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Journal of Microbiology and Immunology 2006年第2期4卷 100-109页

作者： chun yan he QING LIANG LIU Microbiology and Immunology Laboratory Shanghai Institute of Biological Products Shanghai P. R. China

CpG oligodeoxynucleotides （CpG ODN） as adjuvant have been extensively studied in recent years. Phosphodiester CpG ODN （PO CpG ODN） can perfectly mimic bacterial DNA in enhancing immune response but are vulnerable to nucleases in vivo. This study aimed to evaluate the immunostimulatory potential arid safety of phosphodiester CpG ODN encapsulated in nonphospholipid liposomes. BALB/c mice were immunized intramuscularly with different formulations of liposomes, CpG ODN and hepatitis B surface antigen （HBsAg）. The results demonstrated that the encapsulated PO CpG ODN were protected against rapid degradation in vivo and retained their adjuvant activity. PO CpG ODN encapsulated with HBsAg in liposomes induced strong Th1-biased or Th1/Th2 mixed humoral immune response in mice with the magnitude similar to their phosphothioate equivalent in the same formulation. High IFN-gamma production induced by this formulation confirmed the generation of strong cellular immune response. Additionally, co-delivery of HBsAg arid PO CpG ODN improved the immune response over that obtained with separate delivery. Safety experiment showed that liposome-encapsulaed PO CpG ODN and HBsAg caused mild systemic and moderate local adverse reaction. In conclusion, our data shows that PO CpG ODN encapsulated in liposomes fully exhibit their Th1-type adjuvant activity arid act as a potential adjuvant for vaccines.

关键词： CpG oligodeoxynucleotide Phosphodiester hepatitis B surface antigen Liposome

Expression of Annexin-1 in patients with endometriosis

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Chinese Medical Journal 2008年第10期121卷 927-931页

作者： LI chun-yan LANG Jing-he LIU Hai-yuan ZHOU Hui-mei Department of Obstetrics and Gynecology Peking Union Medical College Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Beijing 100730 China

Background Annexin-1 was identified as an endometriosis-related protein by comparative proteomics in previous study. As an endogeneous anti-inflammatory mediator, Annexin-1 has been shown to regulate the immune response, cell proliferation and apoptosis. To investigate whether Annexin-1 is involved in the pathogenesis of endometriosis, we examined the expression of Annexin-1 in eutopic endometrium of women with or without endometriosis, and detected its expression in peritoneal fluids of those with endometriosis. Methods Eutopic endometrium samples from twenty-five women with endometriosis and those from sixteen age-matched women without endometriosis were collected. Peritoneal fluids were obtained from ten patients with endometriosis. The expression of Annexin-1 protein in eutopic endometrium was detected by immunohistochemistry and Western blotting, and mRNA detected by real-time PCR. Annexin-1 protein in the peritoneal fluids was detected by Western blotting.Results Annexin-1 mRNA and protein were overexpressed in eutopic endometrium of endometriosis without significant differences between the proliferative and secretory phase. Immunohistochemistry showed that Annexin-1 protein was expressed mainly in endometrial glandular celts throughout the menstrual cycle. Annexin-1 protein was detected in the peritoneal fluids of all the ten patients with endometriosis. Conclusions Annexin-1 is overexpressed in eutopic endometrium and presents in the peritoneal fluids of patients with endometriosis, and may play a role in the pathogenesis of endometriosis.

关键词： Annexin-1 endometriosis endometrium ascitic fluid

Clinical efficacy of the modified helicobacter pylori eradication therapy for helicobacter pylori-negative gastric mucosa-associated lymphoid tissue lymphoma:a meta analysis

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Chinese Medical Journal 2020年第11期133卷 1337-1346页

作者： Ya-Lin Xie chun-yan he Si-Qi Wei Wen-Ju Guan Zheng Jiang departm ent of Gastroenterology The First Affiliated Hospital of Chongqing Medical UniversityChongqing Medical UniversityChongqing 400016China Department of Oncology The First Affiliated Hospital of Chongqing Medical UniversityChongqing Medical UniversityChongqing 400016China

Background::helicobacter pylori(HP)has been considered to be one of the primary causes of gastric mucosa-associated lymphoid tissue(MALT)lymphoma since ***-grade gastric MALT lymphoma with HP is widely treated with HP eradication therapy,according to each specific clinical ***,several studies and guidelines indicate that the modified HP eradication therapy is also valid for HP-negative gastric MALT *** aim of this study was to perform a meta-analysis of the clinical efficacy of the modified HP eradication therapy for gastric MALT lymphoma without ***::We searched studies that reported the response rate of the modified HP eradication therapy regimen for gastric MALT lymphoma without HP by using PubMed,Medline,and Ebsco from January 1971 until February *** statistical analyses were carried out using R 3.5.3(Mathsoft Company,Cambridge,MA,USA).The pooled response rate was expressed as a *** heterogeneity test was performed using the I-squared(I2)***::A total of 14 studies were selected with a total of 148 patients with HP-negative gastric MALT *** overall pooled response rate was 0.38(95%confidence interval[CI]:0.29-0.47).The combined estimate is I2=57%(Phe study subjects were categorized by factors(area of patients).The pooled response rate of the sub-groups(Korea,Japan,China,and Western countries)was 0.63(95%CI:0.50-0.76),0.16(95%CI:0.05-0.30),0.38(95%CI:0.20-0.55),and 0.57(95%CI:0.08-1.00).The response rate showed that the modified HP eradication therapy was effective for patients with HP-negative gastric MALT lymphoma,especially in Korea and Western ***::Therefore,the modified HP eradication therapy can be considered an optional therapy for patients with low-grade HP-negative gastric MALT ***,several limitations were revealed in the *** systematic reviews and research are required.

关键词： Therapy helicobacter pylori Gastric MALT lymphoma Meta-analysis

Association between physiological responses after exercise at low altitude and acute mountain sickness upon ascent is sex-dependent

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Military Medical Research 2021年第2期8卷 174-182页

作者： yang Shen Yuan-Qi yang Chuan Liu Jie yang Ji-Hang Zhang Jun Jin Hu Tan Fang-Zheng-Yuan Yuan Jing-Bin Ke chun-yan he Lai-Ping Zhang Chen Zhang Jie Yu Lan Huang Institute of Cardiovascular Diseases of PLA the Second Affiliated HospitalArmy Medical UniversityChongqing 400037China Department of Cardiology the Second Affiliated HospitalArmy Medical UniversityChongqing 400037China

Background:Acute mountain sickness(AMS)is the mildest form of acute altitude illnesses,and consists of nonspecific symptoms when unacclimatized persons ascend to elevation of≥2500 *** factors of AMS include:the altitude,individual susceptibility,ascending rate and degree of *** the current study,we examined whether physiological response at low altitude could predict the development of ***:A total of 111 healthy adult healthy volunteers participated in this trial;and 99(67 men and 32 women)completed the entire study *** were asked to complete a 9-min exercise program using a mechanically braked bicycle ergometer at low altitude(500 m).heart rate,blood pressure(BP)and pulse oxygen saturation(SpO2)were recorded prior to and during the last minute of *** ascent from 500 m to 4100 m was completed in 2 *** was defined as≥3 points in a 4-item Lake Louise Score,with at least one point from headache wat 6–8 h after the ***:Among the 99 assessable subjects,47(23 men and 24 women)developed AMS at 4100 *** comparison to the subjects without AMS,those who developed AMS had lower proportion of men(48.9%vs.84.6%,Pheight(168.4±5.9 cm vs.171.3±6.1 cm,P=0.019),weight(62.0±10.0 kg vs.66.7±8.6 kg,P=0.014)and proportion of smokers(23.4%vs.51.9%,P=0.004).Multivariate regression analysis revealed the following independent risks for AMS:female sex(odds ratio(OR)=6.32,Phe ascent(OR=0.96,P=0.029).Women had larger reduction in SpO2 after the ascent,higher AMS percentage and absolute AMS *** reduction of SpO2 after exercise was associated with both AMS incidence(P=0.001)and AMS score(P<0.001)in men but not in ***:Larger SpO2 reduction after exercise at low altitude was an independent risk for AMS upon *** an association was more robust in men than in *** registration:Chinese Clinical

关键词： High altitude Exercise testing Sex differences Acute mountain sickness Individual susceptibility

Geology and mineralization of the Sanshandao supergiant gold deposit(1200 t)in the Jiaodong Peninsula,China:A review

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China Geology 2021年第4期4卷 686-719页

作者： Ming-chun Song Zheng-jiang Ding Jun-jin Zhang Ying-xin Song Jun-wei Bo Yu-qun Wang Hong-bo Liu Shi-yong Li Jie Li Rui-xiang Li in Wang Xiang-dong Liu Liang-liang Zhang Lei-lei Dong Jian Li chun-yan he Shandong Provincial No.6 Exploration Institute of Geology and Mineral Resources Weihai 264209China Shandong Provincial Bureau of Geology and Mineral Resources Jinan 250013China Shandong Provincial No.3 Exploration Institute of Geology and Mineral Resources Yantai 264003China Shandong Institute of Geological Sciences Jinan 250013China Shandong Provincial Ruihai Mining Limited Company Laizhou 261400China Shandong Institute of Geophysical&Geochemical Exploration Jinan 250013China hebei Key Laboratory of Strategic Critical Mineral Resources Hebei GEO UniversityShijiazhuang 050031China School of Civil and Resource Engineering University of Science and Technology BeijingBeijing 100083China School of Resources and Environmental Engineering Shandong University of TechnologyZibo 255000China

The Jiaodong Peninsula in Shandong Province,China is the world’s third-largest gold metallogenic area,with cumulative proven gold resources exceeding 5000 *** the past few years,breakthroughs have been made in deep prospecting at a depth of 500‒2000 m,particularly in the Sanshandao area where a huge deep gold orebody was *** on previous studies and the latest prospecting progress achieved by the project team of this study,the following results are summarized.(1)3D geological modeling results based on deep drilling core data reveal that the Sanshandao gold orefield,which was previously considered to consist of several independent deposits,is a supergiant deposit with gold resources of more than 1200 t(including 470 t under the sea area).The length of the major orebody is nearly 8 km,with a greatest depth of 2312 m below sea level and a maximum length of more than 3 km along their dip direction.(2)Thick gold orebodies in the Sanshandao gold deposit mainly occur in the specific sections of the ore-controlling fault where the fault plane changes from steeply to gently inclined,forming a stepped metallogenic model from shallow to deep *** reason for this strong structural control on mineralization forms is that when ore-forming fluids migrated along faults,the pressure of fluids greatly fluctuated in fault sections where the fault dip angle *** the solubility of gold in the ore-forming fluid is sensitive to fluid pressure,these sections along the fault plane serve as the target areas for deep prospecting.(3)Thermal uplifting-extensional structures provide thermodynamic conditions,migration pathways,and deposition spaces for gold ***,the changes in mantle properties induced the transformation of the geochemical properties of the lower crust and magmatic *** further led to the reactivation of ore-forming elements,which provided rich materials for gold mineralization.(4)It can be concluded from previous research re

关键词： Gold deposit Deep prospecting Thermal uplifting-extension mineralization Transformation of mantle properties Stepped metallogenic model Mineral exploration engineering Jiaodong-type gold deposits Sanshandao Jiaodong Peninsula China

Transcriptional profiling of the native LDL-stimulated THP-1 reveals the relationship of LDL oxidation and the prevention and diagnosis of atherosclerosis

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Transcriptional profiling of the native LDL-stimulated THP-1...

Deciphering Water Oxidation Catalysts:The Dominant Role of Surface Chemistry over Reconstruction Degree in Activity Promotion

脂质组学与脂蛋白的新功能——第十二届全国脂质与脂蛋白学术会议

作者： Jian Song Jing-wei Wang Xiao-yan Gao Bing-bing Xu chun-yan he Jun-Zhu Wu Department of Biochemistry and Molecular biology College of Basic MedicineWuhan University

Background:Pathogenesis of atherosclerosis is a mystery wrapped in controversy,the earliest stages of the development of atherosclerosis are mediated,in large part,by the inflammatory cascade was generally *** compensatory mechanism between monocytes and neutrophils in CHD patients is associated with LDL oxidation and is expected to become an early diagnostic marker of *** investigated the Transcriptional

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Nano-Micro Letters 2025年第3期17卷 340-354页

作者： Li An Jianyi Li Yuanmiao Sun Jiamin Zhu Justin Zhu Yeow Seow Hong Zhang Nan Zhang Pinxian Xi * Zhichuan JXu chun‑Hua yan State Key Laboratory of Applied Organic Chemistry Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu ProvinceFrontiers Science Center for Rare IsotopesCollege of Chemistry and Chemical EngineeringLanzhou UniversityLanzhou 730000People’s Republic of China School of Materials Science and Engineering Nanyang Technological UniversitySingapore 639798Singapore Faculty of Materials Science and Energy Engineering Institute of Technology for Carbon NeutralityShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055People’s Republic of China Key Laboratory of Electromagnetic Materials and Devices National Center for International Research On Photoelectric and Energy MaterialsSchool of Materials and EnergyElectron Microscopy CenterYunnan UniversityKunming 650091People’s Republic of China State Key Laboratory of Baiyunobo Rare Earth Resource Researches and Comprehensive Utilization Baotou Research Institute of Rare EarthsBaotou 014030People’s Republic of China Beijing National Laboratory for Molecular Sciences State Key Laboratory of Rare Earth Materials Chemistry and ApplicationsPKU‑HKU Joint Laboratory in Rare Earth Materials and Bioinorganic ChemistryPeking UniversityBeijing 100871People’s Republic of China

Water splitting hinges crucially on the availability of electrocatalysts for the oxygen evolution *** surface reconstruction has been widely observed in perovskite catalysts,and the reconstruction degree has been often correlated with the activity ***,a systematic study on the roles of Fe substitution in activation of perovskite LaNiO_(3)is *** substituting Fe content influences both current change tendency and surface reconstruction ***_(0.9)Fe_(0.1)O_(3)is found exhibiting a volcano-peak intrinsic activity in both pristine and reconstructed among all substituted perovskites in the LaNi_(1-x)Fe_(x)O_(3)(x=0.00,0.10,0.25,0.50,0.75,1.00)*** reconstructed LaNi_(0.9)Fe_(0.1)O_(3)shows a higher intrinsic activity than most reported NiFe-based ***,density functional theory calculations reveal that Fe substitution can lower the O 2p level,which thus stabilize lattice oxygen in LaNi0.9Fe0.1O3 and ensure its long-term ***,it is vital interesting that activity of the reconstructed catalysts relied more on the surface chemistry rather than the reconstruction *** effect of Fe on the degree of surface reconstruction of the perovskite is decoupled from that on its activity enhancement after surface *** finding showcases the importance to customize the surface chemistry of reconstructed catalysts for water oxidation.

关键词： Oxygen evolution reaction Perovskite oxides Doping Activation and reconstruction

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可拓营销理论研究

数学的实践与认识 2001年第6期31卷 696-701页

作者：杨春燕何斌蔡文广东工业大学可拓工程研究所广州510080

利用物元理论、事元理论和可拓集合理论 ,对需要、产品、市场、资源、企业等进行可拓分析 ,提出可拓营销的基本理论——产品开拓规律、可拓市场、可拓资源。

关键词：可拓营销可拓集合市场物元理论产品开拓

沉积含Si过渡层对于不锈钢上沉积的DLC薄膜的性能影响

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导航与控制 2014年第4期13卷 56-61页

作者：崔砚柳文涛闫春和北京航天控制仪器研究所

本文介绍了采用RF-PECVD法在3Cr13不锈钢基体圆片上沉积制备类金刚石多层膜,其內层薄膜为掺Si的过渡层,外层为不同厚度的在50nm;000 nm之间的类金刚石薄膜（DLC）。实验结果表明沉积过渡层可以有效提高薄膜与基体的结合力。类金刚石薄... 详细信息

本文介绍了采用RF-PECVD法在3Cr13不锈钢基体圆片上沉积制备类金刚石多层膜,其內层薄膜为掺Si的过渡层,外层为不同厚度的在50nm;000 nm之间的类金刚石薄膜（DLC）。实验结果表明沉积过渡层可以有效提高薄膜与基体的结合力。类金刚石薄膜的摩擦系数和薄膜在摩擦过程中的损坏情况都与外层薄膜的厚度有关。

关键词： DLC薄膜 RF-PECVD 含Si过渡层

益气散聚方治疗代谢综合征肥胖高危人群的临床研究

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中西医结合学报 2007年第3期5卷 263-267页

作者：何春燕王文健李玢许得盛陈伟华应健何燕铭复旦大学中西医结合研究所上海200040 上海市奉贤区奉城人民医院内科上海201411

目的:观察益气散聚方在“聚证”学说指导下治疗代谢综合征肥胖高危人群的临床疗效。方法:以30名健康志愿者为参照,将45名中心性肥胖患者随机分为中药组和安慰剂组,分别予益气散聚方和安慰剂治疗10周,观察治疗前后一般状况、胰岛素抵抗... 详细信息

目的:观察益气散聚方在“聚证”学说指导下治疗代谢综合征肥胖高危人群的临床疗效。方法:以30名健康志愿者为参照,将45名中心性肥胖患者随机分为中药组和安慰剂组,分别予益气散聚方和安慰剂治疗10周,观察治疗前后一般状况、胰岛素抵抗、相关炎症因子及纤溶系统因子变化。结果:与对照组相比,肥胖人群胰岛素抵抗指数、C反应蛋白、游离脂肪酸、纤溶酶原激活物抑制物1均有升高,组织纤溶酶原激活物下降;治疗后,中药组体质量指数、腰围、腰臀比及胰岛素抵抗指数、C反应蛋白、游离脂肪酸、纤溶酶原激活物抑制物1均明显改善,与安慰剂组相比,差异有统计学意义。结论:益气散聚方可明显降低代谢综合征肥胖高危人群肥胖和胰岛素抵抗程度,并能改善炎症状态、纤溶系统功能,减轻致动脉粥样硬化的危险性。

关键词：代谢综合征肥胖胰岛素中医药