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Assembly of highly efficient aqueous light-harvesting system from sequence-defined peptoids for cytosolic microRNA detection

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Nano Research 2024年第2期17卷 788-796页

作者： yang song Xiaoli Cai Mingming Wang Dan Du Yuehe Lin chun-Long Chen Department of Mechanical and Materials Engineering Washington State UniversityPullmanWA 99164USA Division of Physical Sciences Pacific Northwest National LaboratoryRichlandWA 99352USA Department of Chemical Engineering University of WashingtonSeattleWA 98195USA

Precisely controlled spatial distributions of artificial light-harvesting systems in aqueous media are of significant importance for mimicking natural light-harvesting systems;however,they are often restrained by the solubility and the aggregation-caused quenching effect of the hydrophobic chromophores.Herein,we report one highly efficient artificial light-harvesting system based on peptoid nanotubes that mimic the hierarchical cylindrical structure of natural systems.The high crystallinity of these nanotubes enabled the organization of arrays of donor chromophores with precisely controlled spatial distributions,favoring an efficient Förster resonance energy transfer(FRET)process in aqueous media.This FRET system exhibits an extremely high efficiency of 98.6%with a fluorescence quantum yield of 40%and an antenna effect of 29.9.We further demonstrated the use of this artificial light-harvesting system for quantifying miR-210 within cancer cells.The fluorescence intensity ratio of donor to acceptor is linearly related to the concentration of intercellular miR-210 in the range of 3.3–156 copies/cell.Such high sensitivity in intracellular detection of miR-210 using this artificial light-harvesting system offers a great opportunity and pathways for biological imaging and detection,and for the further creation of microRNA(miRNA)toolbox for quantitative epigenetics and personalized medicine.

关键词： light-harvesting peptoid nanotube Förster resonance energy transfer intracellular RNA detection

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Artificial neural network-based method for discriminating Compton scattering events in high-purity germaniumγ-ray spectrometer

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Nuclear Science and Techniques 2024年第2期35卷 64-84页

作者： chun-Di Fan Guo-Qiang Zeng Hao-Wen Deng Lei Yan Jian yang Chuan-Hao Hu song Qing yang Hou College of Nuclear Technology and Automation Engineering Chengdu University of TechnologyChengdu 610059China

To detect radioactive substances with low activity levels,an anticoincidence detector and a high-purity germanium(HPGe)detector are typically used simultaneously to suppress Compton scattering background,thereby resulting in an extremely low detection limit and improving the measurement accuracy.However,the complex and expensive hardware required does not facilitate the application or promotion of this method.Thus,a method is proposed in this study to discriminate the digital waveform of pulse signals output using an HPGe detector,whereby Compton scattering background is suppressed and a low minimum detectable activity(MDA)is achieved without using an expensive and complex anticoincidence detector and device.The electric-field-strength and energy-deposition distributions of the detector are simulated to determine the relationship between pulse shape and energy-deposition location,as well as the characteristics of energy-deposition distributions for fulland partial-energy deposition events.This relationship is used to develop a pulse-shape-discrimination algorithm based on an artificial neural network for pulse-feature identification.To accurately determine the relationship between the deposited energy of gamma(γ)rays in the detector and the deposition location,we extract four shape parameters from the pulse signals output by the detector.Machine learning is used to input the four shape parameters into the detector.Subsequently,the pulse signals are identified and classified to discriminate between partial-and full-energy deposition events.Some partial-energy deposition events are removed to suppress Compton scattering.The proposed method effectively decreases the MDA of an HPGeγ-energy dispersive spectrometer.Test results show that the Compton suppression factors for energy spectra obtained from measurements on ^(152)Eu,^(137)Cs,and ^(60)Co radioactive sources are 1.13(344 keV),1.11(662 keV),and 1.08(1332 keV),respectively,and that the corresponding MDAs are 1.4%,5.3%,and 21.6%lower,respectively.

关键词： High-purity germaniumγ-ray spectrometer Pulse-shape discrimination Compton scattering Artificial neural network Minimum detectable activity

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Unique polysulfide reaction on VO2 for restraining shuttle effect in soft-packaged Li-S pouch cells

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Rare Metals 2024年第6期43卷 2842-2850页

作者： Ruo-Xuan yang Qing-chun Zhang Jing-Sheng Cai Xuan Cao Qin yang Ying-Ze song Wei Zhang State Key Laboratory of Environment-Friendly Energy Materials Tianfu Institute of Research and InnovationSchool of Materials and ChemistrySouthwest University of Science and Technology School of Materials Engineering Changshu Institute of Technology Chongqing Institute of Green and Intelligent Technology Chinese Academy of Sciences

The shuttle phenomenon and retarded conversion kinetics of lithium poly sulfides （LiPSs） are relatively severe in lithium-sulfur （Li-S） pouch cells.Owing to their redox potential in the sulfur working window,VO2na... 详细信息

关键词： Vanadium dioxide

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Effect of post rolling stress on phase transformation behavior of microalloyed dual phase steel

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Journal of Iron and Steel Research(International) 2024年第3期31卷 688-699页

作者： Wen-quan Sun Sheng-yi Yong Tie-heng Yuan Ting-song yang An-rui He Chao Liu Rui-chun Guo National Engineering Research Center for Advanced Rolling and Intelligent Manufacturing University of Science and Technology BeijingBeijing 100083China

The slow phase transformation of microalloyed dual phase steel makes the nonuniform stress and temperature fields during the post rolling cooling process have a significant impact on the phase transformation process.Given the relatively slow phase transformation of DP780 steel within the microalloyed dual phase steel series,the influence of stress on the phase transformation behavior of DP780 steel was investigated.To quantify the nonuniform thermal and stress conditions in the steel coil,a thermo-mechanical coupled finite element model of the hot-rolled strip cooling process was established.Based on the simulation data,DP780 steel was chosen as the research material,and Gleeble 3500 thermal simulation equipment was used for experimental validation.The thermal expansion curves were analyzed through regression to establish the dynamic model of DP780 steel phase transformation under stress.Subsequently,metallographic analysis was conducted to determine phase transformation type and grain size of DP780 steel.The results confirmed that the stress promotes the occurrence of semi-diffusion-type bainite transformation.Furthermore,an appropriate level of stress facilitates the growth of bainitic grains,while the increased stress inhibits the growth of ferritic grains.

关键词： Microalloyed dual phase steel Stress Bainitic transformation Grain Finite element method

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Triple the steady-state reaction rate by decorating the In2O3 surface with SiOx for CO2 hydrogenation

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Journal of Energy Chemistry 2024年第8期95卷 96-105页

作者： Hao Wang chun yang Xiaoyan Yu Mingrui Wang Runze yang Xiaowa Nie Ben Hang Yin Alex C.K.Yip chunshan song Guanghui Zhang Xinwen Guo State Key Laboratory of Fine Chemicals Frontier Science Center for Smart Materials PSU-DUT Joint Center for Energy Research School of Chemical Engineering Dalian University of Technology Paihau-Robinson Research Institute the Mac Diarmid Institute for Advanced Materials and Nanotechnology Victoria University of Wellington Department of Chemical and Process Engineering The University of Canterbury Department of Chemistry the Chinese University of Hong Kong

Indium oxide（In2O3）,as a promising candidate for CO2hydrogenation to C1products,often suffers from sintering and activity decline,closely related to the undesirable structural evolution under reaction conditions.Based on the comprehension of the dynamic evolution,this study presents an efficient strategy to alleviate the agglomeration of In2O3nanoparticles by the surface decoration with highly dispersed silica species（SiOx）.Various structural characterizations combined with density functional theory calculations demonstrated that the sintering resulted from the over-reduction,while the enhanced stability originated from the anchoring effect of highly stable In-OSi bonds,which hinders the substantial formation of metallic In（In0） and the subsequent agglomeration.0.6Si/In2O3exhibited CO2conversion rate of10.0 mmol g-1h-1at steady state vs.3.5 mmol g-1h-1on In2O3in CO2hydrogenation.Enhanced steady-state activity was also achieved on Pd-modified catalysts.Compared to the traditional Pd/In2O3catalyst,the methanol production rate of Pd catalyst supported on 0.6Si/In2O3was enhanced by 23%,showing the potential of In2O3modified by SiOxin serving as a platform material.This work provides a promising method to design new In2O3-based catalysts with improved activity and stability in CO2hydrogenation.

关键词： CO2 hydrogenation DFT simulations Dynamic structural evolution In2O3 sintering Surface SiOx modification

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Reactive oxygen species:Multidimensional regulators of plant adaptation to abiotic stress and development

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Journal of Integrative Plant Biology 2024年第3期66卷 330-367页

作者： Pengtao Wang Wen-Cheng Liu Chao Han Situ Wang Ming-Yi Bai chun-Peng song State Key Laboratory of Crop Stress Adaptation and Improvement School of Life SciencesHenan UniversityKaifeng 475004China The Key Laboratory of Plant Development and Environmental Adaptation Biology Ministry of EducationSchool of Life SciencesShandong UniversityQingdao 266237China Faculty of Science McGill UniversityMontreal H3B1X8Canada

Reactive oxygen species(ROS)are produced as undesirable by-products of metabolism in various cellular compartments,especially in response to unfavorable environmental conditions,throughout the life cycle of plants.Stressinduced ROS production disrupts normal cellular function and leads to oxidative damage.To cope with excessive ROS,plants are equipped with a sophisticated antioxidative defense system consisting of enzymatic and non-enzymatic components that scavenge ROS or inhibit their harmful effects on biomolecules.Nonetheless,when maintained at relatively low levels,ROS act as signaling molecules that regulate plant growth,development,and adaptation to adverse conditions.Here,we provide an overview of current approaches for detecting ROS.We also discuss recent advances in understanding ROS signaling,ROS metabolism,and the roles of ROS in plant growth and responses to various abiotic stresses.

关键词： abiotic stress growth and development plant reactive oxygen species

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A newly proposed heatstroke-induced coagulopathy score in patients with heat illness: A multicenter retrospective study in China

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Chinese Journal of Traumatology 2024年第2期27卷 83-90页

作者： Qing-Wei Lin Lin-Cui Zhong Long-Ping He Qing-Bo Zeng Wei Zhang Qing song Jing-chun song Department of Critical Care Medicine The 908th Hospital of Chinese PLA Logistic Support ForcesNanchang360104Jiangsu ProvinceChina Department of Emergency Medicine The 900th Hospital of Chinese PLA Logistic Support ForcesFuzhou350000China Department of Critical Care Medicine Hainan Hospital of Chinese PLA General HospitalSanya572013Hainan ProvinceChina

Purpose:In patients with heatstroke, disseminated intravascular coagulation (DIC) is associated with greater risk of in-hospital mortality. However, time-consuming assays or a complex diagnostic system may delay immediate treatment. Therefore, the present study proposes a new heatstroke-induced coagulopathy (HIC) score in patients with heat illness as an early warning indicator for DIC.Methods:This retrospective study enrolled patients with heat illness in 24 Chinese hospitals from March 2021 to May 2022. Patients under 18 years old, with a congenital clotting disorder or liver disease, or using anticoagulants were excluded. Data were collected on demographic characteristics, routine blood tests, conventional coagulation assays and biochemical indexes. The risk factors related to coagulation function in heatstroke were identified by regression analysis, and used to construct a scoring system for HIC. The data of patients who met the diagnostic criteria for HIC and International Society on Thrombosis and Haemostasis defined-DIC were analyzed. All statistical analyses were performed using SPSS 26.0.Results:The final analysis included 302 patients with heat illness, of whom 131 (43.4%) suffered from heatstroke, including 7 death (5.3%). Core temperature (OR = 1.681, 95% CI 1.291 - 2.189, p < 0.001), prothrombin time (OR = 1.427, 95% CI 1.175 - 1.733, p < 0.001) and D-dimer (OR = 1.242, 95% CI 1.049 - 1.471, p = 0.012) were independent risk factors for heatstroke, and therefore used to construct an HIC scoring system because of their close relation with abnormal coagulation. A total score ≥ 3 indicated HIC, and HIC scores correlated with the score for International Society of Thrombosis and Hemostasis-DIC (r = 0.8848, p < 0.001). The incidence of HIC (27.5%) was higher than that of DIC (11.2%) in all of 131 heatstroke patients. Meanwhile, the mortality rate of HIC (19.4%) was lower than that of DIC (46.7%). When HIC developed into DIC, parameters of coagulation dysfunction changed significantly: platelet count decrea

关键词： Heat illness Heatstroke Coagulation disorders Diagnosis Disseminated intravascular coagulation

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A method to interpret fracture aperture of rock slope using adaptive shape and unmanned aerial vehicle multi-angle nap-of-the-object photogrammetry

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第3期16卷 924-941页

作者： Mingyu Zhao Shengyuan song Fengyan Wang chun Zhu Dianze Liu Sicong Wang College of Construction Engineering Jilin UniversityChangchun130026China College of Geo-Exploration Science and Technology Jilin UniversityChangchun130026China Institute of Engineering Geology and Geohazards Hohai UniversityNanjing210098China

The aperture of natural rock fractures significantly affects the deformation and strength properties of rock masses,as well as the hydrodynamic properties of fractured rock masses.The conventional measurement methods are inadequate for collecting data on high-steep rock slopes in complex mountainous regions.This study establishes a high-resolution three-dimensional model of a rock slope using unmanned aerial vehicle(UAV)multi-angle nap-of-the-object photogrammetry to obtain edge feature points of fractures.Fracture opening morphology is characterized using coordinate projection and transformation.Fracture central axis is determined using vertical measuring lines,allowing for the interpretation of aperture of adaptive fracture shape.The feasibility and reliability of the new method are verified at a construction site of a railway in southeast Tibet,China.The study shows that the fracture aperture has a significant interval effect and size effect.The optimal sampling length for fractures is approximately 0.5e1 m,and the optimal aperture interpretation results can be achieved when the measuring line spacing is 1%of the sampling length.Tensile fractures in the study area generally have larger apertures than shear fractures,and their tendency to increase with slope height is also greater than that of shear fractures.The aperture of tensile fractures is generally positively correlated with their trace length,while the correlation between the aperture of shear fractures and their trace length appears to be weak.Fractures of different orientations exhibit certain differences in their distribution of aperture,but generally follow the forms of normal,log-normal,and gamma distributions.This study provides essential data support for rock and slope stability evaluation,which is of significant practical importance.

关键词： Unmanned aerial vehicle(UAV) photogrammetry High-steep rock slope Fracture aperture Interval effect Size effect Parameter interpretation

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Gene signatures to therapeutics:Assessing the potential of ivermectin against t(4;14)multiple myeloma

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World Journal of Clinical Oncology 2024年第1期15卷 115-129页

作者： yang song Hao-Jun Zhang Xia song Jie Geng Hong-Yi Li Li-Zhong Zhang Bo yang Xue-chun Lu School of Basic Medicine Medical School of Chinese PLABeijing 100853China School of Basic Medicine Shanxi Medical UniversityTaiyuan 030001Shanxi ProvinceChina Department of Hematology The Second Medical CentreChinese PLA General HospitalBeijing 100853China

BACKGROUND Multiple myeloma(MM)is a terminal differentiated B-cell tumor disease characterized by clonal proliferation of malignant plasma cells and excessive levels of monoclonal immunoglobulins in the bone marrow.The translocation,(t)(4;14),results in high-risk MM with limited treatment alternatives.Thus,there is an urgent need for identification and validation of potential treatments for this MM subtype.Microarray data and sequencing information from public databases could offer opportunities for the discovery of new diagnostic or therapeutic targets.AIM To elucidate the molecular basis and search for potential effective drugs of t(4;14)MM subtype by employing a comprehensive approach.METHODS The transcriptional signature of t(4;14)MM was sourced from the Gene Expression Omnibus.Two datasets,GSE16558 and GSE116294,which included 17 and 15 t(4;14)MM bone marrow samples,and five and four normal bone marrow samples,respectively.After the differentially expressed genes were identified,the Cytohubba tool was used to screen for hub genes.Then,the hub genes were analyzed using Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analysis.Using the STRING database and Cytoscape,protein–protein interaction networks and core targets were identified.Potential small-molecule drugs were identified and validated using the Connectivity Map database and molecular docking analysis,respectively.RESULTS In this study,a total of 258 differentially expressed genes with enriched functions in cancer pathways,namely cytokine receptor interactions,nuclear factor(NF)-κB signaling pathway,lipid metabolism,atherosclerosis,and Hippo signaling pathway,were identified.Ten hub genes(cd45,vcam1,ccl3,cd56,app,cd48,btk,ccr2,cybb,and cxcl12)were identified.Nine drugs,including ivermectin,deforolimus,and isoliquiritigenin,were predicted by the Connectivity Map database to have potential therapeutic effects on t(4;14)MM.In molecular docking,ivermectin showed strong binding affinity to all 10 identified targets,especially cd45 and cybb.Ivermec

关键词： Multiple myeloma Functional enrichment analysis Molecular docking simulation Gene expression profiling Therapeutic target Ivermectin

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Effect of Jianpi Shengxue Tablet on Iron Metabolism and Nutritional Status in Patients with Renal Anemia:A Prospective,Randomized,Open,Parallel Controlled and Multicenter Clinical Study

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Current Medical Science 2024年第3期44卷 603-610页

作者： Juan yang Meng-yuan LIANG Yu LI Hao ZHANG Wei LI Jing LV Li-ping DONG Jing-song JIN Cheng yang Qing-hong ZHANG Li LONG Rong ZOU Yi GAO Dan song chun-qin PAN Ying YAO Xiao-lin ZHAN Xiao-hui WANG Department of Nephrology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Department of Nephrology The First People’s Hospital of GuiyangGuiyang550000China Department of Nephrology The Third Xiangya HospitalCentral South UniversityChangsha410000China Department of Nephrology The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an710061China Department of Nephrology Wuhan No. 4 HospitalWuhan430033China Department of Nephrology Hubei Provincial Hospital of Traditional Chinese MedicineWuhan430060China Department of Nephrology Central Theater General Hospital of PLAWuhan430064China Department of Nephrology Taihe HospitalShiyan442000China Department of Nephrology Third People’s Hospital of Hubei ProvinceWuhan430033China Department of Nephrology Hubei Province Integrated Traditional Chinese and Western Medicine Hospital of Hubei provinceWuhan430024China Department of Nephrology Xi’an No.3 HospitalAffiliated Hospital of Northwest UniversityXi’an710000China Department of Nephrology Shenzhen Guangming District People’s HospitalShenzhen518000China Department of Nephrology Xiantao First People’s HospitalXiantao433000China Department of Nutrition Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Department of Nephrology Huangshi Central HospitalHuangshi435000China Department of Nephrology The Fifth Hospital of WuhanWuhan430050China

Objective This study aimed to analyze the clinical efficacy of the Jianpi Shengxue tablet for treating renal anemia.Methods A total of 200 patients with renal anemia from December 2020 to December 2022 were enrolled and randomly divided into two groups.Patients in the control group were treated with polysaccharide-iron complex,and those in the experimental group were administered Jianpi Shengxue tablet.After 8 weeks of continuous treatment,the therapeutic outcomes regarding anemia were compared between the two groups.Results After treatment,the red blood cell(RBC)count,hematocrit(HCT),reticulocyte percentage(RET),ferritin(SF),serum iron(SI),transferrin saturation(TSAT),and serum albumin(ALB)all increased(P<0.01),and the clinical symptom score and total iron binding capacity decreased(P<0.01)in the experimental group.Moreover,the improvements in RBC,HCT,RET,SF,SI,TAST,ALB,and clinical symptoms(fatigue,anorexia,dull skin complexion,numbness of hands and feet)in the experimental group were significantly greater than those in the control group(P<0.05).The total effective rate for treating renal anemia was significantly higher in the experimental group than in the control group(P<0.01).Conclusion The Jianpi Shengxue tablet demonstrates efficacy in treating renal anemia,leading to significant improvements in the laboratory examination results and clinical symptoms of patients with renal anemia.

关键词： Jianpi Shengxue tablet renal anemia randomized open parallel control multicenter clinical study

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