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Recent Advances in Self-assembled Nano-therapeutics

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Chinese Journal of Polymer Science 2018年第3期36卷 322-346页

作者： chun-xiong zheng Yu Zhao Yang Liu Key Laboratory of Functional Polymer Materials of Ministry of Education Institute of Polymer ChemistryCollege of Chemistryand State Key Laboratory of Medicinal Chemical BiologyNankai UniversityTianjin 300071China

The applications of nanotechnology in biomedicine have gained considerable attentions in recent years owing to the great enhancement of therapeutic *** of self-assembly into nanotechnology has brought tremendous convenience during the formation of *** on distinctive methods of self-assembly,nano-therapeutics have beer~developed to ar~impressive stage with the ability to perform site-specific delivery with temporal and spatial *** review focuses on the recent advances in the preparing methods for nano-therapeutics,and their applications in the treatments of diseases.

关键词： Self-assembly Nano-therapeutics Hydrophobic effect Electrostatic interaction Supramolecular host-guest interaction

Dendrobium officinale polysaccharide attenuates type 2 diabetes in mice model by modulating gut microbiota and alleviating intestinal mucosal barrier damage

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Food Science and Human Wellness 2025年第1期14卷 112-123页

作者： Xiaoxia Chen chun Chen Changyang Ma Wenyi Kang Junlin Wu xiong Fu Guangdong Province Key Laboratory for Green Processing of Natural Products and Product Safety Guangzhou 510640China SCUT-Zhuhai Institute of Modern Industrial Innovation School of Food Science and EngineeringSouth China University of TechnologyGuangzhou 510640China Guangzhou Institute of Modern Industrial Technology Guangzhou 511458China Overseas Expertise Introduction Center for Discipline Innovation of Food Nutrition and Human Health(111 Center) Guangzhou 510640China National R&D Center for Edible Fungus Processing Technology Henan UniversityKaifeng 475004China Guangzhou Wondfo Health Science and Technology Co. Ltd.Guangzhou 510640China

The purpose of this study was to investigate the hypoglycemic effect and mechanism of D endrobium officinale polysaccharide(DOP)on type 2 diabetes mellitus(T2DM)mice established by high-fat diet and *** results showed that DOP improved glycolipid metabolism and serum inflammation levels,and inhibited intestinal-derived lipopolysaccharide(LPS)translocation,suggesting that inhibiting LPS-mediated intestinal barrier damage may be a key target for DOP to alleviate ***,the study found that DOP reduced intestinal inflammation and oxidative stress levels,significantly up-regulated the mRNA expression of tight junction proteins Claudin-1,Occludin and zonula occluden-1(ZO-1),and ameliorated intestinal epithelial *** addition,DOP strongly inhibited the intestinal pathogenic bacteria and LPS-producing bacteria Helicobacter,Enterococcus and Desulfovibrio with a reduction rate of 95%,73% and 9%,respectively,and promoted the proliferation of anti-inflammatory bacteria Bifidobacterium and Lactobacillus by 139% and 8%,*** together,the hypoglycemic effect of DOP was related to the protection of intestinal mucosal barrier,and its underlying mechanism lied in its excellent anti-inflammatory and gut microbiotamodulatory effects,providing a theoretical basis for developing DOP as a novel prebiotic in functional food for diabetes.

关键词： Dendrobium officinale polysaccharide Hypoglycemic Mechanism Lipopolysaccharide Gut microbiota

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“农业面源和重金属污染农田综合防治与修复技术研发”专项组织实施进展分析

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农业环境科学学报 2017年第7期36卷 1242-1246页

作者：徐长春熊炜郑戈林友华农业部科技发展中心北京100122

按照国家科技计划管理改革的整体部署,国家重点研发计划启动了"农业面源和重金属污染农田综合防治与修复技术研发"重点专项。按照"基础研究、共性关键技术研发、技术集成创新研究与示范"全链条设计、一体化实施,专项聚焦产业发展问题,... 详细信息

按照国家科技计划管理改革的整体部署,国家重点研发计划启动了"农业面源和重金属污染农田综合防治与修复技术研发"重点专项。按照"基础研究、共性关键技术研发、技术集成创新研究与示范"全链条设计、一体化实施,专项聚焦产业发展问题,为实现农业面源和重金属污染农田有效防治、农业生态环境健康和农产品质量安全有效提升的多重目标提供科技支撑。通过介绍农业面源专项的整体情况,分析目前专项组织实施的最新进展,总结专项管理机制方面的实践探索,以期为有关科研人员和行业部门提供参考。

关键词：国家重点研发计划农业面源和重金属污染实施进展管理机制

低黏附性正电纳米胶囊用于耐药性细菌生物被膜感染治疗

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高分子学报 2019年第3期50卷 300-310,M0006页

作者：刘晨晖曹京京赵宇郑春雄郑雅丹刘琦张展展刘阳功能高分子材料教育部重点实验室南开大学化学系天津300071

为了增强抗生素在生物被膜内部的渗透性能,并使其在生物被膜底部富集,设计了一种新颖的具有强渗透性和酸响应快速释放药物能力的纳米胶囊.这种纳米载药体系由酸响应内核和强渗透性外壳两部分组成.其中,纳米药物载体的内核由席夫碱键桥... 详细信息

为了增强抗生素在生物被膜内部的渗透性能,并使其在生物被膜底部富集,设计了一种新颖的具有强渗透性和酸响应快速释放药物能力的纳米胶囊.这种纳米载药体系由酸响应内核和强渗透性外壳两部分组成.其中,纳米药物载体的内核由席夫碱键桥联的聚己内酯(bi-PCL)共沉淀形成,外壳则通过原位聚合的方法在其表面形成一层富含2-甲基丙烯酰氧乙基磷酸胆碱(MPC)和N-(2-氨基丙基)甲基丙烯酰胺(APM)的无规交联网状聚合物.由于纳米胶囊表面由正电性的pAPM和低黏附性的pMPC共聚构成,在两者协同作用下,纳米胶囊可迅速渗透至生物被膜底部,同时由bi-PCL构成的内核在生物被膜内部酸性环境刺激下快速断键释放负载的药物.基于这一结构,该纳米胶囊可在给药后短时间内实现药物富集于生物被膜底部,从而快速有效地杀伤生物被膜内部的细菌,显著提高对生物被膜相关细菌感染的治疗效果.

关键词：生物被膜纳米胶囊响应性聚合物两性离子聚合物

Beyond the tumor region:Peritumoral radiomics enhances prognostic accuracy in locally advanced rectal cancer

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World Journal of Gastroenterology 2025年第8期31卷 49-65页

作者： Zhi-Ying Liang Mao-Li Yu Hui Yang Hao-Jiang Li Hui Xie chun-Yan Cui Wei-Jing Zhang Chao Luo Pei-Qiang Cai Xiao-Feng Lin Kun-Feng Liu Lang xiong Li-Zhi Liu Bi-Yun Chen Department of Radiology State Key Laboratory of Oncology in South ChinaGuangdong Provincial Clinical Research Center for CancerSun Yat-sen University Cancer CenterGuangzhou 510060Guangdong ProvinceChina Department of Radiology West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina West China School of Medicine Sichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Medical Imaging First Affiliated Hospital of Gannan Medical UniversityGanzhou 341000Jiangxi ProvinceChina

BACKGROUND The peritumoral region possesses attributes that promote cancer growth and ***,the potential prognostic biomarkers in this region remain relatively underexplored in *** To investigate the prognostic value and importance of peritumoral radiomics in locally advanced rectal cancer(LARC).METHODS This retrospective study included 409 patients with biopsy-confirmed LARC treated with neoadjuvant chemoradiotherapy and *** were divided into training(n=273)and validation(n=136)*** on intratumoral and peritumoral radiomic features extracted from pretreatment axial high-resolution small-field-of-view T2-weighted images,multivariate Cox models for progression-free survival(PFS)prediction were developed with or without clinicoradiological features and evaluated with Harrell’s concordance index(C-index),calibration curve,and decision curve *** stratification,Kaplan-Meier analysis,and permutation feature importance analysis were *** The comprehensive integrated clinical-radiological-omics model(ModelICRO)integrating seven peritumoral,three intratumoral,and four clinicoradiological features achieved the highest C-indices(0.836 and 0.801 in the training and validation sets,respectively).This model showed robust calibration and better clinical net benefits,effectively distinguished high-risk from low-risk patients(PFS:97.2%vs 67.6%and 95.4%vs 64.8%in the training and validation sets,respectively;both P<0.001).Three most influential predictors in the comprehensive ModelICRO were,in order,a peritumoral,an intratumoral,and a clinicoradiological ***,the peritumoral model outperformed the intratumoral model(C-index:0.754 vs 0.670;P=0.015);peritumoral features significantly enhanced the performance of models based on clinicoradiological or intratumoral features or their *** Peritumoral radiomics holds greater prognostic value than intratumoral radiomics for predicting PFS in L

关键词： Rectal cancer Peritumoral radiomics Intratumoral radiomics Prognosis analysis Variable importance analysis Tumor microenvironment

非均匀采样在小分子化合物结构鉴定中的应用策略——以附子灵为例

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药学学报 2025年第1期60卷 218-224页

作者：张莉莉张可刘杰蒙春旺冯芮熊亮成都中医药大学药学院西南特色中药资源国家重点实验室四川成都611137 成都中医药大学医学技术学院四川成都611137

二维核磁共振(2D NMR)是一种广泛应用于小分子化合物结构解析的技术,可获得化合物的氢-氢相关、氢-碳单键相关、氢-碳远程相关及氢-氢空间排布等信息,在小分子化合物结构鉴定中具有不可替代的作用。然而植物化学研究中微量成分的样品量... 详细信息

二维核磁共振(2D NMR)是一种广泛应用于小分子化合物结构解析的技术,可获得化合物的氢-氢相关、氢-碳单键相关、氢-碳远程相关及氢-氢空间排布等信息,在小分子化合物结构鉴定中具有不可替代的作用。然而植物化学研究中微量成分的样品量极低,采用传统采样方法(即均匀采样法)存在谱图质量较差和耗时过长的问题。通过增大扫描次数会导致单个二维谱的采集时间长达数小时,这又引起核磁共振仪机时紧张的问题。非均匀采样(non-uniform sampling,NUS)技术在保证2D NMR谱图质量的同时,还可较大程度缩短数据采集时间,这大大提高了二维谱图采集的效率。本文选择附子药材中小分子化合物——附子灵为研究对象,以均匀采样(uniform sampling,US)和NUS方法分别采集其1H-^(13)C HSQC、^(1)H-^(1)H COSY、HMBC和NOESY谱,对比两种采样方法的附子灵中三类基团核磁信号的积分值,证实了NUS技术在小分子化合物结构鉴定中具有提高谱图质量和缩短采集时间的优势;并在HMBC谱中,进一步证实了NUS技术能提高二维谱图质量和信号分辨率,表明NUS技术可提高小分子化合物结构鉴定的效率和可靠性。

关键词：核磁共振二维核磁共振谱图非均匀采样小分子化合物附子灵

Effect of stress-relief annealing on thermal fatigue cracks for die-casting die steels

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Journal of Iron and Steel Research International 2024年第5期31卷 1164-1176页

作者： Zhi-xiong Bai Xiao-chun Wu School of Materials Science and Engineering Shanghai UniversityShanghai200444China

The effect of stress-relief annealing at different stages of thermal fatigue tests on crack growth was investigated using a self-built thermal cycle *** results showed that annealing could limit crack expansion *** reduced dislocation density and released the accumulation of residual *** addition,the strain accumulation in carbides was reduced by this *** was also found that double annealing was even more effective at inhibiting crack expansion compared to single stress-relief *** 1000 cycles,the maximum crack length was reduced by 31.1%and 45.2%for the samples after using the optimal single and double annealing processes,*** single stress-relief annealing,earlier annealing provides more benefit in delaying crack ***,effective double stress-relief annealing requires a suitable time interval between the annealing ***,after 800 cycles,surface hardness decreased significantly accompanied by an increase in the size and number of carbides,and cracks expanded predominantly along grain boundaries.

关键词： Thermal fatigue Steel Carbide Stress-relief annealing Dislocation Residual stress

Artificial intelligence-driven strategies for managing renal and urinary complications in inflammatory bowel disease

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World Journal of Nephrology 2025年第1期14卷 6-12页

作者： Ya-xiong Guo xiong Yan Xu-Chang Liu Yu-Xiang Liu chun Liu Surgical Unit 1 Shanxi Combined Traditional Chinese and Western Medicine HospitalTaiyuan 030072Shanxi ProvinceChina No.1 Clinical Medical School Shanxi Medical UniversityTaiyuan 030001Shanxi ProvinceChina Department of Nephrology Shanxi Provincial People’s HospitalTaiyuan 030012Shanxi ProvinceChina

In this editorial,we discuss the article by Singh et al published in World Journal of Nephrology,stating the need for timely adjustments in inflammatory bowel disease(IBD)patients'long-term management *** is chronic and lifelong,with recurrence and remission cycles,including ulcerative colitis and Crohn's ***'s exact etiology is unknown but likely *** to gut flora and immune *** intestinal symptoms,IBD can also affect various extrain-testinal manifestations such as those involving the skin,joints,eyes and urinary *** anatomical proximity of urinary system waste disposal to that of the alimentary canal makes early detection and the differentiation of such symptoms very *** studies show that IBD and it's first-line drugs have nephro-toxicity,impacting the patients'life *** guidelines give very few references for kidney lesion *** et al's plan aims to improve treatment management for IBD patients with glomerular filtration rate decline,specifically those at *** of IBD patients are young and they need lifelong *** early therapy cessation,taking into account drug side effects,can be *** intelligence-driven diagnosis and treatment has a big potential for management improvements in IBD and other chronic diseases.

关键词： Inflammatory bowel disease Renal complications Artificial intelligence Long-term management Nephrotoxicity

基于时效性竞争优势的高铁快运动车组物流产品设计

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中国铁路 2025年第1期 115-122页

作者：熊纯李海鹰肖云李元凯王莹北京交通大学交通运输学院北京100044 长江沿岸铁路集团股份有限公司发展规划部湖北武汉430062 中国铁路上海局集团有限公司科技和信息化部上海200071

近年我国快递市场需求不断增长,高铁快运动车组作为快递运输新方式,具有时效性强、运量大、安全性高等优势,适合运输附加值较高且对时效性敏感的货物。为了充分发挥其时效性的优势,采用KANO模型对货物的时效性需求进行调研和分析,并通过... 详细信息

近年我国快递市场需求不断增长,高铁快运动车组作为快递运输新方式,具有时效性强、运量大、安全性高等优势,适合运输附加值较高且对时效性敏感的货物。为了充分发挥其时效性的优势,采用KANO模型对货物的时效性需求进行调研和分析,并通过Better-Worse系数计算不同需求的重要度,进而确定了高铁快运动车组的时效性优势产品。在此基础上,通过与公路、航空运输对比分析,确定了不同时效性产品下高铁快运动车组开行的优势距离。进一步考虑对需求的吸引,确定了在“点对点”一站直达和重要节点沿途停靠2种组织模式下高铁快运动车组开行的优势距离和辐射范围。最后,以沿江高铁为例,设计了2种组织模式下不同节点间的次日达和次晨达物流产品,为沿江高铁快运动车组物流产品设计提供理论支撑。

关键词：高铁快运物流产品设计动车组时效性优势距离