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GCH1 variants contribute to the risk and earlier age-at-onset of Parkinson's disease:a two-cohort case-control study

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Translational Neurodegeneration 2020年第3期9卷 409-420页

作者： Hong-xu Pan yu-wen Zhao Jun-pu Mei Zheng-huan Fang Yige wang Xun Zhou Yang-jie Zhou Rui Zhang Kai-lin Zhang Li Jiang Qian Zeng Yan He Zheng wang Zhen-hua Liu Qian Xu Qi-ying Sun Yang Yang Ya-cen Hu Ya-se Chen Juan Du Li-fang Lei Hai-nan Zhang chun-yu wang Xin-xiang Yan Lu Shen Hong Jiang Jie-qiong Tan Jin-chen Li Bei-sha Tang Ji-feng Guo Department of Neurology Xiangya HospitalCentral South UniversityChangsha 410008China National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangsha 410008China Centre for Medical Genetics and Hunan Key Laboratory of Medical Genetics School of Life SciencesCentral South UniversityChangsha 410008China Department of Geriatrics Xiangya HospitalCentral South UniversityChangsha 410008China Department of Neurology The Third Xiangya HospitalCentral South UniversityChangsha 410013China Department of Neurology The Second Xiangya HospitalCentral South UniversityChangsha 410011China Key Laboratory of Hunan Province in Neurodegenerative Disorders Central South UniversityChangsha 410008China

Background:Common and rare variants of guanosine triphosphate cyclohydrolase 1(GCH1)gene may play important roles in Parkinson's disease(PD).However,there is a lack of comprehensive analysis of GCH1 genotypes,especially in non-coding *** aim of this study was to explore the genetic characteristics of GCH1,including rare and common variants in coding and non-coding regions,in a large population of PD patients in Chinese mainland,as well as the phenotypic characteristics of GCH1 variant ***:In the first cohort of this case-control study,we performed whole-exome sequencing in 1555 patients with early-onset or familial PD and 2234 healthy controls;then in the second cohort,whole-genome sequencing was performed in sporadic late-onset PD samples(1962 patients),as well as 1279 *** at target GCH1 regions were extracted,and then genetic and detailed phenotypic data were analyzed using regression models and the sequence kernel association *** also performed a meta-analysis to correlate deleterious GCH1 variants with age at onset(AAO)in PD ***:For coding variants,we identified a significant burden of GCH1 deleterious variants in early-onset or familial PD cases compared to controls(1.2%VS 0.1%,P<0.0001).In the analysis of possible regulatory variants in GCH1 non-coding regions,rs12323905(P=0.001,odds ratio=1.19,95%CI 1.07-1.32)was significantly associated with PD,and variant sets in untranslated regions and intron regions,GCH1 brain-specific expression quantitative trait loci,and two possible promoter/enhancer(GH14J054857 and GH14J054880)were suggestively associated with *** phenotype correlation analysis revealed that the carriers of GCH1 deleterious variants manifested younger AAO(P<0.0001),and had milder motor symptoms,milder fatigue symptoms and more autonomic nervous ***-analysis of six studies demonstrated 6.4-year earlier onset in GCH1 deleterious variant carriers(P=0.0009).Conclusions:The results

关键词： Parkinson's disease Age at onset GCH1 Deleterious variants Non-coding variants

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L1范数约束的非局部均值正则图像去模糊模型

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北京邮电大学学报 2018年第1期41卷 81-87页

作者：冯象初刘鑫杨春雨王卫卫西安电子科技大学数学与统计学院

为了保护图像边缘、细节等信息,建立了l1范数约束的非局部均值正则模型.首先通过实验证明了非局部均值去噪算法余项的概率密度函数具有较强的拖尾性质,符合Laplace分布的特点.基于此,使用l1范数约束的非局部均值去噪算法余项作为新的正... 详细信息

为了保护图像边缘、细节等信息,建立了l1范数约束的非局部均值正则模型.首先通过实验证明了非局部均值去噪算法余项的概率密度函数具有较强的拖尾性质,符合Laplace分布的特点.基于此,使用l1范数约束的非局部均值去噪算法余项作为新的正则项,提出了新的正则模型.然后利用Bregman算子分裂算法求解得到相应的优化算法,并且可将新算法看成Plug-and-Play Priors算法的推广.实验结果表明,新模型在去除模糊,保护图像边缘、细节等信息方面的性能都优于l2范数约束的非局部均值正则模型和Plug-and-Play Priors模型.

关键词：图像去模糊非局部均值算法正则模型 Bregman算子分裂算法

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Unraveling the significance of cobalt on transformation kinetics,crystallography and impact toughness in high-strength steels

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 380-390页

作者： Yishuang yu Jingxiao Zhao Xuelin wang Hui Guo Zhenjia Xie Chengjia Shang Collaborative Innovation Center of Steel Technology University of Science and Technology BeijingBeijing 100083China School of Materials Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China State Key Laboratory for Advanced Metals and Materials University of Science and Technology BeijingBeijing 100083China

This work reveals the significant effects of cobalt(Co)on the microstructure and impact toughness of as-quenched highstrength steels by experimental characterizations and thermo-kinetic *** results show that the Co-bearing steel exhibits finer blocks and a lower ductile-brittle transition temperature than the steel without ***,the Co-bearing steel reveals higher transformation rates at the intermediate stage with bainite volume fraction ranging from around 0.1 to *** improved impact toughness of the Co-bearing steel results from the higher dense block boundaries dominated by the V1/V2 variant ***,the addition of Co induces a larger transformation driving force and a lower bainite start temperature(BS),thereby contributing to the refinement of blocks and the increase of the V1/V2 variant *** findings would be instructive for the composition,microstructure design,and property optimization of high-strength steels.

关键词： high-strength steel cobalt transformation kinetics crystallography impact toughness

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Silk damping in scalar-induced gravitational waves: a novel probe for new physics

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 79-85页

作者： Yan-Heng yu Sai wang Theoretical Physics Division Institute of High Energy Physics Chinese Academy of Sciences School of Physics University of Chinese Academy of Sciences

Silk damping is well known in the study of cosmic microwave background（CMB） and accounts for suppression of the angular power spectrum of CMB on large angular multipoles. In this article, we study the effect of Silk damping on the scalar-induced gravitational waves（SIGWs）. Resulting from the dissipation of cosmic fluid, the Silk damping notably suppresses the energydensity spectrum of SIGWs on scales comparable to a diffusion scale at the decoupling time of weakly-interacting particles. The effect offers a novel observable for probing the underlying particle interaction, especially for those mediated by heavy gauge bosons beyond the standard model of particles. We anticipate that pulsar timing arrays are sensitive to gauge bosons with mass ～10～3-10～4 GeV, while space-and ground-based interferometers to those with mass ～10～7-1012GeV, leading to essential complements to on-going and future experiments of high-energy physics.

关键词： scalar-induced gravitational waves Silk damping new physics

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High-energy-density lithium manganese iron phosphate for lithium-ion batteries: Progresses, challenges, and prospects

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Journal of Energy Chemistry 2025年第1期100卷 1-17页

作者： Bokun Zhang Xiaoyun wang Shuai wang Yan Li Libo Chen Handong Jiao Zhijing yu Jiguo Tu State Key Laboratory of Advanced Metallurgy University of Science and Technology Beijing Research Institute for Intelligent Wearable Systems The Hong Kong Polytechnic University Institute of Advanced Structure Technology Beijing Institute of Technology

The soaring demand for smart portable electronics and electric vehicles is propelling the advancements in high-energy–density lithium-ion *** manganese iron phosphate (LiMnxFe1-xPO4) has garnered significant attention as a promising positive electrode material for lithium-ion batteries due to its advantages of low cost,high safety,long cycle life,high voltage,good high-temperature performance,and high energy *** LiMnxFe1-xPO4has made significant breakthroughs in the past few decades,there are still facing great challenges in poor electronic conductivity and Li-ion diffusion,manganese dissolution affecting battery cycling performance,as well as low tap *** review systematically summarizes the reaction mechanisms,various synthesis methods,and electrochemical properties of LiMnxFe1-xPO4to analyze reaction processes accurately and guide material ***,the main challenges currently faced are concluded,and the corresponding various modification strategies are discussed to enhance the reaction kinetics and electrochemical performance of LiMnxFe1-xPO4,including multi-scale particle regulation,heteroatom doping,surface coating,as well as microscopic morphology ***,in view of the current research challenges faced by intrinsic reaction processes,kinetics,and energy storage applications,the promising research directions are *** importantly,it is expected to provide key insights into the development of high-performance and stable LiMnxFe1-xPO4materials,to achieve practical energy storage requirements.

关键词： Lithium manganese iron phosphate High energy density Lithium-ion batteries Reaction mechanism Tap density

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基于沼肥不同利用情景的秸秆沼气工程能值分析——以河北省青县耿官屯为例

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生态学杂志 2016年第10期35卷 2814-2823页

作者：王红彦王亚静王道龙高春雨王磊孙宁毕于运中国农业科学院农业资源与农业区划研究所北京100081

对沼肥不同处理方式的秸秆沼气集中供气系统进行能值分析,评价其生态经济性和可持续发展能力。以河北省沧州市青县耿官屯秸秆沼气集中供气工程为例,按照沼肥不同利用方式,设定为常规情景(情景1)、现实情景(情景2)和假设情景(情景3),进而... 详细信息

对沼肥不同处理方式的秸秆沼气集中供气系统进行能值分析,评价其生态经济性和可持续发展能力。以河北省沧州市青县耿官屯秸秆沼气集中供气工程为例,按照沼肥不同利用方式,设定为常规情景(情景1)、现实情景(情景2)和假设情景(情景3),进而对3种不同情景的沼气工程能值投入、产出及其能值评价指标进行比较分析。结果表明:情景1、情景2和情景3的能值产出率分别为1.0023、1.0020和1.0029,能值投资率分别为441.45、497.93和341.61,能值可持续发展指数分别为1.08、0.80和0.61;秸秆沼气工程在能源生产、农作物秸秆处理方面均具有一定生态经济效益;随着有机肥生产规模的扩大,工程对购买能值资源的依赖性加强,可持续性下降;系统的经济再生产特性不断加强,向高投入、高产出的方向发展。

关键词：秸秆沼气工程能值分析指标评价沼肥加工

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高粱子粒单宁含量和颜色QTL分析

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植物遗传资源学报 2017年第5期18卷 860-866页

作者：白春明王春语王平朱振兴陆晓春辽宁省农业科学院创新中心沈阳110161

高粱在我国酿酒行业和农业结构调整中均有重要作用。子粒单宁含量和粒色是高粱两个重要的品质性状,但有关高粱子粒单宁和粒色分子遗传的报道还较少。本研究用白粒低单宁的BTx623与浅粉高单宁Rio两个品种为亲本,构建了含325个株系的重组... 详细信息

高粱在我国酿酒行业和农业结构调整中均有重要作用。子粒单宁含量和粒色是高粱两个重要的品质性状,但有关高粱子粒单宁和粒色分子遗传的报道还较少。本研究用白粒低单宁的BTx623与浅粉高单宁Rio两个品种为亲本,构建了含325个株系的重组自交系基因定位群体,开展高粱子粒单宁和粒色基因定位研究。筛选出118个SSR标记和8个INDEL亲本多态性标记用于定位群体株系的基因型检测,结合亲本和定位群体子粒单宁和粒色2年测定数据,采用QTL Ici Mapping 4.1软件中的完备区间作图法,对高粱子粒单宁和粒色2个性状进行QTL定位,共检测到3个与单宁含量相关和6个粒色相关的QTL位点。与单宁含量相关的QTL qTan4-1即为已克隆的Sb04g031730,另外检测到新的qTan1-1(txp11~txp279,贡献率1.29%)和qTan2-1(txp298~SB1292,贡献率1.28%),但2014年未检测到。控制粒色的6个QTL中,qGC1-1(贡献率1.00%和12.03%)在txp11~txp279之间;qGC1-2(贡献率2.64%和16.96%)在txp43~txp11之间;qGC1-3(2014年贡献率22.81%)在1d1A3~sam44127标记之间;qGC2-1(2014年贡献率1.00%)在txp72~txp298之间;qGC2-2(贡献率1.19%和3.66%)在txp298~SB1292之间;qGC6-1(2015年贡献率15.08%)在txp57~sam43683之间。本研究为高粱子粒单宁和粒色2个性状的精细定位、基因克隆和分子标记辅助选择研究奠定了基础。

关键词：高粱粒色单宁 QTL

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热挤压和锻造制备高延性和高吸能超细晶粒Mg-Mn-Ce合金

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Transactions of Nonferrous Metals Society of China 2023年第12期33卷 3661-3672页

作者：张宇修张至柔王春雨康宏辉 Hiromi NAGAUMI 杨续跃中南大学材料科学与工程学院长沙410083 苏州大学沙钢钢铁学院苏州215100

采用挤压和锻造低温变形方法制备高压缩延性和高吸能性超细晶粒Mg-0.9Mn-0.5Ce(质量分数,%)合金。首先将合金在温度为150℃、挤压比为12:1的条件下进行挤压;随后,在200℃下沿挤压方向进行真应变为1.2的锻造处理。采用光学显微镜、扫描... 详细信息

采用挤压和锻造低温变形方法制备高压缩延性和高吸能性超细晶粒Mg-0.9Mn-0.5Ce(质量分数,%)合金。首先将合金在温度为150℃、挤压比为12:1的条件下进行挤压;随后,在200℃下沿挤压方向进行真应变为1.2的锻造处理。采用光学显微镜、扫描电镜、电子背散射衍射和透射电镜对合金的显微组织和塑性机理进行表征。结果表明,经低温挤压后合金组织由超细的动态再结晶晶粒和破碎的未再结晶晶粒组成,其平均晶粒尺寸为1.9μm。在随后的锻造过程中,逐渐产生新的超细晶粒,获得均匀的超细晶粒组织,其平均晶粒尺寸为2.7μm,织构强度也在锻造处理后减弱。均匀的超细晶粒组织和基面滑移使合金表现出较优的综合性能:压缩延性为45.0%,吸能为122.72 MJ/m^(3)。

关键词： Mg-Mn-Ce合金超细晶延性吸能

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Boosting bidirectional sulfur conversion enabled by introducing boron-doped atoms and phosphorus vacancies in Ni2P for lithium-sulfur batteries

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Journal of Energy Chemistry 2025年第1期100卷 760-769页

作者： Lin Peng yu Bai Hang Li Meixiu Qu Zhenhua wang Kening Sun Advanced Research Institute of Multidisciplinary Science Beijing Institute of Technology Beijing Key Laboratory of Chemical Power Source and Green Catalysis School of Chemistry and Chemical Engineering Beijing Institute of Technology

Lithium-sulfur （Li-S） batteries have gained great attention due to the high theoretical energy density and low cost,yet their further commercialization has been obstructed by the notorious shuttle effect and sluggish redox ***,we supply a strategy to optimize the electron structure of Ni2P by concurrently introducing B-doped atoms and P vacancies in Ni2P （Vp-B-Ni2P）,thereby enhancing the bidirectional sulfur *** study indicates that the simultaneous introduction of B-doped atoms and P vacancies in Ni2P causes the redistribution of electron around Ni atoms,bringing about the upward shift of d-band center of Ni atoms and effective d-p orbital hybridization between Ni atoms and sulfur species,thus strengthening the chemical anchoring for lithium polysulfides （LiPSs） as well as expediting the bidirectional conversion kinetics of sulfur ***,theoretical calculations reveal that the incorporation of B-doped atoms and P vacancies in Ni2P selectively promotes Li2S dissolution and nucleation ***,the Li-S batteries with Vp-B-Ni2P-separators present outstanding rate ability of 777 m A h g-1at 5 C and high areal capacity of 8.03 mA h cm-2under E/S of 5μL mg-1and sulfur loading of 7.20 mg *** work elucidates that introducing heteroatom and vacancy in metal phosphide collaboratively regulates the electron structure to accelerate bidirectional sulfur conversion.

关键词： Lithium sulfur batteries

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A novel angiographic technique, StentBoost, in comparison with intravascular ultrasound to assess stent expansion

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Chinese Medical Journal 2011年第6期124卷 939-942页

作者： YANG Fei-fei ZHANG Li-wei HUANG Dang-sheng SHEN Dong SUN Hong-yan ZHANG chun-hong wang yu-mei ZHANG Xu-wen BAI Jing MA Yong-jiang Department of Cardiology First Affiliated Hospital of General Hospital of Chinese People's Liberation Army Beijing 100048China

Background StentBoost （SB） is a novel angiographic technique which can enhance stent visualization and improve detection of inadequate stent expansion. Studies of SB that compare it with intravascular ultrasound （IVUS）, which is the current gold standard for detection of stent underexpansion, remain inadequate. This study aimed to test the correlation of IVUS and SB, and to evaluate the effect of SB guiding the stent *** From March 2009 to June 2010, 52 patients were analyzed using quantitative coronary angiography （QCA）,IVUS, and SB. They included 37 patients （54 stents） with postdilatation and 15 patients （21 stents） without *** of stent diameter between the three modalities were *** The minimum diameter, maximum diameter and average diameter of postdilatation obtained by QCA, IVUS,SB were significantly larger than that of poststenting, and the ratio （maximum stent diameter （MaxLD）-minimum stent diameter （MinLD））/MaxLD of postdilatation was smaller. Correlations of MinLD were the highest between IVUS and SB （r=0.979, P 〈0.0001） when compared with QCA and SB （r=0.973, P 〈0.0001）, and QCA and IVUS （r=0.964, P 〈0.0001）.Conclusions SB has superior correlations for stent expansion measured by IVUS when compared with QCA. In addition, there is an important advantage for SB in guiding the stent postdilatation.

关键词： angiography coronary disease imaging stents postdilatation

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