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Effect of palmitoylethanolamide on degeneration of a human-derived retinal pigment epithelial cell induced by all-trans retinal

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International Journal of Ophthalmology(English edition) 2023年第2期16卷 191-200页

作者： Yun Han Kun-Huan yang Dan-Xue He Chao-Feng Yu Lei Tao chun-yan liao Bin-Xiang Cai Zu-Guo Liu yan Qiu Ya-Lin Wu Eye Institute of Xiamen University Fujian Provincial Key Laboratory of Ophthalmology and Visual ScienceEngineering and Research Center of Eye Regenerative MedicineSchool of MedicineXiamen UniversityXiamen 361102Fujian ProvinceChina Department of Ophthalmology Xiang’an Hospital of Xiamen UniversityXiamen 361102Fujian ProvinceChina Xiamen University Affiliated Xiamen Eye Center Xiamen 361102Fujian ProvinceChina Shenzhen Research Institute of Xiamen University Shenzhen 518000Guangdong ProvinceChina

AIM:To study the effect of palmitoylethanolamide(PEA)on apoptosis of retinal pigment epithelial(RPE)cells induced by all-trans retinal(at RAL)and to explore the possible molecular ***:Cell Titer 96■Aqueous One Solution Cell Proliferation Assay(MTS)was used to detect the effect of PEA on human-derived retinal epithelial cells(ARPE-19)viability induced by at RAL.A Leica DMi8 inverted microscope was used to observe cell *** oxygen species(ROS)production was evaluated with 2’,7’-dichlorodihydrofluorescein diacetate(H2DCFDA)staining and fluorescence *** of c-Jun N-terminal kinase(JNK),phosphorylated JNK(p-JNK),c-Jun,phosphorylated c-Jun(p-c-Jun),Bak,cleaved caspase-3,C/EBP homologous protein(CHOP),and binding(Bip)protein levels were tested by Western ***4-/-Rdh8-/-mice,mouse models of at RAL clearance defects which displays some symbolic characteristics of dry age-related macular degeneration(AMD)and Stargardt disease(STGD1).In the animal models,PEA was injected *** full-field electroretinogram was used to detect visual function under scotopic conditions traced from *** coherence tomography showed reconstitution or thickening of the retinal pigment epithelium *** of PEA on fundus injury induced by light in Abca4-/-Rdh8-/-mice was observed by fundus ***:PEA ameliorated ARPE-19 cells apoptosis and inhibited ROS(including mitochondrial ROS)production induced by at *** improved the retinal functional,prohibited both RPE and photoreceptor from death,ameliorates light-induced fundus impairment in Abca4-/-Rdh8-/-*** vitro and in vivo,PEA inhibited JNK,p-JNK,c-Jun,p-c-Jun,Bak,cleaved caspase-3,CHOP,and Bip protein levels induced by all-trans retinal in ARPE-19 ***:PEA has effect on treating RPE cells apoptosis in retinopathy caused by at RAL *** is a potential treatment strategy for dry AMD and *** molecular mechanism is affecting the

关键词： palmitoethanolamide ARPE-19 fundus all-trans retinal apoptosis

Th17/Treg细胞比例、诱导型一氧化氮合酶基因多态性与慢性阻塞性肺疾病患者脏腑虚损的相关性研究

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中国现代医学杂志 2022年第7期32卷 65-70页

作者：廖春燕徐丹王娜娜新疆维吾尔自治区中医医院呼吸与危重症医学科新疆乌鲁木齐830099 新疆维吾尔自治区中医医院中医临床研究基地新疆乌鲁木齐830099

目的探讨辅助性T细胞17/调节性T细胞(Th17/Treg)细胞比例、诱导型一氧化氮合酶(iNOS)基因多态性与慢性阻塞性肺疾病(COPD)患者脏腑虚损状况的相关性。方法选取2017年1月—2020年1月新疆维吾尔自治区中医医院收治的130例COPD稳定期患者,... 详细信息

目的探讨辅助性T细胞17/调节性T细胞(Th17/Treg)细胞比例、诱导型一氧化氮合酶(iNOS)基因多态性与慢性阻塞性肺疾病(COPD)患者脏腑虚损状况的相关性。方法选取2017年1月—2020年1月新疆维吾尔自治区中医医院收治的130例COPD稳定期患者,根据患者疾病所属中医证型分为肺脾气虚组67例和肺肾气虚组63例,另选取同期该院健康体检者60例作为对照组。比较3组的肺功能,血清Th17、Treg及Th17/Treg细胞比例,iNOS基因型频率和等位基因频率。采用Pearson相关分析法分析Th17/Treg细胞比例与COPD脏腑虚损状况的相关性,多因素Logistic回归分析COPD脏腑虚损状况的影响因素。结果肺脾气虚组和肺肾气虚组患者的用力肺活量(FVC)、第1秒用力呼气容积(FEV_(1))低于对照组(P<0.05),肺脾气虚组患者FVC、FEV_(1)大于肺肾气虚组(P<0.05)。肺脾气虚组和肺肾气虚组患者的Th17、Th17/Treg高于对照组(P<0.05),Treg低于对照组(P<0.05);肺脾气虚组患者Th17、Th17/Treg水平低于肺肾气虚组(P<0.05),Treg水平高于肺肾气虚组(P<0.05)。Pearson相关分析结果显示,Th17/Treg与FVC、FEV_(1)、第1秒用力呼气容积占用力肺活量比值(FEV_(1)%)呈负相关(r=-0.407、-0.438和-0.504,均P<0.05),与肺脾气虚、肺肾气虚呈正相关(r=0.321和0.565,均P<0.05)。肺脾气虚组和肺肾气虚组患者GG基因型频率低于对照组(P<0.05),TT基因型频率高于对照组(P<0.05),T等位基因频率高于对照组(P<0.05);肺脾气虚组GG基因型频率高于肺肾气虚组(P<0.05),TT基因型频率低于肺肾气虚组(P<0.05),T等位基因频率低于肺肾气虚组(P<0.05)。Logistic回归分析结果显示,iNOS基因多态性中TT基因型[O^R=2.417(1.336,4.691),P<0.05]是影响COPD脏腑虚损的独立危险因素。结论Th17/Treg细胞比例与COPD患者脏腑虚损有明显相关性,且随着患者脏腑虚损进展,呈正相关,TT基因型是影响COPD脏腑虚损的独立危险因素。

关键词：慢性阻塞性肺疾病辅助性T细胞17/调节性T细胞诱导型一氧化氮合酶基因多态性脏腑虚损

Human-induced pluripotent stem cell-derived neural stem cell exosomes improve blood-brain barrier function after intracerebral hemorrhage by activating astrocytes via PI3K/AKT/MCP-1 axis

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Neural Regeneration Research 2025年第2期20卷 518-532页

作者： Conglin Wang Fangyuan Cheng Zhaoli Han Bo yan Pan liao Zhenyu Yin Xintong Ge Dai Li Rongrong Zhong Qiang Liu Fanglian Chen Ping Lei Department of Geriatrics Tianjin Medical University General HospitalTianjinChina School of Medicine Nankai UniversityTianjinChina Tianjin Neurological Institute TianjinChina

Cerebral edema caused by blood-brain barrier injury after intracerebral hemorrhage is an important factor leading to poor ***-induced pluripotent stem cell-derived neural stem cell exosomes(hiPSC-NSC-Exos)have shown potential for brain injury repair in central nervous system *** this study,we explored the impact of hiPSC-NSC-Exos on blood-brain barrier preservation and the underlying *** results indicated that intranasal delivery of hiPSC-NSC-Exos mitigated neurological deficits,enhanced blood-brain barrier integrity,and reduced leukocyte infiltration in a mouse model of intracerebral ***,hiPSC-NSC-Exos decreased immune cell infiltration,activated astrocytes,and decreased the secretion of inflammatory cytokines like monocyte chemoattractant protein-1,macrophage inflammatory protein-1α,and tumor necrosis factor-αpost-intracerebral hemorrhage,thereby improving the inflammatory *** sequencing indicated that hiPSC-NSC-Exo activated the PI3K/AKT signaling pathway in astrocytes and decreased monocyte chemoattractant protein-1 secretion,thereby improving blood-brain barrier *** with the PI3K/AKT inhibitor LY294002 or the monocyte chemoattractant protein-1 neutralizing agent C1142 abolished these *** summary,our findings suggest that hiPSC-NSC-Exos maintains blood-brain barrier integrity,in part by downregulating monocyte chemoattractant protein-1 secretion through activation of the PI3K/AKT signaling pathway in astrocytes.

关键词： AKT astrocyte blood-brain barrier cerebral edema exosomes human-induced pluripotent stem cells intracerebral hemorrhage neural stem cells neuroinflammation PI3K

Advances in ethnopharmacology,phytochemistry and pharmacology of Erigerontis Herba and its Chinese medicine prescriptions

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Traditional Medicine Research 2025年第1期10卷 44-61页

作者： yang Zhou Yuan-yan Huang Ding-Yue Shang Ying Chen Meng Tian Cheng-Yu Jin Xin Lu Bing-chun yan Han-Qing Pang Institute of Translational Medicine School of MedicineYangzhou UniversityYangzhou 225009China Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile Diseases Yangzhou UniversityYangzhou 225009China School of Medicine Nanjing University of Chinese MedicineNanjing 210023China State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources Guangxi Normal UniversityGuiling 541004China.

Erigerontis Herba(EH),the dried whole plant of Erigeron breviscapus,is well-known for circulating blood,activating meridians to alleviate pain,expelling wind,and clearing away *** has been extensively utilized in southern China for the treatment of stroke hemiplegia,chest stuffiness and pains,rheumatic arthralgia,headache,and *** review focuses on the botany,ethnopharmacology,phytochemistry,pharmacology and toxicity of EH and its related prescriptions to offer new insights for prospective research of *** information about EH was retrieved from ancient records and books,PubMed,China National Knowledge Infrastructure,Chinese Pharmacopoeia,Web of Science,Doctoral and Master’s Theses,and various electronic *** is a member of Compositae family and is mainly grown in southern *** Chinese medicine records that EH has the effects of circulating blood and removing blood stasis,expelling wind,and removing cold,as well as relieving rigidity of muscle and relieving *** now,nearly 200 ingredients have been characterized from EH,including flavonoids,caffeoyls,aromatic acids,coumarins,pentacyclic terpenoids,volatile oil and other *** extracts,EH related prescriptions(Dengzhan Xixin injection,Dengzhan Shengmai capsules,etc.)or compounds(scutellarin,scutellarein,etc.)possessed obvious therapeutic effects of ischemic stroke,cerebral hemorrhage,myocardial infarction,Alzheimer’s disease,diabetes and its complications,gastric cancer,bone,and joint degenerative ***,the major active compound of EH,has been used as a quality *** no obvious toxicity of EH has been *** to its traditional applications,ethnopharmacology,phytochemistry,pharmacology,and toxicity,EH was applied as a valuable herb for clinical application in food and medicine *** several compounds have been shown to possess diverse biological activities,the underlying mechanisms of their actions remain *** fully exploi

关键词： Erigeron breviscapus traditional applications ethnopharmacology phytochemistry pharmacology

A Hybrid Method of Domain Lexicon Construction for Opinion Targets Extraction Using Syntax and Semantics

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Journal of Computer Science & Technology 2016年第3期31卷 595-603页

作者： chun liao Chong Feng Sen yang He-yan Huang Department of Computer Science and Technology Beijing Institute of Technology Beijing 100081 China Beijing Engineering Research Center of High Volume Language Information Processing and Cloud Computing Applications Beijing Institute of Technology Beijing 100081 China

Opinion targets extraction of Chinese microblogs plays an important role in opinion mining. There has been a significant progress in this area recently, especially the method based on conditional random field （CRF）. However, this method only takes lexicon-related features into consideration and does not excavate the implied syntactic and semantic knowledge. We propose a novel approach which incorporates domain lexicon with groups of syntactical and semantic features. The approach acquires domain lexicon through a novel way which explores syntactic and semantic information through Part- of-Speech, dependency structure, phrase structure, semantic role and semantic similarity based on word embedding. And then we combine the domain lexicon with opinion targets extracted from CRF with groups of features for opinion targets extraction. Experimental results on COAE2014 dataset show the outperformance of the approach compared with other well-known methods on the task of opinion targets extraction.

关键词： domain lexicon opinion targets extraction syntactic structure semantic role word embedding

Atmospheric and Oceanic Excitations to LOD Change on Quasi-biennial Tune Scales

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Chinese Journal of Astronomy and Astrophysics 2006年第6期6卷 759-768页

作者： Li-Hua Ma De-chun liao yan-Ben Han National Astronomical Observatories Chinese Academy of Sciences Beijing 100012 Shanghai Astronomical Observatory Chinese Academy of Sciences Shanghai 200030

We use wavelet transform to study the time series of the Earth＇s rotation rate （length-of-day, LOD）, the axial components of atmospheric angular momentum （AAM） and oceanic angular momentum （OAM） in the period 1962-2005, and discuss the quasi-biennial oscillations （QBO） of LOD change. The results show that the QBO of LOD change varies remarkably in amplitude and phase. It was weak before 1978, then became much stronger and reached maximum values during the strong El Nino events in around 1983 and 1997. Results from analyzing the axial AAM indicate that the QBO signals in axial AAM are extremely consistent with the QBOs of LOD change. During 1963-2003, the QBO variance in the axial AAM can explain about 99.0% of that of the LOD, in other words, all QBO signals of LOD change are almost excited by the axial AAM, while the weak QBO signals of the axial OAM are quite different from those of the LOD and the axial AAM in both time-dependent characteristics and magnitudes. The combined effects of the axial AAM and OAM can explain about 99.1% of the variance of QBO in LOD change during this period.

关键词： Earth's variable rotation - atmospheric angular momentum - oceanic angular momentum

Minimum Amount of Extracting Solvent of (A_(1)A_(2)…A_(t−1))/(A_(2)A_(3)…A_(t)) Separation When Using Non-barren Extracting Solvent

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Chinese Journal of Chemistry 2014年第10期32卷 1022-1028页

作者： Fu-Xiang Cheng Sheng Wu Song-Ling Wang Bo Zhang yan Liu chun-Sheng liao chun-Hua yan Beijing National Laboratory for Molecular Sciences State Key Laboratory of Rare Earth Materials Chemistry and ApplicationsPKU-HKU Joint Lab on Rare Earth Materials and Bioinorganic ChemistryPeking UniversityBeijing 100871China China Minmetals(Beijing)Research Institute of RE Co. LtdBeijing 100085China

Hyperlink extraction technology,by virtue of its remarkable advantage of decreasing the use of chemicals in multi-component separation,has been extensively employed in rare earth separation industry in *** hyperlink processes,non-barren extracting solvent and scrubbing agent solution which contain the component(s)involved in starting feed are employed in order to save both alkali for saponification and acid for *** amount of extracting solvent(denoted as S_(min))and that of scrubbing agent solution(denoted as W_(min))are important parameters to determine the consumption amounts of alkali and acid for a given countercurrent extraction *** article therefore discusses the influence of using non-barren extracting solvent and scrubbing agent solution on S_(min) and W_(min) of an(A_(1)A_(2)…A_(t−1))/(A_(2)A_(3)…A_(t))*** equations for S_(min) and W_(min) are derived,and the variation of the composition of final raffinate as well as that of final extract are determined,which will provide a valuable guidance for the design of hyperlink extraction processes of multi-component separation,such as rare earths separation.

关键词： minimum amount of extracting solvent rare earths hyperlink process multi-component separation

豆浆中风味物质形成、与蛋白的互作机制及生物法改善豆浆风味的研究进展

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食品科学 2025年第2期46卷 280-289页

作者：高宇齐宝坤廖一闫世长李杨黄雨洋东北农业大学食品学院黑龙江哈尔滨150030 哈尔滨商业大学食品工程学院黑龙江哈尔滨150028

豆浆作为一种营养丰富的植物基蛋白饮品,在全球范围内受到消费者的喜爱。然而,其特有的不良风味往往影响消费者的接受度,限制了豆浆产品的市场推广。本文探讨豆浆中风味物质的形成机理、这些风味物质与豆浆中的蛋白质之间的相互作用机... 详细信息

豆浆作为一种营养丰富的植物基蛋白饮品,在全球范围内受到消费者的喜爱。然而,其特有的不良风味往往影响消费者的接受度,限制了豆浆产品的市场推广。本文探讨豆浆中风味物质的形成机理、这些风味物质与豆浆中的蛋白质之间的相互作用机制以及通过生物方法改善豆浆风味的研究进展。通过无脂氧合酶大豆品种的开发、酶处理和微生物发酵等生物方法,可以有效地改善豆浆的风味,同时保持其营养价值。最后对未来改善豆浆风味的研究方向做出展望,以期为豆浆及其制品的品质提升和市场推广提供理论依据,为推动我国大豆制品市场的发展做出贡献。

关键词：豆浆风味物质-蛋白质互作生物方法风味改良

Molecular ferroelectrics for efficient perovskite solar cells

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Science China Chemistry 2021年第2期64卷 169-170页

作者： chun-Hua yan Beijing National Laboratory for Molecular Sciences State Key Laboratory of Rare Earth Materials Chemistry and ApplicationsPKU-HKU Joint Laboratory in Rare Earth Materials and Bioinorganic ChemistryCollege of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871China College of Chemistry and Chemical Engineering Lanzhou UniversityLanzhou 730000China

During the past decade,the power conversion efficiencies(PCEs)of organic-inorganic hybrid perovskite solar cells(PSCs)have exceeded 25%[1],which is expected to be one of the candidates for the next generation of thin-film photovoltaic *** speaking,the performance of PSCs mainly depends on the light absorption capacity,defect passivation and photo-induced exciton separation and extraction of perovskite *** the light illumination,photo-induced excitons were separated and extracted by the built-in electric field of PSCs.

关键词： perovskite illumination inorganic