检索结果-南通市图书馆

Construction of an anchoring SSR marker genetic linkage map and detection of a sex-linked region in two dioecious populations of red bayberry

引用

Horticulture Research 2020年第1期7卷 2262-2270页

作者： yan Wang Hui-Min Jia Yu-Tong Shen Hai-Bo Zhao Qin-Song yang Chang-Qing Zhu De-Li Sun Guo-Yun Wang Chao-Chao Zhou Yun Jiao chun-yan chai Li-Ju yan Xiong-Wei Li Hui-Juan Jia Zhong-Shan Gao Fruit Science Institute College of Agriculture and BiotechnologyZhejiang University310058 HangzhouChina Shanghai Center for Plant Stress Biology CAS Center for Excellence in Molecular Plant SciencesChinese Academy of Sciences201602 ShanghaiChina Yuyao Forestry Technology Extension Center 315400 NingboChina Institute of Forestry Ningbo Academy of Agricultural ScienceNingboChina Cixi Forestry Technology Extension Center 315300 CixiChina Linhai Forestry Technology Extension Center 317000 TaizhouChina Forest&Fruit Tree Institute Shanghai Academy of Agricultural Sciences201403 ShanghaiChina

Red bayberry(Morella rubra)is an evergreen fruit tree found in southern China whose whole-genome sequence has recently been *** updated the linkage map of the species by adding 118 SSR markers and the femalespecific marker MrFT2_*** integrated map included eight linkage groups and spanned 491 *** sexassociated markers were identified,six of which were located in linkage group 8,in agreement with the previously reported location of the sex-determining *** MrFT2_BD-SEX marker was genotyped in 203 cultivated *** the females of the accessions,we found two female-specific alleles,designated W-b(151 bp)and W-d(129 bp).We previously found that‘Dongkui’,a female cultivar,could produce viable pollen(we refer to such plants‘Dongkui-male’)and serve as the paternal parent in *** genotypes of the MrFT2_BD-SEX marker were W-b/Z in‘Biqi’and W-d/Z in‘Dongkui-male’.The progeny of a cross between these parents produced a 3:1 female(W-)to male(ZZ)ratio and the expected 1:1:1:1 ratio of W-b/W-d:W-b/Z:W-d/Z:Z/*** addition,the flowering and fruiting phenotypes of all the F1 progeny fit their *** results confirm the existence of ZW sex determination and show that the female phenotype is controlled by a single dominant locus(W)in a small genomic region(59 kb and less than 3.3 cM).Furthermore,we have produced a homozygous“super female”(WW)that should produce all-female offspring in the F2 generation,providing a foundation for commercial use and presenting great potential for use in modern breeding programs.

关键词： breeding cultivar linkage

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

机械应力调控血管平滑肌细胞的凋亡

引用

中国组织工程研究 2025年第5期29卷 1064-1072页

作者：徐飞闫金强柴守栋北京航空航天大学生物与医学工程学院北京市100083 聊城市人民医院中心实验室山东省聊城市252000 聊城市人民医院病理科山东省聊城市252000 聊城市人民医院心外科山东省聊城市252000

背景:随着生物力学的发展,其在心血管疾病中的研究也日益广泛,通过研究血管的力学特性可以有效地揭示动脉粥样硬化、再狭窄等心血管疾病的发病机制,开发心血管疾病治疗的新思路和新方法。目的:综述机械应力刺激对血管平滑肌细胞凋亡的... 详细信息

背景:随着生物力学的发展,其在心血管疾病中的研究也日益广泛,通过研究血管的力学特性可以有效地揭示动脉粥样硬化、再狭窄等心血管疾病的发病机制,开发心血管疾病治疗的新思路和新方法。目的:综述机械应力刺激对血管平滑肌细胞凋亡的研究现状,寻找临床治疗潜在靶分子和信号通路,以期改善临床动脉粥样硬化及再狭窄等心血管疾病的临床治疗效果。方法:检索1992年1月至2023年5月在中国知网、PubMed及ScienceDirect数据库收录的文献。中文检索词为“血管平滑肌细胞,机械应力,剪切力,牵张力,凋亡”;英文检索词为“vascular smooth muscle cell,mechanical stress,shear stress,stretch stress,apoptosis”,最终纳入63篇文献进行综述分析。结果与结论:①血管平滑肌细胞的生理性和病理性凋亡都是为了适应血管力学变化而发生的适应性重构。不同部位的平滑肌细胞承受不同的力学刺激,其发病机制也不同。②低剪切力、生理剪切力和高剪切力可通过直接与平滑肌细胞表面分子、受体及蛋白等作用调控凋亡信号分子和抑制增殖实现对血管平滑肌细胞凋亡的调控,该部分未对促进增殖的研究进行综述。③低牵张力、生理牵张力和高牵张力可导致平滑肌细胞凋亡,但仍存在争议。平滑肌表面存在多种力学感受分子(如整合素及受体络氨酸激酶等)可以将力学信号转导为细胞内的化学信号(如Hippo通路),启动平滑肌细胞的凋亡信号,调控平滑肌细胞的凋亡。④总之,不同力学刺激通过多种信号分子,启动多个信号通路共同作用,调控平滑肌细胞的凋亡,例如剪切力主要通过刺激分泌前列腺素、转化生长因子等影响Fas/FasL、Akt通路;而牵张力主要通过Yes相关蛋白等调控YAP通路和Notch通路等。这些分子在不同的作用时间,或不同作用强度下可能发挥相反的双向作用,比如,小鼠血管平滑肌细胞受到10%生理牵张1 h时,其增殖增加;然而,人的血管平滑肌细胞牵张12 h后可以减少其增殖。临床可以通过寻找其关键作用时间点干扰力学转导关键分子,达到预防和治疗临床心血管疾病的目的。

关键词：血管平滑肌细胞机械应力凋亡牵张力剪切应力整合素受体络氨酸激酶 G蛋白偶联受体和G蛋白离子通道

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Advances in ethnopharmacology,phytochemistry and pharmacology of Erigerontis Herba and its Chinese medicine prescriptions

引用

Traditional Medicine Research 2025年第1期10卷 44-61页

作者： yang Zhou Yuan-yan Huang Ding-Yue Shang Ying Chen Meng Tian Cheng-Yu Jin Xin Lu Bing-chun yan Han-Qing Pang Institute of Translational Medicine School of MedicineYangzhou UniversityYangzhou 225009China Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile Diseases Yangzhou UniversityYangzhou 225009China School of Medicine Nanjing University of Chinese MedicineNanjing 210023China State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources Guangxi Normal UniversityGuiling 541004China.

Erigerontis Herba(EH),the dried whole plant of Erigeron breviscapus,is well-known for circulating blood,activating meridians to alleviate pain,expelling wind,and clearing away *** has been extensively utilized in southern China for the treatment of stroke hemiplegia,chest stuffiness and pains,rheumatic arthralgia,headache,and *** review focuses on the botany,ethnopharmacology,phytochemistry,pharmacology and toxicity of EH and its related prescriptions to offer new insights for prospective research of *** information about EH was retrieved from ancient records and books,PubMed,China National Knowledge Infrastructure,Chinese Pharmacopoeia,Web of Science,Doctoral and Master’s Theses,and various electronic *** is a member of Compositae family and is mainly grown in southern *** Chinese medicine records that EH has the effects of circulating blood and removing blood stasis,expelling wind,and removing cold,as well as relieving rigidity of muscle and relieving *** now,nearly 200 ingredients have been characterized from EH,including flavonoids,caffeoyls,aromatic acids,coumarins,pentacyclic terpenoids,volatile oil and other *** extracts,EH related prescriptions(Dengzhan Xixin injection,Dengzhan Shengmai capsules,etc.)or compounds(scutellarin,scutellarein,etc.)possessed obvious therapeutic effects of ischemic stroke,cerebral hemorrhage,myocardial infarction,Alzheimer’s disease,diabetes and its complications,gastric cancer,bone,and joint degenerative ***,the major active compound of EH,has been used as a quality *** no obvious toxicity of EH has been *** to its traditional applications,ethnopharmacology,phytochemistry,pharmacology,and toxicity,EH was applied as a valuable herb for clinical application in food and medicine *** several compounds have been shown to possess diverse biological activities,the underlying mechanisms of their actions remain *** fully exploi

关键词： Erigeron breviscapus traditional applications ethnopharmacology phytochemistry pharmacology

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Synthesis and in vitro-Anti-hepatitis B Virus Activities of Several Ethyl 5-Hydroxy-1H-indole-3-carboxylates

引用

Chemical Research in Chinese Universities 2006年第5期22卷 577-583页

作者： ZHAO chun-shen ZHAO yan-fang chai Hui-fang GONG Ping Liaoning Province Key Laboratory of Innovative Medicine Research and Design Shenyang Pharmaceutical University Shenyang 110016 P. R. China

A series of ethyl 5-hydroxyindole-3-earboxylates 6a-10r was designed and synthesized. The structures of all the compounds were confirmed by IR, ^1H NMR, and MS and their anti-hepatitis B virus （HBV） activities were evaluated in 2.2.15 cells. Among them, compound 7g { ethyl 5-hydroxy-2- [ （ 3-methoxyphenylsulfinyl ） methyl ] -1-methyl-4- [ （4-methylpiperazin-1-yl） methyl ]-1H-indole-3-carboxylate} displays a significant anti-HBV activity, which is more potent than the positive control lamivudine.

关键词： Ethyl 5-hydroxy-1H-indole-3-carboxylates Synthesis Anti-hepatitis B virus activity

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Preparation and Characterization of Poly(vinyl alcohol)/ZIF-8 Porous Composites by Ice-templating Method with High ZIF-8 Loading Amount

引用

Chinese Journal of Polymer Science 2020年第6期38卷 638-643页

作者： Xuan-He yang yan-Qing Yao Mu-Hua Huang chun-Peng chai School of Materials Science and Engineering Beijing Institute of TechnologyBeijing 100081China

A bulk Poly(vinyl alcohol)/ZIF-8(PVA/ZIF-8)porous composite with aligned porous structure was prepared by ice-templating *** microstructure of PVA/ZIF-8 porous composites was characterized by scanning electron microscopy(SEM).The results showed that the composites had regular pore structure and ZIF-8 nanoparticles were evenly distributed on the skeleton of PVA.X-ray diffraction(XRD)test results showed that the crystalline structure of ZIF-8 was well preserved in the *** specific surface area of the composite was characterized by nitrogen adsorption/desorption *** specific surface area of the composite was up to 1160 m^2 g^***/ZIF-8 porous composites could also support a certain weight with almost no volume *** carbon dioxide adsorption quantity of the composite was up to 11.3 cm^3 g^1,proving that PVA/ZIF-8 porous composite has a good application prospect in the field of carbon dioxide adsorption.

关键词： Poly(vinyl alcohol) ZIF-8 Ice-templating Porous composite C02 adsorption

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Microstructure and martensitic transformation behavior of Ni_(56-x)Mn_(25)Fe_xGa_(19) shape memory alloys

引用

Rare Metals 2014年第1期33卷 41-46页

作者： yan Xin Liang chai School of Energy Power and Mechanical Engineering North China Electric Power University Beijing Key Laboratory for Advanced Functional Materials and Thin Film Technology

Microstructure, martensitic transformation behavior, mechanical and shape memory properties of ***25FexGa19 （x = 0, 2, 4, 6, 8） shape memory alloys were investigated using optical microscopy （OM）, X-ray diffraction analysis （XRD）, differential scanning calorimeter （DSC）, and compressive test. It is found that these alloys are composed of single non-modulated martensite phase with tetragonal structure at room temperature, which means substituting Fe for Ni in Ni56Mn25Ga19 alloy has no effect on phase structure. These alloys all exhibit a ther- moelastic martensitic transformation between the cubic parent phase and the tetragonal martensite phase. With the increase of Fe content, the martensitic transformation peak temperature （Mp） decreases from 356℃ for x = 0 to 20℃ for x = 8, which is contributed to the depressed electron concentration and tetragonality of martensite. Fe addition remarkably reduces the transformation hysteresis of Ni-Mn-Ga alloys. Substituting Fe for Ni in Ni56Mn25Ga19 alloy can decrease the strength of the alloys and almost has no influence on the ductility and shape memory property.

关键词： Shape memory alloys Microstructure Martensitic transformation Ni-Mn-Fe-Ga

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Towards Data-Driving Multi-View Evaluation Framework for Scratch

引用

Tsinghua Science and Technology 2024年第2期29卷 517-528页

作者： Xiaolin chai yan Sun yan Gao Department of Computer Science Beijing University of Posts and TelecommunicationBeijing 100876China Intellectual Property Institute Shandong Polytechnic CollegeJining 272067China

As one of the most popular visual programming languages,Scratch has a lot of evaluation around *** evaluation can help programmers understand their projects *** the same time,it can also provide a reference for them to browse other projects in the online *** of the existing evaluations on Scratch are carried from three perspectives:Computational Thinking(CT)ability,visual presentation aesthetics,and code *** them,the assessment of CT and code quality is mainly carried out from the program script,while the evaluation of visual aesthetics is analyzed from the perspective of image sequences generated by project *** single-view evaluation focuses on the performance of a program in a certain aspect and is *** this paper,we propose a multi-view evaluation framework to integrate various evaluations using different *** quantitatively analyze the assessment of different views driven by *** with overall evaluations that represent human opinions,we analyze their differences and *** experiments,we determine the weights of different integration policies,the proposed multi-view evaluation method can generate evaluation results similar to human opinions.

关键词： Scratch Computational Thinking(CT) visual aesthetic static analysis integration policy machine learning

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

WATuning:A Workload-Aware Tuning System with Attention-Based Deep Reinforcement Learning

引用

Journal of Computer Science & Technology 2021年第4期36卷 741-761页

作者： Jia-Ke Ge yan-Feng chai Yun-Peng chai Key Laboratory of Data Engineering and Knowledge Engineering of Ministry of Education Renmin University of China Beijing 100872China School of Information Renmin University of ChinaBeijing 100872China College of Computer Science and Technology Taiyuan University of Science and TechnologyTaiyuan 030027China

Configuration tuning is essential to optimize the performance of systems(e.g.,databases,key-value stores).High performance usually indicates high throughput and low *** present,most of the tuning tasks of systems are performed artificially(e.g.,by database administrators),but it is hard for them to achieve high performance through tuning in various types of systems and in various *** recent years,there have been some studies on tuning traditional database systems,but all these methods have some *** this article,we put forward a tuning system based on attention-based deep reinforcement learning named WATuning,which can adapt to the changes of workload characteristics and optimize the system performance efficiently and ***,we design the core algorithm named ATT-Tune for WATuning to achieve the tuning task of *** algorithm uses workload characteristics to generate a weight matrix and acts on the internal metrics of systems,and then ATT-Tune uses the internal metrics with weight values assigned to select the appropriate ***,WATuning can generate multiple instance models according to the change of the workload so that it can complete targeted recommendation services for different types of ***,WATuning can also dynamically fine-tune itself according to the constantly changing workload in practical applications so that it can better fit to the actual environment to make *** experimental results show that the throughput and the latency of WATuning are improved by 52.6%and decreased by 31%,respectively,compared with the throughput and the latency of CDBTune which is an existing optimal tuning method.

关键词： attention mechanism auto-tuning system reinforcement learning(RL) workload-aware

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Screening of immune cell activators from Astragali Radix using a comprehensive two-dimensional NK-92MI cell membrane chromatography/C18 column/time-of-flight mass spectrometry system

引用

Journal of Pharmaceutical Analysis 2022年第5期12卷 725-732页

作者： Xinyi chai yanqiu Gu Lei Lv chun Chen Fei Feng yan Cao Yue Liu Zhenyu Zhu Zhanying Hong Yifeng chai Xiaofei Chen School of Pharmacy Shanghai Key Laboratory for Pharmaceutical Metabolite ResearchNaval Medical University(Second Military Medical University)Shanghai 200433China Department of Pharmacy Shanghai Ninth People's HospitalShanghai Jiao Tong University School of MedicineShanghai201999China Department of Pharmacy Shanghai Eastern Hepatobiliary Surgery HospitalNaval Medical University(Second Military Medical University)Shanghai200438China

Astragali Radix(AR)is a clinically used herbal medicine with multiple immunomodulatory activities that can strengthen the activity and cytotoxicity of natural killer(NK)***,owing to the complexity of its composition,the specific active ingredients in AR that act on NK cells are not clear *** membrane chromatography(CMC)is mainly used to screen the active ingredients in a complex system of herbal *** this study,a new comprehensive two-dimensional(2D)NK-92MI CMC/C18 column/time-of-flight mass spectrometry(TOFMS)system was established to screen for potential NK cell *** obtain a higher column efficiency,3-mercaptopropyltrimethoxysilane-modified silica was synthesized to prepare the NK-92MI CMC *** total,nine components in AR were screened from this system,which could be washed out from the NK-92MI/CMC column after 10 min,and they showed good affinity for NK-92MI/CMC *** representative active compounds of AR,isoastragaloside Ⅰ and astragaloside IV,promoted the killing effect of NK cells on K562 cells in a dose-dependent *** can thus suggest that isoastragaloside Ⅰ and astragaloside Ⅳ are the main immunomodulatory components of *** comprehensive 2D NK-92MI CMC analytical system is a practical method for screening immune cell activators from other herbal medicines with immunomodulatory effects.

关键词： NK cell activators Cell membrane chromatography Immunomodulatory herbal medicine Covalent bonding

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Molecular ferroelectrics for efficient perovskite solar cells

引用

Science China Chemistry 2021年第2期64卷 169-170页

作者： chun-Hua yan Beijing National Laboratory for Molecular Sciences State Key Laboratory of Rare Earth Materials Chemistry and ApplicationsPKU-HKU Joint Laboratory in Rare Earth Materials and Bioinorganic ChemistryCollege of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871China College of Chemistry and Chemical Engineering Lanzhou UniversityLanzhou 730000China

During the past decade,the power conversion efficiencies(PCEs)of organic-inorganic hybrid perovskite solar cells(PSCs)have exceeded 25%[1],which is expected to be one of the candidates for the next generation of thin-film photovoltaic *** speaking,the performance of PSCs mainly depends on the light absorption capacity,defect passivation and photo-induced exciton separation and extraction of perovskite *** the light illumination,photo-induced excitons were separated and extracted by the built-in electric field of PSCs.

关键词： perovskite illumination inorganic

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：