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Early apoptotic changes in human spermatozoa and their relationships with conventional semen parameters and sperm DNA fragmentation

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Asian Journal of Andrology 2008年第2期10卷 227-235页

作者： Hao-Bo Zhang Shao-Ming Lu chun-yan ma Li Wang Xiao Li Zi-Jiang Chen Center for Reproductive Medicine Affiliated to Shandong University Jinan 250021 China Central Labotrary of Provincial Hospital Affiliated to Shandong University Jinan 250021 China

Aim： To investigate whether early apoptotic changes in spermatozoa can be significant markers for sperm quality. Methods： Two early apoptotic changes in the semen of 56 men were assessed using Annexin V （AN）/propidium iodide （PI） staining for phosphatidylserine externalization and JC-1 staining for mitochondrial membrane potential （MMP）. The results were compared with conventional semen parameters and DNA fragmentation identified using the TUNEL assay. Results： The different labeling patterns in the bivariate Annexin V/PI analysis identified four distinctive spermatozoa populations. The percentage of AN^-/PI^- spermatozoa positively correlated with conventional semen parameters and MMP, but negatively correlated with TUNEL （＋） spermatozoa. As for the AN^-/PI^＋ fraction, we found an opposite result in comparison to AN^-/PI^- spermatozoa. The level of early apoptotic AN^＋/PI^- spermatozoa negatively correlated with MMP and sperm motility. The level of late apoptotic AN^＋/PI^＋ spermatozoa negatively correlated with conventional semen parameters and MMP, and positively correlated with TUNEL （＋） spermatozoa. MMP positively correlated with conventional semen parameters, but negatively correlated with TUNEL （＋） spermatozoa. Conclusion： Although early apoptotic AN^＋/PI^- spermatozoa only negatively correlates with sperm motility, the differences in proportion of each subpopulation of spermatozoa （especially, the percentage of AN^-/PI^- spermatozoa）, and decreased MMP might be significant markers for diagnosing male infertility. They possibly bring additional information to predict the outcome of in vitro fertilization. （Asian J Androl 2008 mar; 10： 227-235）

关键词： Annexin V apoptosis DNA fragmentation infertility mitochondria sperm

Cytosolic calcium oscillations in submandibular gland cells

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Acta Pharmacologica Sinica 2006年第7期27卷 843-847页

作者： Li SU chun-yan ma yan-dong ZHOU yan-hong JIA Zong-jie CUI~2 Institute of Cell Biology,Beijing Normal University,Beijing 100875,China Institute of Cell Biology Beijing Normal University Beijing China

Calcium oscillations can,by default,encode diverse and specific signals by differ-ent modes of *** modulation is illustrated by the activation ofcalcium/calmodulin-dependent protein kinase Ⅱ at unit Hz,and of calcineurin at 10mHz frequencies,*** submandibular gland secretory axis is charac-terized by both potassium and osmolarity gradients from the luminal side of thesecretory *** gradients may play significant physiological roles throughthe feedback modulation of cholinergic *** potassium transformsplateau calcium increases induced by cholinergic stimulation of the submandibu-lar acinar cells into oscillatory calcium *** ductal cells may have simi-lar mechanisms of feedback modulation both by high potassium and by *** feedback mechanisms could modulate the decision-making pro-cess for determining which secretory products are selectively released after nervestimulation.

关键词： submandibular gland secretory axis calcium oscillation

Morphology engineering of ZnO micro/nanostructures under mild conditions for optoelectronic application

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International Journal of Minerals,Metallurgy and materials 2025年第2期32卷 498-503页

作者： Liang Chu Haoyu Shen Hudie Wei Hongyu Chen Guoqiang ma Wensheng yan Institute of Carbon Neutrality and New Energy&School of Electronics and Information Hangzhou Dianzi UniversityHangzhou 310018China School of Applied Physics and materials Wuyi UniversityJiangmen 529020China

Zinc oxide(ZnO)serves as a crucial functional semiconductor with a wide direct bandgap of approximately 3.37 *** reaction is commonly used in the synthesis of ZnO micro/nanostructures,given its low cost,simplicity,and easy ***,ZnO morphology engineering has become desirable through the alteration of minor conditions in the reaction process,particularly at room *** this work,ZnO micro/nanostructures were synthesized in a solution by varying the amounts of the ammonia added at low temperatures(including room temperature).The formation of Zn^(2+)complexes by ammonia in the precursor regulated the reaction rate of the morphology engineering of ZnO,which resulted in various structures,such as nanoparticles,nanosheets,microflowers,and single ***,the obtained ZnO was used in the optoelectronic application of ultraviolet detectors.

关键词： morphology engineering low temperature ZnO nanosheets microflowers ultraviolet detector

IOL master 700与Pentacam测量不同年龄段白内障患者角膜生物参数的分析

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国际眼科杂志 2021年第10期21卷 1792-1797页

作者：马山马艳春刘秀花姜雅琴潍坊眼科医院中国山东省潍坊市261000 中国山东省高密市人民医院眼科 261500

目的:分析比较IOL master 700与Pentacam在不同年龄段白内障患者角膜生物参数的差异性、相关性及一致性。方法:横断面研究。收集2020-02/09就诊于潍坊眼科医院的白内障患者87例162眼,其中男44例80眼,女43例82眼,平均年龄61.2±9.87岁,... 详细信息

目的:分析比较IOL master 700与Pentacam在不同年龄段白内障患者角膜生物参数的差异性、相关性及一致性。方法:横断面研究。收集2020-02/09就诊于潍坊眼科医院的白内障患者87例162眼,其中男44例80眼,女43例82眼,平均年龄61.2±9.87岁,将患者按年龄分为四组,A组(40~50岁)17例32眼,B组(51~60岁)25例47眼,C组(61~70岁)28例53眼,D组(71~80岁)17例30眼,分别用IOL master 700和Pentacam测量各组白内障患者术前角膜生物参数,记录为平坦轴角膜曲率(K1)、陡峭轴角膜曲率(K2)、平均角膜曲率(Km)、角膜散光度数、前房深度(ACD)、中央角膜厚度(CCT)。分析两种生物测量仪器间在不同年龄组测量结果的差异性、相关性及一致性。结果:两种仪器测量C组患者角膜散光度数及D组患者K1、角膜散光度数之间有差异(t=2.746、-2.582、2.637,均Pman分析结果显示IOL master 700与Pentacam测量四组患者K1、K2、Km、角膜散光度数、ACD、CCT的一致性较好。结论:IOL master 700与Pentacam在测量40~60岁白内障患者的角膜生物参数方面无明显差异,在61~70岁患者时散光度数有差异,在71~80岁患者时散光度数、K1值有差异,测量结果显示两种仪器有良好的相关性。总体来说,两种检查设备的一致性较好,角膜散光度数及角膜曲率要综合分析数据进行选择。

关键词： Pentacam IOL master 700 眼前节参数白内障年龄

Commend-slave cell coupling for cytosolic calcium oscillations

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Commend-slave cell coupling for cytosolic calcium oscillatio...

Novel findings in relation to multiple anti-atherosclerotic effects of XueZhiKang in humans

第九届全国钙信号和细胞功能研讨会

作者： Zong Jie Cui,Peng Fei Wang,Xiao Cui Zhao,chun yan ma Institute of Cell Biology,Beijing Normal University,Beijing 100875,China

＜正＞Certain cell types have intrinsic machinery for the induction of cytosolic calcium *** surface receptor once activated by stimulation of appropriate strength induces cytosolic calcium *** cell types typically include the epithelial cells both of the secretory and non-secretory *** for other cell types such intrinsic machinery for cytosolic calcium oscillations are not readily present in the eell *** this mean that these cells do not oscillate in vivo?Our recent works have

关键词： epithelial cells calcium oscillations commend-slave couplets

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Chronic Diseases and Translational Medicine 2018年第2期4卷 117-126页

作者： Rui-Xia Xu yan Zhang Yuan-Lin Guo chun-yan ma Yu-Hong Yao Sha Li Xiao-Lin Li Ping Qing Ying Gao Na-Qiong Wu Cheng-Gang Zhu Geng Liu Qian Dong Jing Sun Jian-Jun Li Division of Dyslipidemia State Key Laboratory of Cardiovascular Disease Fu Wai Hospital National Center for Cardiovascular Disease Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100037 China

Background: Previous studies have clearly demonstrated that XueZhiKang (XZK), an extract of cholestin, can decrease low-density lipoprotein cholesterol (LDL-C) and cardiovascular events. However, the mechanism of the effects of XZK on athero-sclerosis (AS) in humans has been reported less frequently. In the present study, we investigated the impact of XZK on lipoprotein subfractions, oxidized LDL (oxLDL), and interleukin-6 (IL-6). Methods: From October 2015 to July 2016, 40 subjects were enrolled in this study. Of them, 20 subjects with dyslipidemia received XZK 1200 mg/day for 8 weeks (XZK group); 20 additional healthy subjects who did not receive therapy acted as controls. The plasma lipoprotein subfractions, oxLDL, and IL-6 were examined at baseline and again at 8 weeks. Results: Data showed that XZK could significantly decrease not only plasma LDL-C levels (87.26 ± 24.45 vs. 123.34 ± 23.99, Pmall LDL-C (1.78 ± 2.17 vs. 6.33 ± 7.78, Pmall LDL subfraction (1.09 ± 1.12 vs. 3.07 ± 3.09, Pmall LDL subfraction and reduced oxidative stress and inflammatory markers, in addition to affecting the lipid profile, suggesting multiple beneficial effects in coronary artery disease.

关键词： XueZhiKang Hyperlipidemia Low-density lipoprotein cholesterol subfraction Oxidized LDL Interleukin-6

The Citron homology domain of maP4Ks improves outcomes of traumatic brain injury

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Neural Regeneration Research 2025年第11期20卷 3233-3244页

作者： Xiaoling Zhong Wenjiao Tai Meng-Lu Liu Shuaipeng ma Tianjin Shen Yuhua Zou chun-Li Zhang Department of Molecular Biology University of Texas Southwestern Medical CenterDallasTXUSA Hamon Center for Regenerative Science and Medicine University of Texas Southwestern Medical CenterDallasTXUSA Peter O’Donnell Jr.Brain Institute University of Texas Southwestern Medical CenterDallasTXUSA

The mitogen-activated protein kinase kinase kinase kinases(maP4Ks)signaling pathway plays a pivotal role in axonal regrowth and neuronal degeneration following *** targeting this pathway is beneficial to brain injury remains *** this study,we showed that adeno-associated virus-delivery of the Citron homology domain of maP4Ks effectively reduces traumatic brain injury-induced reactive gliosis,tauopathy,lesion size,and behavioral *** inhibition of maP4Ks replicated the ameliorative effects observed with expression of the Citron homology ***,the Citron homology domain acted as a dominant-negative mutant,impeding maP4K-mediated phosphorylation of the dishevelled proteins and thereby controlling the Wnt/β-catenin *** findings implicate a therapeutic potential of targeting maP4Ks to alleviate the detrimental effects of traumatic brain injury.

关键词： adeno-associated virus Citron homology Citron homology domain gene therapy mitogen-activated protein kinase kinase kinase kinases traumatic brain injury

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阻尼层厚度对复合材料夹芯板自由振动的影响

机械设计与制造 2017年第7期 78-81页

作者：翟彦春马军苏建民梁森潍坊科技学院机械工程学院山东寿光262700 青岛理工大学机械工程学院山东青岛266520

由于夹芯层的高阻尼结构,复合材料夹芯板结构具有较好的减振降噪的作用,因此在高端科技中得到大量的应用。基于经典板理论推导了复合材料夹芯板的振动平衡方程,首先通过实例验证了所推导的平衡方程的正确性,其次分两种情况研究了阻尼层... 详细信息

由于夹芯层的高阻尼结构,复合材料夹芯板结构具有较好的减振降噪的作用,因此在高端科技中得到大量的应用。基于经典板理论推导了复合材料夹芯板的振动平衡方程,首先通过实例验证了所推导的平衡方程的正确性,其次分两种情况研究了阻尼层厚度对复合材料夹芯板的自由振动的影响,结果表明:弹性层不变和总厚度不变两种情况下,随着阻尼层厚度的增大,前四阶固有频率逐渐降低,损耗因子值逐渐增大,并且后一种情况下更易获得较大的损耗因子值。

关键词：经典板理论阻尼层复合材料板自由振动

Integration of Electrical Properties and Polarization Loss Modulation on Atomic Fe–N‑RGO for Boosting Electromagnetic Wave Absorption

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Nano-Micro Letters 2025年第2期17卷 517-532页

作者： Kaili Zhang Yuefeng yan Zhen Wang Guansheng ma Dechang Jia Xiaoxiao Huang Yu Zhou State Key Laboratory of Precision Welding&Joining of materials and Structures Harbin Institute of TechnologyHarbin 150001People’s Republic of China School of materials Science and Engineering Harbin Institute of TechnologyHarbin 150001People’s Republic of China MIIT Key Laboratory of Advanced Structural‑Functional Integration materials&Green manufacturing Technology Harbin Institute of TechnologyHarbin 150001People’s Republic of China

Developing effective strategies to regulate graphene’s conduction loss and polarization has become a key to expanding its application in the electromagnetic wave absorption(EMWA)*** on the unique energy band structure of graphene,regulating its bandgap and electrical properties by introducing heteroatoms is considered a feasible ***,metal-nitrogen doping reduced graphene oxide(M–N-RGO)was prepared by embedding a series of single metal atoms M–N_(4) sites(M=Mn,Fe,Co,Ni,Cu,Zn,Nb,Cd,and Sn)in RGO using an N-coordination atom-assisted *** composites had adjustable conductivity and polarization to optimize dielectric loss and impedance matching for efficient EMWA *** results showed that the minimum reflection loss(RL_(min))of Fe–N-RGO reaches−74.05 dB(2.0 mm)and the maximum effective absorption bandwidth(EAB_(max))is 7.05 GHz(1.89 mm)even with a low filler loading of only 1 wt%.Combined with X-ray absorption spectra(XAFS),atomic force microscopy,and density functional theory calculation analysis,the Fe–N_(4) can be used as the polarization center to increase dipole polarization,interface polarization and defect-induced polarization due to d-p orbital hybridization and structural ***,electron migration within the Fe further leads to conduction loss,thereby synergistically promoting energy *** study demonstrates the effectiveness of metal-nitrogen doping in regulating the graphene′s dielectric properties,which provides an important basis for further investigation of the loss mechanism.

关键词： Electromagnetic wave absorption Fe-N-RGO Dipole polarization Conduction loss Impedance matching