome differentially expressed genes immune mechanism

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Drinking water quality & health risk assessment of secondary water supply systems in residential neighborhoods

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Frontiers of Environmental Science & Engineering 2024年第2期18卷 47-62页

作者： Yating Wei dong hu Chengsong Ye Heng Zhang Haoran Li Xin Yu College of the Environment&Ecology Xiamen UniversityXiamen 361102China School of Public Health Shandong First Medical University&Shandong Academy of Medical SciencesJinan 250117China

Secondary water supply systems(SWSSs)are important components of the water supply infrastructure that ensure residents’drinking water *** are characterized by long detention time,warm temperature,and unreasonable management,which may trigger the deterioration of water quality and increase *** this study,drinking water quality index(DWQI)and health risk assessment(HRA)were selected and modified to quantitatively assess the water quality and health risks of SWSSs in residential *** total,121 seasonal water samples were *** was observed that the water quality was excellent with the DWQI of 0.14±0.04,excluding one sample,which was extremely poor owing to its excessive total bacterial *** HRA results revealed that the health risks were low:negligible non-carcinogenic risk for any population;negligible and acceptable carcinogenic risk for children aged 6–17 and ***,samples revealed higher carcinogenic risk(7.63×10−5±3.29×10−6)for children aged 0–5,and arsenic was the major *** samples had poor water quality and higher health risks,which called for *** further investigate the water quality and health risks of SWSSs,monthly sampling was conducted during *** 24 water samples were qualified in Chinese standard(GB 5749-2022)and characterized as excellent *** HRA results were consistent with the seasonal samples’and the health risks were mainly concentrated in ***,our study provides a suitable framework for water quality security,advice for managers,and references for administrators in other cities.

关键词： Drinking water quality Water quality index Health risk assessment Secondary water supply systems Heavy metals

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Risk Factors Asscociated with Hypokalemia during Postanesthesia Recovery and Its Impact on Outcomes in Gynecological Patients:A Propensity Score Matching Study

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Current Medical Science 2024年第2期44卷 441-449页

作者： Bei-bei WANG Li hu Xin-yue hu dong HAN Jing WU Department of Anesthesiology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China Institute of Anesthesia and Critical Care Medicine Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China Key Laboratory of Anesthesiology and Resuscitation(huazhong University of Science and Technology) Ministry of EducationWuhan430022China

Objective:This study aimed to explore the risk factors and outcomes of hypokalemia during the recovery period from anesthesia in the gynecological ***:This retrospective cohort study included 208 patients who underwent gynecological surgery at our institution between January 2021 and March *** were collected for each patient,including demographics,disease status,surgical data,and clinical *** bowel preparation,postoperative gastrointestinal function,and electrolyte levels were compared between the two groups using propensity score matching(PSM).Results:The incidence of hypokalemia(serum potassium level<3.5 mmol/L)during the recovery period from anesthesia was approximately 43.75%.After PSM,oral laxative use(96.4%vs.82.4%,P=0.005),the number of general enemas(P=0.014),and the rate of≥2 general enemas(92.9%vs.77.8%,P=0.004)were identified as risk factors for hypokalemia,which was accompanied by decreased PaCO_(2) and *** were no significant differences in postoperative gastrointestinal outcomes,such as the time to first flatus or feces,the I-FEED score(a scoring system was created to evaluate impaired postoperative gastrointestinal function),or postoperative recovery outcomes,between the hypokalemia group and the normal serum potassium ***:Hypokalemia during postanesthesia recovery period occurred in 43.75%of gynecological patients,which resulted from preoperative mechanical bowel preparation;however,it did not directly affect clinical outcomes,including postoperative gastrointestinal function,postoperative complications,and length of hospital stay.

关键词： hypokalemia gynecological surgery postanesthesia recovery perioperative electrolyte disturbances postoperative recovery

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